IT1304500B1 - Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. - Google Patents
Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati.Info
- Publication number
- IT1304500B1 IT1304500B1 IT1998MI002792A ITMI982792A IT1304500B1 IT 1304500 B1 IT1304500 B1 IT 1304500B1 IT 1998MI002792 A IT1998MI002792 A IT 1998MI002792A IT MI982792 A ITMI982792 A IT MI982792A IT 1304500 B1 IT1304500 B1 IT 1304500B1
- Authority
- IT
- Italy
- Prior art keywords
- recombined
- bacterial
- strips
- production
- natural nucleosides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI002792A IT1304500B1 (it) | 1998-12-23 | 1998-12-23 | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
JP2000591198A JP2002533126A (ja) | 1998-12-23 | 1999-12-23 | 天然ヌクレオシドおよびその改変類縁体を産生するための組換え細菌株 |
PCT/EP1999/010416 WO2000039307A2 (en) | 1998-12-23 | 1999-12-23 | Recombinant bacterial strains for the production of natural nucleosides and modified analogues thereof |
AT99965565T ATE278021T1 (de) | 1998-12-23 | 1999-12-23 | Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon |
ES99965565T ES2229807T3 (es) | 1998-12-23 | 1999-12-23 | Cepas bacterianas recombinantes para la produccion de nucleosidos naturales y analogos modificados de los mismos. |
DE69920749T DE69920749T2 (de) | 1998-12-23 | 1999-12-23 | Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon |
AU21030/00A AU2103000A (en) | 1998-12-23 | 1999-12-23 | Recombinant bacterial strains for the production of natural nucleosides and modified analogues thereof |
EP99965565A EP1141328B1 (en) | 1998-12-23 | 1999-12-23 | Recombinant bacterial strains for the production of natural nucleosides and modified analogues thereof |
US09/891,865 US6911341B2 (en) | 1998-12-23 | 2001-06-25 | Vectors, host cells, and methods for production of uridine phosphorylase and purine nucleoside phosphorylase |
US11/036,497 US7781189B2 (en) | 1998-12-23 | 2005-01-14 | Catalyzing transglycosylation using a recombinant host cell overexpressing uridine phosphorylase and purine nucleoside phosphorylase |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI002792A IT1304500B1 (it) | 1998-12-23 | 1998-12-23 | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI982792A1 ITMI982792A1 (it) | 2000-06-23 |
IT1304500B1 true IT1304500B1 (it) | 2001-03-19 |
Family
ID=11381317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1998MI002792A IT1304500B1 (it) | 1998-12-23 | 1998-12-23 | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
Country Status (9)
Country | Link |
---|---|
US (2) | US6911341B2 (it) |
EP (1) | EP1141328B1 (it) |
JP (1) | JP2002533126A (it) |
AT (1) | ATE278021T1 (it) |
AU (1) | AU2103000A (it) |
DE (1) | DE69920749T2 (it) |
ES (1) | ES2229807T3 (it) |
IT (1) | IT1304500B1 (it) |
WO (1) | WO2000039307A2 (it) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1304500B1 (it) * | 1998-12-23 | 2001-03-19 | Norpharma Spa | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
US7037718B2 (en) * | 2001-10-26 | 2006-05-02 | Cornell Research Foundation, Inc. | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
US7488598B2 (en) | 2001-10-26 | 2009-02-10 | Cornell Center For Technology Enterprise And Commercialization | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
ES2235638B1 (es) * | 2003-12-17 | 2006-10-16 | Cellerix, S.L. | Nuevo vector retroviral de alto titulo y metodos de transduccion. |
PT1835035E (pt) * | 2006-03-15 | 2010-05-26 | Explora Lab Sa | Processo para a imobilização de células em resina |
EP2338985A1 (en) * | 2009-12-22 | 2011-06-29 | Institut Univ. de Ciència i Tecnologia, s.a. | Thermostable biocatalyst combination for nucleoside synthesis |
JP2016198075A (ja) * | 2015-04-14 | 2016-12-01 | プラズミア バイオテック,エス.エル. | シトシンヌクレオシドアナログの酵素産生 |
CN113969299B (zh) * | 2021-10-17 | 2023-10-20 | 拓新药业集团股份有限公司 | 一种生物转化合成尿苷的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1573777A (en) * | 1977-11-03 | 1980-08-28 | Wellcome Found | 9-d-arabinonucleosides and an enzymatic process for their preparation |
JPS56164793A (en) * | 1980-04-23 | 1981-12-17 | Wellcome Found | Pyridine derivative |
US4347315A (en) * | 1980-04-25 | 1982-08-31 | Burroughs Wellcome Co. | Synthesis of ribosides using bacterial phosphorylase |
US4835104A (en) | 1987-06-16 | 1989-05-30 | Ajinomoto Co., Inc., Patent & Licensing Department | Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides |
JP2619710B2 (ja) * | 1989-02-27 | 1997-06-11 | 日本製紙 株式会社 | 2′,3′−ジデオキシプリンヌクレオシド類の製造方法 |
EP0423641A3 (en) * | 1989-10-18 | 1992-01-15 | Nippon Mining Company Limited | Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha |
JPH06253854A (ja) * | 1993-02-26 | 1994-09-13 | Yamasa Shoyu Co Ltd | 組換えdna手法によるヌクレオシド・ホスホリラーゼの製造法 |
JP4304727B2 (ja) * | 1996-11-21 | 2009-07-29 | 味の素株式会社 | ヌクレオシド−5’−燐酸エステルの製造法 |
US6229001B1 (en) * | 1997-01-03 | 2001-05-08 | Southern Research Institute | Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase |
JPH10286097A (ja) * | 1997-04-15 | 1998-10-27 | Yamasa Shoyu Co Ltd | プリンアラビノシドの酵素的製造法 |
JP3799784B2 (ja) | 1997-11-14 | 2006-07-19 | 味の素株式会社 | 2,6−ジアミノプリン−2’−デオキシリボシドおよび2’−デオキシグアノシンの製造法 |
IT1304500B1 (it) * | 1998-12-23 | 2001-03-19 | Norpharma Spa | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
-
1998
- 1998-12-23 IT IT1998MI002792A patent/IT1304500B1/it active
-
1999
- 1999-12-23 DE DE69920749T patent/DE69920749T2/de not_active Expired - Lifetime
- 1999-12-23 JP JP2000591198A patent/JP2002533126A/ja active Pending
- 1999-12-23 EP EP99965565A patent/EP1141328B1/en not_active Expired - Lifetime
- 1999-12-23 AU AU21030/00A patent/AU2103000A/en not_active Abandoned
- 1999-12-23 WO PCT/EP1999/010416 patent/WO2000039307A2/en active IP Right Grant
- 1999-12-23 ES ES99965565T patent/ES2229807T3/es not_active Expired - Lifetime
- 1999-12-23 AT AT99965565T patent/ATE278021T1/de not_active IP Right Cessation
-
2001
- 2001-06-25 US US09/891,865 patent/US6911341B2/en not_active Expired - Fee Related
-
2005
- 2005-01-14 US US11/036,497 patent/US7781189B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69920749T2 (de) | 2006-03-02 |
DE69920749D1 (de) | 2004-11-04 |
US6911341B2 (en) | 2005-06-28 |
JP2002533126A (ja) | 2002-10-08 |
ATE278021T1 (de) | 2004-10-15 |
EP1141328A2 (en) | 2001-10-10 |
WO2000039307A2 (en) | 2000-07-06 |
US20050142645A1 (en) | 2005-06-30 |
US7781189B2 (en) | 2010-08-24 |
AU2103000A (en) | 2000-07-31 |
ITMI982792A1 (it) | 2000-06-23 |
WO2000039307A3 (en) | 2000-11-09 |
ES2229807T3 (es) | 2005-04-16 |
EP1141328B1 (en) | 2004-09-29 |
US20030059870A1 (en) | 2003-03-27 |
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