IL155506A0 - Process for folding chemically synthesized polypeptides - Google Patents
Process for folding chemically synthesized polypeptidesInfo
- Publication number
- IL155506A0 IL155506A0 IL15550601A IL15550601A IL155506A0 IL 155506 A0 IL155506 A0 IL 155506A0 IL 15550601 A IL15550601 A IL 15550601A IL 15550601 A IL15550601 A IL 15550601A IL 155506 A0 IL155506 A0 IL 155506A0
- Authority
- IL
- Israel
- Prior art keywords
- chemically synthesized
- folding
- synthesized polypeptides
- cysteine
- reducing agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00204207 | 2000-11-27 | ||
PCT/EP2001/014163 WO2002050099A2 (en) | 2000-11-27 | 2001-11-27 | Process for folding chemically synthesized polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL155506A0 true IL155506A0 (en) | 2003-11-23 |
Family
ID=8172340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15550601A IL155506A0 (en) | 2000-11-27 | 2001-11-27 | Process for folding chemically synthesized polypeptides |
Country Status (22)
Country | Link |
---|---|
US (2) | US20020082384A1 (es) |
EP (2) | EP1679318A1 (es) |
JP (1) | JP2004516300A (es) |
KR (1) | KR20030081315A (es) |
CN (2) | CN1830999A (es) |
AT (1) | ATE322501T1 (es) |
AU (2) | AU2002229603B2 (es) |
BR (1) | BR0113091A (es) |
CA (1) | CA2416054A1 (es) |
CU (1) | CU23034A3 (es) |
DE (1) | DE60118598T2 (es) |
DK (1) | DK1337549T3 (es) |
ES (1) | ES2261509T4 (es) |
HU (1) | HUP0302395A3 (es) |
IL (1) | IL155506A0 (es) |
MX (1) | MXPA03003576A (es) |
NO (1) | NO20032356L (es) |
NZ (1) | NZ523679A (es) |
PL (1) | PL364932A1 (es) |
RU (1) | RU2275377C2 (es) |
WO (1) | WO2002050099A2 (es) |
ZA (1) | ZA200300642B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091310B2 (en) * | 2002-09-13 | 2006-08-15 | Chemokine Therapeutics Corporation | Chemokine analogs for the treatment of human disease |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
EP2338333B1 (en) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylation methods and proteins/peptides produced by the methods |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
AU2005298840B2 (en) * | 2004-10-26 | 2010-09-16 | Lonza Ag | S-alkyl-sulphenyl protection groups in solid-phase synthesis |
SI2586456T1 (sl) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
AU2006203792B2 (en) | 2005-01-10 | 2011-11-03 | Ratiopharm Gmbh | Glycopegylated Granulocyte Colony Stimulating Factor |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
WO2006134173A2 (en) * | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
JP2009520739A (ja) * | 2005-12-23 | 2009-05-28 | アプラゲン ゲーエムベーハー | ジスルフィド架橋の形成方法 |
JP2009535402A (ja) * | 2006-05-03 | 2009-10-01 | マリンクロッド・インコーポレイテッド | 保護ペプチドを樹脂から放出するための組成物および方法 |
JP2009544327A (ja) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー/エス | O−結合型グリコシル化配列によるペプチドのグリコシル化 |
US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
EP2144923B1 (en) | 2007-04-03 | 2013-02-13 | BioGeneriX AG | Methods of treatment using glycopegylated g-csf |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
US20100203001A1 (en) * | 2007-07-11 | 2010-08-12 | Aplagen Gmbh | Process for forming disulfide bridges |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
CN104844693B (zh) * | 2015-06-10 | 2018-08-03 | 成都圣诺生物科技股份有限公司 | 一种合成利那洛肽的方法 |
WO2019149918A1 (en) | 2018-02-02 | 2019-08-08 | Novo Nordisk A/S | Drug injection device with deflectable transducer |
CN111100188A (zh) * | 2018-10-25 | 2020-05-05 | 成都医学院 | 一种制备蜘蛛抗菌肽的方法 |
CN109593119A (zh) * | 2019-01-27 | 2019-04-09 | 上海丽珠制药有限公司 | 一种[2-d-组氨酸]-醋酸亮丙瑞林的制备方法 |
JP7453745B2 (ja) * | 2019-03-28 | 2024-03-21 | 株式会社ヤクルト本社 | 毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法 |
CN110845595A (zh) * | 2019-11-14 | 2020-02-28 | 连云港职业技术学院 | 一种固相合成5-tmara标记的铁调素-25的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2923787A1 (de) * | 1979-06-12 | 1980-12-18 | Max Planck Gesellschaft | Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel |
DE3236849A1 (de) * | 1982-10-05 | 1984-04-05 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue thiohydrazin-1,2-dicarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung |
IL96682A0 (en) * | 1989-12-15 | 1991-09-16 | Amgen Inc | Production of biologically active platelet-derived growth factor from high expression host cell systems |
CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
EP0628573A1 (en) * | 1993-05-24 | 1994-12-14 | Kao Corporation | Process for producing solubilized protein |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
DE4431317A1 (de) * | 1994-09-02 | 1996-03-07 | Biotechnolog Forschung Gmbh | Schutz- bzw. Ankergruppen und deren Verwendung |
-
2001
- 2001-11-27 WO PCT/EP2001/014163 patent/WO2002050099A2/en active IP Right Grant
- 2001-11-27 AT AT01990489T patent/ATE322501T1/de not_active IP Right Cessation
- 2001-11-27 PL PL01364932A patent/PL364932A1/xx not_active Application Discontinuation
- 2001-11-27 AU AU2002229603A patent/AU2002229603B2/en not_active Expired - Fee Related
- 2001-11-27 HU HU0302395A patent/HUP0302395A3/hu unknown
- 2001-11-27 EP EP06075237A patent/EP1679318A1/en not_active Withdrawn
- 2001-11-27 EP EP01990489A patent/EP1337549B1/en not_active Expired - Lifetime
- 2001-11-27 ES ES01990489T patent/ES2261509T4/es not_active Expired - Lifetime
- 2001-11-27 IL IL15550601A patent/IL155506A0/xx unknown
- 2001-11-27 KR KR10-2003-7004957A patent/KR20030081315A/ko not_active Application Discontinuation
- 2001-11-27 RU RU2003119075/04A patent/RU2275377C2/ru not_active IP Right Cessation
- 2001-11-27 JP JP2002551992A patent/JP2004516300A/ja active Pending
- 2001-11-27 NZ NZ523679A patent/NZ523679A/en unknown
- 2001-11-27 DE DE60118598T patent/DE60118598T2/de not_active Expired - Fee Related
- 2001-11-27 CA CA002416054A patent/CA2416054A1/en not_active Abandoned
- 2001-11-27 CN CNA2006100047520A patent/CN1830999A/zh active Pending
- 2001-11-27 US US09/995,335 patent/US20020082384A1/en not_active Abandoned
- 2001-11-27 AU AU2960302A patent/AU2960302A/xx active Pending
- 2001-11-27 MX MXPA03003576A patent/MXPA03003576A/es active IP Right Grant
- 2001-11-27 DK DK01990489T patent/DK1337549T3/da active
- 2001-11-27 CN CNB018147968A patent/CN1249078C/zh not_active Expired - Fee Related
- 2001-11-27 BR BR0113091-9A patent/BR0113091A/pt not_active IP Right Cessation
- 2001-11-27 CU CU20030094A patent/CU23034A3/es unknown
-
2003
- 2003-01-23 ZA ZA200300642A patent/ZA200300642B/en unknown
- 2003-05-26 NO NO20032356A patent/NO20032356L/no unknown
-
2005
- 2005-05-19 US US11/132,987 patent/US20050239162A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2960302A (en) | 2002-07-01 |
EP1337549A2 (en) | 2003-08-27 |
CN1830999A (zh) | 2006-09-13 |
RU2275377C2 (ru) | 2006-04-27 |
NO20032356D0 (no) | 2003-05-26 |
MXPA03003576A (es) | 2003-10-14 |
WO2002050099A3 (en) | 2002-09-19 |
DK1337549T3 (da) | 2006-07-31 |
HUP0302395A2 (hu) | 2003-10-28 |
KR20030081315A (ko) | 2003-10-17 |
US20020082384A1 (en) | 2002-06-27 |
DE60118598D1 (de) | 2006-05-18 |
CU23034A3 (es) | 2005-03-22 |
EP1679318A1 (en) | 2006-07-12 |
PL364932A1 (en) | 2004-12-27 |
EP1337549B1 (en) | 2006-04-05 |
JP2004516300A (ja) | 2004-06-03 |
WO2002050099A2 (en) | 2002-06-27 |
DE60118598T2 (de) | 2007-02-15 |
AU2002229603B2 (en) | 2007-11-08 |
HUP0302395A3 (en) | 2007-05-02 |
NO20032356L (no) | 2003-05-26 |
ES2261509T3 (es) | 2006-11-16 |
BR0113091A (pt) | 2003-07-08 |
CN1449406A (zh) | 2003-10-15 |
ATE322501T1 (de) | 2006-04-15 |
ES2261509T4 (es) | 2008-02-16 |
US20050239162A1 (en) | 2005-10-27 |
CN1249078C (zh) | 2006-04-05 |
NZ523679A (en) | 2005-10-28 |
ZA200300642B (en) | 2004-07-16 |
CA2416054A1 (en) | 2002-06-27 |
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