IT1277950B1 - Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6- - Google Patents
Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6-Info
- Publication number
- IT1277950B1 IT1277950B1 ITRM950831A IT1277950B1 IT 1277950 B1 IT1277950 B1 IT 1277950B1 IT RM950831 A ITRM950831 A IT RM950831A IT 1277950 B1 IT1277950 B1 IT 1277950B1
- Authority
- IT
- Italy
- Prior art keywords
- solution
- crystallisation
- crystalline
- deionised water
- prepn
- Prior art date
Links
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title abstract 3
- 238000002425 crystallisation Methods 0.000 title abstract 2
- 239000008367 deionised water Substances 0.000 title abstract 2
- 229960004647 iopamidol Drugs 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 3
- 239000007810 chemical reaction solvent Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000003226 decolorizating effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95RM000831 IT1277950B1 (it) | 1995-12-19 | 1995-12-19 | Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6- |
ES96928403T ES2140887T3 (es) | 1995-09-08 | 1996-08-02 | Procedimiento para cristalizar en agua (s)-n-n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida. |
KR1019970702994A KR100270411B1 (ko) | 1995-09-08 | 1996-08-02 | (s)-n,n'-비스[2-히드록시-1-(히드록시메틸)에틸-5-[(2-히드록시-1-옥소프로필)아미노]-2,4,6-트리요오도-1,3-벤젠디카복사미드의물로부터의결정화방법 |
DE69605528T DE69605528T2 (de) | 1995-09-08 | 1996-08-02 | Verfahren zur kristallisierung aus wasser von (s)-n,n'-bis[2-hydroxy-1-(hydroxymethiel)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzoldicarboxamide |
AU67888/96A AU708195B2 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (S)-N,N'-bis{2-hydroxy-1-(hydroxymethyl)ethyl}-5-{(2-hydroxy -1-oxopropyl)amino}-2,4,6-triiodo-1,3-benzendicarboxamide |
HU9801837A HU220965B1 (hu) | 1995-09-08 | 1996-08-02 | Eljárás (S)-N,N'-bisz[2-hidroxi-1-(hidroxi-metil)-etil]-5-[(2-hidroxi-1-oxo-propil)-amino]-2,4,6-trijód-1,3-benzol-dikarboxamid vízből való kristályosítására |
CA002204734A CA2204734C (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
AT96928403T ATE187437T1 (de) | 1995-09-08 | 1996-08-02 | Verfahren zur kristallisierung aus wasser von (s)-n,n'-bis(2-hydroxy-1-(hydroxymethiel)ethyl> 5-((2-hydroxy-1-oxopropyl)amino>-2,4,6-triiodo- ,3- benzoldicarboxamide |
PL96320027A PL184937B1 (pl) | 1995-09-08 | 1996-08-02 | Sposób┴wytwarzania┴krystalicznej┴bezwodnej┴postaci┴(S)-NĆN'-bis[2-hydroksy-1-(hydroksymetylo)┴etylo]-5-[(2-hydroksy-1-oksopropylo)┴amino]-2Ć4Ć6-trijodo-1Ć3-benzenodikarboksyamidu |
BR9606624A BR9606624A (pt) | 1995-09-08 | 1996-08-02 | Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água |
CN96191028A CN1070843C (zh) | 1995-09-08 | 1996-08-02 | (s)-n,n'-二[2-羟基-1-(羟甲基)乙基)-5-[(2-羟基-1-氧代丙基)氨基]-2,4,6-三碘-1,3-苯二羧酰胺从水中结晶的方法 |
PCT/EP1996/003399 WO1997009300A1 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
JP50604597A JP4070235B2 (ja) | 1995-09-08 | 1996-08-02 | (s)−n,n’−ビス[2−ヒドロキシ−1−(ヒドロキシメチル)エチル]−5−[(2−ヒドロキシ−1−オキソプロピル)アミノ]−2,4,6−トリヨード−1,3−ベンゼンジカルボキサアミドの、水からの結晶化方法 |
EP96928403A EP0790979B1 (en) | 1995-09-08 | 1996-08-02 | Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide |
CZ19971385A CZ288645B6 (cs) | 1995-09-08 | 1996-08-02 | Způsob krystalizace Iopamidolu |
US08/708,668 US5689002A (en) | 1995-09-08 | 1996-09-05 | Process for the crystallization from water of (S)-N,N'-bis 2-hydroxy-1-(hydroxymethyl)ethyl!-5- 2-hydroxy-1-oxopropyl)amino!-2,4,6-triiodo-1,3-benzendicarboxamide |
NO971863A NO308841B1 (no) | 1995-09-08 | 1997-04-23 | FremgangsmÕte ved krystallisasjon av (S)-N,N'-bis[2-hydroksy- 1-(hydroksymetyl)etyl]-5[(2-hydroksy-1-oksopropyl)amino]-2,4,6- trijod-1,3-benzendikarboksamid fra vann, samt anvendelser av (C1- C4-alkoholer |
MXPA/A/1997/003341A MXPA97003341A (en) | 1995-09-08 | 1997-05-07 | Process for the crystallization of (s) -n, n'-bis [2-hydroxy-1- (hydroxymethyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2,4,6-triyodo -1,3-bencendicarboxamide from a |
HK98100990A HK1001861A1 (en) | 1995-09-08 | 1998-02-10 | Process for the crystallization from water of (s)-n,n'-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-benzendicarboxamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95RM000831 IT1277950B1 (it) | 1995-12-19 | 1995-12-19 | Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6- |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM950831A0 ITRM950831A0 (it) | 1995-12-19 |
ITRM950831A1 ITRM950831A1 (it) | 1997-06-19 |
IT1277950B1 true IT1277950B1 (it) | 1997-11-12 |
Family
ID=11403721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95RM000831 IT1277950B1 (it) | 1995-09-08 | 1995-12-19 | Processo per la cristallizzazione da acqua della s-n,n'-bis (2-idrossi -1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino).2,4,6- |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1277950B1 (it) |
-
1995
- 1995-12-19 IT IT95RM000831 patent/IT1277950B1/it active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITRM950831A0 (it) | 1995-12-19 |
ITRM950831A1 (it) | 1997-06-19 |
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