IN2003CH00929A - - Google Patents
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- Publication number
- IN2003CH00929A IN2003CH00929A IN929CH2003A IN2003CH00929A IN 2003CH00929 A IN2003CH00929 A IN 2003CH00929A IN 929CH2003 A IN929CH2003 A IN 929CH2003A IN 2003CH00929 A IN2003CH00929 A IN 2003CH00929A
- Authority
- IN
- India
- Prior art keywords
- sub
- pcaf
- mum
- compounds
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Abstract
In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC<SUB>50</SUB>-1 muM) and pCAF (IC<SUB>50</SUB>-15 muM). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN929CH2003 IN2003CH00929A (en) | 2003-11-13 | 2003-11-13 | |
PCT/IB2004/052294 WO2005047457A2 (en) | 2003-11-13 | 2004-11-04 | Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof |
AT04799059T ATE549309T1 (en) | 2003-11-13 | 2004-11-04 | POLYISOPREVONL BENZOPHENONE AS INHIBITORS OF HISTONE ACETYLTRANSDFERASES AND APPLICATIONS THEREOF |
US10/579,219 US7402706B2 (en) | 2003-11-13 | 2004-11-04 | Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof |
EP04799059A EP1694622B1 (en) | 2003-11-13 | 2004-11-04 | Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN929CH2003 IN2003CH00929A (en) | 2003-11-13 | 2003-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2003CH00929A true IN2003CH00929A (en) | 2008-10-06 |
Family
ID=34586954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN929CH2003 IN2003CH00929A (en) | 2003-11-13 | 2003-11-13 |
Country Status (5)
Country | Link |
---|---|
US (1) | US7402706B2 (en) |
EP (1) | EP1694622B1 (en) |
AT (1) | ATE549309T1 (en) |
IN (1) | IN2003CH00929A (en) |
WO (1) | WO2005047457A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022254465A1 (en) * | 2021-06-02 | 2022-12-08 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006270322A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
AR057579A1 (en) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | SPIROCICLICAL COMPOUNDS AS INHIBITORS OF ACETYLASE HISTONE (HDAC) |
KR101005173B1 (en) * | 2008-02-18 | 2011-01-04 | 인제대학교 산학협력단 | Fraction from stem bark of Vietnamese medicinal plant Garcinia oblongifoliaClusiaceae and compounds isolated therefrom having antioxidant and cytotoxic activities |
CN102575236B (en) * | 2009-09-07 | 2014-10-01 | 贾瓦哈拉尔尼赫鲁高级科学研究中心 | Inhibition of histone acetyltransferases by CTK7A and methods thereof |
JP5804432B2 (en) | 2010-12-09 | 2015-11-04 | インダス・バイオテック・プライベート・リミテッド | Complex of garcinol and cyclodextrin and method thereof |
WO2013148114A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Florida Research Foundation, Inc. | P300/cbp inhibitors and methods of use |
GB201215942D0 (en) * | 2012-09-06 | 2012-10-24 | Glaxo Group Ltd | Method of treatent |
JP2020525425A (en) * | 2017-06-22 | 2020-08-27 | サミ ラブズ リミテッド | Garcinol composition for therapeutic management of endoplasmic reticulum stress |
DK3681885T3 (en) | 2017-09-15 | 2024-04-15 | Forma Therapeutics Inc | TETRAHYDRO-IMIDAZO-QUINOLINE COMPOUNDS AS CBP/P300 INHIBITORS |
CN116178369A (en) | 2018-06-29 | 2023-05-30 | 福马疗法公司 | Inhibition of CREB Binding Protein (CBP) |
US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08259493A (en) * | 1995-03-20 | 1996-10-08 | Sugimoto Masami | Anti-mrsa active substance |
-
2003
- 2003-11-13 IN IN929CH2003 patent/IN2003CH00929A/en unknown
-
2004
- 2004-11-04 AT AT04799059T patent/ATE549309T1/en active
- 2004-11-04 WO PCT/IB2004/052294 patent/WO2005047457A2/en active Application Filing
- 2004-11-04 EP EP04799059A patent/EP1694622B1/en not_active Not-in-force
- 2004-11-04 US US10/579,219 patent/US7402706B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022254465A1 (en) * | 2021-06-02 | 2022-12-08 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2005047457B1 (en) | 2005-12-01 |
US20070254961A1 (en) | 2007-11-01 |
EP1694622A2 (en) | 2006-08-30 |
EP1694622B1 (en) | 2012-03-14 |
WO2005047457A3 (en) | 2005-08-04 |
WO2005047457A2 (en) | 2005-05-26 |
US7402706B2 (en) | 2008-07-22 |
ATE549309T1 (en) | 2012-03-15 |
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