IL78472A - Hepatitis b surface antigen formed by recombinant dna techniques, vaccines, diagnostics, cell lines and method of forming same - Google Patents
Hepatitis b surface antigen formed by recombinant dna techniques, vaccines, diagnostics, cell lines and method of forming sameInfo
- Publication number
- IL78472A IL78472A IL7847286A IL7847286A IL78472A IL 78472 A IL78472 A IL 78472A IL 7847286 A IL7847286 A IL 7847286A IL 7847286 A IL7847286 A IL 7847286A IL 78472 A IL78472 A IL 78472A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- coding region
- protein coding
- vector
- protein
- Prior art date
Links
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
- G01N33/5764—Hepatitis B surface antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP85104521 | 1985-04-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL78472A0 IL78472A0 (en) | 1986-08-31 |
IL78472A true IL78472A (en) | 2004-08-31 |
Family
ID=8193449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL7847286A IL78472A (en) | 1985-04-15 | 1986-04-10 | Hepatitis b surface antigen formed by recombinant dna techniques, vaccines, diagnostics, cell lines and method of forming same |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0719863A1 (zh) |
JP (1) | JPS6255088A (zh) |
CN (1) | CN86102640A (zh) |
AP (1) | AP8600035A0 (zh) |
AT (1) | ATE139795T1 (zh) |
DE (1) | DE3650536T2 (zh) |
ES (1) | ES8802440A1 (zh) |
FI (1) | FI861417A0 (zh) |
HK (1) | HK1003794A1 (zh) |
IE (1) | IE75355B1 (zh) |
IL (1) | IL78472A (zh) |
SG (1) | SG43220A1 (zh) |
YU (1) | YU60986A (zh) |
ZA (1) | ZA862797B (zh) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816564A (en) * | 1986-01-31 | 1989-03-28 | Merck & Co., Inc. | Method for producing hepatitis B virus proteins in yeast |
JPS62236493A (ja) * | 1986-04-08 | 1987-10-16 | Green Cross Corp:The | HBウイルスのPre S領域を含むHBsAgの製造方法 |
IL79740A0 (en) * | 1986-08-17 | 1986-11-30 | Yeda Res & Dev | Hepatitis vaccine |
US5026828A (en) * | 1987-02-27 | 1991-06-25 | Merck & Co., Inc. | Method of purifying recombinant pres-1/S-2/S/S hepatitis B antigen from yeast |
EP0288198A3 (en) * | 1987-04-20 | 1989-03-29 | Takeda Chemical Industries, Ltd. | Production of peptide |
ATE145558T1 (de) * | 1987-05-01 | 1996-12-15 | Gen Hospital Corp | Transkaryotische einpflanzung |
WO1988010300A1 (en) * | 1987-06-22 | 1988-12-29 | Medico Labs Ag | Heterologous viral peptide particle immunogens |
KR970007153B1 (ko) * | 1987-06-22 | 1997-05-03 | 메데바 홀딩스 비브이 | B형 간염 표면 항원 백신 |
EP1088830A3 (en) * | 1987-06-22 | 2004-04-07 | Medeva Holdings B.V. | Hepatitis b surface antigen particles |
US5011915A (en) * | 1987-10-26 | 1991-04-30 | Merck & Co., Inc. | Process for purifying recombinant hepatitis antigens |
JPH0216975A (ja) * | 1988-02-09 | 1990-01-19 | Eugene Tech Internatl Inc | 異成分混交性のプレーsに富んだb型肝炎表面抗原 |
US6306625B1 (en) | 1988-12-30 | 2001-10-23 | Smithkline Beecham Biologicals, Sa | Method for obtaining expression of mixed polypeptide particles in yeast |
DE69012903T2 (de) * | 1989-02-07 | 1995-05-11 | Bio-Technology General Corp., Iselin, N.J. | Verfahren zur herstellung und reinigung von hepatitis b-impfstoff. |
JP2957195B2 (ja) * | 1989-05-17 | 1999-10-04 | 株式会社シノテスト | B型肝炎ウイルス抗体検出システム |
US5091300A (en) * | 1989-08-03 | 1992-02-25 | Merck & Co., Inc. | Radio-immuno assay for hepatitis b virus pres2 antibodies |
EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
IL101653A0 (en) * | 1991-04-29 | 1992-12-30 | Merck & Co Inc | Multiple hepatitis b virus surface proteins which form particles |
EP0533263A3 (en) * | 1991-09-20 | 1994-06-08 | Merck & Co Inc | A multivalent hepatitis b virus vaccine |
AU3269793A (en) * | 1991-12-27 | 1993-07-28 | Gensci Limited | Method for obtaining recombinant surface antigen of hepatitis B, antigen and vaccine based on it |
EP0642355B1 (en) | 1992-05-23 | 1998-07-15 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Combined vaccines comprising hepatitis b surface antigen and other antigens |
ES2108278T3 (es) | 1992-06-25 | 1997-12-16 | Smithkline Beecham Biolog | Composicion de vacuna con coadyuvantes. |
DK0672136T3 (da) * | 1992-07-08 | 2000-08-21 | Innogenetics Nv | Polypeptider, der er afledt fra endonexin 2 og har hepatitis B virus-receptoraktivitet, og deres anvendelse i diagnostiske |
CN1063343C (zh) * | 1993-04-27 | 2001-03-21 | 中国科学院上海生物化学研究所 | 氨端带前表面抗原决定簇的乙型肝炎表面抗原蛋白 |
CN1059927C (zh) * | 1994-03-10 | 2000-12-27 | 中国科学院上海生物化学研究所 | 羧端带有前表面抗原1抗原决定簇的乙肝表面抗原融合基因及其编码蛋白 |
US6100043A (en) * | 1995-08-04 | 2000-08-08 | The Perkin-Elmer Corporation | Recombinant clone selection system |
US5843656A (en) * | 1995-08-07 | 1998-12-01 | The Perkin-Elmer Corporation | Recombinant clone selection system |
AU6844696A (en) * | 1995-08-07 | 1997-03-05 | Perkin-Elmer Corporation, The | Recombinant clone selection system |
CN1067721C (zh) * | 1996-07-04 | 2001-06-27 | 中国科学院上海生物化学研究所 | 含前表面抗原1和2免疫决定簇的乙肝表面抗原 |
GB9623233D0 (en) | 1996-11-07 | 1997-01-08 | Smithkline Beecham Biolog | Vaccine composition |
EP2266604A3 (en) | 1998-10-16 | 2011-05-11 | GlaxoSmithKline Biologicals S.A. | Adjuvant systems and vaccines |
UA79735C2 (uk) | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
US6583279B1 (en) | 2001-01-26 | 2003-06-24 | Becton, Dickinson And Company | Sequences and methods for detection of hepatitis B virus |
GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
US7176022B2 (en) * | 2002-12-20 | 2007-02-13 | Cell Genesys, Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
DK1648931T3 (da) | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunktionelle cytokiner |
CN100381171C (zh) * | 2004-12-30 | 2008-04-16 | 成都生物制品研究所 | 含前s1、前s2和s抗原决定簇的乙肝表面抗原复合颗粒 |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
EP2066344B2 (en) | 2006-09-07 | 2016-06-29 | GlaxoSmithKline Biologicals S.A. | Inactivated Poliovirus combination vaccine |
PT2468300T (pt) | 2006-09-26 | 2018-01-30 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
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Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN151589B (zh) * | 1978-12-22 | 1983-05-28 | Biogen Nv | |
IE52036B1 (en) * | 1979-05-24 | 1987-05-27 | Univ California | Non-passageable viruses |
JPH0783715B1 (zh) * | 1981-11-23 | 1995-09-13 | ||
JPS60500358A (ja) * | 1982-12-23 | 1985-03-22 | アメリカ合衆国 | マウスの細胞内で組み換えdnaによって生産されたヒト成長ホルモン |
FR2559159B1 (fr) * | 1984-02-02 | 1986-09-12 | Inst Nat Sante Rech Med | Vecteurs viraux de clonage et d'expression d'une proteine dans une cellule eucaryote, comportant au moins une partie du genome d'un retro-virus; cellules eucaryotes transfectees; procede utilisant de telles cellules et proteines obtenues |
-
1986
- 1986-04-01 FI FI861417A patent/FI861417A0/fi not_active Application Discontinuation
- 1986-04-10 IL IL7847286A patent/IL78472A/en unknown
- 1986-04-14 ES ES553953A patent/ES8802440A1/es not_active Expired
- 1986-04-14 IE IE96586A patent/IE75355B1/en not_active IP Right Cessation
- 1986-04-14 AP APAP/P/1986/000035A patent/AP8600035A0/en unknown
- 1986-04-15 EP EP95119966A patent/EP0719863A1/en not_active Withdrawn
- 1986-04-15 ZA ZA862797A patent/ZA862797B/xx unknown
- 1986-04-15 SG SG1996005752A patent/SG43220A1/en unknown
- 1986-04-15 YU YU00609/86A patent/YU60986A/xx unknown
- 1986-04-15 DE DE3650536T patent/DE3650536T2/de not_active Expired - Fee Related
- 1986-04-15 EP EP86105183A patent/EP0198474B1/en not_active Expired - Lifetime
- 1986-04-15 AT AT86105183T patent/ATE139795T1/de not_active IP Right Cessation
- 1986-04-15 CN CN198686102640A patent/CN86102640A/zh active Pending
- 1986-04-15 JP JP61087863A patent/JPS6255088A/ja active Pending
-
1998
- 1998-04-09 HK HK98103014A patent/HK1003794A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3650536D1 (de) | 1996-08-01 |
IE860965L (en) | 1986-10-15 |
HK1003794A1 (en) | 1998-11-06 |
ATE139795T1 (de) | 1996-07-15 |
JPS6255088A (ja) | 1987-03-10 |
ES553953A0 (es) | 1988-06-01 |
YU60986A (en) | 1988-10-31 |
IE75355B1 (en) | 1997-08-27 |
ES8802440A1 (es) | 1988-06-01 |
CN86102640A (zh) | 1987-04-08 |
EP0198474B1 (en) | 1996-06-26 |
SG43220A1 (en) | 1997-10-17 |
EP0198474A1 (en) | 1986-10-22 |
DE3650536T2 (de) | 1997-02-27 |
FI861417A0 (fi) | 1986-04-01 |
ZA862797B (en) | 1988-04-27 |
IL78472A0 (en) | 1986-08-31 |
AP8600035A0 (en) | 1987-10-14 |
EP0719863A1 (en) | 1996-07-03 |
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