IN2014DN06710A - - Google Patents
Info
- Publication number
- IN2014DN06710A IN2014DN06710A IN6710DEN2014A IN2014DN06710A IN 2014DN06710 A IN2014DN06710 A IN 2014DN06710A IN 6710DEN2014 A IN6710DEN2014 A IN 6710DEN2014A IN 2014DN06710 A IN2014DN06710 A IN 2014DN06710A
- Authority
- IN
- India
- Prior art keywords
- same
- bacel
- inhibitors
- disorders
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/94—Spiro compounds containing "free" spiro atoms
Abstract
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the ß secretase enzyme (BACEl) activity pharmaceutical compositions containing the same and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders disorders characterized by cognitive decline cognitive impairment dementia and diseases characterized by production of ß amyloid aggregates.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261606786P | 2012-03-05 | 2012-03-05 | |
PCT/US2013/028796 WO2013134085A1 (en) | 2012-03-05 | 2013-03-04 | Inhibitors of beta-secretase |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN06710A true IN2014DN06710A (en) | 2015-05-22 |
Family
ID=47902355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN6710DEN2014 IN2014DN06710A (en) | 2012-03-05 | 2013-03-04 |
Country Status (40)
Country | Link |
---|---|
US (4) | US8981112B2 (en) |
EP (1) | EP2822930B1 (en) |
JP (1) | JP6161643B2 (en) |
KR (1) | KR20140138774A (en) |
CN (1) | CN104271558B (en) |
AP (1) | AP4029A (en) |
AR (1) | AR090241A1 (en) |
AU (2) | AU2013230523B2 (en) |
BR (1) | BR112014021269A2 (en) |
CA (1) | CA2864143C (en) |
CL (1) | CL2014002334A1 (en) |
CO (1) | CO7091177A2 (en) |
CY (1) | CY1117543T1 (en) |
DK (1) | DK2822930T3 (en) |
EA (1) | EA024995B1 (en) |
EC (1) | ECSP14020640A (en) |
ES (1) | ES2568928T3 (en) |
HK (1) | HK1205739A1 (en) |
HR (1) | HRP20160415T1 (en) |
HU (1) | HUE027289T2 (en) |
IL (1) | IL233887A (en) |
IN (1) | IN2014DN06710A (en) |
MA (1) | MA35945B1 (en) |
ME (1) | ME02390B (en) |
MX (1) | MX353432B (en) |
MY (1) | MY171091A (en) |
NZ (1) | NZ629239A (en) |
PE (1) | PE20141972A1 (en) |
PH (1) | PH12014501963A1 (en) |
PL (1) | PL2822930T3 (en) |
RS (1) | RS54730B1 (en) |
SG (1) | SG11201404600VA (en) |
SI (1) | SI2822930T1 (en) |
SM (1) | SMT201600114B (en) |
TN (1) | TN2014000326A1 (en) |
TW (1) | TWI557112B (en) |
UA (1) | UA113641C2 (en) |
UY (1) | UY34654A (en) |
WO (1) | WO2013134085A1 (en) |
ZA (1) | ZA201405846B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2789684B1 (en) | 2008-05-23 | 2016-12-21 | Siwa Corporation | Methods and compositions for facilitating regeneration |
AR075854A1 (en) | 2009-03-13 | 2011-05-04 | Vitae Pharmaceuticals Inc | BETA-SECRETASA INHIBITORS |
CN102812005B (en) | 2010-02-24 | 2014-12-10 | 生命医药公司 | Inhibitors of beta-secretase |
TWI557112B (en) | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | Inhibitors of beta-secretase |
JP6030752B2 (en) | 2012-05-09 | 2016-11-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Method for producing oxetane-3-ylmethanamine |
TW201422592A (en) | 2012-08-27 | 2014-06-16 | Boehringer Ingelheim Int | Inhibitors of beta-secretase |
EP2900650A1 (en) | 2012-09-28 | 2015-08-05 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
US9079832B2 (en) | 2012-11-21 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Process for making N-sulfinyl α-amino amides |
US10053453B2 (en) | 2014-10-07 | 2018-08-21 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
JP6722293B2 (en) | 2016-02-19 | 2020-07-15 | シワ コーポレーション | Methods and compositions for treating cancer, killing metastatic cancer cells, and preventing cancer metastasis using antibodies against advanced glycation end products (AGE) |
CA3057829A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
CA3039026A1 (en) * | 2016-09-07 | 2018-03-15 | The Regents Of The University Of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
JP2020516648A (en) | 2017-04-13 | 2020-06-11 | シワ コーポレーション | Humanized monoclonal advanced glycation end product antibody |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
CN113082209A (en) * | 2021-03-31 | 2021-07-09 | 中国科学技术大学 | CD4+Application of T cell-derived BACE1, EP2 and EP4 as Alzheimer disease treatment target |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5745185A (en) | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
EP0602060A1 (en) | 1991-08-28 | 1994-06-22 | PHARMACIA & UPJOHN COMPANY | Spirocyclic benzopyran imidazolines, their preparation and their use as potassium channel activators |
EP0758313A4 (en) | 1994-05-06 | 1999-09-15 | Pharmacopeia Inc | Combinatorial dihydrobenzopyran library |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP1699455B1 (en) | 2003-12-15 | 2013-05-08 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP1756087B1 (en) | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
KR20070026811A (en) | 2004-06-16 | 2007-03-08 | 와이어쓰 | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of beta-secretase |
CA2583342A1 (en) | 2004-10-13 | 2006-04-27 | Merck And Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease |
WO2006138217A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
KR20080031189A (en) | 2005-06-14 | 2008-04-08 | 쉐링 코포레이션 | Aspartyl protease inhibitors |
AU2006266167A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation |
TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
EP1913193B1 (en) | 2005-07-29 | 2018-12-05 | Koninklijke Philips N.V. | Steam ironing devive for generating a burst of steam |
TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
JP2009509957A (en) | 2005-09-26 | 2009-03-12 | ワイス | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as β-secretase inhibitors |
CN103936690B (en) | 2005-10-25 | 2016-06-08 | 盐野义制药株式会社 | Aminodihydrothiazinederivative derivative |
US7872009B2 (en) | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
DE102005057688A1 (en) | 2005-12-01 | 2007-06-14 | Endress + Hauser Flowtec Ag | Device for determining and / or monitoring the mass flow rate of a gaseous medium |
JP2009520027A (en) | 2005-12-19 | 2009-05-21 | ワイス | 2-Amino-5-piperidinylimidazolone compounds and their use in the regulation of β-secretase |
WO2007076284A2 (en) | 2005-12-20 | 2007-07-05 | Fieldbus Foundation | System and method for implementing safety instrumented systems |
WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
AR061264A1 (en) | 2006-06-12 | 2008-08-13 | Schering Corp | ASPARTILE-PROTEASES INHIBITORS DERIVED FROM PYRIMIDINE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES TO TREAT COGNITIVE OR NEURODEGENERATIVE DISEASES, AND AS HIV VIRUS INHIBITORS. |
CN101489984B (en) | 2006-07-18 | 2013-04-03 | 安斯泰来制药株式会社 | Aminoindan derivative or salt thereof |
AU2007293416A1 (en) | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
TW200831091A (en) | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
WO2008076043A1 (en) | 2006-12-20 | 2008-06-26 | Astrazeneca Ab | Novel 2-amino-5,5-diaryl-imidazol-4-ones |
TW200831484A (en) | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
PE20090160A1 (en) | 2007-03-20 | 2009-02-11 | Wyeth Corp | AMINO-5- [4- (DIFLUOROMETOXI) SUBSTITUTE PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS |
CL2008000791A1 (en) | 2007-03-23 | 2008-05-30 | Wyeth Corp | COMPOUNDS DERIVED FROM 2-AMINO-5- (4-DIFLUOROMETOXI-FENIL) -5-FENIL-IMIDAZOLIDIN-4-ONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH EXCESSIVE BACE ACTIVITY, SUCH AS ILLNESS |
EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Pharmaceutical composition for treatment of alzheimer's disease |
MX2009011498A (en) | 2007-04-24 | 2009-11-10 | Shionogi & Co | Aminodihydrothiazine derivatives substituted with cyclic groups. |
UY31083A1 (en) | 2007-05-15 | 2009-01-05 | Astrazeneca Ab | SULFOXIMINAL DERIVATIVES FOR THE INHIBITION OF B-SECRETASE |
EP2077637B1 (en) | 2007-12-12 | 2020-03-11 | Alcatel Lucent | System and method for protecting payload information in radio transmission |
BRPI0907563A2 (en) | 2008-02-18 | 2015-08-04 | Hoffmann La Roche | 4,5-Dihydroxazol-2-ylamine derivatives |
TWI431004B (en) | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Bace inhibitors |
WO2010013302A1 (en) | 2008-07-28 | 2010-02-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Spiroaminodihydrothiazine derivative |
AU2009277485B2 (en) | 2008-07-28 | 2013-05-02 | Eisai R&D Management Co., Ltd. | Spiroaminodihydrothiazine derivatives |
WO2010021680A2 (en) | 2008-08-19 | 2010-02-25 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
US8426447B2 (en) | 2008-09-11 | 2013-04-23 | Amgen Inc. | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use |
PE20110777A1 (en) * | 2008-11-23 | 2011-10-29 | Pfizer | NEW LACTAMS AS BETA SECRETASE INHIBITORS |
AR075854A1 (en) * | 2009-03-13 | 2011-05-04 | Vitae Pharmaceuticals Inc | BETA-SECRETASA INHIBITORS |
WO2011072064A1 (en) | 2009-12-08 | 2011-06-16 | Array Biopharma Inc. | S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors |
CN102812005B (en) * | 2010-02-24 | 2014-12-10 | 生命医药公司 | Inhibitors of beta-secretase |
US20120065195A1 (en) | 2010-03-31 | 2012-03-15 | Clark Christopher T | Compounds for treating neurodegenerative diseases |
US8415483B2 (en) * | 2010-12-22 | 2013-04-09 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
TWI557112B (en) | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | Inhibitors of beta-secretase |
-
2013
- 2013-02-06 TW TW102104519A patent/TWI557112B/en not_active IP Right Cessation
- 2013-03-04 SG SG11201404600VA patent/SG11201404600VA/en unknown
- 2013-03-04 BR BR112014021269A patent/BR112014021269A2/en active Search and Examination
- 2013-03-04 NZ NZ629239A patent/NZ629239A/en not_active IP Right Cessation
- 2013-03-04 IN IN6710DEN2014 patent/IN2014DN06710A/en unknown
- 2013-03-04 MX MX2014010625A patent/MX353432B/en active IP Right Grant
- 2013-03-04 PE PE2014001347A patent/PE20141972A1/en active IP Right Grant
- 2013-03-04 CN CN201380012529.9A patent/CN104271558B/en not_active Expired - Fee Related
- 2013-03-04 DK DK13710937.7T patent/DK2822930T3/en active
- 2013-03-04 AP AP2014007900A patent/AP4029A/en active
- 2013-03-04 UA UAA201410695A patent/UA113641C2/en unknown
- 2013-03-04 SI SI201330173A patent/SI2822930T1/en unknown
- 2013-03-04 MY MYPI2014002293A patent/MY171091A/en unknown
- 2013-03-04 WO PCT/US2013/028796 patent/WO2013134085A1/en active Application Filing
- 2013-03-04 ME MEP-2016-74A patent/ME02390B/en unknown
- 2013-03-04 PL PL13710937.7T patent/PL2822930T3/en unknown
- 2013-03-04 HU HUE13710937A patent/HUE027289T2/en unknown
- 2013-03-04 EA EA201491534A patent/EA024995B1/en not_active IP Right Cessation
- 2013-03-04 JP JP2014560985A patent/JP6161643B2/en not_active Expired - Fee Related
- 2013-03-04 US US13/784,032 patent/US8981112B2/en active Active
- 2013-03-04 UY UY0001034654A patent/UY34654A/en active IP Right Grant
- 2013-03-04 ES ES13710937.7T patent/ES2568928T3/en active Active
- 2013-03-04 KR KR1020147026838A patent/KR20140138774A/en not_active Application Discontinuation
- 2013-03-04 RS RS20160246A patent/RS54730B1/en unknown
- 2013-03-04 CA CA2864143A patent/CA2864143C/en not_active Expired - Fee Related
- 2013-03-04 AU AU2013230523A patent/AU2013230523B2/en not_active Ceased
- 2013-03-04 EP EP13710937.7A patent/EP2822930B1/en active Active
- 2013-03-05 AR ARP130100706A patent/AR090241A1/en active IP Right Grant
-
2014
- 2014-07-30 IL IL233887A patent/IL233887A/en active IP Right Grant
- 2014-07-31 TN TNP2014000326A patent/TN2014000326A1/en unknown
- 2014-08-08 ZA ZA2014/05846A patent/ZA201405846B/en unknown
- 2014-09-02 PH PH12014501963A patent/PH12014501963A1/en unknown
- 2014-09-02 CL CL2014002334A patent/CL2014002334A1/en unknown
- 2014-09-26 MA MA37375A patent/MA35945B1/en unknown
- 2014-09-29 EC ECIEPI201420640A patent/ECSP14020640A/en unknown
- 2014-09-29 CO CO14215177A patent/CO7091177A2/en unknown
-
2015
- 2015-02-04 US US14/613,550 patent/US9526727B2/en active Active
- 2015-06-30 HK HK15106248.0A patent/HK1205739A1/en not_active IP Right Cessation
-
2016
- 2016-04-19 SM SM201600114T patent/SMT201600114B/en unknown
- 2016-04-19 CY CY20161100327T patent/CY1117543T1/en unknown
- 2016-04-20 HR HRP20160415TT patent/HRP20160415T1/en unknown
- 2016-12-19 US US15/383,287 patent/US9949975B2/en active Active
-
2017
- 2017-10-02 AU AU2017236042A patent/AU2017236042B2/en not_active Ceased
-
2018
- 2018-03-12 US US15/918,546 patent/US20180344734A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2014DN06710A (en) | ||
IN2015DN01137A (en) | ||
EA201300669A1 (en) | SUBSTITUTED 1-BENZYL CYCLOALKYL CARBONIC ACIDS AND THEIR APPLICATION | |
HK1214832A1 (en) | Compositions and methods for treatment of metabolic disorders and diseases | |
CR20130410A (en) | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK | |
ECSP14013159A (en) | METALOENZYM INHIBITING COMPOUNDS | |
MX2014008591A (en) | Pyran-spirocyclic piperidine amides as modulators of ion channels. | |
MX2013008192A (en) | Bace-2 inhibitors for the treatment of metabolic disorders. | |
UA109459C2 (en) | 5,6-Dihydroimidazo derivatives [1,2-a] Pyrazine-8-ylamine, Suitable as BACE-SECRETASE INHIBITORS (BACE) | |
PH12017502224A1 (en) | Positive allosteric modulators of muscarinic md receptor | |
GB201213484D0 (en) | Pharmaceutical compositions comprising 15-OHEPA and methods of using the same | |
TN2019000083A1 (en) | 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof | |
MX2013010367A (en) | Compositions and methods for the therapy and diagnosis of influenza. | |
MX2013002261A (en) | Substituted n-phenethyltriazoloneacetamides and use thereof. | |
WO2014052398A8 (en) | Inhibitors of beta-secretase | |
GB201115977D0 (en) | Neurodevelopmental disorders | |
CL2012001580A1 (en) | Compounds derived from 2,5-dihydropyrroline and 3,6-dihydro-2h-pyridine, p75 inhibitors; preparation procedure; pharmaceutical composition; Useful in the treatment of central and peripheral neurodegenerative diseases, such as senile dementia, epilepsy, Alzheimer's, Parkinson's, among others. | |
MA37955A1 (en) | Beta-secretase inhibitors | |
MX369774B (en) | Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders. |