IL63960A - Pharmaceutical compositions comprising prostaglandins and ascorbyl palmitate as stabilizer - Google Patents

Pharmaceutical compositions comprising prostaglandins and ascorbyl palmitate as stabilizer

Info

Publication number
IL63960A
IL63960A IL63960A IL6396081A IL63960A IL 63960 A IL63960 A IL 63960A IL 63960 A IL63960 A IL 63960A IL 6396081 A IL6396081 A IL 6396081A IL 63960 A IL63960 A IL 63960A
Authority
IL
Israel
Prior art keywords
ascorbyl palmitate
pharmaceutical compositions
prostaglandins
stabilizer
prostaglandin
Prior art date
Application number
IL63960A
Other versions
IL63960A0 (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL63960A0 publication Critical patent/IL63960A0/en
Publication of IL63960A publication Critical patent/IL63960A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Orally administrable pharmaceutical compositions in the form of a soft gelatin capsule containing a prostaglandin and ascorbic acid or ascorbyl palmitate which are dissolved in polyethylene glycol or polyoxyethylene sorbitan esters of fatty acids or combinations thereof. The compositions are especially useful in improving bioavailability and stability of the prostaglandin in pharmaceutical dosage form.
IL63960A 1980-10-09 1981-09-28 Pharmaceutical compositions comprising prostaglandins and ascorbyl palmitate as stabilizer IL63960A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/195,575 US4310543A (en) 1980-10-09 1980-10-09 Prostaglandin compositions

Publications (2)

Publication Number Publication Date
IL63960A0 IL63960A0 (en) 1981-12-31
IL63960A true IL63960A (en) 1985-05-31

Family

ID=22721933

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63960A IL63960A (en) 1980-10-09 1981-09-28 Pharmaceutical compositions comprising prostaglandins and ascorbyl palmitate as stabilizer

Country Status (13)

Country Link
US (1) US4310543A (en)
EP (1) EP0049852B1 (en)
JP (1) JPS5793911A (en)
AT (1) ATE14981T1 (en)
AU (1) AU547175B2 (en)
CA (1) CA1176567A (en)
DE (1) DE3171928D1 (en)
DK (1) DK442881A (en)
IE (1) IE51637B1 (en)
IL (1) IL63960A (en)
NZ (1) NZ198533A (en)
PH (1) PH17073A (en)
ZA (1) ZA816852B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA835226B (en) * 1982-07-19 1985-03-27 Syntex Inc Pge-type compositions encapsulated by acid isolated gelatin
US4431833A (en) * 1982-12-27 1984-02-14 American Cyanamid Company Prostaglandin and hydroxylated fatty acid ester formulations
FR2549371B1 (en) * 1983-07-20 1985-09-13 Sanofi Sa NOVEL PHARMACEUTICAL COMPOSITION CONTAINING VALPROIC ACID OR ONE OF ITS SALTS
KR850700213A (en) * 1984-02-08 1985-12-26 제이.데스몬드 다비스 Acetaminophen Gelatin Capsule
DE3438830A1 (en) * 1984-10-23 1986-04-30 Rentschler Arzneimittel PHARMACEUTICAL FORM CONTAINING NIFEDIPIN AND METHOD FOR THE PRODUCTION THEREOF
NO882653D0 (en) * 1988-06-15 1988-06-15 Apothekernes Lab DOSAGE FORM.
CA2042972C (en) * 1990-05-22 1996-10-15 Ryuji Ueno Treatment of ocular hypertension with a synergistic combination for ocular administration
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
US6180666B1 (en) 1997-09-05 2001-01-30 Anmax, Inc. Use of gallic acid esters to increase bioavailability of orally administered pharmaceutical compounds
US5962522A (en) * 1997-09-05 1999-10-05 Avmax, Inc. Propyl gallate to increase bioavailability of orally administered pharmaceutical compounds
AU6107500A (en) * 1999-07-13 2001-01-30 Avmax, Inc. Improvement of bioavailability with vitamin c fatty acid esters
KR100649860B1 (en) * 2000-09-01 2006-11-24 주식회사종근당 Transmucosal and transdermal delivery preparation of alprostadil
DE60143615D1 (en) * 2000-09-13 2011-01-20 Asahi Glass Co Ltd EYE DROP
US20060199863A1 (en) * 2003-07-31 2006-09-07 Santen Pharmaceutical Co., Ltd. Product containing prostaglandin
PL1660047T3 (en) 2003-08-13 2014-05-30 Biocon Ltd Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
CA2538078C (en) * 2003-09-25 2012-12-04 Activbiotics, Inc. Rifalazil formulations
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
CN102526064A (en) * 2004-12-09 2012-07-04 参天制药株式会社 Product containing prostaglandin having fluorine atom in its molecule
SI1829545T1 (en) * 2004-12-24 2012-08-31 Santen Pharmaceutical Co Ltd Prostaglandin f2 alpha derivative containing products
EP2056835A4 (en) * 2006-04-06 2013-01-30 Activbiotics Pharma Llc Pharmaceutical compositions and uses thereof
JP5390519B2 (en) * 2007-07-19 2014-01-15 株式会社アールテック・ウエノ Pharmaceutical composition containing 11-deoxy-prostaglandin compound and method for stabilizing the same
US20100222311A1 (en) * 2007-10-19 2010-09-02 Purdue Research Foundation Solid formulations of crystalline compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2889252A (en) * 1956-05-14 1959-06-02 American Cyanamid Co Gelatin capsule containing hexylresorcinol and a lower polyalkylene glycol
ZA721937B (en) * 1971-10-22 1972-12-27 Upjohn Co Pharmaceutical preparations and uses thereof
CA1043259A (en) * 1972-12-08 1978-11-28 Geoffrey F. Thompson Medicament preparations and vehicles therefor
US3932634A (en) * 1973-06-28 1976-01-13 Pfizer Inc. High potency vitamin water dispersible formulations
US4052446A (en) * 1973-08-06 1977-10-04 Hoffmann-La Roche Inc. 11,16-substituted prostaglandins
JPS6019734B2 (en) * 1977-05-12 1985-05-17 三共株式会社 Method for producing stable prostaglandin E preparations
JPS6046094B2 (en) * 1977-06-01 1985-10-14 科研製薬株式会社 Stabilized prostaglandin E powder formulation
FI790043A (en) * 1978-01-17 1979-07-18 Sandoz Ag PROSTAGLANDINER INNEHAOLLANDE TERAPEUTISK SAMMANSAETTNING

Also Published As

Publication number Publication date
EP0049852A3 (en) 1983-01-26
DE3171928D1 (en) 1985-09-26
ZA816852B (en) 1982-09-29
NZ198533A (en) 1984-12-14
PH17073A (en) 1984-05-24
AU7606881A (en) 1982-04-22
IE812354L (en) 1982-04-09
DK442881A (en) 1982-04-10
IE51637B1 (en) 1987-01-21
EP0049852B1 (en) 1985-08-21
US4310543A (en) 1982-01-12
ATE14981T1 (en) 1985-09-15
JPH032848B2 (en) 1991-01-17
IL63960A0 (en) 1981-12-31
JPS5793911A (en) 1982-06-11
CA1176567A (en) 1984-10-23
EP0049852A2 (en) 1982-04-21
AU547175B2 (en) 1985-10-10

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