IL160045A0 - Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues - Google Patents

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues

Info

Publication number
IL160045A0
IL160045A0 IL16004502A IL16004502A IL160045A0 IL 160045 A0 IL160045 A0 IL 160045A0 IL 16004502 A IL16004502 A IL 16004502A IL 16004502 A IL16004502 A IL 16004502A IL 160045 A0 IL160045 A0 IL 160045A0
Authority
IL
Israel
Prior art keywords
compounds
preparation
analogues
levetiracetam
manufacturing
Prior art date
Application number
IL16004502A
Other languages
English (en)
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of IL160045A0 publication Critical patent/IL160045A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL16004502A 2001-08-10 2002-08-05 Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues IL160045A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01119396 2001-08-10
PCT/EP2002/008717 WO2003014080A2 (fr) 2001-08-10 2002-08-05 Composes d'oxopyrrolidine, preparation de ces composes et utilisation de ceux-ci dans la fabrication de levetiracetam et d'analogues

Publications (1)

Publication Number Publication Date
IL160045A0 true IL160045A0 (en) 2004-06-20

Family

ID=8178301

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16004502A IL160045A0 (en) 2001-08-10 2002-08-05 Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
IL160045A IL160045A (en) 2001-08-10 2004-01-26 Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacture of levetiracetam and analogues

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160045A IL160045A (en) 2001-08-10 2004-01-26 Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacture of levetiracetam and analogues

Country Status (10)

Country Link
US (3) US7122682B2 (fr)
EP (1) EP1419144B1 (fr)
JP (1) JP4334344B2 (fr)
AT (1) ATE410412T1 (fr)
AU (1) AU2002329233B2 (fr)
CA (1) CA2455155C (fr)
DE (1) DE60229267D1 (fr)
ES (1) ES2314090T3 (fr)
IL (2) IL160045A0 (fr)
WO (1) WO2003014080A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60229267D1 (de) * 2001-08-10 2008-11-20 Ucb Pharma Sa Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen
EP1517893A2 (fr) * 2003-02-03 2005-03-30 Teva Pharmaceutical Industries Limited Procede de production de levetiracetam
WO2005023763A1 (fr) * 2003-09-05 2005-03-17 Ranbaxy Laboratories Limited Procede de preparation de levetiracetam pur
EP1667967B1 (fr) * 2003-09-24 2012-08-01 UCB Pharma, S.A. Procede de preparation des derives de 2-oxo-1-pyrrolidin
DE602004031037D1 (de) * 2003-11-19 2011-02-24 Array Biopharma Inc Heterocyclische inhibitoren von mek
CA2488325C (fr) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Methode de synthese amelioree du (s)-alpha-ethyl-2-oxo-1-pyrrolidine-acetamide et du (r)-alpha-ethyl-2-oxo-1-pyrroldine-acetamide
WO2006095362A1 (fr) * 2005-03-10 2006-09-14 Rubamin Limited Procede de preparation du levetiracetam
JP2009507870A (ja) * 2005-09-15 2009-02-26 ユセベ ファルマ ソシエテ アノニム ４−置換ピロリジン−２−オン及びそれらの使用
US8338621B2 (en) * 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
CN101511786A (zh) * 2006-07-25 2009-08-19 Zach***股份公司 制备左乙拉西坦的方法
EP2147911A1 (fr) 2008-07-24 2010-01-27 ZaCh System S.p.A. Procédé de préparation de lévétiracetam
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
CN106349143A (zh) * 2013-06-19 2017-01-25 成都百途医药科技有限公司 一种奥拉西坦的合成方法
CN103553998B (zh) * 2013-11-06 2015-11-25 温州智创科技有限公司 (s)-奥拉西坦晶型iii的制备方法
CN103553997B (zh) * 2013-11-06 2015-11-25 温州智创科技有限公司 一种(s)-奥拉西坦晶型iii的制备方法
WO2016075082A1 (fr) 2014-11-10 2016-05-19 Sandoz Ag Amination réductrice stéréosélective d'aldéhydes alpha-chiraux au moyen d'ω-transaminases pour la synthèse de précurseurs de la prégabaline et du brivaracétam
WO2016191435A1 (fr) * 2015-05-25 2016-12-01 Peng Wang Procédés de production du brivaracetam
CN106591179B (zh) * 2016-12-05 2018-07-03 长兴制药股份有限公司 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用
CN110799494B (zh) * 2017-08-08 2023-06-06 浙江华海药业股份有限公司 一种无溶剂制备左乙拉西坦的方法
CN110799495B (zh) * 2017-08-08 2022-12-13 浙江华海药业股份有限公司 一种左乙拉西坦的合成方法
WO2019028671A1 (fr) * 2017-08-08 2019-02-14 浙江华海药业股份有限公司 Procédé de préparation de lévétiracétam
CN110452157B (zh) * 2018-12-28 2020-11-03 广州市朗启医药科技有限责任公司 常山酮及其中间体的合成方法
CN113816872A (zh) * 2020-06-19 2021-12-21 浙江华海药业股份有限公司 一种（s）-2-氨基丁酰胺的合成方法
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
CN114409586A (zh) * 2021-12-23 2022-04-29 山东诚汇双达药业有限公司 一种左乙拉西坦的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB0004297D0 (en) * 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6686477B2 (en) * 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
DE60229267D1 (de) * 2001-08-10 2008-11-20 Ucb Pharma Sa Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen

Also Published As

Publication number Publication date
US7122682B2 (en) 2006-10-17
JP4334344B2 (ja) 2009-09-30
ATE410412T1 (de) 2008-10-15
AU2002329233B2 (en) 2007-08-16
WO2003014080A2 (fr) 2003-02-20
EP1419144A2 (fr) 2004-05-19
DE60229267D1 (de) 2008-11-20
US20040204476A1 (en) 2004-10-14
US20060258734A1 (en) 2006-11-16
IL160045A (en) 2010-06-30
EP1419144B1 (fr) 2008-10-08
CA2455155A1 (fr) 2003-02-20
US20070142647A1 (en) 2007-06-21
WO2003014080A3 (fr) 2003-11-06
JP2005507378A (ja) 2005-03-17
CA2455155C (fr) 2012-04-10
ES2314090T3 (es) 2009-03-16
US7563912B2 (en) 2009-07-21

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