IN2012DN00862A - - Google Patents

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Publication number
IN2012DN00862A
IN2012DN00862A IN862DEN2012A IN2012DN00862A IN 2012DN00862 A IN2012DN00862 A IN 2012DN00862A IN 862DEN2012 A IN862DEN2012 A IN 862DEN2012A IN 2012DN00862 A IN2012DN00862 A IN 2012DN00862A
Authority
IN
India
Prior art keywords
ring
present
provides
lactone
novel
Prior art date
Application number
Inventor
Megan Alene Foley
Timothy F Jamison
Oljan Repic
Original Assignee
Novartis Ag
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Massachusetts Inst Technology filed Critical Novartis Ag
Publication of IN2012DN00862A publication Critical patent/IN2012DN00862A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof.
IN862DEN2012 2009-08-11 2010-08-11 IN2012DN00862A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23288609P 2009-08-11 2009-08-11
US23288009P 2009-08-11 2009-08-11
PCT/US2010/045121 WO2011019789A1 (en) 2009-08-11 2010-08-11 The ring opening of lactones and lactams

Publications (1)

Publication Number Publication Date
IN2012DN00862A true IN2012DN00862A (en) 2015-07-10

Family

ID=42813428

Family Applications (1)

Application Number Title Priority Date Filing Date
IN862DEN2012 IN2012DN00862A (en) 2009-08-11 2010-08-11

Country Status (12)

Country Link
US (1) US8779198B2 (en)
EP (1) EP2464623B1 (en)
JP (1) JP5746696B2 (en)
KR (1) KR101755052B1 (en)
CN (1) CN102686556A (en)
AU (1) AU2010282623B2 (en)
BR (1) BR112012003255B1 (en)
CA (1) CA2769186C (en)
IN (1) IN2012DN00862A (en)
MX (3) MX2012001850A (en)
RU (1) RU2550691C2 (en)
WO (1) WO2011019789A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
CN102351734B (en) * 2011-09-05 2014-02-26 浙江普洛医药科技有限公司 Preparation method for aliskiren
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
CN108940117B (en) * 2018-08-03 2020-07-24 郑州轻工业学院 Hydroxyl-linking-group-containing nonionic glycosyl gemini surfactant and preparation method thereof
CN110452231B (en) * 2019-08-16 2023-03-28 上海应用技术大学 Tryptophan compound and preparation method and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
EP0236734A3 (en) 1986-02-07 1988-05-11 Ciba-Geigy Ag 5-Amino-4-hydroxyvaleryl derivatives substituted by s-containing groups
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
WO2003103653A1 (en) * 2002-06-11 2003-12-18 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
EP2266951A1 (en) * 2003-11-26 2010-12-29 Novartis AG Organic compounds
GB0419361D0 (en) * 2004-08-31 2004-10-06 Novartis Ag Organic compounds
GB0511686D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
GB0521083D0 (en) 2005-10-17 2005-11-23 Novartis Ag Organic compounds
GB0605780D0 (en) * 2006-03-22 2006-05-03 Syngenta Ltd Formulations
US8338620B2 (en) * 2007-04-03 2012-12-25 Novartis Ag Methods for the production of C-8 lactam lactone compounds

Also Published As

Publication number Publication date
BR112012003255B1 (en) 2018-10-23
AU2010282623A1 (en) 2012-02-23
CA2769186C (en) 2016-10-04
MX347956B (en) 2017-05-16
AU2010282623B2 (en) 2013-12-12
CA2769186A1 (en) 2011-02-17
EP2464623B1 (en) 2020-11-04
US8779198B2 (en) 2014-07-15
JP2013501797A (en) 2013-01-17
MX2012001850A (en) 2012-03-07
RU2550691C2 (en) 2015-05-10
US20120165555A1 (en) 2012-06-28
MX344328B (en) 2016-12-13
CN102686556A (en) 2012-09-19
RU2012108932A (en) 2013-09-20
KR20120054628A (en) 2012-05-30
KR101755052B1 (en) 2017-07-06
EP2464623A1 (en) 2012-06-20
JP5746696B2 (en) 2015-07-08
BR112012003255A2 (en) 2016-03-01
BR112012003255A8 (en) 2016-05-17
WO2011019789A1 (en) 2011-02-17

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