IT1196033B - Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche - Google Patents

Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche

Info

Publication number
IT1196033B
IT1196033B IT19735/84A IT1973584A IT1196033B IT 1196033 B IT1196033 B IT 1196033B IT 19735/84 A IT19735/84 A IT 19735/84A IT 1973584 A IT1973584 A IT 1973584A IT 1196033 B IT1196033 B IT 1196033B
Authority
IT
Italy
Prior art keywords
cyclodextrine
complexation
beta
compound
pharmaceutical formulations
Prior art date
Application number
IT19735/84A
Other languages
English (en)
Other versions
IT8419735A0 (it
Inventor
Paolo Chiesi
Vittorino Servadio
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of IT8419735A0 publication Critical patent/IT8419735A0/it
Priority to IT19735/84A priority Critical patent/IT1196033B/it
Priority to BE0/213844A priority patent/BE900836A/fr
Priority to ZA848156A priority patent/ZA848156B/xx
Priority to ES536909A priority patent/ES8504789A1/es
Priority to US06/670,979 priority patent/US4603123A/en
Priority to EP84113923A priority patent/EP0153998B1/en
Priority to DE8484113923T priority patent/DE3482041D1/de
Priority to AT84113923T priority patent/ATE52263T1/de
Priority to DE198484113923T priority patent/DE153998T1/de
Priority to JP59245845A priority patent/JPS60208979A/ja
Priority to IE32585A priority patent/IE58231B1/en
Priority to NZ211114A priority patent/NZ211114A/en
Priority to AU38923/85A priority patent/AU550007B2/en
Priority to DK076085A priority patent/DK164911C/da
Priority to PH31877A priority patent/PH22075A/en
Priority to KR1019850001074A priority patent/KR870001960B1/ko
Priority to CA000474850A priority patent/CA1234106A/en
Priority to PT79997A priority patent/PT79997B/pt
Priority to MYPI87002570A priority patent/MY101374A/en
Application granted granted Critical
Publication of IT1196033B publication Critical patent/IT1196033B/it
Priority to SG536/90A priority patent/SG53690G/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
IT19735/84A 1984-02-22 1984-02-22 Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche IT1196033B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT19735/84A IT1196033B (it) 1984-02-22 1984-02-22 Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
BE0/213844A BE900836A (fr) 1984-02-22 1984-10-17 Composes antiinflammatoires obtenus par complexation de piroxicame avec une cyclodextrine, leur preparation et leur utilisation.
ZA848156A ZA848156B (en) 1984-02-22 1984-10-18 Compounds having antiinflammatory activity,obtained by complexation with beta-cyclodextrin,and pharmaceutical compositions containing them
ES536909A ES8504789A1 (es) 1984-02-22 1984-10-19 Procedimiento para la preparacion de compuestos complejos de piroxicam con ciclodestrinas
US06/670,979 US4603123A (en) 1984-02-22 1984-11-13 Compounds having antiinflammatory activity, obtained by complexation of piroxican with β-cyclodextrin, and pharmaceutical compositions containing them
EP84113923A EP0153998B1 (en) 1984-02-22 1984-11-17 New compounds having antiinflammatory activity, obtained by complexation with beta-cyclodextrin, and pharmaceutical compositions containing them
DE8484113923T DE3482041D1 (de) 1984-02-22 1984-11-17 Verbindungen mit entzuendungshemmender aktivitaet, hergestellt durch komplexierung mit beta-cyclodextrin und pharmazeutische zusammensetzungen welche diese enthalten.
AT84113923T ATE52263T1 (de) 1984-02-22 1984-11-17 Verbindungen mit entzuendungshemmender aktivitaet, hergestellt durch komplexierung mit beta- cyclodextrin und pharmazeutische zusammensetzungen welche diese enthalten.
DE198484113923T DE153998T1 (de) 1984-02-22 1984-11-17 Verbindungen mit entzuendungshemmender aktivitaet, hergestellt durch komplexierung mit beta-cyclodextrin und pharmazeutische zusammensetzungen welche diese enthalten.
JP59245845A JPS60208979A (ja) 1984-02-22 1984-11-20 シクロデキストリンとの複合化包接化合物、その製造方法および該化合物を含有する抗炎症、鎮痛および解熱効果を有する医薬組成物
IE32585A IE58231B1 (en) 1984-02-22 1985-02-11 New compounds having antiinflammatory activity, obtain by complexation with beta -cyclodextrin, and pharmaceutical compositions containing them
NZ211114A NZ211114A (en) 1984-02-22 1985-02-13 Piroxicam/cyclodextrin complexes and pharmaceutical compositions
AU38923/85A AU550007B2 (en) 1984-02-22 1985-02-18 Complex of 4-hydroxy-2-methyl-n-2-pyridyl-2h-1, 2-benzothiazine-3-carboxamide-1, 1-dioxide and alpha, beta, gamma-type cyclodextrin
DK076085A DK164911C (da) 1984-02-22 1985-02-19 Inklusionskompleks mellem piroxicam og cyklodextriner og analogifremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende et saadant kompleks
PH31877A PH22075A (en) 1984-02-22 1985-02-19 New complex compounds of piroxicam with cyclodextrin having antiinflammatory activity and pharmaceutical compositions containing them
KR1019850001074A KR870001960B1 (ko) 1984-02-22 1985-02-21 피록시캄 착물의 제조 방법
CA000474850A CA1234106A (en) 1984-02-22 1985-02-21 COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY, OBTAINED BY COMPLEXATION WITH .beta.-CYCLODEXTRIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT79997A PT79997B (en) 1984-02-22 1985-02-21 Process for preparing complex compounds of piroxicam with cyclodextrins
MYPI87002570A MY101374A (en) 1984-02-22 1987-09-30 New compounds having anti inflammatory activity, obtained by complexation with b-cyclodextrin, and pharmaceutical compositions containing them
SG536/90A SG53690G (en) 1984-02-22 1990-07-11 New compounds having antiinflammatory activity,obtained by complexation with beta-cyclodextrin,and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19735/84A IT1196033B (it) 1984-02-22 1984-02-22 Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche

Publications (2)

Publication Number Publication Date
IT8419735A0 IT8419735A0 (it) 1984-02-22
IT1196033B true IT1196033B (it) 1988-11-10

Family

ID=11160778

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19735/84A IT1196033B (it) 1984-02-22 1984-02-22 Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche

Country Status (19)

Country Link
US (1) US4603123A (it)
EP (1) EP0153998B1 (it)
JP (1) JPS60208979A (it)
KR (1) KR870001960B1 (it)
AT (1) ATE52263T1 (it)
AU (1) AU550007B2 (it)
BE (1) BE900836A (it)
CA (1) CA1234106A (it)
DE (2) DE3482041D1 (it)
DK (1) DK164911C (it)
ES (1) ES8504789A1 (it)
IE (1) IE58231B1 (it)
IT (1) IT1196033B (it)
MY (1) MY101374A (it)
NZ (1) NZ211114A (it)
PH (1) PH22075A (it)
PT (1) PT79997B (it)
SG (1) SG53690G (it)
ZA (1) ZA848156B (it)

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YU43290B (en) * 1986-11-13 1989-06-30 Lek Tovarna Farmacevtskih Process for preparing inclusioned complex of ibuproxane with beta-cyclodextrine
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
DE3809808A1 (de) * 1988-03-23 1989-10-05 Hexal Pharma Gmbh & Co Kg Feste, insbesondere festorale und rektale, etofenamat enthaltende arzneimittel
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
IT1241088B (it) * 1990-03-27 1993-12-29 Chiesi Farma Spa Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche
US5180716A (en) * 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
ATE196426T1 (de) * 1991-06-21 2000-10-15 Takeda Chemical Industries Ltd Zyklodextrin-zusammensetzung enthaltend fumagillol-derivate
US5602112A (en) 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
US20040014695A1 (en) * 1992-06-19 2004-01-22 Supergen, Inc. Pharmaceutical formulation
IL111184A (en) * 1993-10-08 2000-08-13 Farmarc Nederland B V Of Cito Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
IT1269578B (it) * 1994-04-22 1997-04-08 Chiesi Farma Spa Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo acido, una ciclodestrina e una base.
ZA959469B (en) * 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
US5824668A (en) * 1996-11-07 1998-10-20 Supergen, Inc. Formulation for administration of steroid compounds
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
US6667056B2 (en) * 1997-07-23 2003-12-23 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions containing an effervescent acid-base couple
IT1293764B1 (it) * 1997-07-23 1999-03-10 Chiesi Farma Spa Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua
FR2786395A1 (fr) * 1998-12-01 2000-06-02 Virbac Sa Compositions seches solubles en presence d'eau et evitant la reaction de maillard a l'etat sec, leur preparation et leurs applications
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
WO2002045713A2 (en) * 2000-12-04 2002-06-13 Sepracor, Inc. Orally-bioavailable formulations of fentanyl and congeners thereof
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
EP1374906B1 (en) * 2002-06-17 2007-04-18 CHIESI FARMACEUTICI S.p.A. A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds
EP1582221A1 (en) * 2004-03-31 2005-10-05 Chiesi S.A. Pharmaceutical oral compositions with a taste masking effect
ATE504316T1 (de) * 2004-04-01 2011-04-15 Pf Medicament Einschlusskomplexe enthaltend piroxicam, ein cyklodextrin und arginin
ATE349199T1 (de) * 2004-04-15 2007-01-15 Helm Ag Verfahren zur herstellung von freifliessenden, pulverförmigen valsartan-adsorbaten
US20060024922A1 (en) * 2004-07-27 2006-02-02 Da-Tung Wen Method for cutting wafer
CN101123989B (zh) * 2004-08-02 2010-12-15 奇斯药制品公司 制备吡罗昔康：β-环糊精包合物的方法
FR2876910B1 (fr) 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
US20070010485A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070010486A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070010465A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
US20070010487A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070009531A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar
GB0612695D0 (en) * 2006-06-27 2006-08-09 Univ Gent Process for preparing a solid dosage form
CL2007003876A1 (es) * 2007-12-28 2008-03-07 Univ De Concepcion Y Lab Andro Complejo de inclusion que esta formado por disulfiram y ciclodextrina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de la dependencia de alcohol y ***a.
KR101383941B1 (ko) 2012-03-09 2014-04-10 동아에스티 주식회사 피록시캄 또는 약제학적으로 허용되는 그의 염과 히알루론산 또는 약제학적으로 허용되는 그의 염의 안정한 액상 조성물 및 그 제조방법

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Also Published As

Publication number Publication date
DE153998T1 (de) 1986-04-10
ZA848156B (en) 1985-06-26
ATE52263T1 (de) 1990-05-15
DE3482041D1 (de) 1990-05-31
ES536909A0 (es) 1985-05-01
EP0153998A2 (en) 1985-09-11
KR870001960B1 (ko) 1987-10-23
SG53690G (en) 1990-11-23
IE850325L (en) 1985-08-22
EP0153998A3 (en) 1987-01-14
PT79997B (en) 1987-01-13
DK164911B (da) 1992-09-07
KR850006133A (ko) 1985-10-02
AU3892385A (en) 1985-08-29
BE900836A (fr) 1985-02-15
CA1234106A (en) 1988-03-15
DK164911C (da) 1993-01-18
MY101374A (en) 1991-10-23
DK76085D0 (da) 1985-02-19
PT79997A (en) 1985-03-01
NZ211114A (en) 1987-09-30
ES8504789A1 (es) 1985-05-01
IE58231B1 (en) 1993-08-11
IT8419735A0 (it) 1984-02-22
AU550007B2 (en) 1986-02-27
DK76085A (da) 1985-08-23
JPS60208979A (ja) 1985-10-21
EP0153998B1 (en) 1990-04-25
US4603123A (en) 1986-07-29
JPH0370705B2 (it) 1991-11-08
PH22075A (en) 1988-05-20

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