IL94349A - Protonase inhibitors of biconin from humans that have undergone modification - Google Patents

Protonase inhibitors of biconin from humans that have undergone modification

Info

Publication number: IL94349A
Authority: IL; Israel
Prior art keywords: bikunin; leu; sequence; amino acid; lys
Prior art date: 1989-05-13

Application number

IL94349A

Other languages

English (en)

Hebrew (he)

Other versions

IL94349A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1990-05-10

Publication date

1998-01-04

1990-05-10 Application filed by Bayer Ag filed Critical Bayer Ag

1991-03-10 Publication of IL94349A0 publication Critical patent/IL94349A0/xx

1998-01-04 Publication of IL94349A publication Critical patent/IL94349A/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Diabetes (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Reproductive Health (AREA)
Plant Pathology (AREA)
Cardiology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Microbiology (AREA)

IL94349A 1989-05-13 1990-05-10 Protonase inhibitors of biconin from humans that have undergone modification IL94349A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915689		1989-05-13
DE4001244		1990-01-18

Publications (2)

Publication Number	Publication Date
IL94349A0 IL94349A0 (en)	1991-03-10
IL94349A true IL94349A (en)	1998-01-04

Family

ID=25880860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL94349A IL94349A (en)	1989-05-13	1990-05-10	Protonase inhibitors of biconin from humans that have undergone modification

Country Status (17)

Country	Link
US (1)	US5407915A (ko)
EP (1)	EP0401508B1 (ko)
JP (2)	JP3126975B2 (ko)
KR (1)	KR0156246B1 (ko)
AT (1)	ATE114332T1 (ko)
AU (1)	AU623769B2 (ko)
CA (1)	CA2016627C (ko)
DE (1)	DE59007737D1 (ko)
DK (1)	DK0401508T3 (ko)
ES (1)	ES2066033T3 (ko)
GR (1)	GR3015124T3 (ko)
HU (1)	HU214985B (ko)
IE (1)	IE65710B1 (ko)
IL (1)	IL94349A (ko)
NZ (1)	NZ233635A (ko)
PH (1)	PH27530A (ko)
PT (1)	PT94016B (ko)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
CA2055425A1 (en) *	1990-11-13	1992-05-14	Hideaki Morishita	Polypeptide, dna fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same
ES2124203T3 (es) *	1991-03-01	2004-04-16	Dyax Corp.	Inhibidores de la elastasa neutrofila humana y la catepsina g humana.
CA2082226A1 (en) *	1991-11-08	1993-05-09	Hideaki Morishita	Polypeptide, dna fragment encoding the same, drug composition containing the same and process for producing the same
IL104327A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Variant of human kunitz-type protease inhibitor
JP2769083B2 (ja) *	1993-02-22	1998-06-25	日清食品株式会社	エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
JP3570558B2 (ja) *	1993-05-01	2004-09-29	持田製薬株式会社	Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
ATE529444T1 (de)	1994-01-11	2011-11-15	Dyax Corp	Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
AU4868096A (en) *	1995-02-23	1996-09-11	Adeza Biomedical Corporation	Polypeptides derived from urinastatin having calcium channel blocking activity and their use to delay premature delivery
BR9708021A (pt) *	1996-03-11	1999-07-27	Bayer Ag	Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína
ES2209542T3 (es) *	1998-12-22	2004-06-16	Bayer Aktiengesellschaft	Metodo para acelerar la velocidad de eliminacion mucociliar usando un inhibidor de serinproteasa de tipo kunitz.
US20070140979A1 (en) *	1998-12-22	2007-06-21	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
US6660482B1 (en) *	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
EP1374469A1 (en) *	2001-03-27	2004-01-02	Aware, Inc.	Receiver transparent q-mode
CA2488558C (en)	2002-06-07	2013-08-20	Dyax Corp.	Prevention and reduction of blood loss
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
DK2386310T3 (en)	2002-08-28	2019-02-25	Dyax Corp	Methods of preserving organs and tissues
DE602004031589D1 (de) *	2003-01-07	2011-04-14	Dyax Corp	Kunitz-domäne-bibliothek
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2010080833A1 (en) *	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
SI2521568T1 (sl)	2010-01-06	2019-01-31	Dyax Corp.	Proteini, ki vežejo plazemski kalikrein
IL269565B2 (en)	2011-01-06	2024-06-01	Dyax Corp	KALLIKREIN PLASMA BINDING PROTEINS
EP3110434B1 (en)	2014-02-24	2018-09-19	Takeda GmbH	Uti fusion proteins
BR112016022318A2 (pt)	2014-03-27	2017-10-31	Dyax Corp	método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo
JP7003354B2 (ja)	2015-12-11	2022-03-04	武田薬品工業株式会社	遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途
US11725043B2 (en)	2020-03-05	2023-08-15	DiaMedica USA Inc.	Ulinastatin polypeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) *	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) *	1986-07-02	1990-01-19	Transgene Sa	Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
EP0255011A3 (en) *	1986-07-29	1988-11-23	Miles Inc.	Human inter-alpha-trypsin inhibitor gene

1990
- 1990-05-01 DK DK90108284.2T patent/DK0401508T3/da active
- 1990-05-01 AT AT90108284T patent/ATE114332T1/de not_active IP Right Cessation
- 1990-05-01 DE DE59007737T patent/DE59007737D1/de not_active Expired - Fee Related
- 1990-05-01 ES ES90108284T patent/ES2066033T3/es not_active Expired - Lifetime
- 1990-05-01 EP EP90108284A patent/EP0401508B1/de not_active Expired - Lifetime
- 1990-05-02 PH PH40464A patent/PH27530A/en unknown
- 1990-05-10 NZ NZ233635A patent/NZ233635A/en unknown
- 1990-05-10 IL IL94349A patent/IL94349A/en not_active IP Right Cessation
- 1990-05-11 PT PT94016A patent/PT94016B/pt active IP Right Grant
- 1990-05-11 HU HU903010A patent/HU214985B/hu not_active IP Right Cessation
- 1990-05-11 JP JP02120186A patent/JP3126975B2/ja not_active Expired - Fee Related
- 1990-05-11 IE IE171390A patent/IE65710B1/en not_active IP Right Cessation
- 1990-05-11 AU AU54970/90A patent/AU623769B2/en not_active Ceased
- 1990-05-11 CA CA002016627A patent/CA2016627C/en not_active Expired - Fee Related
- 1990-05-12 KR KR1019900006865A patent/KR0156246B1/ko not_active IP Right Cessation
1993
- 1993-03-05 US US08/027,602 patent/US5407915A/en not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940403586T patent/GR3015124T3/el unknown
2000
- 2000-09-13 JP JP2000278172A patent/JP2001112492A/ja active Pending

Also Published As

Publication number	Publication date
CA2016627A1 (en)	1990-11-13
IE65710B1 (en)	1995-11-15
GR3015124T3 (en)	1995-05-31
PT94016B (pt)	1997-05-28
HU214985B (hu)	1998-08-28
ATE114332T1 (de)	1994-12-15
EP0401508A3 (de)	1991-03-27
IE901713L (en)	1990-11-13
US5407915A (en)	1995-04-18
PT94016A (pt)	1991-01-08
CA2016627C (en)	2000-08-22
JPH03255099A (ja)	1991-11-13
PH27530A (en)	1993-08-18
JP2001112492A (ja)	2001-04-24
DE59007737D1 (de)	1995-01-05
AU623769B2 (en)	1992-05-21
AU5497090A (en)	1990-11-15
KR900017607A (ko)	1990-12-19
HU903010D0 (en)	1990-09-28
JP3126975B2 (ja)	2001-01-22
EP0401508B1 (de)	1994-11-23
EP0401508A2 (de)	1990-12-12
IL94349A0 (en)	1991-03-10
KR0156246B1 (ko)	1998-11-16
NZ233635A (en)	1991-12-23
DK0401508T3 (da)	1995-05-15
ES2066033T3 (es)	1995-03-01

Legal Events

Date	Code	Title
1998-06-15	FF	Patent granted
1998-11-26	KB	Patent renewed
2000-08-31	KB	Patent renewed
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL94349A (en)	1998-01-04	Protonase inhibitors of biconin from humans that have undergone modification
US5373090A (en)	1994-12-13	Aprotinin analogues and a process for the production thereof
US5436153A (en)	1995-07-25	Human amyloid protein precursor homolog and Kunitz-type inhibitor
HU218104B (hu)	2000-06-28	Humán, Kunitz-típusú proteázgátló változatai
US5464822A (en)	1995-11-07	Polypeptides and polypeptide analogues
CZ164894A3 (en)	1994-12-15	Novel human inhibitor of kunitz-type protease and variants thereof
CZ164694A3 (en)	1994-12-15	Human variant of kunitz-type protease inhibitor
SI9520043A (en)	1997-08-31	Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors.
WO1994012637A2 (en)	1994-06-09	Novel human amyloid protein precursor homologue and kunitz-type inhibitors
US5378614A (en)	1995-01-03	Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
US5164482A (en)	1992-11-17	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL171158A (en)	2011-05-31	Cliquin inhibitors
US5817484A (en)	1998-10-06	Thermoresistant α-1-antitrypsin mutein
US5876971A (en)	1999-03-02	Thrombin inhibitor from the saliva of protostomia
AU705267B2 (en)	1999-05-20	Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
IE890559L (en)	1989-08-23	A hirudin derivative
WO1994016085A9 (en)	1994-09-01	Hybrid proteins having cross-linking and tissue-binding activities
US5231010A (en)	1993-07-27	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
EP0662514A1 (en)	1995-07-12	Hirustasin, an antistasin type serine proteinase inhibitor from Hiruda