ATE183995T1 - Herstellung von mit enantiomer angereicherten ortho-substituierten alpha, alpha-diaromatischen methanolen - Google Patents

Herstellung von mit enantiomer angereicherten ortho-substituierten alpha, alpha-diaromatischen methanolen

Info

Publication number
ATE183995T1
ATE183995T1 AT96903991T AT96903991T ATE183995T1 AT E183995 T1 ATE183995 T1 AT E183995T1 AT 96903991 T AT96903991 T AT 96903991T AT 96903991 T AT96903991 T AT 96903991T AT E183995 T1 ATE183995 T1 AT E183995T1
Authority
AT
Austria
Prior art keywords
alpha
diaromatic
methanols
enantiomer
ortho
Prior art date
Application number
AT96903991T
Other languages
English (en)
Inventor
Wen-Chung Shieh
William Rhodes Cantrell
John Alan Carlson
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE183995T1 publication Critical patent/ATE183995T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT96903991T 1995-02-17 1996-02-06 Herstellung von mit enantiomer angereicherten ortho-substituierten alpha, alpha-diaromatischen methanolen ATE183995T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/390,255 US5646330A (en) 1995-02-17 1995-02-17 Production of enantiomerically enriched ortho-substituted α,α-diaromatic methanols

Publications (1)

Publication Number Publication Date
ATE183995T1 true ATE183995T1 (de) 1999-09-15

Family

ID=23541741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96903991T ATE183995T1 (de) 1995-02-17 1996-02-06 Herstellung von mit enantiomer angereicherten ortho-substituierten alpha, alpha-diaromatischen methanolen

Country Status (8)

Country Link
US (1) US5646330A (de)
EP (1) EP0809626B1 (de)
JP (1) JP3868488B2 (de)
AT (1) ATE183995T1 (de)
AU (1) AU4787696A (de)
CA (1) CA2211981C (de)
DE (1) DE69604054T2 (de)
WO (1) WO1996025390A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008094992A2 (en) * 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
NZ585063A (en) 2007-11-02 2012-05-25 Vertex Pharma [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta
EP2328896B1 (de) 2008-07-23 2013-10-23 Vertex Pharmaceuticals Incorporated Tricyclische pyrazolopyridine als kinaseinhibitoren
KR20110039563A (ko) 2008-07-23 2011-04-19 버텍스 파마슈티칼스 인코포레이티드 피라졸로피리딘 키나제 억제제
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
JP2011530527A (ja) 2008-08-06 2011-12-22 バーテックス ファーマシューティカルズ インコーポレイテッド アミノピリジンキナーゼ阻害剤
JP5627675B2 (ja) 2009-05-06 2014-11-19 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ピラゾロピリジン
CN102869664A (zh) 2010-01-27 2013-01-09 沃泰克斯药物股份有限公司 吡唑并嘧啶类激酶抑制剂
US9067932B2 (en) 2010-01-27 2015-06-30 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
JP2013518113A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピラジンキナーゼ阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772752A (en) * 1986-08-29 1988-09-20 Aldrich-Boranes, Inc. Mono- and diisopinocampheylhaloboranes as new chiral reducing agents
US4866181A (en) * 1986-08-29 1989-09-12 Aldrich-Boranes, Inc. Process for producing optically active alcohols
US5043479A (en) * 1986-08-29 1991-08-27 Aldrich Chemical Company, Inc. Chemically and optically pure diisopinocampheylhaloboranes
US4868344A (en) * 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
US4950791A (en) * 1988-03-30 1990-08-21 Brown Herbert C Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
DK0580550T3 (da) * 1992-07-21 1998-02-02 Ciba Geigy Ag Oxamidsyrederivater som hypercholesterolæmiske midler

Also Published As

Publication number Publication date
AU4787696A (en) 1996-09-04
US5646330A (en) 1997-07-08
CA2211981C (en) 2008-04-15
JP3868488B2 (ja) 2007-01-17
EP0809626A1 (de) 1997-12-03
JPH11500118A (ja) 1999-01-06
WO1996025390A1 (en) 1996-08-22
DE69604054T2 (de) 2000-01-27
DE69604054D1 (de) 1999-10-07
CA2211981A1 (en) 1996-08-22
EP0809626B1 (de) 1999-09-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties