IT1237798B - Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). - Google Patents
Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).Info
- Publication number
- IT1237798B IT1237798B IT02207589A IT2207589A IT1237798B IT 1237798 B IT1237798 B IT 1237798B IT 02207589 A IT02207589 A IT 02207589A IT 2207589 A IT2207589 A IT 2207589A IT 1237798 B IT1237798 B IT 1237798B
- Authority
- IT
- Italy
- Prior art keywords
- amino
- propandiols
- fenyl
- stereo
- reversal process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02207589A IT1237798B (it) | 1989-10-20 | 1989-10-20 | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
AT90119803T ATE116957T1 (de) | 1989-10-20 | 1990-10-16 | Verfahren zur stereochemischen inversion von (2s,3s)-2-amino-3-phenyl-1,3-propandiolen in ihre (2r,3r)-enantiomere. |
DK90119803.6T DK0423705T3 (da) | 1989-10-20 | 1990-10-16 | Fremgangsmåde til stereokemisk inversion af (2S,3 S)-2-amino-3-phenyl-1,3-propandioler til deres tilsvarende (2R,3R)-enantiomerer |
ES90119803T ES2066931T3 (es) | 1989-10-20 | 1990-10-16 | Procedimiento para la inversion estereoquimica de los (2s,3s)-2-amino-3-fenil-1,3-propanodioles en sus (2r,3r)-enantiomeros. |
DE69015956T DE69015956T2 (de) | 1989-10-20 | 1990-10-16 | Verfahren zur stereochemischen Inversion von (2S,3S)-2-Amino-3-phenyl-1,3-Propandiolen in ihre (2R,3R)-Enantiomere. |
EP90119803A EP0423705B1 (en) | 1989-10-20 | 1990-10-16 | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers |
US07/599,881 US5202484A (en) | 1989-10-20 | 1990-10-19 | Process for the stereochemical inversion of (2s,3s)-2-amino-3-phenyl-1,3-propanediols into their (2r,3r) enantiomers |
JP2283237A JP2852801B2 (ja) | 1989-10-20 | 1990-10-19 | (2s,3s)―2―アミノ―3―フェニル―1,3―プロパンジオールから(2r,3r)―鏡像異性体への変換方法 |
US07/992,747 US5284966A (en) | 1989-10-20 | 1992-12-18 | Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers |
US08/127,506 US5401852A (en) | 1989-10-20 | 1993-09-28 | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers |
GR950400833T GR3015686T3 (en) | 1989-10-20 | 1995-04-04 | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02207589A IT1237798B (it) | 1989-10-20 | 1989-10-20 | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8922075A0 IT8922075A0 (it) | 1989-10-20 |
IT1237798B true IT1237798B (it) | 1993-06-17 |
Family
ID=11191106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02207589A IT1237798B (it) | 1989-10-20 | 1989-10-20 | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
Country Status (9)
Country | Link |
---|---|
US (3) | US5202484A (it) |
EP (1) | EP0423705B1 (it) |
JP (1) | JP2852801B2 (it) |
AT (1) | ATE116957T1 (it) |
DE (1) | DE69015956T2 (it) |
DK (1) | DK0423705T3 (it) |
ES (1) | ES2066931T3 (it) |
GR (1) | GR3015686T3 (it) |
IT (1) | IT1237798B (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5243056A (en) * | 1983-06-02 | 1993-09-07 | Zambon S.P.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
ATE115123T1 (de) * | 1990-10-25 | 1994-12-15 | Schering Corp | Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. |
IT1249048B (it) | 1991-02-21 | 1995-02-11 | Zambon Spa | Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite |
US5352832A (en) * | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
IT1271800B (it) * | 1994-12-27 | 1997-06-09 | Zambon Spa | Processo di preparazione degli enantiomeri dell'acido 2- (2-fluoro- 4-bifenil) propionico |
WO2004087628A1 (fr) * | 2003-04-04 | 2004-10-14 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Ligand amino-alcool et son utilisation dans la preparation d'alcools tertiaires propargyliques et d'amines tertiaires par le biais d'une reaction d'addition eniantioselective |
US7126005B2 (en) | 2003-10-06 | 2006-10-24 | Aurobindo Pharma Limited | Process for preparing florfenicol |
WO2007030405A2 (en) * | 2005-09-07 | 2007-03-15 | Schering-Plough Ltd. | A process for preparing ester oxazolidine compounds and their conversion to florfenicol |
US7975794B2 (en) * | 2005-09-28 | 2011-07-12 | Simmons, Inc. | Suspension for tracked vehicles |
US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
JP2010534667A (ja) * | 2007-07-25 | 2010-11-11 | インターベツト・インターナシヨナル・ベー・ベー | オキサゾリジンおよびオキサゾリジノンアミノジオール類ならびに関連中間体を調製するためのプロセス |
CN106278964B (zh) * | 2016-07-31 | 2018-01-16 | 浙江润康药业有限公司 | 氟苯尼考的制备方法 |
CN108017549A (zh) * | 2017-12-07 | 2018-05-11 | 南通常佑药业科技有限公司 | 一种1-芳基-2-氨基-1,3-丙二醇盐酸盐衍生物的制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2538763A (en) * | 1949-02-12 | 1951-01-23 | Parke Davis & Co | Phenylaminopropandiols |
US2483885A (en) * | 1949-02-12 | 1949-10-04 | Parke Davis & Co | Nitrophenyl acyl amido alkane diols |
US2699451A (en) * | 1950-11-08 | 1955-01-11 | Parke Davis & Co | Process for the production of organic amino diol derivatives |
US2721207A (en) * | 1952-11-01 | 1955-10-18 | Parke Davis & Co | Process for the production of amino diols and intermediate products utilized in said process |
US2717268A (en) * | 1952-12-16 | 1955-09-06 | Parke Davis & Co | Process for preparing phenyldichloro-acetamidopropanediols |
US2744136A (en) * | 1953-02-16 | 1956-05-01 | Du Pont | Amides of sulfonylserinophenones |
US2742500A (en) * | 1953-12-22 | 1956-04-17 | Du Pont | Resolution of phenylaminopropanediols and intermediates |
US2759970A (en) * | 1956-05-09 | 1956-08-21 | Sterling Drug Inc | Acylamidoaceto-mercaptophenones |
US3962271A (en) * | 1974-03-04 | 1976-06-08 | Tenneco Chemicals, Inc. | Monocyclic polyoxymethyleneoxazolidines and biocidal compositions containing same |
US4235892A (en) * | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
US5105009A (en) * | 1983-06-02 | 1992-04-14 | Zambon S.P.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives |
EP0678506A3 (en) * | 1983-06-02 | 1996-07-24 | Zambon Spa | Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives. |
IT1164387B (it) * | 1983-08-05 | 1987-04-08 | Zambon Spa | Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo |
IT1164389B (it) * | 1983-08-05 | 1987-04-08 | Zambon Spa | Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo |
US4782163A (en) * | 1984-10-05 | 1988-11-01 | Smithkline Beckman Corporation | 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines |
US4723986A (en) * | 1986-05-19 | 1988-02-09 | Stauffer Chemical Company | Herbicidal oxazolidines and methods of use |
-
1989
- 1989-10-20 IT IT02207589A patent/IT1237798B/it active IP Right Grant
-
1990
- 1990-10-16 AT AT90119803T patent/ATE116957T1/de not_active IP Right Cessation
- 1990-10-16 DE DE69015956T patent/DE69015956T2/de not_active Expired - Lifetime
- 1990-10-16 DK DK90119803.6T patent/DK0423705T3/da active
- 1990-10-16 EP EP90119803A patent/EP0423705B1/en not_active Expired - Lifetime
- 1990-10-16 ES ES90119803T patent/ES2066931T3/es not_active Expired - Lifetime
- 1990-10-19 JP JP2283237A patent/JP2852801B2/ja not_active Expired - Lifetime
- 1990-10-19 US US07/599,881 patent/US5202484A/en not_active Expired - Lifetime
-
1992
- 1992-12-18 US US07/992,747 patent/US5284966A/en not_active Expired - Lifetime
-
1993
- 1993-09-28 US US08/127,506 patent/US5401852A/en not_active Expired - Lifetime
-
1995
- 1995-04-04 GR GR950400833T patent/GR3015686T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE116957T1 (de) | 1995-01-15 |
US5202484A (en) | 1993-04-13 |
IT8922075A0 (it) | 1989-10-20 |
US5401852A (en) | 1995-03-28 |
EP0423705B1 (en) | 1995-01-11 |
ES2066931T3 (es) | 1995-03-16 |
DE69015956T2 (de) | 1995-06-08 |
JP2852801B2 (ja) | 1999-02-03 |
DE69015956D1 (de) | 1995-02-23 |
DK0423705T3 (da) | 1995-03-27 |
GR3015686T3 (en) | 1995-07-31 |
EP0423705A2 (en) | 1991-04-24 |
US5284966A (en) | 1994-02-08 |
JPH03188050A (ja) | 1991-08-16 |
EP0423705A3 (en) | 1992-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940929 |