IT1271679B - Derivati del fenilcarbammato atti all'impiego come anticolinesterasici - Google Patents
Derivati del fenilcarbammato atti all'impiego come anticolinesterasiciInfo
- Publication number
- IT1271679B IT1271679B ITMI941494A ITMI941494A IT1271679B IT 1271679 B IT1271679 B IT 1271679B IT MI941494 A ITMI941494 A IT MI941494A IT MI941494 A ITMI941494 A IT MI941494A IT 1271679 B IT1271679 B IT 1271679B
- Authority
- IT
- Italy
- Prior art keywords
- anticolinesterasic
- phenyl carbamate
- carbamate derivatives
- derivatives
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivati del fenilcarbammato atti all'impiego come anticolinesterasici aventi formula generale (I) (FORMULA I) in cui il significato dei sostituenti R1-R7 ed X e di n verrà definito nel testo.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941494A IT1271679B (it) | 1994-07-18 | 1994-07-18 | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
US08/776,052 US5869484A (en) | 1994-07-18 | 1995-07-13 | Phenylcarbamate derivatives suitable to the use as anticholinesterase substances |
AU30783/95A AU3078395A (en) | 1994-07-18 | 1995-07-13 | Phenylcarbamate derivatives suitable to the use as anticholinesterase substances |
EP95943500A EP0772608A1 (en) | 1994-07-18 | 1995-07-13 | Phenylcarbamate derivatives suitable to the use as anticholinesterase substances |
PCT/EP1995/002752 WO1996002524A1 (en) | 1994-07-18 | 1995-07-13 | Phenylcarbamate derivatives suitable to the use as anticholinesterase substances |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941494A IT1271679B (it) | 1994-07-18 | 1994-07-18 | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941494A0 ITMI941494A0 (it) | 1994-07-18 |
ITMI941494A1 ITMI941494A1 (it) | 1996-01-18 |
IT1271679B true IT1271679B (it) | 1997-06-04 |
Family
ID=11369297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941494A IT1271679B (it) | 1994-07-18 | 1994-07-18 | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
Country Status (5)
Country | Link |
---|---|
US (1) | US5869484A (it) |
EP (1) | EP0772608A1 (it) |
AU (1) | AU3078395A (it) |
IT (1) | IT1271679B (it) |
WO (1) | WO1996002524A1 (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9756B (en) * | 1996-01-16 | 1997-07-17 | Warner Lambert Co | Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines |
ATE377585T1 (de) | 1996-12-18 | 2007-11-15 | Teva Pharma | Aminoindanderivate |
US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
KR100457790B1 (ko) * | 2001-08-08 | 2004-12-08 | 충남대학교산학협력단 | 감염성을 갖는 hcv 유사입자의 제조 |
KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
UA80841C2 (en) | 2002-10-07 | 2007-11-12 | Univ California | Fatty acid amide hydrolase inhibitors, pharmaceutical composition (variants) and method to treat appetite disorders, glaucoma, pain, and related neurological disorders (variants) |
EP1689704A2 (en) * | 2003-10-21 | 2006-08-16 | CoLucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
JP2009518433A (ja) | 2005-12-09 | 2009-05-07 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 神経保護用の低用量ラドスチギルの使用 |
TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
EP2125709A2 (en) | 2007-02-02 | 2009-12-02 | Colucid Pharmaceuticals, Inc. | Compounds that inhibit cholinesterase |
AU2010232496A1 (en) * | 2009-04-02 | 2011-11-24 | Colucid Pharmaceuticals, Inc. | Compositions of cholinesterase inhibitors |
CN109414441A (zh) | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
EP3628315A1 (en) | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Combination of acetylcholinesterase inhibitor and 5-ht4 receptor agonist as neuroprotective agent in the treatment of neurodegenerative diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
JPS63170356A (ja) * | 1986-12-30 | 1988-07-14 | Yamanouchi Pharmaceut Co Ltd | アニリン誘導体及びその製造法 |
AU649953B2 (en) * | 1990-06-27 | 1994-06-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydroisoquinolinylcarbamates of 1,2,3,3A,8,8A-hexahydro-1,3A,8-trimethylpyrrolo(2,3-B)indole |
IT1254996B (it) * | 1992-06-25 | 1995-10-11 | Mediolanum Farmaceutici Srl | Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione |
-
1994
- 1994-07-18 IT ITMI941494A patent/IT1271679B/it active IP Right Grant
-
1995
- 1995-07-13 US US08/776,052 patent/US5869484A/en not_active Expired - Fee Related
- 1995-07-13 EP EP95943500A patent/EP0772608A1/en not_active Withdrawn
- 1995-07-13 WO PCT/EP1995/002752 patent/WO1996002524A1/en not_active Application Discontinuation
- 1995-07-13 AU AU30783/95A patent/AU3078395A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITMI941494A1 (it) | 1996-01-18 |
EP0772608A1 (en) | 1997-05-14 |
US5869484A (en) | 1999-02-09 |
WO1996002524A1 (en) | 1996-02-01 |
AU3078395A (en) | 1996-02-16 |
ITMI941494A0 (it) | 1994-07-18 |
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Legal Events
Date | Code | Title | Description |
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0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |