IL48400A0 - Piperidylidene derivatives of xanthene,thioxanthene and dibenzoxepine,pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms - Google Patents

Piperidylidene derivatives of xanthene,thioxanthene and dibenzoxepine,pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms

Info

Publication number
IL48400A0
IL48400A0 IL48400A IL4840075A IL48400A0 IL 48400 A0 IL48400 A0 IL 48400A0 IL 48400 A IL48400 A IL 48400A IL 4840075 A IL4840075 A IL 4840075A IL 48400 A0 IL48400 A0 IL 48400A0
Authority
IL
Israel
Prior art keywords
dibenzoxepine
thioxanthene
xanthene
pharmaceutical compositions
antipsychotic activity
Prior art date
Application number
IL48400A
Other versions
IL48400A (en
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IL48400A0 publication Critical patent/IL48400A0/en
Publication of IL48400A publication Critical patent/IL48400A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL48400A 1974-11-06 1975-11-02 Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepine and pharmaceutical compositions having antipsychotic activity without extrapyramidal symptoms containing them IL48400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52121674A 1974-11-06 1974-11-06

Publications (2)

Publication Number Publication Date
IL48400A0 true IL48400A0 (en) 1976-01-30
IL48400A IL48400A (en) 1979-01-31

Family

ID=24075868

Family Applications (1)

Application Number Title Priority Date Filing Date
IL48400A IL48400A (en) 1974-11-06 1975-11-02 Piperidylidene derivatives of xanthene, thioxanthene and dibenzoxepine and pharmaceutical compositions having antipsychotic activity without extrapyramidal symptoms containing them

Country Status (17)

Country Link
JP (1) JPS5826754B2 (en)
AU (1) AU498298B2 (en)
BE (1) BE835224A (en)
CA (1) CA1055945A (en)
CH (1) CH624403A5 (en)
DE (1) DE2549841A1 (en)
DK (1) DK139429B (en)
ES (1) ES442357A1 (en)
FR (1) FR2290202A1 (en)
HU (1) HU174639B (en)
IE (1) IE42137B1 (en)
IL (1) IL48400A (en)
LU (1) LU73714A1 (en)
NL (1) NL7512974A (en)
NZ (1) NZ179139A (en)
PH (1) PH12158A (en)
ZA (1) ZA756550B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (en) * 1976-07-09 1978-02-03 Merck & Co Inc Carboxy-thioxanthenylidene-piperidine - useful as appetite stimulants and antiallergics
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US4089961A (en) * 1976-11-08 1978-05-16 Smithkline Corporation Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
EP1306376A1 (en) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1644373A1 (en) * 2003-06-27 2006-04-12 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators
WO2007030089A1 (en) 2004-08-05 2007-03-15 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
CN101119992A (en) 2004-12-22 2008-02-06 詹森药业有限公司 Tricyclic delta-opioid modulators
US7439239B2 (en) 2004-12-22 2008-10-21 Janssen Pharmaceutica N.V. Tricyclic δ- opioid modulators
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
JP2008526878A (en) 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid regulator
CA2612491A1 (en) 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
JP5044562B2 (en) 2006-09-29 2012-10-10 日本臓器製薬株式会社 Oxepin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260070A (en) * 1960-02-25
NL122808C (en) * 1961-09-29
DE1670118A1 (en) * 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Process for the preparation of new derivatives of 6,11-dihydro-dibenz [b, e] oxepins and their salts
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
JPS5018478A (en) * 1973-05-17 1975-02-26

Also Published As

Publication number Publication date
NZ179139A (en) 1978-04-28
HU174639B (en) 1980-02-28
BE835224A (en) 1976-05-04
LU73714A1 (en) 1976-06-11
DK495775A (en) 1976-05-07
IL48400A (en) 1979-01-31
PH12158A (en) 1978-11-10
DE2549841C2 (en) 1988-07-07
NL7512974A (en) 1976-05-10
DK139429C (en) 1979-08-06
JPS5170768A (en) 1976-06-18
ES442357A1 (en) 1977-04-01
FR2290202B1 (en) 1980-05-23
CH624403A5 (en) 1981-07-31
DE2549841A1 (en) 1976-05-13
JPS5826754B2 (en) 1983-06-04
ZA756550B (en) 1976-09-29
IE42137B1 (en) 1980-06-04
AU498298B2 (en) 1979-03-01
FR2290202A1 (en) 1976-06-04
AU8624775A (en) 1977-05-05
IE42137L (en) 1976-05-06
DK139429B (en) 1979-02-19
CA1055945A (en) 1979-06-05

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