IN2014MN01521A - - Google Patents

Info

Publication number
IN2014MN01521A
IN2014MN01521A IN1521MUN2014A IN2014MN01521A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A IN 1521MUN2014 A IN1521MUN2014 A IN 1521MUN2014A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A
Authority
IN
India
Prior art keywords
formula
compound
preparation
disclosed
eribulin
Prior art date
Application number
Inventor
Fabio E S Souza
Alena Rudolph
Ming Pan
Boris Gorin
Dino Alberico
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Publication of IN2014MN01521A publication Critical patent/IN2014MN01521A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Disclosed is a compound of formula 1 as shown below where R R R R R R and R are as described herein. Also disclosed is a process for the preparation of compounds of formula 1 and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin.
IN1521MUN2014 2011-12-29 2012-12-24 IN2014MN01521A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161581164P 2011-12-29 2011-12-29
PCT/CA2012/050939 WO2013097042A1 (en) 2011-12-29 2012-12-24 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
IN2014MN01521A true IN2014MN01521A (en) 2015-05-01

Family

ID=48696142

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1521MUN2014 IN2014MN01521A (en) 2011-12-29 2012-12-24

Country Status (9)

Country Link
US (1) US9062020B2 (en)
EP (1) EP2797945B1 (en)
JP (1) JP6300030B2 (en)
CN (1) CN104080793B (en)
AU (1) AU2012363334B2 (en)
CA (1) CA2860446C (en)
IN (1) IN2014MN01521A (en)
SI (1) SI2797945T1 (en)
WO (1) WO2013097042A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2785687B1 (en) 2011-11-30 2019-02-20 Sandoz AG Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
WO2013086634A1 (en) 2011-12-16 2013-06-20 Alphora Research Inc. Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
WO2013142999A1 (en) * 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
TW201617326A (en) 2014-03-06 2016-05-16 Ａｌｐｈｏｒａ研發股份有限公司 Crystalline derivatives of (S)-1-((2R,3R,4S,5S)-5-allyl-3-methoxy-4-(tosylmethyl)tetrahydrofuran-2-yl)-3-aminopropan-2-ol
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10147463B2 (en) 2014-12-10 2018-12-04 Nxp Usa, Inc. Video processing unit and method of buffering a source video stream
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX2018010562A (en) 2016-03-02 2019-02-20 Eisai R&D Man Co Ltd Eribulin-based antibody-drug conjugates and methods of use.
JP6978758B2 (en) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ Palladium-mediated ketolization
MX2019011982A (en) 2017-04-05 2019-11-08 Harvard College Macrocyclic compound and uses thereof.
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
IL295588B2 (en) 2017-07-06 2024-03-01 Harvard College Synthesis of halichondrins
CN117924310A (en) 2017-11-15 2024-04-26 哈佛大学的校长及成员们 Macrocyclic compounds and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
CA2166898C (en) 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
DE122011100031I1 (en) * 1998-06-17 2011-12-15 Eisai R&D Man Co Ltd Macrocyclic analogues and methods for their use and preparation.
US7001982B2 (en) 2003-03-31 2006-02-21 Council Of Scientific And Industrial Research Non-natural C-linked carbo-β-peptides with robust secondary structures
CN108997267A (en) * 2004-06-03 2018-12-14 卫材R&D管理有限公司 It is used to prepare the intermediate of the analog of halichondrin B
CA3028453C (en) 2004-06-03 2021-07-27 Eisai R&D Management Co., Ltd. Intermediates for the preparation of analogs of halichondrin b
RU2517167C2 (en) 2008-04-04 2014-05-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Halichondrin b analogues
EP2785687B1 (en) 2011-11-30 2019-02-20 Sandoz AG Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
WO2013086634A1 (en) 2011-12-16 2013-06-20 Alphora Research Inc. Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
WO2013142999A1 (en) 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
TW201514159A (en) 2013-05-15 2015-04-16 Alphora Res Inc 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydro furan-2-yl)propanol derivatives, their preparation and intermediates useful thereof

Also Published As

Publication number Publication date
CA2860446C (en) 2017-01-10
AU2012363334B2 (en) 2017-02-02
SI2797945T1 (en) 2016-07-29
EP2797945B1 (en) 2016-03-16
JP2015503525A (en) 2015-02-02
AU2012363334A1 (en) 2014-08-21
CN104080793B (en) 2017-09-19
CA2860446A1 (en) 2013-07-04
US20150011776A1 (en) 2015-01-08
US9062020B2 (en) 2015-06-23
JP6300030B2 (en) 2018-03-28
EP2797945A1 (en) 2014-11-05
CN104080793A (en) 2014-10-01
EP2797945A4 (en) 2015-06-03
WO2013097042A1 (en) 2013-07-04

Similar Documents

Publication Publication Date Title
IN2014MN01521A (en)
IN2014MN02106A (en)
IN2014MN02496A (en)
UA110354C2 (en) Anti-viral compounds
TN2011000400A1 (en) Inhibitors of beta-secretase
MD20180040A2 (en) Inhibitors of hepatitis C virus
MX2013011257A (en) Process for preparation of dronedarone by n-butylation.
AU2012313888A8 (en) 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
IN2014MN02459A (en)
MX2016006336A (en) Pyrazolopyrimidine compounds.
PH12015500008B1 (en) Dimethyl-benzoic acid compounds
IN2013MN02014A (en)
EP2681204A4 (en) Synthesis of intermediate for treprostinil production
EP2590649A4 (en) Process for the synthesis of substituted morphinans
CR20130501A (en) NOVEDOUS DERIVATIVES OF CEPHALOSPORINS AND PHARMACEUTICAL COMPOSITIONS OF THESE
IN2014CN04449A (en)
MX364400B (en) Tetracycline compounds.
IN2014KN01062A (en)
IN2014DN00144A (en)
IN2014MN00850A (en)
MX2013000294A (en) Intermediates and process for preparing a thrombin specific inhibitor.
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
SG10201901578UA (en) Processes for the preparation of pyrimidinylcyclopentane compounds
MX2013004193A (en) Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives.
MX2013006670A (en) 2-carboxamide-4-piperazinyl-benzofuran derivative.