JOP20200078A1 - أجسام مضادة خاصة بـ cd47 وpd-l1 - Google Patents
أجسام مضادة خاصة بـ cd47 وpd-l1Info
- Publication number
- JOP20200078A1 JOP20200078A1 JOP/2020/0078A JOP20200078A JOP20200078A1 JO P20200078 A1 JOP20200078 A1 JO P20200078A1 JO P20200078 A JOP20200078 A JO P20200078A JO P20200078 A1 JOP20200078 A1 JO P20200078A1
- Authority
- JO
- Jordan
- Prior art keywords
- antibodies
- relates
- antibodies specific
- antigen
- present
- Prior art date
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 2
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 2
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 2
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
أجسام مضادة خاصة بـ CD47 وPD-L1 الملخص يتعلق الاختراع الحالي بمجال الهندسة الحيوية، وتحديداً بأجسام مضادة أو شظايا منها رابطة لمولد الضد، وباستخدامها. وبشكل أكثر تحديداً، يتعلق الاختراع الحالي بأجسام مضادة والتي ترتبط على وجه الخصوص بـ CD47 وPD-L1. يتعلق الاختراع أيضاً بحمض نووي والذي يقوم بترميز الجسم المضاد المحدد أو لشظية منه رابطة لمولد الضد، بناقل التعبير الوراثي، وبطريقة لإنتاج الجسم المضاد، وباستخدام الأجسام المضادة والتركيبات المذكورة سابقاً في علاج السرطان.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201791961A EA039662B1 (ru) | 2017-10-03 | 2017-10-03 | Антитела, специфичные к cd47 и pd-l1 |
PCT/EA2018/050001 WO2019068302A1 (ru) | 2017-10-03 | 2018-10-03 | Антитела, специфичные к cd47 и pd-l1 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20200078A1 true JOP20200078A1 (ar) | 2020-04-30 |
Family
ID=65994976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0078A JOP20200078A1 (ar) | 2017-10-03 | 2018-10-03 | أجسام مضادة خاصة بـ cd47 وpd-l1 |
Country Status (21)
Country | Link |
---|---|
US (1) | US11840567B2 (ar) |
EP (1) | EP3693390A4 (ar) |
JP (2) | JP2020535839A (ar) |
KR (1) | KR20200058542A (ar) |
CN (1) | CN111801352A (ar) |
AR (1) | AR113342A1 (ar) |
AU (1) | AU2018345458A1 (ar) |
BR (1) | BR112020006706A2 (ar) |
CA (1) | CA3078413A1 (ar) |
CL (1) | CL2020000919A1 (ar) |
CO (1) | CO2020004199A2 (ar) |
EA (1) | EA039662B1 (ar) |
EC (1) | ECSP20024555A (ar) |
JO (1) | JOP20200078A1 (ar) |
MA (1) | MA49599B1 (ar) |
MX (1) | MX2020004027A (ar) |
PE (1) | PE20210460A1 (ar) |
PH (1) | PH12020550214A1 (ar) |
TW (1) | TWI768129B (ar) |
WO (1) | WO2019068302A1 (ar) |
ZA (1) | ZA202002047B (ar) |
Families Citing this family (27)
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AU2017336867B2 (en) | 2016-09-29 | 2024-03-14 | Beijing Hanmi Pharmaceutical Co., Ltd. | Heterodimeric immunoglobulin constructs and preparation methods thereof |
EP3533804A4 (en) | 2016-11-18 | 2020-06-17 | Beijing Hanmi Pharmaceutical Co., Ltd. | BISPECIFIC ANTIBODY TYPE ANTI-PD -1 / ANTI-HER2 NATURAL ANTIBODY HETERODIMERIC FORM AND PREPARATION THEREOF |
KR20200093639A (ko) * | 2017-12-04 | 2020-08-05 | 북경한미약품 유한공사 | 천연 항체 구조-유사 헤테로다이머 형태의 항 pd-l1/항 cd47 이중특이성 항체 및 이의 제조 |
CN109970860A (zh) * | 2017-12-27 | 2019-07-05 | 信达生物制药(苏州)有限公司 | 三链抗体、其制备方法及其用途 |
US11713353B2 (en) | 2018-01-15 | 2023-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-1 |
WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
EP3564263A1 (en) * | 2018-05-03 | 2019-11-06 | Universitätsklinikum Hamburg-Eppendorf | Fusion proteins comprising a cell surface marker specific vhh |
US20220289848A1 (en) * | 2019-05-17 | 2022-09-15 | Nanjing GenScript Biotech Co., Ltd. | Anti-cd47/anti-pd-l1 multiple antigen binding proteins and methods of use thereof |
KR20220036998A (ko) * | 2019-06-25 | 2022-03-23 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | 항 cd47/pd-l1 이중특이성 항체를 포함하는 제제, 이의 제조 방법 및 용도 |
CN114072426B (zh) * | 2019-07-08 | 2024-01-26 | 南京金斯瑞生物科技有限公司 | 抗cd47/抗pd-1双特异抗体及其制备方法和应用 |
CA3156160A1 (en) * | 2019-09-27 | 2021-04-01 | Beijing Starmab Biomed Technology Ltd. | Monospecific and multi-specific antibodies |
CN112745392B (zh) * | 2019-10-30 | 2022-07-01 | 上海洛启生物医药技术有限公司 | 抗pd-l1/cd47双特异性抗体及其用途 |
IL293926A (en) * | 2019-12-17 | 2022-08-01 | Pfizer | Antibodies unique to d47, pd-l1 and their uses |
CN115315445A (zh) * | 2020-02-12 | 2022-11-08 | 上海诗健生物科技有限公司 | 一种靶向人cd47的单域抗体及其用途 |
WO2022057939A1 (en) * | 2020-09-21 | 2022-03-24 | I-Mab Biopharma Co., Ltd. | Pharmaceutical composition comprising cd47 antibody and pd-1/pd-l1 inhibitor |
US20240067728A1 (en) * | 2020-11-06 | 2024-02-29 | Bio-Thera Solutions, Ltd. | Bispecific antibody and use thereof |
EP4253415A1 (en) * | 2020-11-12 | 2023-10-04 | Mabwell (Shanghai) Bioscience Co., Ltd. | Antibody and preparation method therefor |
KR20220118961A (ko) * | 2021-02-19 | 2022-08-26 | (주)샤페론 | Cd47에 대한 단일 도메인 항체 및 이의 용도 |
KR20220118963A (ko) * | 2021-02-19 | 2022-08-26 | (주)샤페론 | Pd-l1 및 cd47에 대한 이중특이적 단일 도메인 항체 및 이의 용도 |
WO2022177393A1 (ko) * | 2021-02-19 | 2022-08-25 | (주)샤페론 | Pd-l1에 대한 단일 도메인 항체 및 이의 용도 |
CN117279948A (zh) * | 2021-05-07 | 2023-12-22 | 益免安协公司 | 与cd47和pd-l1特异性结合的双特异性抗体 |
AR126185A1 (es) * | 2021-06-21 | 2023-09-27 | Joint Stock Company Biocad | Anticuerpo biespecífico aislado que se une específicamente a cd47 y pd-l1 |
CN115702931A (zh) * | 2021-08-06 | 2023-02-17 | 百奥泰生物制药股份有限公司 | 抗pd-l1/cd47双特异抗体在治疗疾病中的应用 |
WO2023051680A1 (zh) * | 2021-09-30 | 2023-04-06 | 正大天晴药业集团股份有限公司 | 针对免疫检查点的双特异性抗体 |
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CN105330741B (zh) | 2005-07-01 | 2023-01-31 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
EP2262837A4 (en) * | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
ES2592216T3 (es) | 2008-09-26 | 2016-11-28 | Dana-Farber Cancer Institute, Inc. | Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos |
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NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
HUE060541T2 (hu) | 2010-05-14 | 2023-03-28 | Univ Leland Stanford Junior | Humanizált és kiméra monoklonális CD47 elleni ellenanyagok |
SI2812443T1 (sl) | 2012-02-06 | 2019-10-30 | Inhibrx Inc | Protitelesa CD47 in postopki za njihovo uporabo |
JP6392770B2 (ja) * | 2012-12-03 | 2018-09-19 | ノビミューン エスアー | 抗cd47抗体およびその使用方法 |
AU2013359167B2 (en) | 2012-12-12 | 2018-08-23 | Arch Oncology, Inc. | Therapeutic CD47 antibodies |
GB201300706D0 (en) | 2013-01-15 | 2013-02-27 | Cancer Rec Tech Ltd | Antibody |
KR102276974B1 (ko) | 2013-02-06 | 2021-07-13 | 인히브릭스, 인크. | 비-혈소판 및 비-적혈구 세포 격감성 cd47 항체 및 이를 이용하는 방법 |
WO2016023001A1 (en) * | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
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JP2018535692A (ja) | 2015-09-21 | 2018-12-06 | エラスムス ユニバーシティ メディカル センターErasmus University Medical Center | 抗cd47抗体及び使用方法 |
RU2665790C1 (ru) * | 2017-04-17 | 2018-09-04 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело к pd-l1 |
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2017
- 2017-10-03 EA EA201791961A patent/EA039662B1/ru unknown
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2018
- 2018-09-28 TW TW107134503A patent/TWI768129B/zh active
- 2018-10-03 WO PCT/EA2018/050001 patent/WO2019068302A1/ru unknown
- 2018-10-03 CA CA3078413A patent/CA3078413A1/en active Pending
- 2018-10-03 BR BR112020006706-7A patent/BR112020006706A2/pt unknown
- 2018-10-03 EP EP18864490.0A patent/EP3693390A4/en active Pending
- 2018-10-03 CN CN201880078338.5A patent/CN111801352A/zh active Pending
- 2018-10-03 PE PE2020000513A patent/PE20210460A1/es unknown
- 2018-10-03 KR KR1020207012767A patent/KR20200058542A/ko active Search and Examination
- 2018-10-03 JO JOP/2020/0078A patent/JOP20200078A1/ar unknown
- 2018-10-03 JP JP2020519341A patent/JP2020535839A/ja active Pending
- 2018-10-03 AU AU2018345458A patent/AU2018345458A1/en active Pending
- 2018-10-03 MX MX2020004027A patent/MX2020004027A/es unknown
- 2018-10-03 US US16/753,587 patent/US11840567B2/en active Active
- 2018-10-03 MA MA49599A patent/MA49599B1/fr unknown
- 2018-10-04 AR ARP180102862A patent/AR113342A1/es unknown
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2020
- 2020-04-03 PH PH12020550214A patent/PH12020550214A1/en unknown
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- 2020-04-08 CO CONC2020/0004199A patent/CO2020004199A2/es unknown
- 2020-05-04 ZA ZA2020/02047A patent/ZA202002047B/en unknown
- 2020-05-06 EC ECSENADI202024555A patent/ECSP20024555A/es unknown
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MA49599B1 (fr) | 2023-05-31 |
BR112020006706A2 (pt) | 2020-10-06 |
TW201922781A (zh) | 2019-06-16 |
RU2020115122A (ru) | 2021-10-29 |
CL2020000919A1 (es) | 2020-10-16 |
MA49599A1 (fr) | 2021-01-29 |
PE20210460A1 (es) | 2021-03-08 |
AU2018345458A2 (en) | 2020-05-21 |
JP2023130455A (ja) | 2023-09-20 |
MX2020004027A (es) | 2020-08-13 |
EP3693390A1 (en) | 2020-08-12 |
ECSP20024555A (es) | 2020-06-30 |
AR113342A1 (es) | 2020-04-22 |
RU2020115122A3 (ar) | 2021-10-29 |
WO2019068302A1 (ru) | 2019-04-11 |
US11840567B2 (en) | 2023-12-12 |
KR20200058542A (ko) | 2020-05-27 |
JP2020535839A (ja) | 2020-12-10 |
EA201791961A1 (ru) | 2019-04-30 |
PH12020550214A1 (en) | 2021-02-15 |
EP3693390A4 (en) | 2021-11-03 |
CO2020004199A2 (es) | 2020-04-24 |
EA039662B1 (ru) | 2022-02-24 |
AU2018345458A1 (en) | 2020-05-14 |
ZA202002047B (en) | 2022-08-31 |
CA3078413A1 (en) | 2019-04-11 |
TWI768129B (zh) | 2022-06-21 |
CN111801352A (zh) | 2020-10-20 |
US20200270345A1 (en) | 2020-08-27 |
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