IT1141999B - PYRAZOLOPYRIDINONE AND PYRIDYLNICOTINATES USEFUL AS CARDIOTONICS - Google Patents

PYRAZOLOPYRIDINONE AND PYRIDYLNICOTINATES USEFUL AS CARDIOTONICS

Info

Publication number
IT1141999B
IT1141999B IT20272/81A IT2027281A IT1141999B IT 1141999 B IT1141999 B IT 1141999B IT 20272/81 A IT20272/81 A IT 20272/81A IT 2027281 A IT2027281 A IT 2027281A IT 1141999 B IT1141999 B IT 1141999B
Authority
IT
Italy
Prior art keywords
pyridylnicotinates
pyrazolopyridinone
cardiotonics
useful
pyridylnicotinates useful
Prior art date
Application number
IT20272/81A
Other languages
Italian (it)
Other versions
IT8120272A0 (en
Inventor
George Yohe Lesher
Monte Deane Gruett
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/130,623 external-priority patent/US4265895A/en
Priority claimed from US06/130,628 external-priority patent/US4264612A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of IT8120272A0 publication Critical patent/IT8120272A0/en
Application granted granted Critical
Publication of IT1141999B publication Critical patent/IT1141999B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46Oxygen atoms
    • C07D213/50Ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • C07D213/85Nitriles in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
IT20272/81A 1980-03-17 1981-03-10 PYRAZOLOPYRIDINONE AND PYRIDYLNICOTINATES USEFUL AS CARDIOTONICS IT1141999B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/130,623 US4265895A (en) 1980-03-17 1980-03-17 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics
US06/130,628 US4264612A (en) 1980-03-17 1980-03-17 Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics

Publications (2)

Publication Number Publication Date
IT8120272A0 IT8120272A0 (en) 1981-03-10
IT1141999B true IT1141999B (en) 1986-10-08

Family

ID=26828659

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20272/81A IT1141999B (en) 1980-03-17 1981-03-10 PYRAZOLOPYRIDINONE AND PYRIDYLNICOTINATES USEFUL AS CARDIOTONICS

Country Status (16)

Country Link
AU (1) AU6813881A (en)
DE (1) DE3110313A1 (en)
DK (1) DK117081A (en)
ES (1) ES500395A0 (en)
FI (1) FI810779L (en)
FR (1) FR2478098A1 (en)
GB (1) GB2073179A (en)
IL (1) IL62306A0 (en)
IT (1) IT1141999B (en)
LU (1) LU83221A1 (en)
NL (1) NL8101269A (en)
NO (1) NO810833L (en)
NZ (1) NZ196453A (en)
PH (1) PH15978A (en)
PT (1) PT72674B (en)
SE (1) SE8101592L (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2953571A (en) * 1957-12-13 1960-09-20 Gen Aniline & Film Corp Pyrazolopyridines
AU454992B2 (en) * 1970-06-03 1974-10-28 Euclid Inc Exhaust diverting valve for dumpable vehicles having heated dump bodies
DE2232038A1 (en) * 1972-06-30 1974-01-10 Hoechst Ag 3-AMINO-1H-PYRAZOLO SQUARE CLAMP ON 3.4-ANGLE BRACKET FOR PYRIDINE, THEIR PRODUCTION AND USE
US4081451A (en) * 1975-03-20 1978-03-28 Schering Corporation Process for preparing 2-halogeno nicotinic acids
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
IL62306A0 (en) 1981-05-20
ES8205410A1 (en) 1982-06-01
DE3110313A1 (en) 1981-12-24
DK117081A (en) 1981-09-18
GB2073179A (en) 1981-10-14
NL8101269A (en) 1981-10-16
NO810833L (en) 1981-09-18
PH15978A (en) 1983-05-16
FI810779L (en) 1981-09-18
NZ196453A (en) 1983-12-16
PT72674B (en) 1982-03-22
ES500395A0 (en) 1982-06-01
SE8101592L (en) 1981-09-18
PT72674A (en) 1981-04-01
AU6813881A (en) 1981-09-24
FR2478098A1 (en) 1981-09-18
LU83221A1 (en) 1981-10-30
IT8120272A0 (en) 1981-03-10

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