ITTO950002A0 - Trombopoietina. - Google Patents
Trombopoietina.Info
- Publication number
- ITTO950002A0 ITTO950002A0 ITTO950002A ITTO950002A ITTO950002A0 IT TO950002 A0 ITTO950002 A0 IT TO950002A0 IT TO950002 A ITTO950002 A IT TO950002A IT TO950002 A ITTO950002 A IT TO950002A IT TO950002 A0 ITTO950002 A0 IT TO950002A0
- Authority
- IT
- Italy
- Prior art keywords
- thrombopoietin
- Prior art date
Links
- 102000036693 Thrombopoietin Human genes 0.000 title 1
- 108010041111 Thrombopoietin Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Vehicle Body Suspensions (AREA)
- Information Transfer Systems (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17655394A | 1994-01-03 | 1994-01-03 | |
US18560794A | 1994-01-21 | 1994-01-21 | |
US08/196,689 US8357513B1 (en) | 1994-01-03 | 1994-02-15 | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
US22326394A | 1994-04-04 | 1994-04-04 | |
US08/249,376 US8192955B1 (en) | 1994-01-03 | 1994-05-25 | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
US34865894A | 1994-12-02 | 1994-12-02 | |
US08/348,657 US6660256B1 (en) | 1994-01-03 | 1994-12-02 | Porcine mpl ligand |
Publications (3)
Publication Number | Publication Date |
---|---|
ITTO950002A0 true ITTO950002A0 (it) | 1995-01-02 |
ITTO950002A1 ITTO950002A1 (it) | 1995-07-03 |
IT1283770B1 IT1283770B1 (it) | 1998-04-30 |
Family
ID=27569151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95TO000002A IT1283770B1 (it) | 1994-01-03 | 1995-01-02 | Trombopoietina. |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0738323A1 (it) |
JP (2) | JPH09508262A (it) |
CN (1) | CN1134539C (it) |
AU (1) | AU704266B2 (it) |
BG (1) | BG63639B1 (it) |
CA (1) | CA2178482C (it) |
CZ (1) | CZ296130B6 (it) |
DK (1) | DK149194A (it) |
ES (1) | ES2114786B1 (it) |
FI (1) | FI121573B (it) |
FR (1) | FR2714670B1 (it) |
GB (1) | GB2285446B (it) |
HR (1) | HRP941020A2 (it) |
HU (1) | HUT75657A (it) |
IE (1) | IE72517B1 (it) |
IL (1) | IL112184A (it) |
IT (1) | IT1283770B1 (it) |
LU (1) | LU88573A1 (it) |
LV (1) | LV11632B (it) |
NL (1) | NL9500010A (it) |
NO (1) | NO326903B1 (it) |
NZ (1) | NZ278726A (it) |
PT (1) | PT101627B (it) |
RO (1) | RO117110B1 (it) |
SG (1) | SG47030A1 (it) |
SI (1) | SI9420079A (it) |
SK (1) | SK282265B6 (it) |
WO (1) | WO1995018858A1 (it) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
EP0675201A1 (en) * | 1994-03-31 | 1995-10-04 | Amgen Inc. | Compositions and methods for stimulating megakaryocyte growth and differentiation |
US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
TW387940B (en) * | 1995-01-17 | 2000-04-21 | Kirin Brewery | Anti-tpo monodonal antibody |
JPH11500308A (ja) | 1995-02-03 | 1999-01-12 | ジー.ディー.サール アンド カンパニー | 新規c−MPLリガンド |
CN1161468C (zh) * | 1995-02-15 | 2004-08-11 | 安姆根有限公司 | Mpl配体类似物 |
US5696250A (en) | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
ZA964382B (en) * | 1995-06-06 | 1997-12-01 | Genentech Inc | Lymphotoxin and thrombopoietin for use in the treatment of cancer. |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
ZA964814B (en) * | 1995-06-07 | 1998-02-09 | Glaxo Group Ltd | Peptides and compounds that bind to a receptor. |
TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
AU728881B2 (en) * | 1996-08-13 | 2001-01-18 | Zymogenetics Inc. | Expression vectors, cells, and methods for preparing thrombopoietin polypeptides |
EP0983082A1 (en) * | 1997-05-21 | 2000-03-08 | Genentech, Inc. | Novel administration of thrombopoietin |
US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
KR20000006549A (ko) * | 1998-06-30 | 2000-01-25 | 윤재승 | 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체 |
US20030228666A1 (en) | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
DE122009000039I1 (de) | 1998-10-23 | 2009-11-05 | Kirin Amgen Inc | Thrombopoietin substitute |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
US20050177884A1 (en) | 2001-11-15 | 2005-08-11 | Kirin Beer Kabushiki Kaisha | Chimeric nonhuman animal |
KR100467750B1 (ko) * | 2001-11-29 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
CA2499625A1 (en) | 2002-09-18 | 2004-04-01 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
SI1675606T1 (sl) | 2003-08-28 | 2017-07-31 | Janssen Pharmaceuticals, Inc. | Peptidi in spojine, ki se vežejo na trombopoietinske receptorje |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
JP2007537755A (ja) | 2004-05-18 | 2007-12-27 | イントレクソン コーポレイション | Dnaクローニングベクタープラスミドのダイナミックなベクター構築のための方法 |
CA2572765C (en) | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
WO2007098547A1 (en) * | 2006-03-01 | 2007-09-07 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
EP2044197B8 (en) | 2006-07-24 | 2018-03-07 | The University Of Queensland | Method of producing a population of cells |
TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
EP2738257A1 (en) | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
EP2390261A4 (en) | 2009-01-20 | 2012-11-14 | Hanall Biopharma Co Ltd | MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND METHOD FOR THE PRODUCTION THEREOF |
WO2014089478A1 (en) * | 2012-12-07 | 2014-06-12 | University Of Tennessee Research Foundation | Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same |
CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
CN103555760B (zh) * | 2013-10-18 | 2015-05-20 | 江苏康禾生物制药有限公司 | 一种重组人血小板生成素的制备方法及其制剂 |
EP3255055B1 (en) * | 2015-12-21 | 2024-06-05 | BrainOn Inc. | Composition for improving memory, learning ability and cognition |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
CA3148158A1 (en) * | 2019-09-20 | 2021-03-25 | Longcheng Li | Nucleic acid molecule for treating thrombocytopenia and use thereof |
IL294098A (en) | 2019-12-20 | 2022-08-01 | Instil Bio Uk Ltd | Devices and methods for isolating lymphocytes infiltrating tumors and their use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260417A (en) | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
JPH07501703A (ja) * | 1991-12-06 | 1995-02-23 | ジェネンテク,インコーポレイテッド | プロホルモンコンバターゼで形質転換された細胞およびポリペプチド合成 |
IL139335A (en) | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
-
1994
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en active IP Right Grant
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
- 1994-12-30 ES ES09402681A patent/ES2114786B1/es not_active Expired - Fee Related
- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
-
1995
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
-
1996
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
-
1997
- 1997-03-27 JP JP9074906A patent/JPH10113186A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |