IT1401498B1 - Idrogelo a base di acido ialuronico e suo uso in ortopedia - Google Patents

Idrogelo a base di acido ialuronico e suo uso in ortopedia

Info

Publication number
IT1401498B1
IT1401498B1 ITMI2010A001451A ITMI20101451A IT1401498B1 IT 1401498 B1 IT1401498 B1 IT 1401498B1 IT MI2010A001451 A ITMI2010A001451 A IT MI2010A001451A IT MI20101451 A ITMI20101451 A IT MI20101451A IT 1401498 B1 IT1401498 B1 IT 1401498B1
Authority
IT
Italy
Prior art keywords
orthopedics
hyaluronic acid
hydrogel based
hydrogel
hyaluronic
Prior art date
Application number
ITMI2010A001451A
Other languages
English (en)
Inventor
Davide Cremascoli
Enzo Meani
Carlo Luca Romano'
Fabio Palumbo
Gaetano Giammona
Giovanna Pitarresi
Original Assignee
Mero Srl
Novagenit Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mero Srl, Novagenit Srl filed Critical Mero Srl
Priority to ITMI2010A001451A priority Critical patent/IT1401498B1/it
Priority to PCT/IB2011/053384 priority patent/WO2012014180A1/en
Priority to EP11754490.8A priority patent/EP2598180B1/en
Priority to US13/813,422 priority patent/US9283283B2/en
Priority to ES11754490.8T priority patent/ES2564253T3/es
Publication of ITMI20101451A1 publication Critical patent/ITMI20101451A1/it
Application granted granted Critical
Publication of IT1401498B1 publication Critical patent/IT1401498B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
ITMI2010A001451A 2010-07-30 2010-07-30 Idrogelo a base di acido ialuronico e suo uso in ortopedia IT1401498B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI2010A001451A IT1401498B1 (it) 2010-07-30 2010-07-30 Idrogelo a base di acido ialuronico e suo uso in ortopedia
PCT/IB2011/053384 WO2012014180A1 (en) 2010-07-30 2011-07-29 Hyaluronic acid based hydrogel and use thereof in surgery
EP11754490.8A EP2598180B1 (en) 2010-07-30 2011-07-29 Hyaluronic acid based hydrogel and use thereof in surgery
US13/813,422 US9283283B2 (en) 2010-07-30 2011-07-29 Hyaluronic acid based hydrogel and use thereof in surgery
ES11754490.8T ES2564253T3 (es) 2010-07-30 2011-07-29 Hidrogel basado en ácido hialurónico y uso del mismo en cirugía

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A001451A IT1401498B1 (it) 2010-07-30 2010-07-30 Idrogelo a base di acido ialuronico e suo uso in ortopedia

Publications (2)

Publication Number Publication Date
ITMI20101451A1 ITMI20101451A1 (it) 2012-01-31
IT1401498B1 true IT1401498B1 (it) 2013-07-26

Family

ID=43646148

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A001451A IT1401498B1 (it) 2010-07-30 2010-07-30 Idrogelo a base di acido ialuronico e suo uso in ortopedia

Country Status (5)

Country Link
US (1) US9283283B2 (it)
EP (1) EP2598180B1 (it)
ES (1) ES2564253T3 (it)
IT (1) IT1401498B1 (it)
WO (1) WO2012014180A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
US9526602B1 (en) * 2013-03-15 2016-12-27 Anne Piche-Radley Method of applying adhesion barriers
KR20150000670A (ko) * 2013-06-25 2015-01-05 주식회사 메가젠임플란트 표면에 생리활성 물질이 고정된 임플란트의 제조방법 및 이에 따라 제조된 임플란트
ITMI20131755A1 (it) * 2013-10-21 2015-04-22 Mero S R L Composizione bioriassorbibile contenente agenti antibatterici per il trattamento del dolore lombare
EP3231457A4 (en) * 2014-12-10 2018-08-15 Toray Industries, Inc. Laminated film and sheet for medical use
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
ITUA20164153A1 (it) 2016-06-07 2017-12-07 Jointherapeutics S R L Composizioni polisaccaridiche impiegabili nella riparazione tissutale
WO2018056937A2 (en) 2016-07-29 2018-03-29 Karaca Esra Nanofibrous adhesion barrier
JP7138110B2 (ja) * 2017-01-05 2022-09-15 コーメディクス・インコーポレーテッド 成熟バイオフィルムに対して有効な、抗菌ヒドロゲルを含む抗菌組成物
KR20200007776A (ko) 2017-03-22 2020-01-22 제넨테크, 인크. 히드로겔 가교된 히알루론산 전구약물 조성물 및 방법
WO2019071245A1 (en) 2017-10-06 2019-04-11 Foundry Therapeutics, Inc. IMPLANTABLE DEPOSITS FOR REGULATED RELEASE OF ANALGESICS TO TREAT POSTHOPERATIVE PAIN ASSOCIATED WITH ORTHOPEDIC SURGERY, AND RELATED DEVICES, SYSTEMS, AND METHODS
IT201800001890A1 (it) 2018-01-25 2019-07-25 Fidia Farm Spa Composizioni farmaceutiche per il trattamento del dolore postoperatorio
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11795320B2 (en) * 2019-09-20 2023-10-24 Bausch + Lomb Ireland Limited Grafted polymer and use thereof
CN110894302A (zh) * 2019-11-19 2020-03-20 福建医科大学孟超肝胆医院(福州市传染病医院) 一种基于亚胺键和酰腙键的抗菌水凝胶及其制备方法
CN111265723B (zh) * 2020-01-21 2021-09-17 南京师范大学 一种3d打印的皮肤及其制备方法
US11896738B2 (en) 2020-03-12 2024-02-13 The Regents Of The University Of California Biomimetic electrically conductive hyaluronic acid-based hydrogels
IT202100025940A1 (it) * 2021-10-11 2023-04-11 Novagenit S R L Processo per la preparazione di un materiale biocompatibile per l'uso in chirurgia

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60251898A (ja) 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
IT1271001B (it) 1994-07-26 1997-05-26 Poli Ind Chimica Spa Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
CN1301139C (zh) 1995-08-29 2007-02-21 菲迪亚高级生物聚合物公司 包括透明质酸衍生物的用于预防手术后粘连的生物材料
WO2000033895A1 (en) 1998-12-07 2000-06-15 Baylor College Of Medicine Preventing and removing biofilm from the surface of medical devices
FR2809112B1 (fr) 2000-05-16 2004-05-07 Centre Nat Rech Scient Materiaux a base de polymeres biodegradables et son procede de preparation
ES2362354T3 (es) 2001-12-21 2011-07-04 Novozymes Biopharma Dk A/S Métodos para producir hialuronano en una célula huésped recombinante.
US7820638B2 (en) 2002-08-09 2010-10-26 Arthrex, Inc. Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density
TW200524959A (en) * 2003-09-08 2005-08-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modification product and drug carrier therefrom
KR20070009527A (ko) * 2003-09-30 2007-01-18 신테스 아게 츄어 정형외과 인플란트의 항균성 히알루론산 코팅
ITRM20040318A1 (it) 2004-06-28 2004-09-28 Univ Palermo Idrogeli di acido ialuronico e alfa, beta-poliaspartilidrazide e loro applicazioni in campo biomedico e farmaceutico.
CN101133102A (zh) 2004-12-30 2008-02-27 诺维信生物聚合物公司 与α-羟酸的聚合物连接的透明质酸
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
EP2213315A1 (en) 2009-01-30 2010-08-04 Mero S.r.L. Antibacterial hydrogel and use thereof in orthopedics

Also Published As

Publication number Publication date
WO2012014180A1 (en) 2012-02-02
EP2598180B1 (en) 2015-12-09
US20130129800A1 (en) 2013-05-23
EP2598180A1 (en) 2013-06-05
US9283283B2 (en) 2016-03-15
ITMI20101451A1 (it) 2012-01-31
ES2564253T3 (es) 2016-03-21

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