IL250677A0 - Treatment of cancers using anti-nkg2a agents - Google Patents

Treatment of cancers using anti-nkg2a agents

Info

Publication number
IL250677A0
IL250677A0 IL250677A IL25067717A IL250677A0 IL 250677 A0 IL250677 A0 IL 250677A0 IL 250677 A IL250677 A IL 250677A IL 25067717 A IL25067717 A IL 25067717A IL 250677 A0 IL250677 A0 IL 250677A0
Authority
IL
Israel
Prior art keywords
cancers
treatment
nkg2a
agents
nkg2a agents
Prior art date
Application number
IL250677A
Other languages
Hebrew (he)
Other versions
IL250677B (en
Original Assignee
Innate Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innate Pharma filed Critical Innate Pharma
Publication of IL250677A0 publication Critical patent/IL250677A0/en
Publication of IL250677B publication Critical patent/IL250677B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
IL250677A 2014-10-23 2017-02-20 Treatment of cancers using anti-nkg2a agents IL250677B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462067642P 2014-10-23 2014-10-23
PCT/EP2015/074581 WO2016062851A1 (en) 2014-10-23 2015-10-23 Treatment of cancers using anti-nkg2a agents

Publications (2)

Publication Number Publication Date
IL250677A0 true IL250677A0 (en) 2017-03-30
IL250677B IL250677B (en) 2021-03-25

Family

ID=54347541

Family Applications (1)

Application Number Title Priority Date Filing Date
IL250677A IL250677B (en) 2014-10-23 2017-02-20 Treatment of cancers using anti-nkg2a agents

Country Status (11)

Country Link
US (2) US10329348B2 (en)
EP (2) EP3209687A1 (en)
JP (1) JP6889660B2 (en)
KR (1) KR102598068B1 (en)
CN (1) CN107073116A (en)
AU (1) AU2015334886B9 (en)
CA (1) CA2959841A1 (en)
IL (1) IL250677B (en)
RU (1) RU2721271C2 (en)
SG (2) SG11201701388UA (en)
WO (1) WO2016062851A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3708190A1 (en) 2010-02-26 2020-09-16 Novo Nordisk A/S Stable antibody containing compositions
CN103635487B (en) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 Selectivity eliminates aggressivity cell
JP6767362B2 (en) 2014-09-16 2020-10-14 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． Neutralization of inhibitory pathways in lymphocytes
US10676523B2 (en) 2014-09-16 2020-06-09 Innate Pharma Treatment regimens using anti-NKG2A antibodies
CN107073116A (en) 2014-10-23 2017-08-18 依奈特制药公司 Use anti-NKG2A agent therapies cancer
CN107850596B (en) 2015-07-24 2020-12-04 先天制药公司 Method for detecting tissue infiltrating NK cells
SG10202000645SA (en) 2016-01-21 2020-03-30 Innate Pharma Neutralization of Inhibitory Pathways in Lymphocytes
DE102017001875A1 (en) * 2017-02-27 2018-08-30 Wolfgang Würfel Drug for malignant treatment
DE102017005815A1 (en) * 2017-06-20 2018-12-20 Wolfgang Würfel Vaccine for the treatment of a malignancy
US11447545B2 (en) 2017-07-10 2022-09-20 Innate Pharma Combination therapy using antibody to human Siglec-9 and antibody to human NKG2A for treating cancer
WO2019165307A1 (en) * 2018-02-23 2019-08-29 Abexxa Biologics, Inc. Combination cancer therapy with anti-cancer agents and antibodies targeting a complex comprising non-classical hla-i and neoantigen
US11464840B2 (en) 2018-02-26 2022-10-11 Swey-Shen Chen Universal non-classical MHC I vaccines: HLA-E-restricted antigenic peptides as universal vaccines to treat allergy, inflammation, autoimmune and infectious diseases, and cancers
MA51995A (en) 2018-03-13 2021-01-20 Innate Pharma TREATMENT OF HEAD AND NECK CANCER
CA3107001A1 (en) * 2018-07-23 2020-01-30 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical hla-i and neoantigen and their methods of use
EP3878869A4 (en) * 2018-11-07 2023-04-19 Shanghai Hyamab Biotech Co., Ltd. Nkg2a antibody, preparation method therefor and application thereof
AU2019380307A1 (en) 2018-11-16 2021-07-01 Bristol-Myers Squibb Company Anti-NKG2A antibodies and uses thereof
EP4045535A1 (en) * 2019-10-14 2022-08-24 Innate Pharma Treatment of cancer with ilt-2 inhibitors
US11976120B2 (en) 2020-06-01 2024-05-07 Boehringer Ingelheim International Gmbh Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981997B1 (en) 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981996B1 (en) 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
PE20240372A1 (en) * 2021-06-01 2024-03-05 Servier Lab ANTI-NKG2A ANTIBODIES AND COMPOSITIONS

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US122637A (en) 1872-01-09 Improvement in vapor-burners
CU22545A1 (en) 1994-11-18 1999-03-31 Centro Inmunologia Molecular OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5459061A (en) 1990-01-26 1995-10-17 W. Alton Jones Cell Science Center, Inc. Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
ES2144440T3 (en) 1992-08-18 2000-06-16 Centro Inmunologia Molecular MONOCLONAL ANTIBODIES THAT RECOGNIZE THE RECEPTOR OF THE EPIDERMIC GROWTH FACTOR, CELLS AND METHODS FOR ITS PRODUCTION AND COMPOUNDS THAT CONTAIN THEM.
GB9401182D0 (en) 1994-01-21 1994-03-16 Inst Of Cancer The Research Antibodies to EGF receptor and their antitumour effect
IT1277827B1 (en) 1995-03-01 1997-11-12 Ministero Uni Ricerca Scient E CHIMERIC MURINE/HUMAN MONOCLONAL ANTIBODY OR ITS FRAGMENT SPECIFIC FOR THE EGF RECEPTOR (EGF-R)
WO1996040210A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
US5942602A (en) 1997-02-13 1999-08-24 Schering Aktiengessellschaft Growth factor receptor antibodies
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
GB9725764D0 (en) 1997-12-04 1998-02-04 Isis Innovation HLA-E binding
PT1071700E (en) 1998-04-20 2010-04-23 Glycart Biotechnology Ag Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
ES2694002T3 (en) 1999-01-15 2018-12-17 Genentech, Inc. Polypeptide comprising an Fc region of variant human IgG1
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
PT1914244E (en) 1999-04-09 2013-07-26 Kyowa Hakko Kirin Co Ltd Method of modulating the activity of functional immune molecules
US6794494B1 (en) 2003-04-14 2004-09-21 Arius Research, Inc. Cancerous disease modifying antibodies
US20040091485A1 (en) 2000-05-19 2004-05-13 Ellis John Robert Maxwell Humanised antibodies to the epidermal growth factor receptor
EP1361893B1 (en) 2001-02-19 2012-10-24 Merck Patent GmbH Modified anti-egfr antibodies with reduced immunogenicity
US20030095965A1 (en) 2001-05-02 2003-05-22 Katrien Van Beneden Antibodies to Ly49E and CD94/NKG2 receptors
WO2002092771A2 (en) 2001-05-11 2002-11-21 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CN100497389C (en) 2001-06-13 2009-06-10 根马布股份公司 Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CA2456236A1 (en) 2001-08-03 2003-02-20 Commonwealth Scientific And Industrial Research Organisation Methods of screening based on the egf receptor crystal structure
AU2002326531A1 (en) 2001-08-03 2003-02-17 The Trustees Of The University Of Pennsylvania Monoclonal antibodies to activated erbb family members and methods of use thereof
EP1443961B1 (en) 2001-10-25 2009-05-06 Genentech, Inc. Glycoprotein compositions
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
DE60334453D1 (en) 2002-05-30 2010-11-18 Macrogenics Inc CD16A BINDING PROTEINS AND USE FOR THE TREATMENT OF IMMUNE DISEASES
CA2495251C (en) 2002-08-14 2018-03-06 Macrogenics, Inc. Fc.gamma.riib-specific antibodies and methods of use thereof
JP2004126818A (en) 2002-09-30 2004-04-22 Toshiba Corp Electronic equipment system, battery unit, and operation control method for battery unit
AU2003304145A1 (en) 2002-10-18 2004-12-13 Macrogenics, Inc. Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus borrelia
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
JP2006524039A (en) 2003-01-09 2006-10-26 マクロジェニクス，インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
JP3803790B2 (en) 2003-02-17 2006-08-02 株式会社東北テクノアーチ Novel diabody-type bispecific antibody
AU2004259398A1 (en) 2003-06-27 2005-02-03 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
EP1697415A1 (en) 2003-11-12 2006-09-06 Biogen Idec MA Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
US20050142133A1 (en) 2003-12-03 2005-06-30 Xencor, Inc. Optimized proteins that target the epidermal growth factor receptor
KR20070038453A (en) 2004-04-16 2007-04-10 마크로제닉스, 인크. FCgamma;RIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
KR101297146B1 (en) 2004-05-10 2013-08-21 마크로제닉스, 인크. HUMANIZED FcγRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
AU2005335714B2 (en) 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
EP1831258B2 (en) 2004-12-28 2023-06-07 Innate Pharma S.A. Monoclonal antibodies against nkg2a
EP2402374A1 (en) 2005-02-07 2012-01-04 GlycArt Biotechnology AG Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
EP1888638A2 (en) 2005-06-03 2008-02-20 Genentech, Inc. Method of producing antibodies with modified fucosylation level
DK1919503T3 (en) 2005-08-10 2014-12-15 Macrogenics Inc Identification and preparation of antibodies with variant fc regions and methods of use thereof
AU2007226752A1 (en) 2006-03-10 2007-09-20 Macrogenics, Inc. Identification and engineering of antibodies with variant heavy chains and methods of using same
EP2021029B1 (en) 2006-05-26 2014-06-11 MacroGenics, Inc. Humanized fc gamma riib-specific antibodies and methods of use thereof
US7932055B2 (en) 2006-06-22 2011-04-26 Novo Nordisk A/S Soluble heterodimeric CD94/NKG2 receptors fusion proteins
WO2008002933A2 (en) 2006-06-26 2008-01-03 Macrogenics, Inc. Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
JP5829004B2 (en) 2006-06-30 2015-12-09 ノボ・ノルデイスク・エー／エス Anti-NKG2A antibody and use thereof
AR062223A1 (en) 2006-08-09 2008-10-22 Glycart Biotechnology Ag MOLECULES OF ADHESION TO THE ANTIGEN THAT ADHER TO EGFR, VECTORS THAT CODE THEM, AND THEIR USES OF THESE
MX2010007935A (en) * 2008-01-24 2010-08-23 Novo Nordisk As Humanized anti-human nkg2a monoclonal antibody.
JP2012518680A (en) 2009-03-31 2012-08-16 ロシュ グリクアート アクチェンゲゼルシャフト Treatment of cancer with humanized anti-EGFR IgG1 antibody and irinotecan
EP3708190A1 (en) 2010-02-26 2020-09-16 Novo Nordisk A/S Stable antibody containing compositions
CA2791658C (en) 2010-03-04 2019-10-01 Macrogenics, Inc. Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
CN103635487B (en) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 Selectivity eliminates aggressivity cell
WO2016032334A1 (en) 2014-08-28 2016-03-03 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Cd94/nkg2a and/or cd94/nkg2b antibody, vaccine combinations
JP6767362B2 (en) 2014-09-16 2020-10-14 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． Neutralization of inhibitory pathways in lymphocytes
US10676523B2 (en) 2014-09-16 2020-06-09 Innate Pharma Treatment regimens using anti-NKG2A antibodies
CN107073116A (en) 2014-10-23 2017-08-18 依奈特制药公司 Use anti-NKG2A agent therapies cancer
SG10202000645SA (en) 2016-01-21 2020-03-30 Innate Pharma Neutralization of Inhibitory Pathways in Lymphocytes

Also Published As

Publication number Publication date
US11225519B2 (en) 2022-01-18
JP2017537069A (en) 2017-12-14
RU2721271C2 (en) 2020-05-18
CA2959841A1 (en) 2016-04-28
US10329348B2 (en) 2019-06-25
KR20170070076A (en) 2017-06-21
AU2015334886B2 (en) 2021-06-10
SG11201701388UA (en) 2017-03-30
SG10202006685XA (en) 2020-08-28
JP6889660B2 (en) 2021-06-18
EP3209687A1 (en) 2017-08-30
KR102598068B1 (en) 2023-11-06
RU2017107559A3 (en) 2019-04-15
EP3659625A1 (en) 2020-06-03
US20170313773A1 (en) 2017-11-02
RU2017107559A (en) 2018-11-27
US20190322744A1 (en) 2019-10-24
AU2015334886A1 (en) 2017-03-16
AU2015334886B9 (en) 2021-07-08
CN107073116A (en) 2017-08-18
IL250677B (en) 2021-03-25
WO2016062851A1 (en) 2016-04-28

Similar Documents

Publication Publication Date Title
IL250677B (en) Treatment of cancers using anti-nkg2a agents
IL259783A (en) Methods of treatment of malignancies
GB201701673D0 (en) Methods of well treatment
FI3851537T3 (en) Treatment of hyperbilirubinemia
HUE053654T2 (en) Combinations of fgfr- and cmet-inhibitors for the treatment of cancer
IL247267A0 (en) Improved methods for the treatment of vascularizing cancers
HK1231561A1 (en) Cancer treatment
IL263835A (en) Exosome-guided treatment of cancer
GB201416832D0 (en) Methods of treatment
GB201408297D0 (en) Treatment of cancer
GB201412010D0 (en) Treatment of hypertransaminasemia
GB201411027D0 (en) Treatment
GB201417456D0 (en) Treatment of cancer
GB201512139D0 (en) Methods of treatment
GB201407837D0 (en) Methods of cancer therapy
GB201622214D0 (en) treatment of cancer
GB201417465D0 (en) Treatment of cancers
GB201604621D0 (en) Treatment of cancer
GB201604293D0 (en) Treatment of cancer
GB201409362D0 (en) Treatment of cancer
PT3851537T (en) Treatment of hyperbilirubinemia
GB201405449D0 (en) Treatment of cancer
GB201405075D0 (en) Treatment of cancer
GB201512723D0 (en) Treatment of cancer
GB201507928D0 (en) Treatment of cancer

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed