IT1274984B - Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri - Google Patents
Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeriInfo
- Publication number
- IT1274984B IT1274984B ITRM940797A ITRM940797A IT1274984B IT 1274984 B IT1274984 B IT 1274984B IT RM940797 A ITRM940797 A IT RM940797A IT RM940797 A ITRM940797 A IT RM940797A IT 1274984 B IT1274984 B IT 1274984B
- Authority
- IT
- Italy
- Prior art keywords
- solutions
- therapeutic
- sodium hyaluronate
- laser
- viscosized
- Prior art date
Links
- 229920002385 Sodium hyaluronate Polymers 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 title abstract 2
- 229940010747 sodium hyaluronate Drugs 0.000 title abstract 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 238000002679 ablation Methods 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- -1 citrate ions Chemical class 0.000 abstract 1
- 210000004087 cornea Anatomy 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910001425 magnesium ion Inorganic materials 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
Abstract
Soluzioni acquose viscosizzate con ialuronato di sodio di peso molecolare compreso tra 1.200.000 e 2.200.000 dalton in concentrazione compresa tra lo 0,10% e lo 0,40% in peso vengono proposte per l'uso come fluido maschera per la fotocheratectomia terapeutica mediante laser a eccimeri (PTK), che realizza l'ablazione di strati superficiali di tessuto corneale per l'eliminazione di irregolarità ed opacità derivanti da diverse condizioni patologiche o traumatiche. Preferibilmente le soluzioni proposte contengono anche una o più specie cationiche scelta tra ioni sodio, potassio, calcio e magnesio e una o più specie anioniche scelta tra ioni cloruro, fosfato e citrato nonché, vantaggiosamente, glucosio.Le soluzioni secondo l'invenzione bagnano la cornea e ne proteggono le zone depresse durante l'intervento. permettendo l'ottenimento di superfici ablate regolari e levigate, e ciò anche perché rendono possibile l'esecuzione di controlli topografici corneali intraoperatori.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940797A IT1274984B (it) | 1994-12-09 | 1994-12-09 | Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri |
| ES95119025T ES2124486T3 (es) | 1994-12-09 | 1995-12-04 | Soluciones viscosas de hialuronato de sodio para su utilizacion como fluido protector en fotoqueratectomia terapeutica mediante un laser de excimeros. |
| AT95119025T ATE171623T1 (de) | 1994-12-09 | 1995-12-04 | Natriumhyaluronat enthaltende viskose lösungen zur verwendung als maskierungsmittel in therapeutischer photokeratektomie durch excimer- laser |
| DK95119025T DK0719559T3 (da) | 1994-12-09 | 1995-12-04 | Viskøse natriumhyaluronatopløsninger til anvendelse som maskerende væsker i terapeutisk fotokeratektomi under anvendelse af |
| EP95119025A EP0719559B1 (en) | 1994-12-09 | 1995-12-04 | Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser |
| DE69505095T DE69505095T2 (de) | 1994-12-09 | 1995-12-04 | Natriumhyaluronat enthaltende viskose Lösungen zur Verwendung als Maskierungsmittel in therapeutischer Photokeratektomie durch Excimer-Laser |
| CA002164770A CA2164770C (en) | 1994-12-09 | 1995-12-08 | Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser |
| JP34590395A JP4097720B2 (ja) | 1994-12-09 | 1995-12-08 | エキシマレーザによる治療的フォトケラテクトミにおいてマスキング流体として用いられるヒアルロン酸ナトリウム粘性溶液 |
| ZA9510441A ZA9510441B (en) | 1994-12-09 | 1995-12-08 | Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser |
| US08/570,097 US5871772A (en) | 1994-12-09 | 1995-12-11 | Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940797A IT1274984B (it) | 1994-12-09 | 1994-12-09 | Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM940797A0 ITRM940797A0 (it) | 1994-12-09 |
| ITRM940797A1 ITRM940797A1 (it) | 1996-06-09 |
| IT1274984B true IT1274984B (it) | 1997-07-29 |
Family
ID=11402853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM940797A IT1274984B (it) | 1994-12-09 | 1994-12-09 | Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5871772A (it) |
| EP (1) | EP0719559B1 (it) |
| JP (1) | JP4097720B2 (it) |
| AT (1) | ATE171623T1 (it) |
| CA (1) | CA2164770C (it) |
| DE (1) | DE69505095T2 (it) |
| DK (1) | DK0719559T3 (it) |
| ES (1) | ES2124486T3 (it) |
| IT (1) | IT1274984B (it) |
| ZA (1) | ZA9510441B (it) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1291291B1 (it) * | 1997-04-30 | 1999-01-07 | Chemedica Sa | Uso di acido ialuronico e relativi sali per la preparazione di una soluzione acquosa utile come liquido di lavaggio intra-articolare |
| AU2002232437A1 (en) * | 2000-12-20 | 2002-07-01 | Alcon Universal Ltd. | Ophthalmic lubricating solution adapted for use in lasik surgery |
| US6878694B2 (en) * | 2000-12-20 | 2005-04-12 | Alcon, Inc. | Ophthalmic irrigating solution adapted for use in lasik surgery |
| EP1256360A1 (fr) * | 2001-05-10 | 2002-11-13 | Université de Liège | Composition médicamenteuse hypertonique et en particulier utilisation dans la fluidothérapie |
| IL165910A0 (en) * | 2002-07-03 | 2006-01-15 | Pericor Science Inc | Compositions of hyaluronic acid and methods of use |
| EP2147686A1 (en) * | 2004-10-01 | 2010-01-27 | Menicon Co., Ltd. | Method for packaging contact lenses |
| EP2194904A4 (en) * | 2007-09-10 | 2013-03-13 | Alcon Lensx Inc | DEVICE, SYSTEMS AND TECHNIQUES AS AN INTERFACE CONNECTION WITH AN EYE IN LASER SURGERY |
| US8845624B2 (en) | 2010-06-25 | 2014-09-30 | Alcon LexSx, Inc. | Adaptive patient interface |
| US9089401B2 (en) | 2011-05-06 | 2015-07-28 | Alcon Lensx, Inc. | Adjusting ophthalmic docking system |
| US8939967B2 (en) | 2011-08-03 | 2015-01-27 | Alcon Lensx, Inc. | Patient interface defogger |
| US9044304B2 (en) | 2011-12-23 | 2015-06-02 | Alcon Lensx, Inc. | Patient interface with variable applanation |
| US10335315B2 (en) | 2013-02-01 | 2019-07-02 | Alcon Lensx, Inc. | Bi-radial patient interface |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4517295A (en) * | 1983-02-18 | 1985-05-14 | Diagnostic, Inc. | Hyaluronic acid from bacterial culture |
| US5093487A (en) * | 1986-01-06 | 1992-03-03 | Mobay Corporation | Low viscosity high molecular weight filter sterilizable hyaluronic acid |
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| IL80298A (en) * | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| EP0346467A4 (en) * | 1987-12-26 | 1990-11-28 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying hyaluronic acid |
| IT1247175B (it) * | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| US5492135A (en) * | 1992-09-09 | 1996-02-20 | Devore; Dale P. | Collagen modulators for use in photoablation excimer laser keratectomy |
-
1994
- 1994-12-09 IT ITRM940797A patent/IT1274984B/it active IP Right Grant
-
1995
- 1995-12-04 DK DK95119025T patent/DK0719559T3/da active
- 1995-12-04 AT AT95119025T patent/ATE171623T1/de active
- 1995-12-04 ES ES95119025T patent/ES2124486T3/es not_active Expired - Lifetime
- 1995-12-04 DE DE69505095T patent/DE69505095T2/de not_active Expired - Lifetime
- 1995-12-04 EP EP95119025A patent/EP0719559B1/en not_active Expired - Lifetime
- 1995-12-08 CA CA002164770A patent/CA2164770C/en not_active Expired - Lifetime
- 1995-12-08 JP JP34590395A patent/JP4097720B2/ja not_active Expired - Fee Related
- 1995-12-08 ZA ZA9510441A patent/ZA9510441B/xx unknown
- 1995-12-11 US US08/570,097 patent/US5871772A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE171623T1 (de) | 1998-10-15 |
| DK0719559T3 (da) | 1999-06-21 |
| ITRM940797A1 (it) | 1996-06-09 |
| EP0719559A1 (en) | 1996-07-03 |
| ITRM940797A0 (it) | 1994-12-09 |
| CA2164770C (en) | 2008-04-22 |
| CA2164770A1 (en) | 1996-06-10 |
| ES2124486T3 (es) | 1999-02-01 |
| JPH08253505A (ja) | 1996-10-01 |
| ZA9510441B (en) | 1996-06-19 |
| JP4097720B2 (ja) | 2008-06-11 |
| DE69505095T2 (de) | 1999-04-15 |
| US5871772A (en) | 1999-02-16 |
| EP0719559B1 (en) | 1998-09-30 |
| DE69505095D1 (de) | 1998-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |