IT1307786B1 - Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. - Google Patents
Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.Info
- Publication number
- IT1307786B1 IT1307786B1 IT1999FI000169A ITFI990169A IT1307786B1 IT 1307786 B1 IT1307786 B1 IT 1307786B1 IT 1999FI000169 A IT1999FI000169 A IT 1999FI000169A IT FI990169 A ITFI990169 A IT FI990169A IT 1307786 B1 IT1307786 B1 IT 1307786B1
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- ceramid
- tumoral
- analogs
- tumors
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- OTGQIQQTPXJQRG-UHFFFAOYSA-N N-(octadecanoyl)ethanolamine Chemical class CCCCCCCCCCCCCCCCCC(=O)NCCO OTGQIQQTPXJQRG-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 ceramide analog compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999FI000169A IT1307786B1 (it) | 1999-07-22 | 1999-07-22 | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. |
| US10/031,692 US6956109B1 (en) | 1999-07-22 | 2000-07-21 | Ceramide analogs, process for their preparation and their use as antitumor agents |
| JP2001512504A JP4652647B2 (ja) | 1999-07-22 | 2000-07-21 | セラミド類似体類、それらの調製方法及び抗腫瘍剤としてのそれらの使用 |
| AT00956250T ATE417831T1 (de) | 1999-07-22 | 2000-07-21 | Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel |
| EP00956250A EP1198458B1 (en) | 1999-07-22 | 2000-07-21 | Ceramide analogs, process for their preparation and their use as antitumor agents |
| AU68267/00A AU6826700A (en) | 1999-07-22 | 2000-07-21 | Ceramide analogs, process for their preparation and their use as antitumor agents |
| PCT/EP2000/007023 WO2001007418A2 (en) | 1999-07-22 | 2000-07-21 | Ceramide analogs, process for their preparation and their use as antitumor agents |
| DE60041137T DE60041137D1 (de) | 1999-07-22 | 2000-07-21 | Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel |
| US10/919,867 US7214794B2 (en) | 1999-07-22 | 2004-08-17 | Ceramide analogs, process for their preparation and their use as antitumor agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999FI000169A IT1307786B1 (it) | 1999-07-22 | 1999-07-22 | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITFI990169A0 ITFI990169A0 (it) | 1999-07-22 |
| ITFI990169A1 ITFI990169A1 (it) | 2001-01-22 |
| IT1307786B1 true IT1307786B1 (it) | 2001-11-19 |
Family
ID=11353048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999FI000169A IT1307786B1 (it) | 1999-07-22 | 1999-07-22 | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6956109B1 (it) |
| EP (1) | EP1198458B1 (it) |
| JP (1) | JP4652647B2 (it) |
| AT (1) | ATE417831T1 (it) |
| AU (1) | AU6826700A (it) |
| DE (1) | DE60041137D1 (it) |
| IT (1) | IT1307786B1 (it) |
| WO (1) | WO2001007418A2 (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858383B2 (en) | 2000-12-22 | 2005-02-22 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor |
| US20080138334A1 (en) | 2006-05-31 | 2008-06-12 | Sabbadini Roger A | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same |
| US9274129B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| BRPI0718118A2 (pt) | 2006-10-27 | 2017-05-30 | Lpath Inc | composições e métodos para ligação de sphingosine-1-fosfato |
| DE102008023040B4 (de) * | 2008-05-09 | 2011-04-28 | Eurocopter Deutschland Gmbh | Flugführungsanzeige für einen Hubschrauber |
| US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
| PE20161219A1 (es) | 2011-11-11 | 2016-11-17 | Pfizer | 2-tiopirimidinonas |
| CU20170134A7 (es) | 2015-05-05 | 2017-12-08 | Pfizer | 2-tiopirimidinonas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5587777A (en) * | 1978-12-27 | 1980-07-02 | Ono Pharmaceut Co Ltd | Pyrimidine derivative, its preparation and antitumorigenic agent |
| JPH0625163B2 (ja) * | 1985-04-16 | 1994-04-06 | 久光製薬株式会社 | ウラシル誘導体 |
| EP0714658A1 (en) | 1994-04-14 | 1996-06-05 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis inducer |
| DE69527438T2 (de) * | 1994-12-29 | 2003-03-06 | Univ California | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
| US6323201B1 (en) * | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
-
1999
- 1999-07-22 IT IT1999FI000169A patent/IT1307786B1/it active
-
2000
- 2000-07-21 AT AT00956250T patent/ATE417831T1/de not_active IP Right Cessation
- 2000-07-21 DE DE60041137T patent/DE60041137D1/de not_active Expired - Lifetime
- 2000-07-21 US US10/031,692 patent/US6956109B1/en not_active Expired - Fee Related
- 2000-07-21 JP JP2001512504A patent/JP4652647B2/ja not_active Expired - Fee Related
- 2000-07-21 EP EP00956250A patent/EP1198458B1/en not_active Expired - Lifetime
- 2000-07-21 AU AU68267/00A patent/AU6826700A/en not_active Abandoned
- 2000-07-21 WO PCT/EP2000/007023 patent/WO2001007418A2/en active Application Filing
-
2004
- 2004-08-17 US US10/919,867 patent/US7214794B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7214794B2 (en) | 2007-05-08 |
| EP1198458A2 (en) | 2002-04-24 |
| ITFI990169A1 (it) | 2001-01-22 |
| WO2001007418A2 (en) | 2001-02-01 |
| JP4652647B2 (ja) | 2011-03-16 |
| JP2003505451A (ja) | 2003-02-12 |
| ITFI990169A0 (it) | 1999-07-22 |
| ATE417831T1 (de) | 2009-01-15 |
| EP1198458B1 (en) | 2008-12-17 |
| US20050020533A1 (en) | 2005-01-27 |
| WO2001007418A3 (en) | 2001-05-10 |
| DE60041137D1 (de) | 2009-01-29 |
| AU6826700A (en) | 2001-02-13 |
| US6956109B1 (en) | 2005-10-18 |
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