IL41034A - 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents
6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL41034A IL41034A IL41034A IL4103472A IL41034A IL 41034 A IL41034 A IL 41034A IL 41034 A IL41034 A IL 41034A IL 4103472 A IL4103472 A IL 4103472A IL 41034 A IL41034 A IL 41034A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- carbon
- compound according
- compound
- benzodiazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Claims (1)
1. CLAIMS A 6 or the formula where is a R2 and are halogen or lower is alkanoyloxy or carboxyalkanoyloxy of 2 to 6 carbon lower or Z is nitrogen or is lower alkyl lower alkyl stituted with oycloalkyl of 3 to 6 carbon a lower lower alkanoyl of 2 to 6 carbon of 2 to 7 carbon mono or dl lower of 2 to 7 carbon lower substituted to 7 aeobered saturated cyclio containing 0 to 1 additional nitrogen or oxygen and A is an alk group 1 to 6 carbon where Alkyl a alkyl or two hydrogen atoms and the can also in the tautomeric or or where Alkyl is a alkyl and pharmacologically acceptable salts A compound according to Claim 1 where is alkoxy or lower is lower lower alkyl substituted with cyc alkyl of 3 to 6 carbon lower lower mono or di lower alkyl aminoalkyl of 2 to 7 carbon lower alkyl substituted a to 7 saturated ring ing 0 to 1 additional oxygen and A is an alk group with 1 to 6 or two hydrogen and the tautomeric form as defined in Claim 1 and acceptable salts compound according to Claim 1 wherein any haloge present has an atomic weight of 9 to compound according to Claim wherein is A compound according to Claim 4 wherein are fluorine or A is is is E or and is H or alkyl of 1 to 4 carbon A compound accordin to Claim wherein and are both compound according to wherein gen and is fluorine or A compound according Claim 7 wherein is in the A compound according to Claim wherein is A compound according to Claim 5 wherein is A composition having tranquilizer activity comprising an amount for such activity of a compound of Claim 1 a acceptable A method of a tranquiliaing effect in a human mammal comprising administering to the mammal an amount of the composition of Claim 1 sufficient to induce such method according to Claim 12 wherein the compound is method according to Claim 12 the compound is administered 83 insufficientOCRQuality
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL44720A IL44720A (en) | 1972-12-08 | 1974-04-26 | 5-phenyl-6-aza-7-amino-1,2-dihydro-3h1,4-benzodiazepin-2-one derivatives,their preparation and pharmaceutical compositions containing them |
| IL44888A IL44888A (en) | 1972-12-08 | 1974-05-23 | 6-aza-3h-1,4-benzodiazepines,their preparation and pharmacceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1060471A AT333284B (en) | 1971-12-09 | 1971-12-09 | PROCESS FOR THE PREPARATION OF NEW 6-AZA-3H-1,4-BENZODIAZEPINES, THEIR OPTICAL ISOMERS AND THEIR SALTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41034A0 IL41034A0 (en) | 1973-02-28 |
| IL41034A true IL41034A (en) | 1976-10-31 |
Family
ID=3623479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41034A IL41034A (en) | 1971-12-09 | 1972-12-08 | 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them |
Country Status (26)
| Country | Link |
|---|---|
| JP (4) | JPS569509B2 (en) |
| AR (3) | AR201201A1 (en) |
| AT (4) | AT333284B (en) |
| AU (1) | AU473253B2 (en) |
| BE (1) | BE792541A (en) |
| CH (4) | CH603644A5 (en) |
| CS (1) | CS212736B2 (en) |
| DD (1) | DD105448A5 (en) |
| DE (1) | DE2259471C2 (en) |
| DK (1) | DK138425B (en) |
| EG (1) | EG10918A (en) |
| ES (2) | ES409090A1 (en) |
| FI (1) | FI54710C (en) |
| FR (1) | FR2162482B1 (en) |
| GB (1) | GB1400755A (en) |
| HU (1) | HU169468B (en) |
| IL (1) | IL41034A (en) |
| IT (1) | IT1035053B (en) |
| NL (1) | NL171986C (en) |
| NO (1) | NO137094C (en) |
| PL (3) | PL91876B1 (en) |
| RO (4) | RO65263A (en) |
| SE (1) | SE404803B (en) |
| SU (4) | SU468423A3 (en) |
| YU (2) | YU305972A (en) |
| ZA (1) | ZA728497B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2364636C2 (en) * | 1973-12-24 | 1982-11-04 | Degussa Ag, 6000 Frankfurt | Process for the preparation of 2-benzoyl-6-chloro-3-nitro-pyridines |
| ATE7295T1 (en) * | 1980-01-16 | 1984-05-15 | Lacer, S.A. | 2-HALO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. |
| JPS60132610A (en) * | 1983-12-20 | 1985-07-15 | Japan Organo Co Ltd | Sludge dehydrating apparatus |
| JPS6219221A (en) * | 1985-07-16 | 1987-01-28 | Chiyoda Chem Eng & Constr Co Ltd | Filtration method and apparatus for removing fine grain incorporated in raw liquid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US3523939A (en) * | 1967-07-03 | 1970-08-11 | Hoffmann La Roche | 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation |
-
1971
- 1971-12-09 AT AT1060471A patent/AT333284B/en not_active IP Right Cessation
- 1971-12-09 AT AT902174A patent/AT332877B/en active
- 1971-12-09 AT AT902274A patent/AT332878B/en active
-
1972
- 1972-11-29 ES ES409090A patent/ES409090A1/en not_active Expired
- 1972-11-29 ES ES409089A patent/ES409089A1/en not_active Expired
- 1972-11-30 FI FI3390/72A patent/FI54710C/en active
- 1972-11-30 ZA ZA728497A patent/ZA728497B/en unknown
- 1972-12-05 DE DE2259471A patent/DE2259471C2/en not_active Expired
- 1972-12-05 SE SE7215858A patent/SE404803B/en unknown
- 1972-12-06 HU HUDE799A patent/HU169468B/hu unknown
- 1972-12-06 FR FR7243359A patent/FR2162482B1/fr not_active Expired
- 1972-12-06 EG EG502/72A patent/EG10918A/en active
- 1972-12-07 IT IT7254583Q patent/IT1035053B/en active
- 1972-12-07 RO RO7281196A patent/RO65263A/en unknown
- 1972-12-07 RO RO7200073075A patent/RO62312A/en unknown
- 1972-12-07 PL PL1972175581A patent/PL91876B1/en unknown
- 1972-12-07 PL PL1972175582A patent/PL91828B1/en unknown
- 1972-12-07 RO RO7281197A patent/RO67345A/en unknown
- 1972-12-07 NL NLAANVRAGE7216621,A patent/NL171986C/en not_active IP Right Cessation
- 1972-12-07 PL PL1972159365A patent/PL89682B1/en unknown
- 1972-12-07 RO RO7281195A patent/RO65264A/en unknown
- 1972-12-08 DK DK615172AA patent/DK138425B/en not_active IP Right Cessation
- 1972-12-08 CS CS728424A patent/CS212736B2/en unknown
- 1972-12-08 IL IL41034A patent/IL41034A/en unknown
- 1972-12-08 YU YU03059/72A patent/YU305972A/en unknown
- 1972-12-08 BE BE792541A patent/BE792541A/en not_active IP Right Cessation
- 1972-12-08 GB GB5688372A patent/GB1400755A/en not_active Expired
- 1972-12-08 SU SU1855103A patent/SU468423A3/en active
- 1972-12-08 NO NO4536/72A patent/NO137094C/en unknown
- 1972-12-09 JP JP12387872A patent/JPS569509B2/ja not_active Expired
- 1972-12-11 DD DD167428A patent/DD105448A5/xx unknown
- 1972-12-11 CH CH1506676A patent/CH603644A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1794972A patent/CH594665A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1526076A patent/CH603645A5/xx not_active IP Right Cessation
- 1972-12-11 AU AU49931/72A patent/AU473253B2/en not_active Expired
- 1972-12-11 CH CH1506576A patent/CH605946A5/xx not_active IP Right Cessation
-
1973
- 1973-09-10 AR AR250008A patent/AR201201A1/en active
-
1974
- 1974-03-20 AR AR252867A patent/AR200309A1/en active
- 1974-07-08 SU SU742041603A patent/SU674675A3/en active
- 1974-07-08 SU SU7402042686A patent/SU564809A3/en active
- 1974-10-15 SU SU7402067128A patent/SU574156A3/en active
- 1974-10-31 AR AR256352A patent/AR203311A1/en active
- 1974-11-11 AT AT902074A patent/AT338798B/en not_active IP Right Cessation
-
1980
- 1980-04-15 JP JP5022280A patent/JPS55147282A/en active Granted
- 1980-04-15 JP JP5022380A patent/JPS5625181A/en active Granted
- 1980-04-15 JP JP5022180A patent/JPS5625180A/en active Granted
-
1981
- 1981-05-07 YU YU01168/81A patent/YU116881A/en unknown
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