JO3522B1 - تركيب صيدلاني يتألف من كريات حمراء تغلف إنزيم يعتمد على بيريدكسال الفوسفات والعامل المساعد له - Google Patents
تركيب صيدلاني يتألف من كريات حمراء تغلف إنزيم يعتمد على بيريدكسال الفوسفات والعامل المساعد لهInfo
- Publication number
- JO3522B1 JO3522B1 JOP/2015/0030A JOP20150030A JO3522B1 JO 3522 B1 JO3522 B1 JO 3522B1 JO P20150030 A JOP20150030 A JO P20150030A JO 3522 B1 JO3522 B1 JO 3522B1
- Authority
- JO
- Jordan
- Prior art keywords
- plp
- dependent enzyme
- pharmaceutical composition
- cofactor
- erythrocytes
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01005—Tyrosine transaminase (2.6.1.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y404/00—Carbon-sulfur lyases (4.4)
- C12Y404/01—Carbon-sulfur lyases (4.4.1)
- C12Y404/01011—Methionine gamma-lyase (4.4.1.11)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurology (AREA)
Abstract
يتعلق الاختراع الحالي بتركيبة صيدلانية محتوية على إنزيم أساسه PLP واختياريًا العامل المشترك الخاص به، بَيرِيدُكْسال فوسفات (PLP)، و/أو مادة منتجة لـ PLP من فوسفات أو من غير الفوسفات، استخدامه كعقار، طريقة إنتاجه وطريقة علاجية ذات صلة به. تشتمل التركيبة الصيدلانية على كريات حمراء ومادة ناقلة مقبولة صيدلانيًا، الكريات الحمراء التي تُغلّف إنزيم أساسه PLP. يمكن أن يكون الإنزيم الذي أساسه PLP عبارة عن مِثيونيناز، تيروزين فينول - لياز، تيروزين ناقلة الأمين أو سيسْتاتيُونين بيتا - سينثاز.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1451100A FR3017299B1 (fr) | 2014-02-12 | 2014-02-12 | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3522B1 true JO3522B1 (ar) | 2020-07-05 |
Family
ID=50729647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2015/0030A JO3522B1 (ar) | 2014-02-12 | 2015-02-12 | تركيب صيدلاني يتألف من كريات حمراء تغلف إنزيم يعتمد على بيريدكسال الفوسفات والعامل المساعد له |
Country Status (17)
Country | Link |
---|---|
US (3) | US10046009B2 (ar) |
EP (2) | EP3104875B1 (ar) |
JP (1) | JP6563958B2 (ar) |
KR (1) | KR102354103B1 (ar) |
CN (2) | CN106255506B (ar) |
AU (2) | AU2015217045B2 (ar) |
BR (1) | BR112016017337B1 (ar) |
CA (1) | CA2938469C (ar) |
CL (1) | CL2016002020A1 (ar) |
ES (1) | ES2808849T3 (ar) |
FR (1) | FR3017299B1 (ar) |
IL (1) | IL246941B (ar) |
JO (1) | JO3522B1 (ar) |
MX (1) | MX2016010235A (ar) |
RU (2) | RU2744659C2 (ar) |
SG (2) | SG11201606264SA (ar) |
WO (1) | WO2015121348A2 (ar) |
Families Citing this family (23)
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BR112016011195A2 (pt) | 2013-11-18 | 2017-09-19 | Rubius Therapeutics Inc | Células eritroides enucleadas e seus métodos de fabricação, composição farmacêutica e seu uso, uso de uma população de células eritroides, biorreator, mistura de células e dispositivo médico |
FR3017299B1 (fr) | 2014-02-12 | 2018-05-18 | Erytech Pharma | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
DK3125927T3 (da) | 2014-04-01 | 2021-04-19 | Rubius Therapeutics Inc | Fremgangsmåder og sammensætninger til immunmodulering |
EP3187190A1 (en) | 2015-12-31 | 2017-07-05 | Erytech Pharma | Method of treating a mammal, including human, against cancer using methionine and asparagine depletion |
RS62939B1 (sr) | 2016-01-11 | 2022-03-31 | Rubius Therapeutics Inc | Kompozicije i metode u vezi sa multimodalnim terapijskim ćelijskim sistemima u indikacijama kancera |
CN109562185A (zh) | 2016-06-02 | 2019-04-02 | 赛诺菲 | 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 |
US11744859B2 (en) * | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
US11001826B2 (en) | 2017-10-19 | 2021-05-11 | Anticancer, Inc. | Orally administered composition to lower serum methionine levels and method of use |
KR20200095507A (ko) | 2017-12-01 | 2020-08-10 | 사노피 | 글루코오스 감지 단백질에 결합할 수 있는 모이어티 및 약제의 신규 접합체 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
WO2020099592A1 (en) | 2018-11-15 | 2020-05-22 | Erytech Pharma | Synergistic combinations of methionine depletion agents and immune checkpoint modulators |
KR20220005028A (ko) | 2019-04-26 | 2022-01-12 | 루비우스 테라퓨틱스, 아이엔씨. | 탈핵 적혈구를 포함하는 조성물 |
AU2020283752A1 (en) | 2019-05-24 | 2021-12-23 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
AU2020379755A1 (en) | 2019-11-04 | 2022-05-26 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells using myo-inositol |
EP4055148A1 (en) | 2019-11-04 | 2022-09-14 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells using taurine or hypotaurine |
US20230226218A1 (en) | 2020-05-11 | 2023-07-20 | Erytech Pharma | Red Cell Extracellular Vesicles (RCEVs) Containing Cargoes and Methods of Use and Production Thereof |
WO2022150578A1 (en) | 2021-01-08 | 2022-07-14 | Rubius Therapeutics, Inc. | Methods of treating a tumor in a human subject |
WO2022150569A1 (en) | 2021-01-08 | 2022-07-14 | Rubius Therapeutics, Inc. | METHODS OF INCREASING NKp30-POSITIVE LYMPHOCYTES IN A SUBJECT AND USES THEREOF |
TW202304482A (zh) | 2021-03-14 | 2023-02-01 | 美商盧比亞斯治療公司 | 於個體中增加nkg2d陽性淋巴球之方法及其用途 |
CA3220735A1 (en) * | 2021-05-21 | 2022-11-24 | Codexis, Inc. | Engineered methionine gamma lyase variants |
TW202317179A (zh) | 2021-06-03 | 2023-05-01 | 美商盧比亞斯治療公司 | 在個體中治療hpv16-陽性或hpv16-相關的癌症之方法 |
CN113481253B (zh) * | 2021-06-09 | 2022-05-24 | 连云港杰瑞药业有限公司 | 生物催化制备磷酸吡哆醛的方法 |
WO2023067200A1 (en) | 2021-10-24 | 2023-04-27 | Erytech Pharma | Asparaginase encapsulated in red blood cells for the treatment of pancreatic cancer |
Family Cites Families (23)
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FR1354204A (fr) | 1963-01-22 | 1964-03-06 | Auxiliaire De L Entpr Soc | Dispositif de prévention d'accident pour benne de chargement notamment d'une bétonnière |
FR2529463B1 (fr) * | 1982-07-05 | 1986-01-10 | Centre Nat Rech Scient | Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus |
US5631271A (en) * | 1986-11-29 | 1997-05-20 | Serfontein; Willem J. | Methods and preparations for the treatment and prophylaxis of metabolic disturbances |
US5254572A (en) * | 1987-11-27 | 1993-10-19 | Vesta Medicines (Pty) Ltd. | Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed |
US6475767B1 (en) | 1997-03-13 | 2002-11-05 | Shionogi & Co., Ltd. | Process for producing L-methionine γ-lyase crystals |
WO2002029040A2 (en) * | 2000-10-06 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | 25219, a novel human aminotransferase and uses therefor |
WO2005045055A2 (en) | 2003-07-31 | 2005-05-19 | Anticancer, Inc. | The use of plp with peg-rmetase in vivo for enhanced efficacy |
FR2873925B1 (fr) | 2004-08-05 | 2006-10-13 | Erytech Pharma Soc Par Actions | Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes |
FR2884717B1 (fr) | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
RU2362572C2 (ru) * | 2007-07-17 | 2009-07-27 | Юрий Георгиевич Каминский | Способ снижения концентрации аммиака в крови с помощью аммоцитов и инкапсулированной глутаминсинтетазы |
FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
FR2925339B1 (fr) | 2007-12-24 | 2010-03-05 | Erytech Pharma | Medicament pour le traitement du cancer du pancreas |
US20100316620A1 (en) | 2008-02-13 | 2010-12-16 | Vanessa Bourgeaux | Formulation and Method for the Prevention and Treatment of Skeletal Manifestation of Gaucher's Disease |
FR2928270B1 (fr) | 2008-03-10 | 2011-01-21 | Erytech Pharma | Formulation methode pour la prevention ou le traitement des metastases osseuses et autres maladies de l'os |
FR2938332B1 (fr) | 2008-11-07 | 2011-11-25 | Erytech Pharma | Test predictif de la neutralisation de l'activite asparaginase |
CN101429506A (zh) * | 2008-12-15 | 2009-05-13 | 吉林大学 | 基于红细胞载体的fish-in-net固定化酶 |
FR2944106B1 (fr) | 2009-04-03 | 2012-09-28 | Erytech Pharma | Methode de dosage de l'inositol hexaphosphate (ihp). |
PT2493487T (pt) | 2009-10-27 | 2016-11-08 | Erytech Pharma | Composição para induzir uma tolerância imunitária específica |
CN104394884A (zh) | 2012-03-21 | 2015-03-04 | 爱瑞泰克药物公司 | 用于治疗急性髓细胞白血病(aml)的药剂 |
FR3005420B1 (fr) | 2013-05-07 | 2015-09-18 | Erytech Pharma | Procede de stabilisation de suspensions d'erythrocytes encapsulant un principe actif, suspensions obtenues. |
EP2813234A1 (en) | 2013-06-11 | 2014-12-17 | Erytech Pharma | Composition of erythrocytes encapsulating phenylalanine hydroxylase and therapeutic use thereof |
FR3017299B1 (fr) | 2014-02-12 | 2018-05-18 | Erytech Pharma | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
EP3187190A1 (en) * | 2015-12-31 | 2017-07-05 | Erytech Pharma | Method of treating a mammal, including human, against cancer using methionine and asparagine depletion |
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2014
- 2014-02-12 FR FR1451100A patent/FR3017299B1/fr active Active
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2015
- 2015-02-12 SG SG11201606264SA patent/SG11201606264SA/en unknown
- 2015-02-12 CN CN201580007812.1A patent/CN106255506B/zh active Active
- 2015-02-12 EP EP15705563.3A patent/EP3104875B1/en active Active
- 2015-02-12 BR BR112016017337-6A patent/BR112016017337B1/pt active IP Right Grant
- 2015-02-12 KR KR1020167022067A patent/KR102354103B1/ko active IP Right Grant
- 2015-02-12 EP EP20173043.9A patent/EP3718562A1/en active Pending
- 2015-02-12 RU RU2019123935A patent/RU2744659C2/ru active
- 2015-02-12 CN CN202010182496.4A patent/CN111358941B/zh active Active
- 2015-02-12 US US15/117,588 patent/US10046009B2/en active Active
- 2015-02-12 CA CA2938469A patent/CA2938469C/en active Active
- 2015-02-12 ES ES15705563T patent/ES2808849T3/es active Active
- 2015-02-12 RU RU2016133315A patent/RU2697086C2/ru active
- 2015-02-12 WO PCT/EP2015/052962 patent/WO2015121348A2/en active Application Filing
- 2015-02-12 MX MX2016010235A patent/MX2016010235A/es unknown
- 2015-02-12 AU AU2015217045A patent/AU2015217045B2/en active Active
- 2015-02-12 JP JP2016568136A patent/JP6563958B2/ja active Active
- 2015-02-12 JO JOP/2015/0030A patent/JO3522B1/ar active
- 2015-02-12 SG SG10201907367QA patent/SG10201907367QA/en unknown
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2016
- 2016-07-25 IL IL246941A patent/IL246941B/en active IP Right Grant
- 2016-08-10 CL CL2016002020A patent/CL2016002020A1/es unknown
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2018
- 2018-02-21 AU AU2018201237A patent/AU2018201237B2/en active Active
- 2018-08-13 US US16/102,171 patent/US10780126B2/en active Active
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- 2020-09-22 US US17/028,383 patent/US11458170B2/en active Active
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