JOP20210162A1 - جسيم نانوي، وعامل تباين للتصوير بالرنين المغناطيسي يشتمل على الجسيم النانوي، ومركب ترابطي ثنائي القطب - Google Patents
جسيم نانوي، وعامل تباين للتصوير بالرنين المغناطيسي يشتمل على الجسيم النانوي، ومركب ترابطي ثنائي القطبInfo
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- JOP20210162A1 JOP20210162A1 JOP/2021/0162A JOP20210162A JOP20210162A1 JO P20210162 A1 JOP20210162 A1 JO P20210162A1 JO P20210162 A JOP20210162 A JO P20210162A JO P20210162 A1 JOP20210162 A1 JO P20210162A1
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- contrast agent
- nanoparticle
- ligand compound
- magnetic resonance
- resonance imaging
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- 239000002872 contrast media Substances 0.000 title abstract 5
- 238000002595 magnetic resonance imaging Methods 0.000 title abstract 5
- 239000002105 nanoparticle Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
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- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
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Abstract
يتعلق الاختراع الحالي بتقديم جسيم نانوي جديد، عامل تباين للتصوير بالرنين المغناطيسي يحتوي على الجسيم النانوي، ومركب ترابطي ثنائي القطب يستخدم في إنتاج الجسيم النانوي. يمكن استخدام عامل التباين للتصوير MRI وفقاً للاختراع الحالي على نحو مناسب كعامل تباين لـ MRI في المجال الطبي. يكون الجسيم النانوي والمركب الترابطي ثنائي القطب وفقاً للاختراع الحالي قابلين للتطبيق على تركيبات صيدلانية متنوعة وما شابه ذلك، بما في ذلك عامل تباين لـ MRI، ويمكن استخدامها على نطاق واسع في المجالات الصيدلانية، التكنولوجيا الحيوية، وما شابه ذلك، بما في ذلك مختلف طرق التشخيص والمواد الكاشفة للفحص.
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JP2018245927 | 2018-12-27 | ||
PCT/JP2019/051354 WO2020138389A1 (ja) | 2018-12-27 | 2019-12-27 | ナノ粒子、これを含む磁気共鳴イメージング用造影剤及び双性イオンリガンド化合物 |
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JOP/2021/0162A JOP20210162A1 (ar) | 2018-12-27 | 2019-12-27 | جسيم نانوي، وعامل تباين للتصوير بالرنين المغناطيسي يشتمل على الجسيم النانوي، ومركب ترابطي ثنائي القطب |
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CN (1) | CN113227040A (ar) |
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CO (1) | CO2021009388A2 (ar) |
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KR101311295B1 (ko) * | 2011-07-13 | 2013-09-25 | 주식회사 유진로봇 | 이동 로봇의 휠 조립체 |
WO2013090601A2 (en) | 2011-12-16 | 2013-06-20 | Massachusetts Institute Of Technology | Compact nanoparticles for biological applications |
JP6471227B2 (ja) * | 2014-09-15 | 2019-02-13 | マサチューセッツ インスティテュート オブ テクノロジー | 磁気共鳴画像法用途のためのナノ粒子 |
KR20200018579A (ko) * | 2017-06-28 | 2020-02-19 | 리켄 | 나노 입자, 이를 함유하는 자기 공명 영상용 조영제 및 리간드 화합물 |
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2019
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SG11202107083SA (en) | 2021-07-29 |
EP3904331A4 (en) | 2022-10-05 |
CN113227040A (zh) | 2021-08-06 |
IL284383A (en) | 2021-08-31 |
KR20210109574A (ko) | 2021-09-06 |
JP7360577B2 (ja) | 2023-10-13 |
CA3124757A1 (en) | 2020-07-02 |
EP3904331A1 (en) | 2021-11-03 |
MX2021007731A (es) | 2021-08-05 |
JPWO2020138389A1 (ja) | 2021-11-04 |
BR112021012694A2 (pt) | 2021-10-05 |
ZA202104733B (en) | 2022-09-28 |
WO2020138389A1 (ja) | 2020-07-02 |
PH12021551522A1 (en) | 2022-02-28 |
CO2021009388A2 (es) | 2021-07-30 |
AU2019415375A1 (en) | 2021-07-29 |
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