IL63142A0 - 10-(1,2-propadienyl)steroids as irreversible aromatase inhibitors - Google Patents

10-(1,2-propadienyl)steroids as irreversible aromatase inhibitors

Info

Publication number
IL63142A0
IL63142A0 IL63142A IL6314281A IL63142A0 IL 63142 A0 IL63142 A0 IL 63142A0 IL 63142 A IL63142 A IL 63142A IL 6314281 A IL6314281 A IL 6314281A IL 63142 A0 IL63142 A0 IL 63142A0
Authority
IL
Israel
Prior art keywords
propadienyl
steroids
aromatase inhibitors
irreversible
irreversible aromatase
Prior art date
Application number
IL63142A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL63142A0 publication Critical patent/IL63142A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL63142A 1980-06-27 1981-06-22 10-(1,2-propadienyl)steroids as irreversible aromatase inhibitors IL63142A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/163,453 US4289762A (en) 1980-06-27 1980-06-27 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors

Publications (1)

Publication Number Publication Date
IL63142A0 true IL63142A0 (en) 1981-09-13

Family

ID=22590073

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63142A IL63142A0 (en) 1980-06-27 1981-06-22 10-(1,2-propadienyl)steroids as irreversible aromatase inhibitors

Country Status (21)

Country Link
US (1) US4289762A (xx)
JP (1) JPS5738798A (xx)
AT (1) AT377989B (xx)
AU (1) AU539215B2 (xx)
BE (1) BE889404A (xx)
CA (1) CA1173432A (xx)
CH (1) CH647532A5 (xx)
DE (1) DE3124719C2 (xx)
DK (1) DK163129C (xx)
ES (1) ES503451A0 (xx)
FR (1) FR2485544A1 (xx)
GB (1) GB2078750B (xx)
IE (1) IE51352B1 (xx)
IL (1) IL63142A0 (xx)
IT (1) IT1171340B (xx)
NL (1) NL8103098A (xx)
NO (1) NO156694C (xx)
NZ (1) NZ197495A (xx)
PH (1) PH16690A (xx)
SE (1) SE448878B (xx)
ZA (1) ZA814219B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100566B1 (en) * 1982-07-14 1986-02-19 Akzo N.V. Novel 19-thio-androstane derivatives
US4495102A (en) * 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
EP0114033B1 (de) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen
DE3323321A1 (de) * 1983-06-24 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
US4634694A (en) * 1984-01-14 1987-01-06 Akzo N.V. Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
EP1603110A3 (en) 1995-02-01 2006-01-04 Seiko Epson Corporation Active matrix substrate and liquid crystal display device including it
KR20040012751A (ko) * 2001-04-17 2004-02-11 아레스 트레이딩 에스.에이. 보조 생식을 고양하기 위한 아로마타제 저해
DE10141937A1 (de) * 2001-08-28 2003-03-27 Alfred Schmidt Markierung der Aromatase
EP1854465A1 (en) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
EP3666276A1 (en) 2018-12-14 2020-06-17 dcic Biopharmaceutical Limited Medication against estrogen-receptor beta (erbeta) positive breast tumor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102127A (en) * 1962-06-12 1963-08-27 Syntex Corp 19-methylene-androstane derivatives
FR1519387A (fr) * 1966-04-20 1968-03-29 Hoffmann La Roche Procédé pour la préparation de 19-alcényl-stéroïdes
DE2310963A1 (de) * 1972-04-14 1974-09-05 Schering Ag Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten
CH606101A5 (xx) * 1975-01-30 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
AU539215B2 (en) 1984-09-13
IE51352B1 (en) 1986-12-10
SE448878B (sv) 1987-03-23
AT377989B (de) 1985-05-28
JPH0121158B2 (xx) 1989-04-19
GB2078750B (en) 1984-08-22
US4289762A (en) 1981-09-15
NL8103098A (nl) 1982-01-18
DK284481A (da) 1981-12-28
FR2485544A1 (fr) 1981-12-31
IT8148781A0 (it) 1981-06-26
FR2485544B1 (xx) 1983-12-16
DE3124719C2 (de) 1994-03-03
NO156694B (no) 1987-07-27
CA1173432A (en) 1984-08-28
SE8103988L (sv) 1981-12-28
IT1171340B (it) 1987-06-10
AU7236981A (en) 1982-01-07
ZA814219B (en) 1982-07-28
BE889404A (fr) 1981-12-28
CH647532A5 (de) 1985-01-31
ATA285881A (de) 1984-10-15
NO156694C (no) 1987-11-04
PH16690A (en) 1984-01-06
DK163129C (da) 1992-06-09
NZ197495A (en) 1985-01-31
NO812509L (no) 1983-01-24
IE811435L (en) 1981-12-27
ES8400449A1 (es) 1983-11-01
DK163129B (da) 1992-01-20
GB2078750A (en) 1982-01-13
ES503451A0 (es) 1983-11-01
DE3124719A1 (de) 1982-03-18
JPS5738798A (en) 1982-03-03

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Legal Events

Date Code Title Description
RH Patent void