JPS5764609A - Cyclophosphamide composition for rectal administration - Google Patents

Cyclophosphamide composition for rectal administration

Info

Publication number
JPS5764609A
JPS5764609A JP14049280A JP14049280A JPS5764609A JP S5764609 A JPS5764609 A JP S5764609A JP 14049280 A JP14049280 A JP 14049280A JP 14049280 A JP14049280 A JP 14049280A JP S5764609 A JPS5764609 A JP S5764609A
Authority
JP
Japan
Prior art keywords
composition
fatty acid
rectal
injection
cyclophosphamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14049280A
Other languages
Japanese (ja)
Inventor
Kotaro Yasuda
Hiroshi Otsuka
Tatsuo Saito
Koji Matsuura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Priority to JP14049280A priority Critical patent/JPS5764609A/en
Publication of JPS5764609A publication Critical patent/JPS5764609A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: A composition for the rectal administration, containing cyclophosphamide which is an antimalignant tumor agent in a specific base composition, and capable of improving the irritant action of the cyclophospamide and exhibiting a very high absorption rate without damaging the rectal mucous membranes.
CONSTITUTION: A composition prepared by incorporating 100pts.wt. cyclophosphamide with 90W100pts.wt. propylene glycol, 48W55pts.wt. sucrose ester of a fatty acid 2W5pts.wt.sodium lauryl sulfate, 15W30pts.wt. polyoxyethylene sorbitan ester of a fatty acid and 400W500pts.wt. triglyceride of a medium-chain fatty acid. The resultant composition is a white oily suspension, and used as a pharmaceutical for rectal injection of soft gelatin capsule suppository by the conventional method. The resultant absorption rate almost equal to or higher than that of the intravenous injection and applied more easily than the administration by the injection.
COPYRIGHT: (C)1982,JPO&Japio
JP14049280A 1980-10-09 1980-10-09 Cyclophosphamide composition for rectal administration Pending JPS5764609A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14049280A JPS5764609A (en) 1980-10-09 1980-10-09 Cyclophosphamide composition for rectal administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14049280A JPS5764609A (en) 1980-10-09 1980-10-09 Cyclophosphamide composition for rectal administration

Publications (1)

Publication Number Publication Date
JPS5764609A true JPS5764609A (en) 1982-04-19

Family

ID=15269873

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14049280A Pending JPS5764609A (en) 1980-10-09 1980-10-09 Cyclophosphamide composition for rectal administration

Country Status (1)

Country Link
JP (1) JPS5764609A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338081A1 (en) * 1987-09-25 1989-10-25 Fujisawa Pharmaceutical Co., Ltd. Oily rectal instillation
AT390881B (en) * 1987-09-21 1990-07-10 Degussa Process for producing pharmaceutical solutions of oxazaphosphorines with improved stability
US5462951A (en) * 1990-03-23 1995-10-31 The Green Cross Corporation Pharmaceutical composition containing slightly water-soluble drug
US7635675B2 (en) 2003-08-13 2009-12-22 Biocon Limited Micro-particle fatty acid salt solid dosage formulations for therapeutic agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT390881B (en) * 1987-09-21 1990-07-10 Degussa Process for producing pharmaceutical solutions of oxazaphosphorines with improved stability
EP0338081A1 (en) * 1987-09-25 1989-10-25 Fujisawa Pharmaceutical Co., Ltd. Oily rectal instillation
EP0338081A4 (en) * 1987-09-25 1990-12-19 Fujisawa Pharmaceutical Co., Ltd. Oily rectal instillation
US5462951A (en) * 1990-03-23 1995-10-31 The Green Cross Corporation Pharmaceutical composition containing slightly water-soluble drug
US5610169A (en) * 1990-03-23 1997-03-11 The Green Cross Corporation Pharmaceutical Composition containing slightly water-soluble drug
US7635675B2 (en) 2003-08-13 2009-12-22 Biocon Limited Micro-particle fatty acid salt solid dosage formulations for therapeutic agents

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