IT1167724B - IMIDAZO (4,5-B) PYRIDINE DERIVATIVES USEFUL AS CARDIOTONICS AND THEIR PREPARATION - Google Patents

IMIDAZO (4,5-B) PYRIDINE DERIVATIVES USEFUL AS CARDIOTONICS AND THEIR PREPARATION

Info

Publication number
IT1167724B
IT1167724B IT20658/81A IT2065881A IT1167724B IT 1167724 B IT1167724 B IT 1167724B IT 20658/81 A IT20658/81 A IT 20658/81A IT 2065881 A IT2065881 A IT 2065881A IT 1167724 B IT1167724 B IT 1167724B
Authority
IT
Italy
Prior art keywords
cardiotonics
imidazo
preparation
pyridine derivatives
derivatives useful
Prior art date
Application number
IT20658/81A
Other languages
Italian (it)
Other versions
IT8120658A0 (en
Inventor
George Yohe Lesher
Ruth Pauline Brundage
Jr Chester Joseph Opalka
Donald Frederick Page
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/132,907 external-priority patent/US4294836A/en
Priority claimed from US06/135,105 external-priority patent/US4294837A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of IT8120658A0 publication Critical patent/IT8120658A0/en
Application granted granted Critical
Publication of IT1167724B publication Critical patent/IT1167724B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
IT20658/81A 1980-03-24 1981-03-23 IMIDAZO (4,5-B) PYRIDINE DERIVATIVES USEFUL AS CARDIOTONICS AND THEIR PREPARATION IT1167724B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/132,907 US4294836A (en) 1980-03-24 1980-03-24 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use
US06/135,105 US4294837A (en) 1980-03-28 1980-03-28 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use

Publications (2)

Publication Number Publication Date
IT8120658A0 IT8120658A0 (en) 1981-03-23
IT1167724B true IT1167724B (en) 1987-05-13

Family

ID=26830852

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20658/81A IT1167724B (en) 1980-03-24 1981-03-23 IMIDAZO (4,5-B) PYRIDINE DERIVATIVES USEFUL AS CARDIOTONICS AND THEIR PREPARATION

Country Status (14)

Country Link
AU (1) AU6868381A (en)
DE (1) DE3111563A1 (en)
DK (1) DK130381A (en)
ES (1) ES8202006A1 (en)
FI (1) FI810878L (en)
FR (1) FR2478637A1 (en)
GB (1) GB2072187A (en)
IL (1) IL62402A0 (en)
IT (1) IT1167724B (en)
LU (1) LU83251A1 (en)
NL (1) NL8101454A (en)
NO (1) NO810989L (en)
PT (1) PT72710B (en)
SE (1) SE8101841L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
CN103848783B (en) * 2014-01-14 2016-05-04 红太阳集团有限公司 The method of the synthetic 2-chlorine apellagrin of a kind of oxidation step

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000206A1 (en) * 1977-10-13 1979-04-19 Roussel Uclaf New substituted by-products of 1,3-dihydro imidazo(4,5-b)pyridin-2-one,process,application,compositions and intermediate compounds obtained

Also Published As

Publication number Publication date
GB2072187A (en) 1981-09-30
IL62402A0 (en) 1981-05-20
PT72710B (en) 1982-03-24
DK130381A (en) 1981-09-25
DE3111563A1 (en) 1982-06-16
LU83251A1 (en) 1981-10-29
NO810989L (en) 1981-09-25
FR2478637A1 (en) 1981-09-25
ES500605A0 (en) 1982-01-01
AU6868381A (en) 1981-10-01
FI810878L (en) 1981-09-25
SE8101841L (en) 1981-09-25
IT8120658A0 (en) 1981-03-23
NL8101454A (en) 1981-10-16
PT72710A (en) 1981-04-01
ES8202006A1 (en) 1982-01-01

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