JPS5764609A - Cyclophosphamide composition for rectal administration - Google Patents
Cyclophosphamide composition for rectal administrationInfo
- Publication number
- JPS5764609A JPS5764609A JP14049280A JP14049280A JPS5764609A JP S5764609 A JPS5764609 A JP S5764609A JP 14049280 A JP14049280 A JP 14049280A JP 14049280 A JP14049280 A JP 14049280A JP S5764609 A JPS5764609 A JP S5764609A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- fatty acid
- rectal
- injection
- cyclophosphamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: A composition for the rectal administration, containing cyclophosphamide which is an antimalignant tumor agent in a specific base composition, and capable of improving the irritant action of the cyclophospamide and exhibiting a very high absorption rate without damaging the rectal mucous membranes.
CONSTITUTION: A composition prepared by incorporating 100pts.wt. cyclophosphamide with 90W100pts.wt. propylene glycol, 48W55pts.wt. sucrose ester of a fatty acid 2W5pts.wt.sodium lauryl sulfate, 15W30pts.wt. polyoxyethylene sorbitan ester of a fatty acid and 400W500pts.wt. triglyceride of a medium-chain fatty acid. The resultant composition is a white oily suspension, and used as a pharmaceutical for rectal injection of soft gelatin capsule suppository by the conventional method. The resultant absorption rate almost equal to or higher than that of the intravenous injection and applied more easily than the administration by the injection.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14049280A JPS5764609A (en) | 1980-10-09 | 1980-10-09 | Cyclophosphamide composition for rectal administration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14049280A JPS5764609A (en) | 1980-10-09 | 1980-10-09 | Cyclophosphamide composition for rectal administration |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5764609A true JPS5764609A (en) | 1982-04-19 |
Family
ID=15269873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14049280A Pending JPS5764609A (en) | 1980-10-09 | 1980-10-09 | Cyclophosphamide composition for rectal administration |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5764609A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338081A1 (en) * | 1987-09-25 | 1989-10-25 | Fujisawa Pharmaceutical Co., Ltd. | Oily rectal instillation |
AT390881B (en) * | 1987-09-21 | 1990-07-10 | Degussa | Process for producing pharmaceutical solutions of oxazaphosphorines with improved stability |
US5462951A (en) * | 1990-03-23 | 1995-10-31 | The Green Cross Corporation | Pharmaceutical composition containing slightly water-soluble drug |
US7635675B2 (en) | 2003-08-13 | 2009-12-22 | Biocon Limited | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
-
1980
- 1980-10-09 JP JP14049280A patent/JPS5764609A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT390881B (en) * | 1987-09-21 | 1990-07-10 | Degussa | Process for producing pharmaceutical solutions of oxazaphosphorines with improved stability |
EP0338081A1 (en) * | 1987-09-25 | 1989-10-25 | Fujisawa Pharmaceutical Co., Ltd. | Oily rectal instillation |
EP0338081A4 (en) * | 1987-09-25 | 1990-12-19 | Fujisawa Pharmaceutical Co., Ltd. | Oily rectal instillation |
US5462951A (en) * | 1990-03-23 | 1995-10-31 | The Green Cross Corporation | Pharmaceutical composition containing slightly water-soluble drug |
US5610169A (en) * | 1990-03-23 | 1997-03-11 | The Green Cross Corporation | Pharmaceutical Composition containing slightly water-soluble drug |
US7635675B2 (en) | 2003-08-13 | 2009-12-22 | Biocon Limited | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5262213A (en) | Polypluenyl derivatives | |
EP0461630A3 (en) | Production process of microspheres | |
JPS5764609A (en) | Cyclophosphamide composition for rectal administration | |
JPS5393185A (en) | Water gel composition | |
JPS5350141A (en) | Stabilization of prostaglandin and prostaglandin analogues | |
JPS5350316A (en) | Drug composition for oral administration | |
JPS5238507A (en) | Detergent composition | |
JPS5231024A (en) | Process for preparation of epoxysuccinic acid esters | |
JPS53139716A (en) | Pharmaceutical preparation of stable prostaglandine | |
JPS51133227A (en) | Preparation of 2-hydroxyalkyl (meth)acrylate | |
JPS5318529A (en) | Optically active mandelic acid phenylglycinol salt and its preparation | |
JPS51141787A (en) | Fluorescent substance | |
JPS5326316A (en) | Drug containing active vitamin d3 derivatives and its preparation | |
JPS53137244A (en) | Non-toxic stabilized composition of olefinic high polymer | |
JPS5214588A (en) | Brake fluid composition | |
JPS52128288A (en) | Glucose isomerase solution | |
JPS5212125A (en) | Process for preparation of oligoester (meth)acrylate emulsion | |
FR2306684A1 (en) | Immunostimulant compsns. contg. propylene glycol and glycerol - a surfactant, a preservative, a buffer and water | |
JPS5363306A (en) | Preparation of fatty acid partial esters of polyhydric alcohols | |
JPS52102280A (en) | 5,7,8-trimethyltocotrienol-nicotinic acid esters and preparation there of | |
JPS56100712A (en) | Preparation of pharmaceutical of 7-methoxycephalosporin for rectal administration | |
JPS5246067A (en) | Reduction of optically active 5-oxo-2-pyrrolidinacetic acid esters | |
JPS5254084A (en) | Manufacture of 2-gamma-glutamylamino-4-hexynic acid and/or 2-gamma-glutamylamino- 3-hydroxy-4-hexynic acid | |
JPS5359674A (en) | 1-piperidinoalkane-1,1-diphosphonic acid derivatives and herbicidescontaining the same as active agent | |
JPS545948A (en) | Cyclopropanecarboxylic acid esters, process for their prparation, and isecticide having low toxicity to fishees, containing the same as active constituents |