IS6594A - 2-asýl indól afleiður og notkun þeirra sem miðla gegn æxlum - Google Patents
2-asýl indól afleiður og notkun þeirra sem miðla gegn æxlumInfo
- Publication number
- IS6594A IS6594A IS6594A IS6594A IS6594A IS 6594 A IS6594 A IS 6594A IS 6594 A IS6594 A IS 6594A IS 6594 A IS6594 A IS 6594A IS 6594 A IS6594 A IS 6594A
- Authority
- IS
- Iceland
- Prior art keywords
- indole derivatives
- tumor agents
- acyl indole
- acyl
- tumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000120852 DE10020852A1 (de) | 2000-04-28 | 2000-04-28 | 2-Acryl-indolderivate und deren Verwendung als Antitumormittel |
DE2001102629 DE10102629A1 (de) | 2001-01-20 | 2001-01-20 | 2-Acyl-indolderivate und deren Verwendung als Antitumormittel |
PCT/EP2001/004783 WO2001082909A2 (de) | 2000-04-28 | 2001-04-27 | 2-acyl-indolderivate und deren verwendung als antitumormittel |
Publications (1)
Publication Number | Publication Date |
---|---|
IS6594A true IS6594A (is) | 2002-10-25 |
Family
ID=26005501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IS6594A IS6594A (is) | 2000-04-28 | 2002-10-25 | 2-asýl indól afleiður og notkun þeirra sem miðla gegn æxlum |
Country Status (27)
Country | Link |
---|---|
US (2) | US20020091124A1 (is) |
EP (1) | EP1276720B1 (is) |
JP (1) | JP2004501092A (is) |
KR (1) | KR20030024661A (is) |
CN (1) | CN1286810C (is) |
AR (1) | AR029915A1 (is) |
AT (1) | ATE348805T1 (is) |
AU (1) | AU783459B2 (is) |
BG (1) | BG107309A (is) |
BR (1) | BR0110414A (is) |
CA (1) | CA2407677A1 (is) |
CZ (1) | CZ20023544A3 (is) |
DE (1) | DE50111690D1 (is) |
EE (1) | EE200200607A (is) |
GE (1) | GEP20063751B (is) |
HK (1) | HK1054549B (is) |
HR (1) | HRP20020940A2 (is) |
HU (1) | HUP0300480A3 (is) |
IL (1) | IL152477A0 (is) |
IS (1) | IS6594A (is) |
MX (1) | MXPA02010627A (is) |
NO (1) | NO20025150L (is) |
NZ (1) | NZ522246A (is) |
PL (1) | PL358877A1 (is) |
RU (1) | RU2002132253A (is) |
SK (1) | SK15432002A3 (is) |
WO (1) | WO2001082909A2 (is) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1431999A (zh) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 具有血管损伤活性的吲哚衍生物 |
US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
JP2005532280A (ja) | 2002-04-03 | 2005-10-27 | アストラゼネカ アクチボラグ | 化合物 |
TW200400177A (en) | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
SE0300908D0 (sv) * | 2003-03-31 | 2003-03-31 | Astrazeneca Ab | Azaindole derivatives, preparations thereof, uses thereof and compositions containing them |
JP2007513184A (ja) * | 2003-12-04 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なキノキサリン |
JP2008501758A (ja) | 2004-06-09 | 2008-01-24 | グラクソ グループ リミテッド | ピロロピリジン誘導体 |
MX2007003922A (es) * | 2004-10-05 | 2007-06-07 | Merz Pharma Gmbh & Co Kgaa | Nuevas propenonas ciclicas y aciclicas para tratar trastornos del sistema nervioso central. |
EP1848704A4 (en) * | 2005-02-14 | 2011-05-11 | Bionomics Ltd | NEW TUBULIN POLYMERIZATION INHIBITORS |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
EA013525B1 (ru) * | 2005-05-20 | 2010-06-30 | Алантос-Фармасьютикалз Холдинг, Инк. | Гетеробициклические ингибиторы металлопротеазы и их применение |
US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
WO2014033497A1 (en) * | 2012-08-27 | 2014-03-06 | Centre National De La Recherche Scientifique | 5-azaindole compounds with anticancer and antiangiogenic activities |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
WO2014144715A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
WO2016114816A1 (en) * | 2015-01-18 | 2016-07-21 | Sri International | MAP4K4 (HGK) Inhibitors |
CN104945376B (zh) * | 2015-07-09 | 2017-03-15 | 安徽理工大学 | 一种3‑芳酰基吲哚化合物的合成方法 |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
CN107722013B (zh) * | 2016-08-11 | 2021-01-12 | 中国科学院上海药物研究所 | 去氮嘌呤类化合物及其药物组合物、制备方法和用途 |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660430A (en) * | 1969-11-04 | 1972-05-02 | American Home Prod | 2-substituted-3-arylindoles |
US3838167A (en) * | 1972-08-01 | 1974-09-24 | Lilly Co Eli | Process for preparing indoles |
DK3375A (is) * | 1974-01-25 | 1975-09-15 | Ciba Geigy Ag | |
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
NZ334344A (en) * | 1996-09-12 | 2000-08-25 | Cancer Res Campaign Tech | benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs |
AP9801302A0 (en) * | 1997-07-23 | 2000-01-23 | Pfizer | Indole compounds as anti-inflammatory/analgesic agents.. |
-
2001
- 2001-04-27 WO PCT/EP2001/004783 patent/WO2001082909A2/de active IP Right Grant
- 2001-04-27 HU HU0300480A patent/HUP0300480A3/hu unknown
- 2001-04-27 BR BR0110414-4A patent/BR0110414A/pt not_active IP Right Cessation
- 2001-04-27 EP EP01947247A patent/EP1276720B1/de not_active Expired - Lifetime
- 2001-04-27 DE DE50111690T patent/DE50111690D1/de not_active Expired - Fee Related
- 2001-04-27 EE EEP200200607A patent/EE200200607A/xx unknown
- 2001-04-27 NZ NZ522246A patent/NZ522246A/en unknown
- 2001-04-27 CA CA002407677A patent/CA2407677A1/en not_active Abandoned
- 2001-04-27 JP JP2001579784A patent/JP2004501092A/ja not_active Withdrawn
- 2001-04-27 PL PL01358877A patent/PL358877A1/xx unknown
- 2001-04-27 AR ARP010102016A patent/AR029915A1/es not_active Application Discontinuation
- 2001-04-27 CN CNB018104762A patent/CN1286810C/zh not_active Expired - Fee Related
- 2001-04-27 KR KR1020027014523A patent/KR20030024661A/ko not_active Application Discontinuation
- 2001-04-27 MX MXPA02010627A patent/MXPA02010627A/es active IP Right Grant
- 2001-04-27 CZ CZ20023544A patent/CZ20023544A3/cs unknown
- 2001-04-27 AT AT01947247T patent/ATE348805T1/de not_active IP Right Cessation
- 2001-04-27 SK SK1543-2002A patent/SK15432002A3/sk not_active Application Discontinuation
- 2001-04-27 IL IL15247701A patent/IL152477A0/xx unknown
- 2001-04-27 AU AU68984/01A patent/AU783459B2/en not_active Ceased
- 2001-04-27 GE GE5060A patent/GEP20063751B/en unknown
- 2001-04-27 US US09/843,139 patent/US20020091124A1/en not_active Abandoned
- 2001-04-27 RU RU2002132253/04A patent/RU2002132253A/ru not_active Application Discontinuation
-
2002
- 2002-10-24 US US10/279,123 patent/US20030158216A1/en not_active Abandoned
- 2002-10-25 NO NO20025150A patent/NO20025150L/no not_active Application Discontinuation
- 2002-10-25 IS IS6594A patent/IS6594A/is unknown
- 2002-11-25 BG BG107309A patent/BG107309A/bg unknown
- 2002-11-27 HR HR20020940A patent/HRP20020940A2/hr not_active Application Discontinuation
-
2003
- 2003-07-21 HK HK03105237.9A patent/HK1054549B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IS6594A (is) | 2-asýl indól afleiður og notkun þeirra sem miðla gegn æxlum | |
IS6264A (is) | Arýlmetýl-karbónýlamínó-þíósól afleiður og notkunþeirra sem miðla gegn æxlum | |
DK1233943T3 (da) | Ioniserbare indolinon derivater og anvendelse deraf som PTK ligander | |
IS2529B (is) | Nýjar spírótrísýklískar afleiður og notkun þeirra sem fosfódíesterasa-7-hindrar | |
IS6385A (is) | Ný notkun og nýjar N-asabísýkló-amíð afleiður | |
IS6656A (is) | Útskiptar kínasólínafleiður og notkun þeirra sem hemla | |
IS5980A (is) | Indól afleiður og notkun þeirra sem MCP-1 mótlyf | |
DK1133477T3 (da) | Substituerede benzimidazoler og deres anvendelse som parpinhibitorer | |
IS2599B (is) | 3-fenýlsúlfónýl-8-píperasín-1-ýl-kínólín og lyfjafræðilega viðurkenndar afleiður þess | |
IS6411A (is) | Kaspasa tálmar og notkun þeirra | |
NO20024355L (no) | Nukleosidforbindelser og anvendelser derav | |
IS6802A (is) | 3-arýlindólafleiður og notkun þeirra sem CB2 viðtakagerandefni | |
AR028622A1 (es) | Derivados de tropano utiles en terapia | |
AU8664701A (en) | Oxindole derivatives | |
AU8975801A (en) | Novel indole derivatives and their use as medicaments | |
PL357188A1 (en) | Substituted imide derivatives | |
IS2773B (is) | Amínókínólínafleiður og notkun þeirra sem adenósín A3-bindlar | |
ATE299876T1 (de) | Indolderivate | |
IS2607B (is) | Afleiður tryptamíns og hliðstæð efnasambönd ásamt lyfjaforskriftum þeirra | |
ITMI991483A0 (it) | Derivati tassanici e procedimenti per la loro preparazione | |
DK1228041T3 (da) | Indolderivater og anvendelse deraf som SHT2A-ligander | |
NO20001718L (no) | Benzen-fusjonerte heterocykliske derivater og anvendelse derav | |
ATE317386T1 (de) | Dihydroindol- und tetrahydrochinolinderivate | |
DE60118970D1 (de) | Indol- und dihydroindolderivate | |
NO20025135D0 (no) | Antihypertensive midler og anvendelse |