IL94983A0 - Sustained release formulations of water soluble peptides - Google Patents

Sustained release formulations of water soluble peptides

Info

Publication number: IL94983A0
Authority: IL; Israel
Prior art keywords: water soluble; sustained release; release formulations; soluble peptides; peptides
Prior art date: 1989-07-07

Application number

IL94983A

Other versions

IL94983A (en

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-05

Publication date

1991-06-10

1990-07-05 Application filed by Sandoz Ag filed Critical Sandoz Ag

1990-07-05 Priority to IL11228690A priority Critical patent/IL112286A/en

1990-07-05 Priority to IL14168290A priority patent/IL141682A/en

1991-06-10 Publication of IL94983A0 publication Critical patent/IL94983A0/en

1995-01-09 Priority to IL11228695A priority patent/IL112286A0/en

1999-08-17 Publication of IL94983A publication Critical patent/IL94983A/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL9498390A 1989-07-07 1990-07-05 Somatostatin and its analogs and sustained release formulations of such water soluble peptides IL94983A (en)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
IL11228690A IL112286A (en)	1989-07-07	1990-07-05	Process for the production of a microparticle and microparticle obtained thereby
IL14168290A IL141682A (en)	1989-07-07	1990-07-05	Process for the production of microparticles using a water-immiscible organic solvent, and a sustained release formulation comprising said microparticles
IL11228695A IL112286A0 (en)	1989-07-07	1995-01-09	Process for the production of a microparticle and microparticle obtained thereby

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37702389A	1989-07-07	1989-07-07
US41134789A	1989-09-22	1989-09-22

Publications (2)

Publication Number	Publication Date
IL94983A0 true IL94983A0 (en)	1991-06-10
IL94983A IL94983A (en)	1999-08-17

Family

ID=27007654

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL13188090A IL131880A (en)	1989-07-07	1990-07-05	Process for the production of micro particles using a water-in-oil emulsion, and micro particles obtained thereby
IL13188190A IL131881A (en)	1989-07-07	1990-07-05	Sustained release formulation comprising octreotide in a polymeric carrier
IL9498390A IL94983A (en)	1989-07-07	1990-07-05	Somatostatin and its analogs and sustained release formulations of such water soluble peptides

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
IL13188090A IL131880A (en)	1989-07-07	1990-07-05	Process for the production of micro particles using a water-in-oil emulsion, and micro particles obtained thereby
IL13188190A IL131881A (en)	1989-07-07	1990-07-05	Sustained release formulation comprising octreotide in a polymeric carrier

Country Status (27)

Country	Link
JP (5)	JPH0832624B2 (en)
KR (2)	KR100303681B1 (en)
AT (1)	AT406225B (en)
AU (2)	AU641407B2 (en)
BE (1)	BE1004486A3 (en)
CA (1)	CA2020477C (en)
CH (1)	CH685230A5 (en)
CY (1)	CY1965A (en)
DE (2)	DE4042752B4 (en)
DK (1)	DK175849B1 (en)
FI (3)	FI108611B (en)
FR (1)	FR2649319A1 (en)
GB (2)	GB2234896B (en)
GR (1)	GR1001121B (en)
HK (2)	HK97695A (en)
HU (2)	HU221294B1 (en)
IE (2)	IE64411B1 (en)
IL (3)	IL131880A (en)
IT (1)	IT1241460B (en)
LU (1)	LU87764A1 (en)
MY (1)	MY106722A (en)
NL (1)	NL195027C (en)
NO (2)	NO302928B1 (en)
NZ (1)	NZ234384A (en)
PT (1)	PT94628B (en)
SE (1)	SE512992C2 (en)
SG (1)	SG26416G (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4990336A (en) *	1989-02-08	1991-02-05	Biosearch, Inc.	Sustained release dosage form
YU48420B (en) *	1991-03-25	1998-07-10	Hoechst Aktiengesellschaft	PROCEDURE FOR OBTAINING BIOLOGICAL DEGRADABLE MICROPARTICLES WITH LONG TERM ACTION
CH683149A5 (en) *	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Process for the preparation of microspheres of a biodegradable polymeric material.
US5876452A (en) *	1992-02-14	1999-03-02	Board Of Regents, University Of Texas System	Biodegradable implant
US6013853A (en) *	1992-02-14	2000-01-11	The University Of Texas System	Continuous release polymeric implant carrier
DE4218510A1 (en) *	1992-06-02	1993-12-09	Pharmatech Gmbh	Process for the preparation of biodegradable polyesters
AU4198793A (en) †	1992-07-24	1994-01-27	Takeda Chemical Industries Ltd.	Microparticle preparation and production thereof
JP2944419B2 (en) *	1993-05-10	1999-09-06	ノバルティスアクチエンゲゼルシャフト	Stability of pharmacologically active ingredients in sustained release compositions
US5603960A (en) *	1993-05-25	1997-02-18	O'hagan; Derek T.	Preparation of microparticles and method of immunization
GB9310781D0 (en) *	1993-05-25	1993-07-14	Davis Stanley S	Preparation of microparticles
ATE288270T1 (en)	1993-11-19	2005-02-15	Janssen Pharmaceutica Nv	MICRO-ENCAPSULED 1,2-BENZAZOLE
US6270795B1 (en)	1995-11-09	2001-08-07	Microbiological Research Authority	Method of making microencapsulated DNA for vaccination and gene therapy
ATE192334T1 (en)	1995-11-09	2000-05-15	Microbiological Res Authority	MICRO-ENCAPSULED DNA FOR VACCINATION AND GENE THERAPY
DE19545257A1 (en)	1995-11-24	1997-06-19	Schering Ag	Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
US5817343A (en) *	1996-05-14	1998-10-06	Alkermes, Inc.	Method for fabricating polymer-based controlled-release devices
US5968895A (en) *	1996-12-11	1999-10-19	Praecis Pharmaceuticals, Inc.	Pharmaceutical formulations for sustained drug delivery
US6126919A (en) *	1997-02-07	2000-10-03	3M Innovative Properties Company	Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en)	1998-05-13	1998-07-08	Microbiological Res Authority	Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) *	1998-08-14	2003-10-14	Incept Llc	Composite hydrogel drug delivery systems
US7107268B1 (en)	1998-11-12	2006-09-12	Printable Technologies, Inc.	Centralized system and method for managing enterprise operations
US6226656B1 (en)	1998-11-12	2001-05-01	Sourcefinder, Inc.	System and method for creating, generating and processing user-defined generic specs
US6204308B1 (en)	1999-03-01	2001-03-20	Novartis Ag	Organic compounds
EP1044683A1 (en) *	1999-04-15	2000-10-18	Debio Recherche Pharmaceutique S.A.	One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) *	1999-11-16	2002-10-08	Atrix Laboratories, Inc.	Biodegradable polymer composition
KR100392501B1 (en) *	2000-06-28	2003-07-22	동국제약 주식회사	Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) *	2001-08-31	2004-11-30	Alkermes Controlled Therapeutics Inc. Ii	Residual solvent extraction method and microparticles produced thereby
WO2002049620A2 (en)	2000-12-21	2002-06-27	Inhale Therapeutic Systems, Inc.	Induced phase transition method for the production of microparticles containing hydrophobic active agents
US20040097419A1 (en) *	2002-11-19	2004-05-20	Holger Petersen	Organic compounds
PE20050285A1 (en) *	2003-06-24	2005-06-09	Novartis Ag	PHARMACEUTICAL COMPOSITION INCLUDING CYCLIC ANALOGS OF SOMATOSTATIN
DK1660039T3 (en) *	2003-07-18	2017-01-16	Oakwood Laboratories L L C	PREVENTION OF REDUCTION OF THE POLYMER MOLECULE WEIGHT, THE PREPARATION OF PURPOSES AND GELING IN POLYMER COMPOSITIONS
MY158342A (en) *	2003-11-14	2016-09-30	Novartis Ag	Pharmaceutical composition
KR20060129394A (en) *	2004-02-26	2006-12-15	독립행정법인 과학기술진흥기구	Protein drug sustained-release microparticle preparation for injection and process for producing the same
DE102004053373A1 (en) *	2004-11-02	2006-05-04	Justus-Liebig-Universität Giessen	Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) *	2005-07-05	2007-07-24	전북대학교산학협력단	Preparation method of double-layered sphere using oil-in-water and solvent evaporation
PT1968549E (en) *	2005-12-22	2014-08-29	Novartis Ag	Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
KR100816065B1 (en)	2006-11-27	2008-03-24	동국제약 주식회사	Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby
PT2247282E (en)	2008-01-30	2014-11-11	Novartis Ag	Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en)	2010-01-04	2022-10-18	Mapi Pharma Ltd.	Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
AU2011308893B2 (en) *	2010-09-30	2015-04-23	Evonik Corporation	Method for removing residual organic solvent from microparticles
CA2813302A1 (en) *	2010-09-30	2012-04-05	Evonik Corporation	Emulsion method for preparing low residual solvent microparticles
TW201605488A (en)	2013-10-15	2016-02-16	大塚製藥股份有限公司	Drug for preventing and/or treating polycystic kidney disease
KR102464650B1 (en)	2016-05-03	2022-11-10	엘에스일렉트릭(주)	Current limiting device of circuit breaker
CN110382052A (en)	2017-03-26	2019-10-25	Mapi医药公司	The copaxone store system of multiple sclerosis for therapeutic advance type form

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en) *	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
CH649217A5 (en) *	1977-08-25	1985-05-15	Sandoz Ag	BROMOCRIPTIN CONTAINING MICROCAPSULES.
US4622244A (en) *	1979-09-04	1986-11-11	The Washington University	Process for preparation of microcapsules
US4293539A (en) *	1979-09-12	1981-10-06	Eli Lilly And Company	Controlled release formulations and method of treatment
DE19375086I2 (en) *	1979-11-27	2003-01-09	Novartis Ag	Polypeptides Process for their preparation pharmaceutical compositions containing these polypeptides and their use
US4389330A (en) *	1980-10-06	1983-06-21	Stolle Research And Development Corporation	Microencapsulation process
US4675189A (en) *	1980-11-18	1987-06-23	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble active polypeptides
PH19942A (en) *	1980-11-18	1986-08-14	Sintex Inc	Microencapsulation of water soluble polypeptides
IE52535B1 (en) *	1981-02-16	1987-12-09	Ici Plc	Continuous release pharmaceutical compositions
ATE37983T1 (en) *	1982-04-22	1988-11-15	Ici Plc	DELAYED RELEASE AGENT.
CH656884A5 (en) *	1983-08-26	1986-07-31	Sandoz Ag	POLYOLESTERS, THEIR PRODUCTION AND USE.
US4485101A (en) *	1983-10-11	1984-11-27	Administrators Of The Tulane Educational Fund	Peptides
JPH0657658B2 (en) *	1985-04-11	1994-08-03	住友製薬株式会社	Sustained release formulation
JPS60100516A (en) *	1983-11-04	1985-06-04	Takeda Chem Ind Ltd	Preparation of sustained release microcapsule
GB8331158D0 (en) *	1983-11-22	1983-12-29	British Telecomm	Metal/semiconductor deposition
JPS60181029A (en) *	1984-02-29	1985-09-14	Toyo Jozo Co Ltd	Preparation of sustained release preparation
CH660302A5 (en) *	1984-10-17	1987-04-15	Debiopharm Sa	HETEROGENEOUS PHASE MICRO-ENCAPSULATION PROCESS OF WATER-SOLUBLE DRUG SUBSTANCES.
DE3678308D1 (en) *	1985-02-07	1991-05-02	Takeda Chemical Industries Ltd	METHOD FOR PRODUCING MICROCAPSULES.
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
CH665558A5 (en) *	1985-10-09	1988-05-31	Debiopharm Sa	Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
JP2539789B2 (en) *	1986-03-06	1996-10-02	日本原子力研究所	Process for producing sustained-release drug complex composed of polylactone
GB2193891B (en) *	1986-08-18	1990-07-25	Sandoz Ltd	Nasal pharmaceutical composition containing a somatostatin anologue.
JPH0725689B2 (en) *	1986-10-07	1995-03-22	中外製薬株式会社	Sustained-release preparation containing granulocyte colony-stimulating factor
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
CH672887A5 (en) *	1987-10-14	1990-01-15	Debiopharm Sa
DE3738228A1 (en) *	1987-11-11	1989-05-24	Hoechst Ag	METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
JP2653255B2 (en) *	1990-02-13	1997-09-17	武田薬品工業株式会社	Long-term sustained release microcapsules

1990
- 1990-06-25 HU HU974/90A patent/HU221294B1/en unknown
- 1990-07-03 GB GB9014704A patent/GB2234896B/en not_active Expired - Lifetime
- 1990-07-03 SG SG1995907374A patent/SG26416G/en unknown
- 1990-07-05 IE IE43894A patent/IE64411B1/en not_active IP Right Cessation
- 1990-07-05 NO NO903001A patent/NO302928B1/en not_active IP Right Cessation
- 1990-07-05 AU AU58746/90A patent/AU641407B2/en not_active Expired
- 1990-07-05 IL IL13188090A patent/IL131880A/en active IP Right Grant
- 1990-07-05 CA CA002020477A patent/CA2020477C/en not_active Expired - Lifetime
- 1990-07-05 NZ NZ234384A patent/NZ234384A/en unknown
- 1990-07-05 IL IL13188190A patent/IL131881A/en active IP Right Grant
- 1990-07-05 IT IT48113A patent/IT1241460B/en active IP Right Grant
- 1990-07-05 IE IE243590A patent/IE64216B1/en not_active IP Right Cessation
- 1990-07-05 GR GR900100513A patent/GR1001121B/en not_active IP Right Cessation
- 1990-07-05 FR FR9008718A patent/FR2649319A1/en active Granted
- 1990-07-05 NL NL9001537A patent/NL195027C/en not_active IP Right Cessation
- 1990-07-05 BE BE9000693A patent/BE1004486A3/en not_active IP Right Cessation
- 1990-07-05 CH CH2249/90A patent/CH685230A5/en not_active IP Right Cessation
- 1990-07-05 SE SE9002364A patent/SE512992C2/en not_active IP Right Cessation
- 1990-07-05 IL IL9498390A patent/IL94983A/en active IP Right Grant
- 1990-07-05 DK DK199001625A patent/DK175849B1/en not_active IP Right Cessation
- 1990-07-06 MY MYPI90001133A patent/MY106722A/en unknown
- 1990-07-06 FI FI903429A patent/FI108611B/en active IP Right Grant
- 1990-07-06 DE DE4042752A patent/DE4042752B4/en not_active Expired - Lifetime
- 1990-07-06 PT PT94628A patent/PT94628B/en not_active IP Right Cessation
- 1990-07-06 AT AT0144090A patent/AT406225B/en not_active IP Right Cessation
- 1990-07-06 DE DE4021517A patent/DE4021517B4/en not_active Expired - Lifetime
- 1990-07-06 KR KR1019900010224A patent/KR100303681B1/en not_active IP Right Cessation
- 1990-07-06 JP JP2177665A patent/JPH0832624B2/en not_active Expired - Lifetime
- 1990-07-09 LU LU87764A patent/LU87764A1/en unknown
1993
- 1993-03-25 GB GB9306204A patent/GB2265311B/en not_active Expired - Lifetime
1995
- 1995-04-18 JP JP7116539A patent/JPH07309897A/en active Pending
- 1995-04-18 JP JP7116486A patent/JP2931773B2/en not_active Expired - Lifetime
- 1995-06-15 HK HK97695A patent/HK97695A/en not_active IP Right Cessation
- 1995-06-28 HU HU95P/P00523P patent/HU211602A9/en unknown
- 1995-06-29 AU AU23321/95A patent/AU687553B2/en not_active Expired
- 1995-08-15 JP JP7228646A patent/JPH08198771A/en active Pending
1996
- 1996-10-31 HK HK197496A patent/HK197496A/en not_active IP Right Cessation
1997
- 1997-07-04 CY CY196597A patent/CY1965A/en unknown
1998
- 1998-08-26 NO NO19983923A patent/NO320444B1/en unknown
1999
- 1999-09-14 KR KR1019990039209A patent/KR100442931B1/en not_active IP Right Cessation
2000
- 2000-01-12 FI FI20000060A patent/FI109334B/en active
- 2000-01-12 FI FI20000059A patent/FI109543B/en active
2001
- 2001-01-15 JP JP2001006486A patent/JP2001233897A/en active Pending

Also Published As

Publication number	Publication date
JPH08198771A (en)	1996-08-06
FR2649319B1 (en)	1994-12-09
IT1241460B (en)	1994-01-17
DE4021517B4 (en)	2009-04-09
AU2332195A (en)	1995-09-07
JPH07285853A (en)	1995-10-31
NO903001L (en)	1991-01-08
JP2931773B2 (en)	1999-08-09
NL195027B (en)	2003-08-01
SG26416G (en)	1995-09-01
PT94628B (en)	1997-06-30
NZ234384A (en)	1994-05-26
NO903001D0 (en)	1990-07-05
IT9048113A1 (en)	1992-01-05
GR1001121B (en)	1993-04-28
SE9002364D0 (en)	1990-07-05
IL131881A (en)	2001-12-23
FR2649319A1 (en)	1991-01-11
FI108611B (en)	2002-02-28
HU221294B1 (en)	2002-09-28
KR100442931B1 (en)	2004-08-02
DK162590A (en)	1991-01-08
GB2234896B (en)	1994-01-19
HUT54037A (en)	1991-01-28
GB2265311A (en)	1993-09-29
JPH0368511A (en)	1991-03-25
NL195027C (en)	2003-12-02
LU87764A1 (en)	1992-03-11
HK97695A (en)	1995-06-23
CA2020477C (en)	2000-11-21
HK197496A (en)	1996-11-08
IL131880A (en)	2001-12-23
ATA144090A (en)	1999-08-15
HU903974D0 (en)	1990-11-28
DK162590D0 (en)	1990-07-05
DE4021517A1 (en)	1991-01-17
FI109334B (en)	2002-07-15
KR100303681B1 (en)	2002-05-16
JPH0832624B2 (en)	1996-03-29
HU211602A9 (en)	1995-12-28
DE4042752B4 (en)	2009-05-07
NO302928B1 (en)	1998-05-11
KR910002430A (en)	1991-02-25
SE9002364L (en)	1991-01-08
GB9306204D0 (en)	1993-05-19
NO983923D0 (en)	1998-08-26
FI20000060A (en)	2000-01-12
BE1004486A3 (en)	1992-12-01
CA2020477A1 (en)	1991-01-08
GR900100513A (en)	1991-12-10
GB2265311B (en)	1994-02-09
FI903429A0 (en)	1990-07-06
IE64216B1 (en)	1995-07-26
JPH07309897A (en)	1995-11-28
SE512992C2 (en)	2000-06-12
FI20000059A (en)	2000-01-12
NL9001537A (en)	1991-02-01
PT94628A (en)	1991-03-20
AU687553B2 (en)	1998-02-26
AU5874690A (en)	1991-01-10
MY106722A (en)	1995-07-31
JP2001233897A (en)	2001-08-28
GB2234896A (en)	1991-02-20
IL94983A (en)	1999-08-17
NO983923L (en)	1991-01-08
GB9014704D0 (en)	1990-08-22
AT406225B (en)	2000-03-27
FI109543B (en)	2002-08-30
CY1965A (en)	1997-07-04
IE64411B1 (en)	1995-08-09
DK175849B1 (en)	2005-03-29
IE902435A1 (en)	1991-02-13
IT9048113A0 (en)	1990-07-05
CH685230A5 (en)	1995-05-15
NO320444B1 (en)	2005-12-05
AU641407B2 (en)	1993-09-23

Legal Events

Date	Code	Title
1999-12-22	FF	Patent granted
2000-08-13	KB	Patent renewed
2008-11-03	KB	Patent renewed

Publication	Publication Date	Title
GB2265311B (en)	1994-02-09	Sustained release formulations of water soluble peptides
PH30995A (en)	1997-12-23	Sustained release formulations of water soluble peptides.
IL87790A (en)	1992-05-25	Sustained release compositions containing water insoluble polypeptides
GB2230185B (en)	1993-05-12	Sustained release pharmaceutical compositions
ZA907492B (en)	1991-10-30	Stabilized aqueous formulations of small peptides
ZA904925B (en)	1992-02-26	Sustained release pharmaceutical compositions
GB2195893B (en)	1991-05-08	Sustained release pharmaceutical compositions
GB8812928D0 (en)	1988-07-06	Contraceptive methods & compositions
EP0537891A3 (en)	1993-06-30	Water soluble release compositions
IL88148A0 (en)	1989-06-30	Somatotropin sustained release formulations
CY1844A (en)	1996-03-08	Sustained release formulations of water soluble peptides
ZA905327B (en)	1992-03-25	Sustained release formulations of water soluble peptides
GB2237839B (en)	1994-05-11	Powered release of connectors
IL131881A0 (en)	2001-03-19	Sustained release formulation comprising octreotide
IE890932L (en)	1989-09-25	Water soluble ibuprofen compositions
IE871503L (en)	1987-12-06	Sustained release formulations
GB8922061D0 (en)	1989-11-15	Controlled release formulations
ZA898470B (en)	1990-07-25	Sustained release preparations
IE893777L (en)	1990-05-30	Sustained release diltiazen formulation
GB8904109D0 (en)	1989-04-05	New formulations of chloramine
IE880658L (en)	1988-09-09	Sustained release compositions
GB8624214D0 (en)	1986-11-12	Sustained release pharmaceutical compositions
IE862339L (en)	1987-03-03	Disc-like sustained release formulations
NZ234086A (en)	1993-08-26	Preparation of tripeptide aldehydes
GB8908838D0 (en)	1989-06-07	Sustained release