IT1286060B1 - Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity - Google Patents
Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activityInfo
- Publication number
- IT1286060B1 IT1286060B1 ITMI962241A IT1286060B1 IT 1286060 B1 IT1286060 B1 IT 1286060B1 IT MI962241 A ITMI962241 A IT MI962241A IT 1286060 B1 IT1286060 B1 IT 1286060B1
- Authority
- IT
- Italy
- Prior art keywords
- activity
- beta
- preparation
- medicaments
- hydro
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Use of beta -carboline derivatives of formula (I) and their enantiomers, reacemates, diastereomers and salts, for the preparation of pharmaceutical compositions having anti-metastatic activity or inhibitory activity of the tumour invasion process, is new. R = H, 1-5C alkyl, phenyl optionally substituted by 1-5C alkoxy, or (CH2)nCO2H; n = 1-3; R1 = H or CO2R4; R4 = H or 1-5C alkyl; R2 = H or CO2R4; and R3 = H, halo, 1-4C alkoxy or benzyloxy. Also claimed is use of (I) in compositions for treating or preventing conditions associated with the activity of the matrix metallo-proteinases.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI002241 IT1286060B1 (en) | 1996-10-29 | 1996-10-29 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
KR1019980707846A KR20000005175A (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
ES97916410T ES2169857T3 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHIDRO-BETA-CARBOLINAS DERIVATIVES AS ANTIMETASTATIC AGENTS. |
DK97916410T DK0891187T3 (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-carboline derivatives as antimetastatic agents |
AU25069/97A AU710079B2 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
AT97916410T ATE212549T1 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHYDROBETACARBOLINE DERIVATIVES TO PREVENT METASTASIS |
BR9708480A BR9708480A (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-cabolines derivatives as antimetastatic agents |
EP97916410A EP0891187B1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
US09/142,058 US6069150A (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
CN97193568A CN1113648C (en) | 1996-04-04 | 1997-03-27 | Use of derivativ |
PT97916410T PT891187E (en) | 1996-04-04 | 1997-03-27 | USING TETRAHYDRO-BETA-CARBOLINOS DERIVATIVES AS ANTIMESTATIC AGENTS |
CA002250898A CA2250898A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
JP9535798A JP2000508302A (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-.BETA.-carboline derivatives as antimetastatic agents |
TR1998/01970T TR199801970T2 (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-carbolines as antimetastatic agents. |
PCT/EP1997/001582 WO1997037658A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
DE69710182T DE69710182T2 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHYDROBETACARBOLIN DERIVATIVES FOR PREVENTING METASTASIS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI002241 IT1286060B1 (en) | 1996-10-29 | 1996-10-29 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI962241A1 ITMI962241A1 (en) | 1998-04-29 |
IT1286060B1 true IT1286060B1 (en) | 1998-07-07 |
Family
ID=11375116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI002241 IT1286060B1 (en) | 1996-04-04 | 1996-10-29 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1286060B1 (en) |
-
1996
- 1996-10-29 IT IT96MI002241 patent/IT1286060B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI962241A1 (en) | 1998-04-29 |
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