IT8447780A0 - Drivati della fisostigmina con proprieta' di inibizione della aceticolinesterasi e relativo procedimento di produzione - Google Patents
Drivati della fisostigmina con proprieta' di inibizione della aceticolinesterasi e relativo procedimento di produzioneInfo
- Publication number
- IT8447780A0 IT8447780A0 IT8447780A IT4778084A IT8447780A0 IT 8447780 A0 IT8447780 A0 IT 8447780A0 IT 8447780 A IT8447780 A IT 8447780A IT 4778084 A IT4778084 A IT 4778084A IT 8447780 A0 IT8447780 A0 IT 8447780A0
- Authority
- IT
- Italy
- Prior art keywords
- drivates
- physostigmin
- acetycholinesterase
- production procedure
- related production
- Prior art date
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT47780/84A IT1199076B (it) | 1984-03-01 | 1984-03-01 | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
AT85101945T ATE54917T1 (de) | 1984-03-01 | 1985-02-22 | Physostigminderivate mit acetylcholinesteraseinhibitoreigenschaften, und das entsprechende herstellungsverfahren. |
DE8585101945T DE3578789D1 (de) | 1984-03-01 | 1985-02-22 | Physostigminderivate mit acetylcholinesterase-inhibitoreigenschaften, und das entsprechende herstellungsverfahren. |
EP89116950A EP0354594A3 (en) | 1984-03-01 | 1985-02-22 | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
EP85101945A EP0154864B1 (en) | 1984-03-01 | 1985-02-22 | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
JP60038994A JPS60208982A (ja) | 1984-03-01 | 1985-03-01 | アセチルコリンエステラーゼ抑制特性を有するヒソスチグミン誘導体およびその製造方法 |
US06/929,516 US4831155A (en) | 1984-03-01 | 1986-11-12 | Physostigmine derivatives with acetylcholinesterase inhibition properties, and manufacture |
US07/343,282 US5306825A (en) | 1984-03-01 | 1989-04-26 | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT47780/84A IT1199076B (it) | 1984-03-01 | 1984-03-01 | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8447780A0 true IT8447780A0 (it) | 1984-03-01 |
IT1199076B IT1199076B (it) | 1988-12-30 |
Family
ID=11262469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT47780/84A IT1199076B (it) | 1984-03-01 | 1984-03-01 | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
Country Status (6)
Country | Link |
---|---|
US (1) | US4831155A (it) |
EP (2) | EP0354594A3 (it) |
JP (1) | JPS60208982A (it) |
AT (1) | ATE54917T1 (it) |
DE (1) | DE3578789D1 (it) |
IT (1) | IT1199076B (it) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5306825A (en) * | 1984-03-01 | 1994-04-26 | Consiglio Nazionale Delle Ricerche | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
AT400331B (de) * | 1987-05-15 | 1995-12-27 | Hoechst Roussel Pharma | 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b)indole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US5187165A (en) * | 1987-05-15 | 1993-02-16 | Hoechst-Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US5260452A (en) * | 1989-11-03 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Inc. | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof |
US5177101A (en) * | 1989-11-30 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
US4983616A (en) * | 1990-02-01 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds |
US5428043A (en) * | 1990-02-08 | 1995-06-27 | Pfizer Inc. | Tricyclic-cyclic amines as novel cholinesterase inhibitors |
TW197442B (it) * | 1990-02-08 | 1993-01-01 | Pfizer | |
US5216017A (en) * | 1990-05-11 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo[2,3-b]indole-ketones and analogs |
AU634654B2 (en) * | 1990-05-11 | 1993-02-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments |
AU634380B2 (en) * | 1990-05-17 | 1993-02-18 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments |
IT1243917B (it) * | 1990-11-20 | 1994-06-28 | Mediolanum Farmaceutici Spa | Derivati della fisostigmina |
IT1246050B (it) * | 1990-12-21 | 1994-11-07 | Mediolanum Farmaceutici Spa | Impiego dell'eptastigmina nella terapia dell'ictus cerebrale. |
IT1251166B (it) * | 1991-08-09 | 1995-05-04 | Chiesi Farma Spa | Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono |
EP0606366B1 (en) * | 1991-09-26 | 2003-06-04 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES | Substituted phenserines and phenylcarbamates of (-)-eseroline, (-)-n1-noreseroline, and (-)-n1-benzylnoreseroline; as specific inhibitors of acetylcholinesterase |
US5206260A (en) * | 1991-11-07 | 1993-04-27 | Merck & Co., Inc. | Hexahydropyrrolo[2,3-b]indole derivatives |
GB9205670D0 (en) * | 1992-03-16 | 1992-04-29 | Indena Spa | New derivatives of physostigmine,their use and pharmaceutical formulations containing them |
US5302721A (en) * | 1992-07-21 | 1994-04-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparation of physostigmine carbamate derivatives from eseretholes |
IT1271679B (it) * | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
IT1276928B1 (it) * | 1995-10-13 | 1997-11-03 | Angelini Ricerche Spa | Processo migliorato per produrre eptastigmina e nuovo intermedio utile allo scopo |
US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
AU9454098A (en) * | 1997-09-24 | 1999-04-12 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
WO2005072713A2 (en) | 2004-01-27 | 2005-08-11 | The Feinstein Institute For Medical Research | Cholinesterase inhibitors for treating inflammation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2909530A (en) * | 1958-09-26 | 1959-10-20 | Grace W R & Co | Physostigmine derivatives |
CH467776A (de) * | 1965-06-17 | 1969-01-31 | Sandoz Ag | Verfahren zur Herstellung neuer Indol-Derivate |
IT1109003B (it) * | 1977-09-20 | 1985-12-16 | Univ Firenze | Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo |
US4278679A (en) * | 1980-05-01 | 1981-07-14 | Chromalloy American Corporation | Combination of two or more drugs in a single dosage form wherein one of the drugs is a physostigmine compound |
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
-
1984
- 1984-03-01 IT IT47780/84A patent/IT1199076B/it active
-
1985
- 1985-02-22 DE DE8585101945T patent/DE3578789D1/de not_active Expired - Fee Related
- 1985-02-22 EP EP89116950A patent/EP0354594A3/en not_active Withdrawn
- 1985-02-22 EP EP85101945A patent/EP0154864B1/en not_active Expired - Lifetime
- 1985-02-22 AT AT85101945T patent/ATE54917T1/de not_active IP Right Cessation
- 1985-03-01 JP JP60038994A patent/JPS60208982A/ja active Granted
-
1986
- 1986-11-12 US US06/929,516 patent/US4831155A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0354594A2 (en) | 1990-02-14 |
IT1199076B (it) | 1988-12-30 |
JPH0354952B2 (it) | 1991-08-21 |
JPS60208982A (ja) | 1985-10-21 |
US4831155A (en) | 1989-05-16 |
EP0154864A1 (en) | 1985-09-18 |
ATE54917T1 (de) | 1990-08-15 |
EP0354594A3 (en) | 1990-05-09 |
DE3578789D1 (de) | 1990-08-30 |
EP0154864B1 (en) | 1990-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970427 |