IL88957A0 - Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives - Google Patents

Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives

Info

Publication number
IL88957A0
IL88957A0 IL88957A IL8895789A IL88957A0 IL 88957 A0 IL88957 A0 IL 88957A0 IL 88957 A IL88957 A IL 88957A IL 8895789 A IL8895789 A IL 8895789A IL 88957 A0 IL88957 A0 IL 88957A0
Authority
IL
Israel
Prior art keywords
cephalosporin derivatives
stabilizer
stabilization
drying
forms containing
Prior art date
Application number
IL88957A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL88957A0 publication Critical patent/IL88957A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL88957A 1988-01-18 1989-01-15 Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives IL88957A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3801179A DE3801179A1 (de) 1988-01-18 1988-01-18 Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten

Publications (1)

Publication Number Publication Date
IL88957A0 true IL88957A0 (en) 1989-08-15

Family

ID=6345430

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88957A IL88957A0 (en) 1988-01-18 1989-01-15 Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives

Country Status (12)

Country Link
EP (1) EP0325112A1 (pt)
JP (1) JPH01216996A (pt)
KR (1) KR890011894A (pt)
CN (1) CN1034670A (pt)
AU (1) AU2853989A (pt)
DE (1) DE3801179A1 (pt)
DK (1) DK19489A (pt)
HU (1) HUT49487A (pt)
IE (1) IE890126L (pt)
IL (1) IL88957A0 (pt)
PT (1) PT89464A (pt)
ZA (1) ZA89332B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
EP0913177A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
EP0913178A1 (en) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
CN101590061B (zh) * 2009-04-14 2010-09-29 深圳立健药业有限公司 一种头孢替坦二钠的药物组合物
MX361984B (es) 2013-03-13 2018-12-19 Theravance Biopharma Antibiotics Ip Llc Sales clorhidrato de un compuesto antibiótico.
US9949982B2 (en) 2014-09-04 2018-04-24 Shionogi & Co., Ltd. Preparation containing cephalosporin having a catechol moiety

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2017373A1 (de) * 1969-04-15 1971-04-22 Orsymonde S A , Paris Lyophihsierte Produkte und Ver fahren zu ihrer Herstellung
JPS5132723A (ja) * 1974-09-11 1976-03-19 Toyama Chemical Co Ltd Yojokaigatachushayoseizai no shinkiseiho narabini sonoyokaiyosuiyoeki
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
DE3577656D1 (de) * 1984-07-23 1990-06-21 Lilly Co Eli Pharmazeutische zusammensetzungen von ceftazidim.
JP2690009B2 (ja) * 1986-07-10 1997-12-10 エーザイ 株式会社 セフアロスポリン注射剤

Also Published As

Publication number Publication date
JPH01216996A (ja) 1989-08-30
AU2853989A (en) 1989-07-20
DK19489A (da) 1989-07-19
DK19489D0 (da) 1989-01-17
KR890011894A (ko) 1989-08-23
ZA89332B (en) 1989-09-27
HUT49487A (en) 1989-10-30
PT89464A (pt) 1990-02-08
EP0325112A1 (de) 1989-07-26
IE890126L (en) 1989-07-18
CN1034670A (zh) 1989-08-16
DE3801179A1 (de) 1989-07-27

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