IL165777A0 - APO/2 ligand/trail variants and uses thereof - Google Patents
APO/2 ligand/trail variants and uses thereofInfo
- Publication number
- IL165777A0 IL165777A0 IL16577704A IL16577704A IL165777A0 IL 165777 A0 IL165777 A0 IL 165777A0 IL 16577704 A IL16577704 A IL 16577704A IL 16577704 A IL16577704 A IL 16577704A IL 165777 A0 IL165777 A0 IL 165777A0
- Authority
- IL
- Israel
- Prior art keywords
- apo
- ligand
- trail variants
- trail
- variants
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39105002P | 2002-06-24 | 2002-06-24 | |
PCT/US2003/019750 WO2004001009A2 (fr) | 2002-06-24 | 2003-06-23 | Variants du ligand apo-2/trail et utilisations de ceux-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
IL165777A0 true IL165777A0 (en) | 2006-01-15 |
Family
ID=30000661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16577704A IL165777A0 (en) | 2002-06-24 | 2004-12-15 | APO/2 ligand/trail variants and uses thereof |
Country Status (7)
Country | Link |
---|---|
US (4) | US20060141561A1 (fr) |
EP (2) | EP1556076A4 (fr) |
JP (2) | JP4574350B2 (fr) |
AU (2) | AU2003247609A1 (fr) |
CA (1) | CA2489348A1 (fr) |
IL (1) | IL165777A0 (fr) |
WO (1) | WO2004001009A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005508162A (ja) * | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Apo−2リガンド変異体とその使用法 |
GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
BRPI0509201A (pt) | 2004-03-23 | 2007-08-28 | Biogen Idec Inc | agentes de acoplamento de receptor e usos terapêuticos destes |
WO2006029224A2 (fr) * | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Procedes d'utilisation de ligands des recepteurs de mort et d'anticorps cd20 |
GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
KR100886783B1 (ko) * | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
WO2008088582A2 (fr) * | 2006-08-04 | 2008-07-24 | Mayo Foundation For Medical Education And Research | Méthodes et substances associées à des isoformes trail |
RU2472530C2 (ru) | 2007-09-24 | 2013-01-20 | Бар-Илан Юниверсити | Полимерные наночастицы, покрытые оксидом магнитного металла, и их применение |
EP2215246B1 (fr) | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Structures protéiques |
WO2011079293A1 (fr) * | 2009-12-23 | 2011-06-30 | Ambrx, Inc | Ligands polypeptidiques induisant l'apoptose apparentée au facteur de nécrose tumorale et applications associées |
WO2011130324A1 (fr) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Échafaudages multimériques à base de domaine de fibronectine de type iii |
EP3753567A1 (fr) | 2011-10-11 | 2020-12-23 | Viela Bio, Inc. | Échafaudages dérivés de la ténascine-3 et spécifiques du cd40l et leurs méthodes d'utilisation |
US20150056204A1 (en) | 2012-03-28 | 2015-02-26 | Amgen Inc. | Dr5 receptor agonist combinations |
AU2014306867B2 (en) | 2013-08-12 | 2017-10-26 | Genentech, Inc. | Compositions and method for treating complement-associated conditions |
US11299528B2 (en) | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
KR20160147855A (ko) | 2014-05-01 | 2016-12-23 | 제넨테크, 인크. | 항-인자 d 항체 변이체 및 이의 용도 |
KR20150133576A (ko) * | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
JP2018534930A (ja) | 2015-10-30 | 2018-11-29 | ジェネンテック, インコーポレイテッド | 抗d因子抗体及びコンジュゲート |
US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
WO2017177148A1 (fr) | 2016-04-07 | 2017-10-12 | The Johns Hopkins University | Compositions et procédés de traitement de la pancréatite et de la douleur avec des agonistes du récepteur de mort |
IT201900024622A1 (it) * | 2019-12-18 | 2021-06-18 | Univ Degli Studi G Dannunzio Chieti Pescara | Pegilazione innovativa del killer tnf-apoptosis induced ligand (killer-trail) |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
ES2032831T5 (es) | 1986-08-19 | 2001-02-16 | Genentech Inc | Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas. |
WO1989005859A1 (fr) | 1987-12-21 | 1989-06-29 | The Upjohn Company | Transformation par l'agrobacterium de graines de plantes de germination |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
DE59010933D1 (de) | 1989-09-12 | 2003-05-08 | Hoffmann La Roche | TFN-bindende Proteine |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
CA2087267A1 (fr) | 1990-08-17 | 1992-02-18 | Steven H. Bass | Liaison d'hormones polypeptidiques a un recepteur facilitee par un ion metallique |
US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
AU1757092A (en) | 1991-03-28 | 1992-11-02 | Genentech Inc. | Stable growth hormone metal ion formulations |
AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
WO1994012219A2 (fr) | 1992-11-25 | 1994-06-09 | Amgen Boulder Inc. | Facteur de croissance insulinoide modifie |
EP0708655A1 (fr) | 1993-04-07 | 1996-05-01 | Amgen Boulder Inc. | Procedes d'utilisation de proteines de liaison de facteurs de croissance semblables a l'insuline |
AU685187B2 (en) * | 1993-10-29 | 1998-01-15 | Incyte Pharmaceuticals, Inc. | Chimeric proteins including protease nexin-1 variants |
US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
NZ311982A (en) | 1995-06-29 | 1999-08-30 | Immunex Corp | Tnf related apoptosis inducing ligand (trail), a method for producing them and associated antibodies |
CA2230492C (fr) | 1995-09-21 | 2009-05-26 | Genentech, Inc. | Variants de l'hormone de croissance humaine |
US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
PT939804E (pt) | 1996-10-25 | 2005-11-30 | Human Genome Sciences Inc | Neutroquina alfa |
EP2314695A3 (fr) | 1996-12-23 | 2011-12-21 | Immunex Corporation | Ligand pour l'activateur des récepteurs du NF-kappa B, ligand est un membre de la superfamille de TNF |
EP1012274B2 (fr) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Recepteur 4 (dr4:recepteur 4 de mort cellulaire) contenant des domaines de mort cellulaire, membre de la superfamille du recepteur du facteur de necrose tumorale (tnf) et se liant a la trail ( apo-2l) |
CA2279986A1 (fr) | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Conjugats polypeptide-polymere a groupes de fixation ajoutes et/ou retires |
US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
AU747635B2 (en) | 1997-03-17 | 2002-05-16 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
WO1998046643A1 (fr) | 1997-04-16 | 1998-10-22 | Millennium Biotherapeutics, Inc. | PROTEINES TANGO-63d ET TANGO-63e APPARENTEES AU RECEPTEUR DU FACTEUR DE NECROSE DES TUMEURS |
ES2284203T5 (es) | 1997-04-16 | 2016-03-11 | Amgen Inc. | Proteínas de unión a osteoprotegerina y sus receptores |
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
WO1998051793A1 (fr) | 1997-05-15 | 1998-11-19 | Genentech, Inc. | RECEPTEUR D'Apo-2 |
AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
AU751898B2 (en) | 1997-07-14 | 2002-08-29 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
CA2301202A1 (fr) | 1997-08-15 | 1999-02-25 | Idun Pharmaceuticals, Inc. | Recepteurs de trail, acides nucleiques codant ces recepteurs et procedes d'utilisation |
JP2001513994A (ja) | 1997-08-26 | 2001-09-11 | ジェネンテク・インコーポレイテッド | Rtdレセプター |
WO1999011791A2 (fr) | 1997-09-05 | 1999-03-11 | University Of Washington | Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes |
JP2002508962A (ja) | 1998-01-15 | 2002-03-26 | ジェネンテク・インコーポレイテッド | Apo−2リガンド |
ATE517125T1 (de) | 1998-01-26 | 2011-08-15 | Genentech Inc | ANTIKÖRPER GEGEN ßDEATH RECEPTOR 4ß (DR4) UND DEREN VERWENDUNGEN |
AU5596500A (en) | 1999-06-09 | 2000-12-28 | Genentech Inc. | Apo-2l receptor agonist and cpt-11 synergism |
US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
IL147029A0 (en) * | 1999-06-28 | 2002-08-14 | Genentech Inc | Method for making apo-2 ligand using divalent metal ions |
EP1303293B1 (fr) | 2000-07-27 | 2008-12-03 | Genentech, Inc. | Administration sequentielle de cpt-11 et d'apo 2l polypeptide |
JP2005508162A (ja) * | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Apo−2リガンド変異体とその使用法 |
-
2003
- 2003-06-23 AU AU2003247609A patent/AU2003247609A1/en not_active Abandoned
- 2003-06-23 EP EP03761262A patent/EP1556076A4/fr not_active Withdrawn
- 2003-06-23 JP JP2004516142A patent/JP4574350B2/ja not_active Expired - Lifetime
- 2003-06-23 WO PCT/US2003/019750 patent/WO2004001009A2/fr active Application Filing
- 2003-06-23 US US10/519,647 patent/US20060141561A1/en not_active Abandoned
- 2003-06-23 EP EP11183690A patent/EP2500032A1/fr not_active Withdrawn
- 2003-06-23 CA CA002489348A patent/CA2489348A1/fr not_active Abandoned
-
2004
- 2004-12-15 IL IL16577704A patent/IL165777A0/xx unknown
-
2006
- 2006-10-02 US US11/541,821 patent/US20070098681A1/en not_active Abandoned
-
2009
- 2009-08-26 AU AU2009212834A patent/AU2009212834A1/en not_active Abandoned
- 2009-10-07 JP JP2009233816A patent/JP2010065037A/ja active Pending
-
2011
- 2011-06-06 US US13/153,710 patent/US20120165267A1/en not_active Abandoned
-
2012
- 2012-04-06 US US13/441,682 patent/US20130165383A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2489348A1 (fr) | 2003-12-31 |
US20120165267A1 (en) | 2012-06-28 |
EP1556076A2 (fr) | 2005-07-27 |
AU2003247609A1 (en) | 2004-01-06 |
JP4574350B2 (ja) | 2010-11-04 |
EP1556076A4 (fr) | 2009-07-08 |
EP2500032A9 (fr) | 2013-04-17 |
US20060141561A1 (en) | 2006-06-29 |
US20130165383A1 (en) | 2013-06-27 |
AU2009212834A1 (en) | 2009-09-24 |
US20070098681A1 (en) | 2007-05-03 |
JP2010065037A (ja) | 2010-03-25 |
JP2006508640A (ja) | 2006-03-16 |
EP2500032A1 (fr) | 2012-09-19 |
WO2004001009A3 (fr) | 2004-10-28 |
WO2004001009A2 (fr) | 2003-12-31 |
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