ITPD920145A1 - Uso terapeutico della fosforil-l-serina-n-acil-sfingosina - Google Patents

Uso terapeutico della fosforil-l-serina-n-acil-sfingosina

Info

Publication number
ITPD920145A1
ITPD920145A1 IT000145A ITPD920145A ITPD920145A1 IT PD920145 A1 ITPD920145 A1 IT PD920145A1 IT 000145 A IT000145 A IT 000145A IT PD920145 A ITPD920145 A IT PD920145A IT PD920145 A1 ITPD920145 A1 IT PD920145A1
Authority
IT
Italy
Prior art keywords
sphingosine
phosphoryl
serine
acyl
pct
Prior art date
Application number
IT000145A
Other languages
English (en)
Inventor
Gunter Kirschner
Giampaolo Menon
Aurelio Romeo
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of ITPD920145A0 publication Critical patent/ITPD920145A0/it
Priority to ITPD920145A priority Critical patent/IT1260155B/it
Priority to DE69307895T priority patent/DE69307895T2/de
Priority to EP93917729A priority patent/EP0652755B1/en
Priority to AU47062/93A priority patent/AU4706293A/en
Priority to CA002141557A priority patent/CA2141557A1/en
Priority to JP6505008A priority patent/JPH07509478A/ja
Priority to AT93917729T priority patent/ATE148345T1/de
Priority to US08/374,624 priority patent/US5556843A/en
Priority to ES93917729T priority patent/ES2101334T3/es
Priority to PCT/EP1993/002061 priority patent/WO1994003178A1/en
Publication of ITPD920145A1 publication Critical patent/ITPD920145A1/it
Application granted granted Critical
Publication of IT1260155B publication Critical patent/IT1260155B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITPD920145A 1992-08-03 1992-08-03 Uso terapeutico della fosforil-l-serina-n-acil-sfingosina IT1260155B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITPD920145A IT1260155B (it) 1992-08-03 1992-08-03 Uso terapeutico della fosforil-l-serina-n-acil-sfingosina
CA002141557A CA2141557A1 (en) 1992-08-03 1993-08-02 Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine
EP93917729A EP0652755B1 (en) 1992-08-03 1993-08-02 Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine
AU47062/93A AU4706293A (en) 1992-08-03 1993-08-02 Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine
DE69307895T DE69307895T2 (de) 1992-08-03 1993-08-02 Therapeutische verwendung von phosphoryl-l-serin-n-acyl-sphingosin
JP6505008A JPH07509478A (ja) 1992-08-03 1993-08-02 ホスホリル−ｌ−セリン−ｎ−アシル−スフィンゴシンの治療用使用
AT93917729T ATE148345T1 (de) 1992-08-03 1993-08-02 Therapeutische verwendung von phosphoryl-l-serin- n-acyl-sphingosin
US08/374,624 US5556843A (en) 1992-08-03 1993-08-02 Therapeutic use of phosphoryl-L-serine-N-acyl-sphingosine
ES93917729T ES2101334T3 (es) 1992-08-03 1993-08-02 Utilizacion terapeutica de la fosforil-l-serina-n-acil-esfingosina.
PCT/EP1993/002061 WO1994003178A1 (en) 1992-08-03 1993-08-02 Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD920145A IT1260155B (it) 1992-08-03 1992-08-03 Uso terapeutico della fosforil-l-serina-n-acil-sfingosina

Publications (3)

Publication Number Publication Date
ITPD920145A0 ITPD920145A0 (it) 1992-08-03
ITPD920145A1 true ITPD920145A1 (it) 1994-02-03
IT1260155B IT1260155B (it) 1996-03-28

Family

ID=11390037

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD920145A IT1260155B (it) 1992-08-03 1992-08-03 Uso terapeutico della fosforil-l-serina-n-acil-sfingosina

Country Status (10)

Country Link
US (1) US5556843A (it)
EP (1) EP0652755B1 (it)
JP (1) JPH07509478A (it)
AT (1) ATE148345T1 (it)
AU (1) AU4706293A (it)
CA (1) CA2141557A1 (it)
DE (1) DE69307895T2 (it)
ES (1) ES2101334T3 (it)
IT (1) IT1260155B (it)
WO (1) WO1994003178A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083920A (en) * 1995-12-21 2000-07-04 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration
EP0821068A3 (en) * 1996-03-29 1999-06-02 Rohm And Haas Company Novel sphingolipids and a process thereto
EP1293124A3 (en) * 1996-03-29 2003-04-09 Dow AgroSciences LLC Method of treatment of plants with sphingolipids
DE69838789T2 (de) * 1997-03-12 2008-10-30 Suzanne Cambridge de la Monte Verfahren zur behandlung oder prävention der alzheimerischen krankheit
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
JP2002532416A (ja) * 1998-12-17 2002-10-02 マインドセット・バイオファーマシューティカルズ・（ユーエスエイ）・インコーポレイテッド 脳のグルコース利用の増進
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
KR20020027463A (ko) * 1999-07-12 2002-04-13 우에노 도시오 스핀고신-1-인산 수용체 아고니스트 또는스핀고신-1-인산을 유효 성분으로서 함유하는 선유화 억제제
AR074061A1 (es) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc Inhibidores de s1p liasa para el tratamiento de la malaria cerebral y formulacion farmaceutica
KR20170025909A (ko) 2015-08-31 2017-03-08 가천대학교 산학협력단 스핑고신 1-인산 또는 Sphk2의 발현을 상승시키는 물질을 포함하는 대사 기능 장애의 예방 또는 치료용 약학 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01135720A (ja) * 1987-11-20 1989-05-29 Eisai Co Ltd 神経線維再生剤

Also Published As

Publication number Publication date
ATE148345T1 (de) 1997-02-15
CA2141557A1 (en) 1994-02-17
EP0652755B1 (en) 1997-01-29
WO1994003178A1 (en) 1994-02-17
ES2101334T3 (es) 1997-07-01
IT1260155B (it) 1996-03-28
DE69307895T2 (de) 1997-08-14
JPH07509478A (ja) 1995-10-19
AU4706293A (en) 1994-03-03
US5556843A (en) 1996-09-17
DE69307895D1 (de) 1997-03-13
ITPD920145A0 (it) 1992-08-03
EP0652755A1 (en) 1995-05-17

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960701