IN2012DN00907A - - Google Patents

Info

Publication number
IN2012DN00907A
IN2012DN00907A IN907DEN2012A IN2012DN00907A IN 2012DN00907 A IN2012DN00907 A IN 2012DN00907A IN 907DEN2012 A IN907DEN2012 A IN 907DEN2012A IN 2012DN00907 A IN2012DN00907 A IN 2012DN00907A
Authority
IN
India
Prior art keywords
protein
adamts13
methods
sample
cation exchange
Prior art date
Application number
Other languages
English (en)
Inventor
Hasslacher Meinhard
Mitterer Artur
Fiedler Christian
Mayer Christa
Original Assignee
Baxter Healthcare Sa
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare Sa, Baxter Int filed Critical Baxter Healthcare Sa
Publication of IN2012DN00907A publication Critical patent/IN2012DN00907A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN907DEN2012 2009-07-31 2010-08-02 IN2012DN00907A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23030809P 2009-07-31 2009-07-31
PCT/EP2010/061192 WO2011012726A2 (en) 2009-07-31 2010-08-02 Method for purifying recombinant adamts13 and other proteins and compositions thereof

Publications (1)

Publication Number Publication Date
IN2012DN00907A true IN2012DN00907A (da) 2015-04-03

Family

ID=42588355

Family Applications (1)

Application Number Title Priority Date Filing Date
IN907DEN2012 IN2012DN00907A (da) 2009-07-31 2010-08-02

Country Status (23)

Country Link
US (3) US8945895B2 (da)
EP (3) EP4299735A3 (da)
JP (6) JP5907869B2 (da)
KR (7) KR20180087463A (da)
CN (3) CN107988192A (da)
AU (1) AU2010277491B2 (da)
BR (1) BR112012002140A2 (da)
CA (2) CA2916508A1 (da)
CO (1) CO6612194A2 (da)
DK (1) DK2459715T3 (da)
EA (3) EA034292B1 (da)
ES (1) ES2763207T3 (da)
HR (1) HRP20192303T1 (da)
HU (1) HUE046909T2 (da)
IN (1) IN2012DN00907A (da)
LT (1) LT2459715T (da)
MX (2) MX348178B (da)
NZ (2) NZ597756A (da)
PL (1) PL2459715T3 (da)
PT (1) PT2459715T (da)
SG (2) SG193855A1 (da)
SI (1) SI2459715T1 (da)
WO (1) WO2011012726A2 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481693B2 (en) 2007-03-14 2013-07-09 Takeda Vaccines (Montana), Inc. Virus like particle purification
FR2918375B1 (fr) * 2007-07-05 2009-10-16 Lab Francais Du Fractionnement Utilisation d'un support de chromatographie pour reduire la quantite d'adamts13 dans une solution derivee du plasma
DK2686335T3 (da) * 2011-03-14 2018-07-30 Catalant Pharma Solutions Llc Decorinsammensætninger og anvendelse deraf
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013028330A2 (en) 2011-08-19 2013-02-28 Emd Millipore Corporation Methods of reducing level of one of more impurities in a sample during protein purification
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
MY173835A (en) * 2012-06-21 2020-02-24 Baxter Int Virus filtration of cell culture media
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2890782A1 (en) 2012-09-02 2015-07-08 AbbVie Inc. Methods to control protein heterogeneity
ES2768261T3 (es) * 2013-01-09 2020-06-22 Shire Human Genetic Therapies Métodos para la purificación se arilsulfatasa A
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) * 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
US8859252B1 (en) 2014-01-02 2014-10-14 Aerial Biopharma, Llc Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same
AU2015214245B2 (en) * 2014-02-04 2020-09-10 Biogen Ma Inc. Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
EA201990373A1 (ru) 2016-08-04 2019-07-31 Баксалта Инкорпорэйтед Применение adamts13 для лечения, уменьшения интенсивности и/или предупреждения вазоокклюзивного криза при серповидноклеточной анемии, остром повреждении легкого и/или остром респираторном дистресс-синдроме
EP3773969A1 (en) * 2018-04-03 2021-02-17 Merck Patent GmbH Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds
KR102140531B1 (ko) * 2018-08-07 2020-08-04 (주)휴온스 Gly-Tβ4의 제조방법
SG11202110909XA (en) * 2019-04-03 2021-10-28 Genzyme Corp Continuous production of recombinant proteins
US11821000B2 (en) * 2020-11-10 2023-11-21 Dionex Corporation Method of separating viral vectors
WO2023052556A1 (en) * 2021-09-30 2023-04-06 Ichnos Sciences SA Methods of inactivating viral contaminants with a mixture of solvent and detergent
WO2023170553A1 (en) 2022-03-07 2023-09-14 Takeda Pharmaceutical Company Limited Affinity chromatographic production of clinical human igg products
KR20230159284A (ko) * 2022-05-10 2023-11-21 주식회사 녹십자 혈장 단백질에 대한 신규한 액상 제형물
TW202400224A (zh) * 2022-05-10 2024-01-01 南韓商綠十字股份有限公司 用於冷凍乾燥血漿蛋白之新穎液體調配物

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239854A (en) * 1978-04-24 1980-12-16 Sumitomo Chemical Company, Limited Enzyme-immobilization carriers and preparation thereof
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US5283182A (en) * 1986-09-17 1994-02-01 Beecham Group Plc Preparation of immobilized hydantoinase stabilized with divalent metal ions
CA1339946C (en) 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
FR2681867B1 (fr) 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JP4260877B2 (ja) 1992-03-02 2009-04-30 バイオエング・インコーポレーテッド ウイルスの不活性化方法
US5296228A (en) * 1992-03-13 1994-03-22 Allergan, Inc. Compositions for controlled delivery of pharmaceutical compounds
US5288853A (en) 1992-04-30 1994-02-22 Alpha Therapeutic Corporation Factor viii purification process
US5578480A (en) * 1993-04-23 1996-11-26 American Cyanamid Company Methods for the isolation and purification of the recombinantly expressed chondroitinase I and II enzymes from P. vulgaris
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
US5688912A (en) 1995-09-22 1997-11-18 Bayer Corporation Peptide ligands which bind to von willebrand factor
US5786458A (en) * 1996-06-28 1998-07-28 Bayer Corporation Selective stabilization of protein during viral inactivation
US5831003A (en) 1996-06-28 1998-11-03 Bayer Corporation Peptides which bind to prothrombin and thrombin
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
JP4707231B2 (ja) 1998-06-10 2011-06-22 スタテンズ セーラム インスティテュート マンナン結合レクチンを製造するための精製方法及びｍｂｌ医薬品
US6251860B1 (en) * 1998-07-07 2001-06-26 Suomen Punainen Risti Veripalvelu Pharmaceutical preparations
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
US6451978B2 (en) * 2000-01-21 2002-09-17 Biovitrum Ab Purification of antithrombin-III-α and β
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
AU2001294218A1 (en) * 2000-10-11 2002-04-22 Kazusa Dna Research Institute Foundation Novel adamts family polypeptide and gene encoding the same
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
CN1230526C (zh) * 2001-02-27 2005-12-07 成都夸常科技有限公司 一种除去作为病毒灭活剂的有机溶剂和/或去污剂的方法
WO2003016492A2 (en) 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
JP2003144154A (ja) * 2001-11-14 2003-05-20 Mitsubishi Pharma Corp 新規なａｄａｍｔｓファミリーポリペプチドおよびそれをコードする遺伝子
US20060110407A1 (en) * 2001-12-05 2006-05-25 Shelley Stopera Immune globulin formulations for the treatment and prevention of an orthopoxvirus infection
US20030133829A1 (en) * 2001-12-21 2003-07-17 Baxter Healthcare Corporation Process for inactivating pathogens in a biological material
US7122641B2 (en) 2001-12-21 2006-10-17 Immunex Corporation Methods for purifying protein
GB0216002D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
GB0216001D0 (en) 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
WO2004035778A1 (ja) * 2002-10-18 2004-04-29 Japan As Represented By The President Of National Cardiovascular Center フォンビルブランド因子切断酵素の特異的基質および活性測定法
CA2487673C (en) * 2003-12-02 2010-11-02 F. Hoffmann-La Roche Ag Improved method for the recombinant production and purification of protein kinases
GB0405330D0 (en) * 2004-03-10 2004-04-21 Astrazeneca Ab Enzyme and preparation method
EP1740285A4 (en) * 2004-04-13 2007-07-04 Sangart Inc METHOD AND COMPOSITIONS FOR SIMULTANEOUS ISOLATION OF HEMOGLOBIN FROM RED BLOOD BODIES AND INACTIVATION OF VIRUSES
ES2454566T3 (es) 2004-06-07 2014-04-10 Therapure Biopharma Inc. Aislamiento de proteínas de plasma o suero
US7270976B2 (en) 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
DE102004044419B4 (de) * 2004-09-14 2010-04-15 Biotest Ag Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie
CA2592888A1 (en) * 2005-01-05 2006-07-13 Foundation For Fatal Rare Diseases Pharmaceutically active antiviral peptides
US20060193966A1 (en) * 2005-02-28 2006-08-31 Shaowen Wu Multi-anion treated soy proteins and methods for preparation thereof
EP1902141B1 (en) 2005-06-17 2012-02-08 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
FR2887883B1 (fr) 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
JP5067917B2 (ja) 2005-12-28 2012-11-07 アルフレッサファーマ株式会社 Ａｄａｍｔｓ１３の分離精製方法
CN101384728B (zh) 2006-02-16 2013-05-22 三菱化学美迪恩斯株式会社 意识障碍患者的病态检测方法和检测试剂盒
US7468258B2 (en) 2006-03-07 2008-12-23 Wake Forest University Health Sciences Self-quenching homofluorophore compositions for detecting enzyme activity
WO2008057074A1 (en) * 2006-11-06 2008-05-15 Millipore Corporation Method of flow-through chromatography
US8669045B2 (en) 2007-02-13 2014-03-11 Ajinomoto Co., Inc. Method for inactivating viruses with slightly acidic arginine
WO2009001743A1 (ja) * 2007-06-22 2008-12-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 新規adamts-13改変体
FR2918375B1 (fr) * 2007-07-05 2009-10-16 Lab Francais Du Fractionnement Utilisation d'un support de chromatographie pour reduire la quantite d'adamts13 dans une solution derivee du plasma
ATE503763T1 (de) 2007-07-11 2011-04-15 Novo Nordisk As Aufreinigung von faktor viii unter verwendung eines mixed-mode oder multimodalen harzes
JP5570989B2 (ja) * 2007-08-31 2014-08-13 アムジエン・インコーポレーテツド 固体タンパク質製剤
US20090130714A1 (en) * 2007-09-24 2009-05-21 Reliance Life Sciences Pvt.Ltd. Process for purifying recombinanat tissue plasminogen activator (TPA)

Also Published As

Publication number Publication date
JP2021004265A (ja) 2021-01-14
KR20230170815A (ko) 2023-12-19
PT2459715T (pt) 2020-01-09
EP2459715B1 (en) 2019-10-02
JP2016222724A (ja) 2016-12-28
NZ597756A (en) 2014-03-28
US20230242897A1 (en) 2023-08-03
US20110081700A1 (en) 2011-04-07
HRP20192303T1 (hr) 2020-10-02
KR20170096061A (ko) 2017-08-23
BR112012002140A2 (pt) 2015-09-15
CN107267490A (zh) 2017-10-20
CN102482660A (zh) 2012-05-30
SG178175A1 (en) 2012-03-29
WO2011012726A3 (en) 2011-03-31
CN107988192A (zh) 2018-05-04
JP2022171925A (ja) 2022-11-11
EA034292B1 (ru) 2020-01-24
EA201270214A1 (ru) 2012-08-30
KR20180087463A (ko) 2018-08-01
US8945895B2 (en) 2015-02-03
JP2015147815A (ja) 2015-08-20
KR20200146042A (ko) 2020-12-31
EA201992487A1 (ru) 2020-05-31
EP2459715A2 (en) 2012-06-06
KR101769634B1 (ko) 2017-08-18
CA2769362A1 (en) 2011-02-03
AU2010277491A1 (en) 2012-02-16
SG193855A1 (en) 2013-10-30
JP6216930B2 (ja) 2017-10-25
US11661593B2 (en) 2023-05-30
JP5907869B2 (ja) 2016-04-26
KR20220066435A (ko) 2022-05-24
NZ620988A (en) 2015-07-31
ES2763207T3 (es) 2020-05-27
KR20190122272A (ko) 2019-10-29
MX348178B (es) 2017-05-29
KR20120053013A (ko) 2012-05-24
CA2916508A1 (en) 2011-02-03
JP2018203781A (ja) 2018-12-27
AU2010277491B2 (en) 2015-12-17
JP2013500711A (ja) 2013-01-10
EA201500952A1 (ru) 2016-05-31
CO6612194A2 (es) 2013-02-01
SI2459715T1 (sl) 2020-01-31
EP3211077A1 (en) 2017-08-30
WO2011012726A2 (en) 2011-02-03
HUE046909T2 (hu) 2020-04-28
MX2012001263A (es) 2012-05-22
EP4299735A2 (en) 2024-01-03
EA023783B1 (ru) 2016-07-29
EP4299735A3 (en) 2024-04-24
LT2459715T (lt) 2020-01-10
PL2459715T3 (pl) 2020-04-30
DK2459715T3 (da) 2020-01-06
AU2010277491A2 (en) 2012-06-21
US20150104849A1 (en) 2015-04-16
KR101883610B1 (ko) 2018-07-30

Similar Documents

Publication Publication Date Title
IN2012DN00907A (da)
MX2018014395A (es) Aislamiento y purificacion de anticuerpos usando la cromatografia de afinidad de proteina a.
MX341136B (es) Aislamiento y purificacion de los anticuerpos anti-il-13 al usar la cromatografia de afinidad con proteina a.
PH12020500027A1 (en) Purification of iduronate-2-sulfatase
CA2551345C (fr) Procede de separation des proteines fibrinogenes, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
JP2013500711A5 (da)
MX2007003906A (es) Metodos y composiciones para mejorar la produccion de proteinas recombinantes.
MX2015008875A (es) Metodos para la purificacion de arilsulfatasa a.
SG157346A1 (en) Improved purification of collagenases from clostridium histolyticum liquid culture
WO2010048192A3 (en) Viral inactivation during purification of antibodies
MX2011011454A (es) Plantas que tienen mejores rasgos relacionados con el rendimiento y un metodo para producirlas.
DK0891420T4 (da) Fremgangsmåde til replikation af influenzavirus i cellekultur samt de ved fremgangsmåden opnåelige influenzavirus
WO2011097381A8 (en) Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations therof
WO2012024400A3 (en) Elution of proteins from hydroxyapatite resins without resin deterioration
WO2006091535A3 (en) Novel egg receptors for sperm proteins
BRPI1013956B8 (pt) método para isolar uma proteína recombinante, partículas secas por aspersão, composição, e, uso de partículas secas por aspersão
MX2022001166A (es) Metodo para inactivacion viral.
EP1870454A4 (en) PROCESS FOR DIPEPTIDE PRODUCTION
ATE553194T1 (de) Verfahren zur dipeptidherstellung
Moriguchi et al. Reduction of plant-specific arabinogalactan-type O-glycosylation by treating tobacco plants with ferrous chelator 2, 2′-dipyridyl
DE602007012053D1 (de) Affinitätspolypeptid zur reinigung von rekombinanten proteinen
WO2019067743A8 (en) Enzyme compositions with reduced viral and microbial contamination
AU2003277694A1 (en) Porcine uroplakin ii promoter and the production method of useful proteins using said promoter
WO2022133191A3 (en) Protein compositions and methods for producing and using the same