IT1234387B - Processo di purificazione di intermedi utili nella preparazione del diltiazem - Google Patents

Processo di purificazione di intermedi utili nella preparazione del diltiazem

Info

Publication number
IT1234387B
IT1234387B IT8921166A IT2116689A IT1234387B IT 1234387 B IT1234387 B IT 1234387B IT 8921166 A IT8921166 A IT 8921166A IT 2116689 A IT2116689 A IT 2116689A IT 1234387 B IT1234387 B IT 1234387B
Authority
IT
Italy
Prior art keywords
diltiazem
preparation
purification process
useful intermediates
intermediates
Prior art date
Application number
IT8921166A
Other languages
English (en)
Other versions
IT8921166A0 (it
Inventor
Claudio Giordano
Dario Tentorio
Laura Russo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8921166A0 publication Critical patent/IT8921166A0/it
Priority to IT8921166A priority Critical patent/IT1234387B/it
Priority to CH2086/90A priority patent/CH680219A5/it
Priority to CA002020158A priority patent/CA2020158C/en
Priority to FR9008374A priority patent/FR2649706B1/fr
Priority to NL9001515A priority patent/NL9001515A/nl
Priority to JP2178494A priority patent/JP2979240B2/ja
Priority to GB9014799A priority patent/GB2233646B/en
Priority to SE9002410A priority patent/SE509636C2/sv
Priority to ES9001892A priority patent/ES2020722A6/es
Priority to BE9000707A priority patent/BE1003313A3/fr
Priority to AT0147690A priority patent/AT401649B/de
Priority to DE4021999A priority patent/DE4021999C2/de
Application granted granted Critical
Publication of IT1234387B publication Critical patent/IT1234387B/it
Priority to US08/008,892 priority patent/US5315005A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8921166A 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem IT1234387B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT8921166A IT1234387B (it) 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem
CH2086/90A CH680219A5 (it) 1989-07-12 1990-06-22
CA002020158A CA2020158C (en) 1989-07-12 1990-06-29 Process for the purification of (25,35)-2,3-dihydro-3- hydroxy-2-(4-methoxy-phenyl)-1, 5-benzothiazepin-4(5h)-one
FR9008374A FR2649706B1 (fr) 1989-07-12 1990-07-03 Procede de purification de produits intermediaires pour la preparation du diltiazem
NL9001515A NL9001515A (nl) 1989-07-12 1990-07-03 Werkwijze voor de zuivering van tussenprodukten.
GB9014799A GB2233646B (en) 1989-07-12 1990-07-04 Process for the purification of benzothiazepinone intermediates
JP2178494A JP2979240B2 (ja) 1989-07-12 1990-07-04 （２ｓ，３ｓ）―２，３―ジヒドロ―３―ヒドロキシ―２―（４―メトキシフェニル）―１，５―ベンゾチアゼピン―４（５ｈ）―オンの精製方法
SE9002410A SE509636C2 (sv) 1989-07-12 1990-07-11 Förfarande för optisk rening av (2S,3S)-2,3-diväte-3-hydroxi- 2-(4-metoxifenyl)-1,5-bensotiazepin-4(5H)-on
ES9001892A ES2020722A6 (es) 1989-07-12 1990-07-11 Procedimiento para la purificacion de intermedios para la preparacion de benzotiacepinas.
BE9000707A BE1003313A3 (fr) 1989-07-12 1990-07-11 Procede de purification de produits intermediaires pour la preparation du diltiazem.
AT0147690A AT401649B (de) 1989-07-12 1990-07-11 Verfahren zur reinigung von zwischenprodukten
DE4021999A DE4021999C2 (de) 1989-07-12 1990-07-11 Reinigungsverfahren
US08/008,892 US5315005A (en) 1989-07-12 1993-01-25 Process for the single crystallization of enatiomeric ratio's (2S,3S):(2R,3R) of substituted 1,5-benzothiazepinone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921166A IT1234387B (it) 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem

Publications (2)

Publication Number Publication Date
IT8921166A0 IT8921166A0 (it) 1989-07-12
IT1234387B true IT1234387B (it) 1992-05-18

Family

ID=11177746

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921166A IT1234387B (it) 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem

Country Status (13)

Country Link
US (1) US5315005A (it)
JP (1) JP2979240B2 (it)
AT (1) AT401649B (it)
BE (1) BE1003313A3 (it)
CA (1) CA2020158C (it)
CH (1) CH680219A5 (it)
DE (1) DE4021999C2 (it)
ES (1) ES2020722A6 (it)
FR (1) FR2649706B1 (it)
GB (1) GB2233646B (it)
IT (1) IT1234387B (it)
NL (1) NL9001515A (it)
SE (1) SE509636C2 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559229A (en) * 1995-06-01 1996-09-24 Acic (Canada) Inc. Method for the manufacture of benzothiazepine
US7513937B2 (en) 2005-07-08 2009-04-07 Refined Global Solutions, Inc. Oil reconditioning device and associated methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
FR2360124A1 (fr) * 1976-07-30 1978-02-24 Amiens Const Electro Mecan Procede de controle de commutation de la puissance de chauffage dans un appareil electrodomestique a programmateur et dispositif pour la mise en oeuvre dudit procede
EP0059335B1 (en) * 1981-02-27 1985-05-15 Tanabe Seiyaku Co., Ltd. Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
FR2642425A1 (fr) * 1989-01-30 1990-08-03 Sanofi Sa Procede de preparation de derives de benzothiazepine-1,5 one-4
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
ES2069003T3 (es) * 1989-04-28 1995-05-01 Tanabe Seiyaku Co Procedimiento para preparar derivados de 1,5-benzotiazepina.

Also Published As

Publication number Publication date
SE9002410D0 (sv) 1990-07-11
AT401649B (de) 1996-10-25
CA2020158A1 (en) 1991-01-13
NL194274C (it) 2001-11-05
CA2020158C (en) 1997-03-04
GB2233646A (en) 1991-01-16
DE4021999A1 (de) 1991-01-17
FR2649706B1 (fr) 1994-10-07
NL194274B (it) 2001-07-02
JPH0348671A (ja) 1991-03-01
IT8921166A0 (it) 1989-07-12
SE509636C2 (sv) 1999-02-15
GB9014799D0 (en) 1990-08-22
ES2020722A6 (es) 1991-09-01
NL9001515A (nl) 1991-02-01
JP2979240B2 (ja) 1999-11-15
SE9002410L (sv) 1991-01-13
BE1003313A3 (fr) 1992-02-25
GB2233646B (en) 1993-01-27
ATA147690A (de) 1996-03-15
US5315005A (en) 1994-05-24
FR2649706A1 (fr) 1991-01-18
DE4021999C2 (de) 2002-08-29
CH680219A5 (it) 1992-07-15

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970612