IT1251183B - Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono. - Google Patents

Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.

Info

Publication number
IT1251183B
IT1251183B ITMI912310A ITMI912310A IT1251183B IT 1251183 B IT1251183 B IT 1251183B IT MI912310 A ITMI912310 A IT MI912310A IT MI912310 A ITMI912310 A IT MI912310A IT 1251183 B IT1251183 B IT 1251183B
Authority
IT
Italy
Prior art keywords
thrombolithic
activity
contain
dermatan sulphate
pharmaceutical forms
Prior art date
Application number
ITMI912310A
Other languages
English (en)
Inventor
Pietro Bianchini
Original Assignee
Opocrin Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opocrin Spa filed Critical Opocrin Spa
Publication of ITMI912310A0 publication Critical patent/ITMI912310A0/it
Priority to ITMI912310A priority Critical patent/IT1251183B/it
Priority to EP92916443A priority patent/EP0600928B1/en
Priority to JP50486293A priority patent/JP3279316B2/ja
Priority to KR1019940700570A priority patent/KR100233338B1/ko
Priority to DE69223153T priority patent/DE69223153T2/de
Priority to CA002116437A priority patent/CA2116437A1/en
Priority to AU23962/92A priority patent/AU2396292A/en
Priority to ES92916443T priority patent/ES2110008T3/es
Priority to PCT/EP1992/001790 priority patent/WO1993005074A1/en
Priority to DK92916443T priority patent/DK0600928T3/da
Priority to US08/199,229 priority patent/US5547944A/en
Priority to AT92916443T priority patent/ATE160149T1/de
Publication of ITMI912310A1 publication Critical patent/ITMI912310A1/it
Application granted granted Critical
Publication of IT1251183B publication Critical patent/IT1251183B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un dermatan solfato naturale ad attività antitrombinica superiore a 220 U/mg, caratterizzato da una sequenza oligosaccaridica a elevato grado di solfatazione, di formula (I), (dove R6 - H o S03-; U = acido uronico non solfato; A - aminozucchero; n - 3, 4, 5) è estratto da organi, e successivamente purificato in condizioni operative blande, a pH 5-7, comunque inferiore a 7, isolamento e frazionamento essendo effettuati con resine a scambio ionico, macroreticolate, di granulometria 0.3-1.3 mm, e anche <10µ.
ITMI912310A 1991-08-28 1991-08-28 Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono. IT1251183B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITMI912310A IT1251183B (it) 1991-08-28 1991-08-28 Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.
AU23962/92A AU2396292A (en) 1991-08-28 1992-08-06 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it
PCT/EP1992/001790 WO1993005074A1 (en) 1991-08-28 1992-08-06 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it
KR1019940700570A KR100233338B1 (ko) 1991-08-28 1992-08-06 혈전용해 활성을 갖는 황산 더마탄 및 이를 함유하는 약제학적 제형
DE69223153T DE69223153T2 (de) 1991-08-28 1992-08-06 Dermatansulfat mit trombolytischer wirkung und arzneiformen welche dieses enthalten
CA002116437A CA2116437A1 (en) 1991-08-28 1992-08-06 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutica l forms containing it
EP92916443A EP0600928B1 (en) 1991-08-28 1992-08-06 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it
ES92916443T ES2110008T3 (es) 1991-08-28 1992-08-06 Dermatan sulfato que posee una actividad trombolitica y formulaciones farmaceuticas que lo contienen
JP50486293A JP3279316B2 (ja) 1991-08-28 1992-08-06 血栓溶解活性を有するデルマタンスルフェート及びこれを含有する製薬形態
DK92916443T DK0600928T3 (da) 1991-08-28 1992-08-06 Dermatansulfat, som har thrombolytisk aktivitet, og farmaceutiske former, som indeholder det
US08/199,229 US5547944A (en) 1991-08-28 1992-08-06 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it
AT92916443T ATE160149T1 (de) 1991-08-28 1992-08-06 Dermatansulfat mit trombolytischer wirkung und arzneiformen welche dieses enthalten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912310A IT1251183B (it) 1991-08-28 1991-08-28 Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.

Publications (3)

Publication Number Publication Date
ITMI912310A0 ITMI912310A0 (it) 1991-08-28
ITMI912310A1 ITMI912310A1 (it) 1993-02-28
IT1251183B true IT1251183B (it) 1995-05-04

Family

ID=11360588

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912310A IT1251183B (it) 1991-08-28 1991-08-28 Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.

Country Status (12)

Country Link
US (1) US5547944A (it)
EP (1) EP0600928B1 (it)
JP (1) JP3279316B2 (it)
KR (1) KR100233338B1 (it)
AT (1) ATE160149T1 (it)
AU (1) AU2396292A (it)
CA (1) CA2116437A1 (it)
DE (1) DE69223153T2 (it)
DK (1) DK0600928T3 (it)
ES (1) ES2110008T3 (it)
IT (1) IT1251183B (it)
WO (1) WO1993005074A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
HU219339B (en) * 1993-09-30 2001-03-28 Seikagaku Kogyo Co Ltd Dermatan sulphate with low heparin or heparane sulphate content and pharmaceutical compositions comprising them
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU4938397A (en) * 1996-12-24 1998-07-17 Hyal Pharmaceutical Corporation Methods of elevating amounts of hyaluronan in the human body
GB9711443D0 (en) * 1997-06-03 1997-07-30 Leo Pharm Prod Ltd Chemical suppositions
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
US20050164983A1 (en) * 2003-12-19 2005-07-28 Aventis Pharma S.A. Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them
WO2005111231A2 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3124384C2 (de) * 1981-06-22 1985-05-15 Herbert Prof. Dr. 1000 Berlin Voß Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
IT1189085B (it) * 1986-03-25 1988-01-28 Mediolanum Farmaceutici Srl Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides

Also Published As

Publication number Publication date
WO1993005074A1 (en) 1993-03-18
ITMI912310A0 (it) 1991-08-28
CA2116437A1 (en) 1993-03-18
AU2396292A (en) 1993-04-05
DE69223153D1 (de) 1997-12-18
JPH06510081A (ja) 1994-11-10
JP3279316B2 (ja) 2002-04-30
US5547944A (en) 1996-08-20
ATE160149T1 (de) 1997-11-15
KR100233338B1 (ko) 1999-12-01
EP0600928B1 (en) 1997-11-12
DK0600928T3 (da) 1998-07-27
EP0600928A1 (en) 1994-06-15
DE69223153T2 (de) 1998-03-05
ITMI912310A1 (it) 1993-02-28
ES2110008T3 (es) 1998-02-01

Similar Documents

Publication Publication Date Title
IT1251183B (it) Dermatan solfato ad alto titolo, dotato di elevata attivita&#39; trombolitica, e forme farmaceutiche che lo contengono.
EP0831777A4 (it)
CA2159591A1 (en) Aminosugar and Glycosaminoglycan Composition for the Treatment and Repair of Connective Tissue
BR9808013A (pt) Terapia de combinação empregando benzotiepinas de inibição de transporte de ácido biliar ileal e inibidores de redutase de hmg co-a
AU661172B2 (en) A method for purifying granulocyte colony stimulating factor
HK1114774A1 (en) Compositions comprising an aminosugar, chondroitin, and s- adenosylmethionine
BR9900856A (pt) Antibioticos macrolideos de 3,6-cetal e enol-éter
DE3587434D1 (de) Antivirale pharmazeutische zusammensetzungen und ihrer verwendung.
NZ233475A (en) Chymopapain, extraction and purification, compositions and also an inhibitor
KR910000772A (ko) 1, 2―0―이소프로필리덴―α, D―글루코퓨라노오즈 유도체
HK214896A (en) Substituted diaminophtalimides and analogues
BG105885A (en) Remedies for joint diseases
IT8722544A0 (it) Eparan solfato caratterizzato da elevata attivita&#39; antitrombotica elevata biodisponibilita&#39; assenza di attivita&#39; anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
ATE264674T1 (de) Verwendung von hyaluronsäure zur behandlung der bestrahlungs-blasenentzündung
PT81283A (en) Buffered glutaraldehyde sterilizing and disinfecting compositions
ITMI921855A1 (it) Derivati di catecolammine, processo per la loro preparazione e composizioni farmaceutiche che li contengono
BR9915813A (pt) Derivados da higromicina a como agentes antibacterianos
NA Histological study of the possible effects of some dietary items on experimental atherogensis in rabbits
IL101540A0 (en) Method and composition for the treatment of herpes related disorders
Forman et al. Histological variation in the proximal colon of heteromyid and cricetid rodents
RU94037959A (ru) Фунгицидная синергетическая композиция и способ защиты растений
DK32893A (da) Geminale cycloalkyldiphosphonsyrer og farmaceutisk acceptable salte heraf samt farmaceutisk sammensaetning omfattende samme
Im A Life Insurancial Study of Hepatomegaly
AM Levamisole therapy for verrucae

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960826