IL223384A - Hexapluoro isopropyl carbamate derivatives, their preparation and medical application - Google Patents

Hexapluoro isopropyl carbamate derivatives, their preparation and medical application

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Publication number
IL223384A
IL223384A IL223384A IL22338412A IL223384A IL 223384 A IL223384 A IL 223384A IL 223384 A IL223384 A IL 223384A IL 22338412 A IL22338412 A IL 22338412A IL 223384 A IL223384 A IL 223384A
Authority
IL
Israel
Prior art keywords
preparation
therapeutic application
carbamate derivatives
hexafluoroisopropyl
hexafluoroisopropyl carbamate
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IL223384A
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English (en)
Hebrew (he)
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IL223384A0 (en
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Sanofi Sa
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43402192&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL223384(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL223384A0 publication Critical patent/IL223384A0/en
Publication of IL223384A publication Critical patent/IL223384A/en

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IL223384A 2010-06-04 2012-12-02 Hexapluoro isopropyl carbamate derivatives, their preparation and medical application IL223384A (en)

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101653473B1 (ko) 2012-01-06 2016-09-01 어바이드 테라퓨틱스, 인크. 카르바메이트 화합물 및 그의 제조 및 이용 방법
US10539870B2 (en) * 2013-05-31 2020-01-21 Rohm And Haas Electronic Materials Llc Photoresists comprising carbamate component
US9771341B2 (en) 2015-03-18 2017-09-26 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
MX2017014344A (es) 2015-05-11 2018-04-11 Abide Therapeutics Inc Metodos para el tratamiento de la inflacion o el dolor neuropatico.
CU20170166A7 (es) 2015-07-31 2018-03-13 Pfizer Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1, 1, 1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl
US10463753B2 (en) 2016-02-19 2019-11-05 Lundbeck La Jolla Research Center, Inc. Radiolabeled monoacylglycerol lipase occupancy probe
US10781211B2 (en) 2016-05-12 2020-09-22 Lundbeck La Jolla Research Center, Inc. Spirocycle compounds and methods of making and using same
WO2018053447A1 (en) 2016-09-19 2018-03-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
WO2018068296A1 (en) 2016-10-14 2018-04-19 Merck Sharp & Dohme Corp. PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE
WO2018068295A1 (en) * 2016-10-14 2018-04-19 Merck Sharp & Dohme Corp. ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE
JOP20190106A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190105A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
BR112019014688A2 (pt) 2017-01-20 2020-02-18 Pfizer Inc. Derivados de carbamato de 1,1,1-trifluoro-3-hidroxipropan-2-il como inibidores de magl
KR20190097242A (ko) 2017-01-23 2019-08-20 화이자 인코포레이티드 Magl 억제제로서의 헤테로시클릭 스피로 화합물
UA126685C2 (uk) 2017-08-29 2023-01-11 Луннбек Ла-Холья Рісьоч Сенте, Інк. Сполуки, які є модуляторами magl, і способи їх отримання і застосування
EP3675848B1 (en) * 2017-08-29 2022-03-23 H. Lundbeck A/S Spirocycle compounds and methods of making and using same
CN111386269A (zh) 2017-11-28 2020-07-07 豪夫迈·罗氏有限公司 新型杂环化合物
TW201930300A (zh) * 2017-12-15 2019-08-01 瑞士商赫孚孟拉羅股份公司 新雜環化合物
US11332453B2 (en) 2018-05-15 2022-05-17 H. Lundbeck A/S MAGL inhibitors
MX2021000549A (es) * 2018-07-19 2021-03-25 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
EP4139288A1 (en) 2020-04-21 2023-03-01 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor
JP7391460B2 (ja) * 2020-09-16 2023-12-05 エルジー・ケム・リミテッド 化合物、これを含む抗菌消臭組成物、およびその製造方法
US11141404B1 (en) 2020-11-18 2021-10-12 Anebulo Pharmaceuticals, Inc. Formulations and methods for treating acute cannabinoid overdose
AU2022362107A1 (en) 2021-10-11 2024-05-02 Anebulo Pharmaceuticals, Inc. Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017439A2 (en) 1993-12-22 1995-06-29 Shell Internationale Research Maatschappij B.V. Process for preparing carbamates
AU8018298A (en) 1997-06-05 1998-12-21 Imperial Chemical Industries Method for the preparation of carbamates
EP1803453A1 (en) 2005-12-21 2007-07-04 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Carbamate antibiotics
EP2124927A2 (en) 2007-02-26 2009-12-02 Kosan Biosciences Incorporated Carbamate compounds
CA2702946A1 (en) * 2007-10-16 2009-04-23 Northeastern University Monoacylglycerol lipase inhibitors for modulation of cannabinoid activity
US8188098B2 (en) * 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
EP2328897A1 (en) * 2008-07-16 2011-06-08 Schering Corporation Bicyclic heterocycle derivatives and their use as gpcr modulators
FR2938537B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
JP2011132138A (ja) * 2009-12-22 2011-07-07 Dainippon Sumitomo Pharma Co Ltd カルバメート誘導体またはその薬理学的に許容される塩
JP2013523819A (ja) * 2010-04-06 2013-06-17 アリーナ ファーマシューティカルズ, インコーポレイテッド Gpr119レセプターのモジュレーターおよびそれに関連する障害の処置

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