AU498298B2 - Piperidyliden xanthene derivatives - Google Patents

Piperidyliden xanthene derivatives

Info

Publication number
AU498298B2
AU498298B2 AU86247/75A AU8624775A AU498298B2 AU 498298 B2 AU498298 B2 AU 498298B2 AU 86247/75 A AU86247/75 A AU 86247/75A AU 8624775 A AU8624775 A AU 8624775A AU 498298 B2 AU498298 B2 AU 498298B2
Authority
AU
Australia
Prior art keywords
piperidyliden
xanthene derivatives
xanthene
derivatives
piperidyliden xanthene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU86247/75A
Other versions
AU8624775A (en
Inventor
C. L Zirkle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of AU8624775A publication Critical patent/AU8624775A/en
Application granted granted Critical
Publication of AU498298B2 publication Critical patent/AU498298B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU86247/75A 1974-11-06 1975-10-31 Piperidyliden xanthene derivatives Expired AU498298B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52121674A 1974-11-06 1974-11-06
USUS521216 1974-11-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU41844/78A Division AU512658B2 (en) 1978-11-22 1978-11-22 Piperidylidene derivatives and compositions containing same

Publications (2)

Publication Number Publication Date
AU8624775A AU8624775A (en) 1977-05-05
AU498298B2 true AU498298B2 (en) 1979-03-01

Family

ID=24075868

Family Applications (1)

Application Number Title Priority Date Filing Date
AU86247/75A Expired AU498298B2 (en) 1974-11-06 1975-10-31 Piperidyliden xanthene derivatives

Country Status (17)

Country Link
JP (1) JPS5826754B2 (en)
AU (1) AU498298B2 (en)
BE (1) BE835224A (en)
CA (1) CA1055945A (en)
CH (1) CH624403A5 (en)
DE (1) DE2549841A1 (en)
DK (1) DK139429B (en)
ES (1) ES442357A1 (en)
FR (1) FR2290202A1 (en)
HU (1) HU174639B (en)
IE (1) IE42137B1 (en)
IL (1) IL48400A (en)
LU (1) LU73714A1 (en)
NL (1) NL7512974A (en)
NZ (1) NZ179139A (en)
PH (1) PH12158A (en)
ZA (1) ZA756550B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (en) * 1976-07-09 1978-02-03 Merck & Co Inc Carboxy-thioxanthenylidene-piperidine - useful as appetite stimulants and antiallergics
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US4089961A (en) * 1976-11-08 1978-05-16 Smithkline Corporation Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
EP1306376A1 (en) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1644373A1 (en) * 2003-06-27 2006-04-12 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators
WO2007030089A1 (en) 2004-08-05 2007-03-15 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
CN101119992A (en) 2004-12-22 2008-02-06 詹森药业有限公司 Tricyclic delta-opioid modulators
US7439239B2 (en) 2004-12-22 2008-10-21 Janssen Pharmaceutica N.V. Tricyclic δ- opioid modulators
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
JP2008526878A (en) 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid regulator
CA2612491A1 (en) 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
JP5044562B2 (en) 2006-09-29 2012-10-10 日本臓器製薬株式会社 Oxepin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260070A (en) * 1960-02-25
NL122808C (en) * 1961-09-29
DE1670118A1 (en) * 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Process for the preparation of new derivatives of 6,11-dihydro-dibenz [b, e] oxepins and their salts
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
JPS5018478A (en) * 1973-05-17 1975-02-26

Also Published As

Publication number Publication date
NZ179139A (en) 1978-04-28
HU174639B (en) 1980-02-28
BE835224A (en) 1976-05-04
LU73714A1 (en) 1976-06-11
DK495775A (en) 1976-05-07
IL48400A (en) 1979-01-31
PH12158A (en) 1978-11-10
DE2549841C2 (en) 1988-07-07
NL7512974A (en) 1976-05-10
DK139429C (en) 1979-08-06
JPS5170768A (en) 1976-06-18
ES442357A1 (en) 1977-04-01
FR2290202B1 (en) 1980-05-23
CH624403A5 (en) 1981-07-31
DE2549841A1 (en) 1976-05-13
JPS5826754B2 (en) 1983-06-04
ZA756550B (en) 1976-09-29
IE42137B1 (en) 1980-06-04
FR2290202A1 (en) 1976-06-04
AU8624775A (en) 1977-05-05
IE42137L (en) 1976-05-06
IL48400A0 (en) 1976-01-30
DK139429B (en) 1979-02-19
CA1055945A (en) 1979-06-05

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