ITPN20100027A1 - PROCESS FOR THE PREPARATION OF CYLINDERS AND GRANULES USABLE IN THE VETERINARY INDUSTRY AND MANGEMENT CONTAINING PHARMACOLOGICALLY ACTIVE PRINCIPLES, SUPPLEMENTS, NUTRIENTS, VITAMINS OR MICRO-ORGANISMS - Google Patents
PROCESS FOR THE PREPARATION OF CYLINDERS AND GRANULES USABLE IN THE VETERINARY INDUSTRY AND MANGEMENT CONTAINING PHARMACOLOGICALLY ACTIVE PRINCIPLES, SUPPLEMENTS, NUTRIENTS, VITAMINS OR MICRO-ORGANISMS Download PDFInfo
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- ITPN20100027A1 ITPN20100027A1 IT000027A ITPN20100027A ITPN20100027A1 IT PN20100027 A1 ITPN20100027 A1 IT PN20100027A1 IT 000027 A IT000027 A IT 000027A IT PN20100027 A ITPN20100027 A IT PN20100027A IT PN20100027 A1 ITPN20100027 A1 IT PN20100027A1
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- Italy
- Prior art keywords
- active components
- vitamins
- glass transition
- coating
- transition temperature
- Prior art date
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- 239000008187 granular material Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 9
- 230000008569 process Effects 0.000 title claims description 8
- 244000005700 microbiome Species 0.000 title claims description 6
- 229940088594 vitamin Drugs 0.000 title claims description 5
- 235000013343 vitamin Nutrition 0.000 title claims description 5
- 239000011782 vitamin Substances 0.000 title claims description 5
- 229930003231 vitamin Natural products 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 3
- 235000015097 nutrients Nutrition 0.000 title claims 2
- 239000013589 supplement Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 9
- 230000009477 glass transition Effects 0.000 claims description 9
- 239000001993 wax Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000008188 pellet Substances 0.000 claims description 7
- 229920000249 biocompatible polymer Polymers 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 241001553290 Euphorbia antisyphilitica Species 0.000 claims description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 2
- 241000186660 Lactobacillus Species 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 230000001195 anabolic effect Effects 0.000 claims description 2
- 235000013871 bee wax Nutrition 0.000 claims description 2
- 239000012166 beeswax Substances 0.000 claims description 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 2
- 235000013869 carnauba wax Nutrition 0.000 claims description 2
- 239000004203 carnauba wax Substances 0.000 claims description 2
- 229960004203 carnitine Drugs 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 229960002442 glucosamine Drugs 0.000 claims description 2
- 229940039696 lactobacillus Drugs 0.000 claims description 2
- 235000019136 lipoic acid Nutrition 0.000 claims description 2
- 229960003511 macrogol Drugs 0.000 claims description 2
- 239000002831 pharmacologic agent Substances 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 239000006041 probiotic Substances 0.000 claims description 2
- 230000000529 probiotic effect Effects 0.000 claims description 2
- 235000018291 probiotics Nutrition 0.000 claims description 2
- 239000012177 spermaceti Substances 0.000 claims description 2
- 229940084106 spermaceti Drugs 0.000 claims description 2
- 229960002663 thioctic acid Drugs 0.000 claims description 2
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 claims description 2
- 229960004885 tiamulin Drugs 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 229940045860 white wax Drugs 0.000 claims description 2
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 2
- 229940124586 β-lactam antibiotics Drugs 0.000 claims description 2
- 230000000050 nutritive effect Effects 0.000 claims 1
- 235000015927 pasta Nutrition 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000005453 pelletization Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000012438 extruded product Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/11—Coating with compositions containing a majority of oils, fats, mono/diglycerides, fatty acids, mineral oils, waxes or paraffins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P30/00—Shaping or working of foodstuffs characterised by the process or apparatus
- A23P30/20—Extruding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Manufacturing & Machinery (AREA)
- Biophysics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Descrizione Description
L'industria mangimistica e veterinaria ha ideato nel corso degli anni vari sistemi di ricopertura, tuttavia tali sistemi espongono il composto attivo a stress chimico e fisico con notevoli problemi di stabilità dello stesso. Over the years, the animal feed and veterinary industry has devised various coating systems, however these systems expose the active compound to chemical and physical stress with considerable stability problems.
Il processo descritto offre un sistema molto “delicato” per la ricopertura e la protezione dei componenti attivi. I pellets e i granuli si ottengono per estrusione a temperature controllate di una miscela di cere alimentari e/ polimeri biocompatibili ad uso mangimistico con i componenti attivi che si intendono proteggere. The process described offers a very “delicate” system for the coating and protection of the active components. The pellets and granules are obtained by extrusion at controlled temperatures of a mixture of food waxes and biocompatible polymers for feed use with the active components that are intended to be protected.
Tale miscela può essere introdotta nell' estrusore in forma liquida (sospensione) o solida (miscela di polveri o granuli) o semisolida (pasta). L’estruso del diametro desiderato viene tagliato alla lunghezza desiderata e quindi raffreddato. This mixture can be introduced into the extruder in liquid form (suspension) or solid (mixture of powders or granules) or semi-solid (paste). The extrudate of the desired diameter is cut to the desired length and then cooled.
Questi pellets o granuli possono essere utilizzabili: These pellets or granules can be used:
- tali e quali in miscela con i mangimi già pellettizzati ad uso mangimistico comune. - as they are in a mixture with pelleted feeds for common feed use.
- miscelati agli alimenti per animali in fase di pellettizzazione del mangime. - mixed with animal feed in the feed pelletizing phase.
Tali pellets hanno lo scopo di proteggere i componenti attivi, daN'umidità, dal calore e dalla pressione, garantendo una minima degradazione dei composti attivi nelle fasi di lavorazione successive e nel periodo di stoccaggio prima dell' uso. These pellets have the purpose of protecting the active components from humidity, heat and pressure, ensuring minimal degradation of the active compounds in the subsequent processing stages and in the storage period before use.
L’uso di somministrare mangimi pellettizzati agli animali in allevamento, in particolare a bovini ed equini, porta grossi vantaggi nella programmazione dell’alimentazione favorendo miscele a composizione costante e contenente tutti i principi attivi destinati all’alimentazione, evita la formazione di polvere nel luogo di somministrazione e rende più facile per gli allevatori il controllo dei quantitativi somministrati ad ogni singolo animale. The use of feeding pelletized feed to farm animals, in particular to cattle and horses, brings great advantages in feeding planning by favoring mixtures with a constant composition and containing all the active ingredients intended for feeding, avoids the formation of dust in the place. of administration and makes it easier for farmers to control the quantities administered to each individual animal.
Scopo del processo è la produzione di pellets e granuli per l’industria veterinaria e mangimistica che permettano di fornire all' animale principi farmacologicamente attivi, integratori alimentari .nutrienti , vitamine, microorganismi sia con funzione probiotica, nutritiva e/o anabolizzante che con funzione farmacologica. The purpose of the process is the production of pellets and granules for the veterinary and feed industry that allow to provide the animal with pharmacologically active ingredients, nutritional supplements, vitamins, microorganisms both with probiotic, nutritional and / or anabolic function and with pharmacological function. .
Tali pellets assicurano una stabilità dei componenti attivi superiore a quella ottenibile con i metodi comunemente utilizzati. These pellets ensure a stability of the active components higher than that obtainable with the commonly used methods.
Per l’esecuzione del processo produttivo si deve procedere a preparare una miscela per alimentare l'estrusore. Si mescolano quindi con mezzi idonei il componente attivo e la cera alimentare e/o il polimero biocompatibile e/o miscele di questi composti, eventualmente addizionandola di oli in modo da controllare il punto di fusione e la temperatura di transizione vetrosa della stessa. To carry out the production process, a mixture must be prepared to feed the extruder. The active component and the food wax and / or the biocompatible polymer and / or mixtures of these compounds are then mixed with suitable means, possibly adding oils in order to control the melting point and the glass transition temperature of the same.
Si scalda quindi la miscela fino alla temperatura di transizione vetrosa in modo da formare una pasta. The mixture is then heated up to the glass transition temperature to form a paste.
Tale pasta si può ottenere anche per raffreddamento di una sospensione tra cera fusa e i componenti attivi. This paste can also be obtained by cooling a suspension between melted wax and the active components.
L'estrusore è dotato di un sistema per controllare la temperatura, che può essere elettrico o ottenuto mediante la circolazione di un fluido termostatato che circola nelle camicie dell’ estrusore stesso. The extruder is equipped with a system to control the temperature, which can be electric or obtained by the circulation of a thermostated fluid that circulates in the jackets of the extruder itself.
Nell' ultima parte della coclea che spinge la pasta all' interno della trafilatrice la temperatura deve essere di alcuni gradi superiore alla temperatura di transizione vetrosa, e il trafilato in uscita dall’estrusore deve essere a temperatura inferiore a quella di transizione vetrosa. In the last part of the screw that pushes the dough inside the drawing machine, the temperature must be a few degrees higher than the glass transition temperature, and the extruder output from the extruder must be at a lower temperature than the glass transition temperature.
Tale abbassamento di temperatura può essere ottenuto con mezzi idonei quali, ad esempio, una termostatazione della trafila (disco forato di estrusione) o un raffreddamento mediante soffiaggio di aria raffreddata sull' estruso. This lowering of temperature can be obtained with suitable means such as, for example, thermostating of the die (perforated extrusion disc) or cooling by blowing cooled air onto the extrudate.
I sistemi comunemente utilizzati dall' industria per ottenere una protezione dei componenti attivi sono: la granulazione e la ricopertura. The systems commonly used by the industry to obtain protection of the active components are: granulation and coating.
Granulazione Granulation
La granulazione può essere effettuata ad umido, con l'utilizzo di acqua o solventi organici, oppure a secco. Granulation can be carried out wet, with the use of water or organic solvents, or dry.
La granulazione ad umido con acqua ha i seguenti svantaggi: Wet granulation with water has the following disadvantages:
- Non può essere utilizzata con microorganismi secchi, in quanto gli stessi si attivano e quindi muoiono al contatto con l’acqua. - E’ efficace solo con sostanze poco solubili in acqua. - It cannot be used with dry microorganisms, as they are activated and therefore die in contact with water. - It is only effective with substances that are not very soluble in water.
- La fase di essiccamento necessaria per rimuovere l’acqua espone il prodotto al calore. - The drying phase necessary to remove the water exposes the product to heat.
- Richiede l'utilizzo di eccipienti leganti. - Requires the use of binding excipients.
La granulazione ad umido con solventi ha i seguenti svantaggi: Wet granulation with solvents has the following disadvantages:
- Si devono utilizzare i solventi in impianti antideflagranti.con relativi costi e rischi - Solvents must be used in explosion-proof systems, with related costs and risks
- Non può essere utilizzata con microorganismi, in quanto gli stessi sono sensibili agli alcoli normalmente utilizzati. - It cannot be used with microorganisms, as they are sensitive to the alcohols normally used.
- La fase di essiccamento necessaria per rimuovere il solvente espone il prodotto al calore - The drying phase necessary to remove the solvent exposes the product to heat
- Richiede l’utilizzo di eccipienti leganti. - Requires the use of binding excipients.
La granulazione a secco offre la possibilità di ottenere dei pellets e dei granuli, ma per la loro produzione sono necessarie pressioni elevate che compromettono la stabilità dei componenti attivi. Dry granulation offers the possibility of obtaining pellets and granules, but high pressures are required for their production, which compromise the stability of the active components.
Ricopertura Recoating
I sistemi di ricopertura utilizzano lacche o cere , il sistema comunemente utilizzato è la tecnologia WURSTER, che prevede lo spruzzo di cera fusa su un letto fluido di granuli di componente attivo. La ricopertura si applica quindi su prodotti che hanno già subito lo stress di granulazione. The coating systems use lacquers or waxes, the commonly used system is the WURSTER technology, which involves the spray of melted wax on a fluid bed of active component granules. The coating is therefore applied to products that have already undergone granulation stress.
A questo si aggiunge lo stress dovuto alla solidificazione della cera trasferisce ai componenti attivi il calore latente di solidificazione, degradando ulteriormente i componenti attivi presenti. To this is added the stress due to the solidification of the wax transfers the latent heat of solidification to the active components, further degrading the active components present.
II processo riportato e facente parte dell'invenzione, rispetto a tutti i sistemi citati sopra presenta i seguenti vantaggi: The process reported and forming part of the invention, compared to all the systems mentioned above, has the following advantages:
- E' applicabile a componenti attivi in forma di liquidi, polveri o granuli indifferentemente. - It can be applied to active components in the form of liquids, powders or granules indifferently.
- Non è necessario fare assorbire ai componenti attivi il calore latente di solidificazione, in quanto la tecnologia si basa sul cambio di fase dovuto al passaggio per la temperatura di transizione vetrosa, e questo passaggio non trasferisce calore latente al componente attivo. - It is not necessary to make the active components absorb the latent heat of solidification, as the technology is based on the phase change due to the passage through the glass transition temperature, and this passage does not transfer latent heat to the active component.
- E' applicabile a microorganismi secchi ed a tutte le sostanze indipendentemente dalla loro solubilità. - It is applicable to dry microorganisms and to all substances regardless of their solubility.
- Protegge con una sostanza idrofoba, evitando quindi il contatto con l’umidità ambientale. - Protects with a hydrophobic substance, thus avoiding contact with environmental humidity.
- In fase di pellettizzazione dell’ estruso protetto durante la preparazione dei mangimi la cera fonde e protegge il componente attivo dal calore. - In the pelletizing phase of the extruded product protected during the preparation of the feed, the wax melts and protects the active component from heat.
- La temperatura di transizione vetrosa è sempre inferiore alla temperatura di fusione. - The glass transition temperature is always lower than the melting temperature.
Con il seguente processo è possibile ricoprire a titolo di esempio ma non limitativo i seguenti componenti: With the following process it is possible to cover, by way of example but not limitation, the following components:
Lactobacillus Lactobacillus
Saccharomyces cerevisiae Saccharomyces cerevisiae
SAME SAME
Tiamulina HFU Tiamulin HFU
Glucosamina/Conditrina Glucosamine / Chonditrin
Estratti vegetali Plant extracts
Vitamine Vitamins
Acido alfa lipoico Alpha lipoic acid
Acetil L. carnitina Acetyl L. carnitine
Antibiotici beta lattamici Beta lactam antibiotics
L’agente ricoprente può essere cera alimentare e/o un polimero biocompatibile e/o miscele in varie percentuali di questi composti, citati a titolo di esempio ma non limitativo: The coating agent can be food wax and / or a biocompatible polymer and / or mixtures in various percentages of these compounds, cited by way of example but not limited to:
Cera d’api Beeswax
Stearina vegetale Vegetable stearin
Candelilla Candelilla
Cera carnauba Carnauba wax
Macrogol Macrogol
Spermaceti sintetico Synthetic spermaceti
Cera bianca White wax
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000027A ITPN20100027A1 (en) | 2010-05-12 | 2010-05-12 | PROCESS FOR THE PREPARATION OF CYLINDERS AND GRANULES USABLE IN THE VETERINARY INDUSTRY AND MANGEMENT CONTAINING PHARMACOLOGICALLY ACTIVE PRINCIPLES, SUPPLEMENTS, NUTRIENTS, VITAMINS OR MICRO-ORGANISMS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000027A ITPN20100027A1 (en) | 2010-05-12 | 2010-05-12 | PROCESS FOR THE PREPARATION OF CYLINDERS AND GRANULES USABLE IN THE VETERINARY INDUSTRY AND MANGEMENT CONTAINING PHARMACOLOGICALLY ACTIVE PRINCIPLES, SUPPLEMENTS, NUTRIENTS, VITAMINS OR MICRO-ORGANISMS |
Publications (1)
| Publication Number | Publication Date |
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| ITPN20100027A1 true ITPN20100027A1 (en) | 2011-11-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000027A ITPN20100027A1 (en) | 2010-05-12 | 2010-05-12 | PROCESS FOR THE PREPARATION OF CYLINDERS AND GRANULES USABLE IN THE VETERINARY INDUSTRY AND MANGEMENT CONTAINING PHARMACOLOGICALLY ACTIVE PRINCIPLES, SUPPLEMENTS, NUTRIENTS, VITAMINS OR MICRO-ORGANISMS |
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| IT (1) | ITPN20100027A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020756A1 (en) * | 1996-11-14 | 1998-05-22 | Unilever N.V. | Complete flavor mix transformed into the glassy state |
| US5972395A (en) * | 1997-04-25 | 1999-10-26 | Kraft Foods, Inc. | Method of preparing glass stabilized material |
| EP1836902A1 (en) * | 2006-03-23 | 2007-09-26 | Firmenich Sa | Extruded glassy vitamin C particles |
| WO2008101554A1 (en) * | 2007-02-22 | 2008-08-28 | Evonik Röhm Gmbh | Pellets comprising an active substance matrix and a polymer coating, and a method for producing said pellets |
-
2010
- 2010-05-12 IT IT000027A patent/ITPN20100027A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020756A1 (en) * | 1996-11-14 | 1998-05-22 | Unilever N.V. | Complete flavor mix transformed into the glassy state |
| US5972395A (en) * | 1997-04-25 | 1999-10-26 | Kraft Foods, Inc. | Method of preparing glass stabilized material |
| EP1836902A1 (en) * | 2006-03-23 | 2007-09-26 | Firmenich Sa | Extruded glassy vitamin C particles |
| WO2008101554A1 (en) * | 2007-02-22 | 2008-08-28 | Evonik Röhm Gmbh | Pellets comprising an active substance matrix and a polymer coating, and a method for producing said pellets |
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