IT1164239B - Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica - Google Patents
Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimaticaInfo
- Publication number
- IT1164239B IT1164239B IT21281/83A IT2128183A IT1164239B IT 1164239 B IT1164239 B IT 1164239B IT 21281/83 A IT21281/83 A IT 21281/83A IT 2128183 A IT2128183 A IT 2128183A IT 1164239 B IT1164239 B IT 1164239B
- Authority
- IT
- Italy
- Prior art keywords
- retro
- angiotensinogen
- decapeptide
- equine
- high resistance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/32—Modification to prevent enzymatic degradation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21281/83A IT1164239B (it) | 1983-05-25 | 1983-05-25 | Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica |
DE8484200710T DE3466396D1 (en) | 1983-05-25 | 1984-05-17 | A retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis |
EP84200710A EP0127234B1 (en) | 1983-05-25 | 1984-05-17 | A retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis |
AT84200710T ATE29890T1 (de) | 1983-05-25 | 1984-05-17 | Retroinversoanalog des (5-14)-decapeptids von equin angiotensinogen als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse. |
US06/612,798 US4560505A (en) | 1983-05-25 | 1984-05-22 | Retro-inverso analog of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis |
CA000454917A CA1249699A (en) | 1983-05-25 | 1984-05-23 | Retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis |
AU28553/84A AU558572B2 (en) | 1983-05-25 | 1984-05-24 | Retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen |
JP59104834A JPH0672153B2 (ja) | 1983-05-25 | 1984-05-25 | ペプチド |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21281/83A IT1164239B (it) | 1983-05-25 | 1983-05-25 | Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8321281A0 IT8321281A0 (it) | 1983-05-25 |
IT8321281A1 IT8321281A1 (it) | 1984-11-25 |
IT1164239B true IT1164239B (it) | 1987-04-08 |
Family
ID=11179480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT21281/83A IT1164239B (it) | 1983-05-25 | 1983-05-25 | Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica |
Country Status (8)
Country | Link |
---|---|
US (1) | US4560505A (it) |
EP (1) | EP0127234B1 (it) |
JP (1) | JPH0672153B2 (it) |
AT (1) | ATE29890T1 (it) |
AU (1) | AU558572B2 (it) |
CA (1) | CA1249699A (it) |
DE (1) | DE3466396D1 (it) |
IT (1) | IT1164239B (it) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1190389B (it) * | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
EP0253190B1 (en) * | 1986-07-16 | 1992-12-30 | ENIRICERCHE S.p.A. | Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them |
ES2058489T3 (es) * | 1988-01-26 | 1994-11-01 | Sankyo Co | Oligopeptidos con actividades inhibidoras de la renina, su preparacion y su uso. |
US5807979A (en) * | 1988-04-08 | 1998-09-15 | The Scripps Research Institute | Synthetic, three-dimensionally stabilized polypeptide mimics of HIV |
AU3534989A (en) * | 1988-04-08 | 1989-11-03 | Scripps Clinic And Research Foundation | Polypeptides stabilized by covalent hydrogen bond replacements |
DE4004820A1 (de) * | 1989-08-05 | 1991-04-25 | Bayer Ag | Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
US5242903A (en) * | 1989-08-05 | 1993-09-07 | Bayer Aktiengesellschaft | Renin inhibitors |
US6458357B1 (en) | 1997-09-09 | 2002-10-01 | Myelos Corporation | Retro-inverso neurotrophic and analgesic peptides |
AU2004223829A1 (en) * | 2003-03-24 | 2004-10-07 | Sequoia Pharmaceuticals, Inc. | Long acting biologically active conjugates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4269827A (en) * | 1980-06-23 | 1981-05-26 | The Massachusetts General Hospital | Process and composition for reducing blood pressure |
JPS5759846A (en) * | 1980-08-06 | 1982-04-10 | Ferring Pharma Ltd | Polypeptide homologue and manufacture of hydroxy or keto homologue of dipeptide |
NO812612L (no) * | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
IT1212508B (it) * | 1981-12-22 | 1989-11-22 | Anic Spa | Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori |
IT1190891B (it) * | 1982-06-24 | 1988-02-24 | Anic Spa | Metodo per la sintesi in fase solida di polipeptidi retroinvertiti |
-
1983
- 1983-05-25 IT IT21281/83A patent/IT1164239B/it active
-
1984
- 1984-05-17 AT AT84200710T patent/ATE29890T1/de active
- 1984-05-17 DE DE8484200710T patent/DE3466396D1/de not_active Expired
- 1984-05-17 EP EP84200710A patent/EP0127234B1/en not_active Expired
- 1984-05-22 US US06/612,798 patent/US4560505A/en not_active Expired - Fee Related
- 1984-05-23 CA CA000454917A patent/CA1249699A/en not_active Expired
- 1984-05-24 AU AU28553/84A patent/AU558572B2/en not_active Ceased
- 1984-05-25 JP JP59104834A patent/JPH0672153B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU558572B2 (en) | 1987-02-05 |
AU2855384A (en) | 1984-11-29 |
IT8321281A1 (it) | 1984-11-25 |
JPS59231055A (ja) | 1984-12-25 |
JPH0672153B2 (ja) | 1994-09-14 |
EP0127234B1 (en) | 1987-09-23 |
EP0127234A2 (en) | 1984-12-05 |
ATE29890T1 (de) | 1987-10-15 |
US4560505A (en) | 1985-12-24 |
IT8321281A0 (it) | 1983-05-25 |
CA1249699A (en) | 1989-01-31 |
DE3466396D1 (en) | 1987-10-29 |
EP0127234A3 (en) | 1985-09-04 |
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