IL93999A - Napthalenecarboxylic acid intermediates for the production of podophyllotoxin and related compounds and their preparation - Google Patents

Napthalenecarboxylic acid intermediates for the production of podophyllotoxin and related compounds and their preparation

Info

Publication number
IL93999A
IL93999A IL93999A IL9399986A IL93999A IL 93999 A IL93999 A IL 93999A IL 93999 A IL93999 A IL 93999A IL 9399986 A IL9399986 A IL 9399986A IL 93999 A IL93999 A IL 93999A
Authority
IL
Israel
Prior art keywords
podophyllotoxin
related compounds
preparation
production
intermediates
Prior art date
Application number
IL93999A
Other languages
English (en)
Other versions
IL93999A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL93999A0 publication Critical patent/IL93999A0/xx
Publication of IL93999A publication Critical patent/IL93999A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
IL93999A 1985-12-05 1986-12-03 Napthalenecarboxylic acid intermediates for the production of podophyllotoxin and related compounds and their preparation IL93999A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
IL80853A IL80853A (en) 1985-12-05 1986-12-03 Process for the production of podophyllotoxin and related compounds,certain intermediates therefor and their preparation

Publications (2)

Publication Number Publication Date
IL93999A0 IL93999A0 (en) 1991-01-31
IL93999A true IL93999A (en) 1991-09-16

Family

ID=25191684

Family Applications (3)

Application Number Title Priority Date Filing Date
IL80853A IL80853A (en) 1985-12-05 1986-12-03 Process for the production of podophyllotoxin and related compounds,certain intermediates therefor and their preparation
IL93999A IL93999A (en) 1985-12-05 1986-12-03 Napthalenecarboxylic acid intermediates for the production of podophyllotoxin and related compounds and their preparation
IL94000A IL94000A (en) 1985-12-05 1986-12-03 Neopodophyllotoxin benzyl ethers as intermediates for the production of podophyllotoxin and related compounds and their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL80853A IL80853A (en) 1985-12-05 1986-12-03 Process for the production of podophyllotoxin and related compounds,certain intermediates therefor and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL94000A IL94000A (en) 1985-12-05 1986-12-03 Neopodophyllotoxin benzyl ethers as intermediates for the production of podophyllotoxin and related compounds and their preparation

Country Status (13)

Country Link
US (2) US4734512A (xx)
EP (1) EP0224938B1 (xx)
JP (1) JPS62145093A (xx)
KR (1) KR900004129B1 (xx)
AT (1) ATE77380T1 (xx)
AU (2) AU599937B2 (xx)
CA (4) CA1318321C (xx)
DE (1) DE3685727T2 (xx)
ES (1) ES2042488T3 (xx)
GR (1) GR3005053T3 (xx)
HU (5) HU198938B (xx)
IL (3) IL80853A (xx)
ZA (1) ZA869184B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
EP1792927B1 (en) * 2004-09-22 2013-03-06 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
JP5249016B2 (ja) 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
JP5503872B2 (ja) 2006-11-06 2014-05-28 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
WO2009116509A1 (ja) * 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
CN103221054A (zh) 2010-11-17 2013-07-24 日本化药株式会社 新的胞苷类代谢拮抗剂的高分子衍生物
EP2754682B1 (en) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
AU631216B2 (en) 1992-11-19
EP0224938A2 (en) 1987-06-10
CA1321596C (en) 1993-08-24
ZA869184B (en) 1987-07-29
HUT47560A (en) 1989-03-28
HUT47114A (en) 1989-01-30
EP0224938B1 (en) 1992-06-17
AU5715190A (en) 1990-10-04
US4845248A (en) 1989-07-04
CA1318321C (en) 1993-05-25
IL80853A (en) 1991-09-16
IL94000A0 (en) 1991-01-31
IL94000A (en) 1991-09-16
AU599937B2 (en) 1990-08-02
HU198939B (en) 1989-12-28
HUT48878A (en) 1989-07-28
HUT48888A (en) 1989-07-28
HUT47559A (en) 1989-03-28
EP0224938A3 (en) 1989-11-02
KR900004129B1 (ko) 1990-06-16
GR3005053T3 (xx) 1993-05-24
CA1321597C (en) 1993-08-24
CA1321595C (en) 1993-08-24
DE3685727D1 (de) 1992-07-23
AU6587086A (en) 1987-06-11
ES2042488T3 (es) 1993-12-16
IL93999A0 (en) 1991-01-31
HU198940B (en) 1989-12-28
JPS62145093A (ja) 1987-06-29
HU198938B (en) 1989-12-28
HU198465B (en) 1989-10-30
US4734512A (en) 1988-03-29
DE3685727T2 (de) 1993-01-21
ATE77380T1 (de) 1992-07-15
KR870006032A (ko) 1987-07-08

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