IL155317A0 - Methods for detecting modulators of ion channels using thallium (i) sensitive assays - Google Patents
Methods for detecting modulators of ion channels using thallium (i) sensitive assaysInfo
- Publication number
- IL155317A0 IL155317A0 IL15531701A IL15531701A IL155317A0 IL 155317 A0 IL155317 A0 IL 155317A0 IL 15531701 A IL15531701 A IL 15531701A IL 15531701 A IL15531701 A IL 15531701A IL 155317 A0 IL155317 A0 IL 155317A0
- Authority
- IL
- Israel
- Prior art keywords
- thallium
- methods
- ion channels
- sensitive assays
- detecting modulators
- Prior art date
Links
- 102000004310 Ion Channels Human genes 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- ZLUSCZLCHQSJRU-UHFFFAOYSA-N thallium(1+) Chemical compound [Tl+] ZLUSCZLCHQSJRU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24052300P | 2000-10-13 | 2000-10-13 | |
PCT/US2001/032132 WO2002031508A1 (fr) | 2000-10-13 | 2001-10-12 | Methodes de detection de modulateurs de canaux ioniques au moyen de dosages sensibles au thallium (i) |
Publications (1)
Publication Number | Publication Date |
---|---|
IL155317A0 true IL155317A0 (en) | 2003-11-23 |
Family
ID=22906876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15531701A IL155317A0 (en) | 2000-10-13 | 2001-10-12 | Methods for detecting modulators of ion channels using thallium (i) sensitive assays |
Country Status (8)
Country | Link |
---|---|
US (2) | US20020168625A1 (fr) |
EP (1) | EP1327150A1 (fr) |
JP (2) | JP2004530100A (fr) |
AU (2) | AU1535002A (fr) |
CA (1) | CA2425806A1 (fr) |
IL (1) | IL155317A0 (fr) |
MX (1) | MXPA03003223A (fr) |
WO (1) | WO2002031508A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10078087B2 (en) | 2001-05-01 | 2018-09-18 | Senomyx, Inc. | Assays and enhancers of the human delta ENaC sodium channel |
US6770484B2 (en) * | 2001-11-29 | 2004-08-03 | Dong C. Liang | Using flame and graphite furnace atomic absorption spectrometry for analysis of sodium channel activity |
DE10243599A1 (de) * | 2002-09-19 | 2004-04-01 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Messvorrichtung und -verfahren für ein Screening bei auf Elektroden immobilisierten Zellen |
EP1644738A2 (fr) | 2003-07-10 | 2006-04-12 | Senomyx Inc. | Dosages electrophysiologiques ameliores mettant en oeuvre des ovocytes d'expression du canal sodique epithelial humain et l'utilisation de phenamil pour ameliorer l'effet d'amplificateurs de canal sodique epithelial dans des dosages au moyen de colorants rapporteurs a potentiel membranaire |
WO2005069008A1 (fr) * | 2004-01-15 | 2005-07-28 | Evotec Ag | Procede pour etudier l'activite de canaux ioniques |
CA2571540A1 (fr) * | 2004-06-23 | 2006-01-26 | Ortho-Mcneil Pharmaceutical, Inc. | Procedes de mesure de conductivite de canal chlorure |
US20070092970A1 (en) * | 2005-10-25 | 2007-04-26 | Liang Dong C | High-throughput screening assay for Na, K-ATPase using atomic absorption spectroscopy |
DE102007011913A1 (de) * | 2007-03-13 | 2008-10-23 | Sanofi-Aventis | Fluoreszenz-basiertes Assay zum Erkennen von Verbindungen zum Modulieren des Natrium-Calcium-Austauschers (NCX) im "Vorwärtsmodus" |
DE102007012029A1 (de) * | 2007-03-13 | 2008-09-18 | Grünenthal GmbH | Verfahren zur Identifizierung der agonistischen Aktivität einer Zielverbindung auf einen Kaliumkanal |
US8318502B2 (en) * | 2007-06-05 | 2012-11-27 | Life Technologies Corporation | Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol |
WO2009002423A2 (fr) | 2007-06-21 | 2008-12-31 | Schering Corporation | Dérivés de guanine polycycliques et leurs procédés d'utilisation |
JP2011501155A (ja) * | 2007-10-15 | 2011-01-06 | ライフ テクノロジーズ コーポレーション | タリウムの流入および流出測定のための組成物および方法 |
EP2103944A1 (fr) * | 2008-03-20 | 2009-09-23 | sanofi-aventis | Test de détection, basé sur la fluorescence, de composés qui modulent le "forward mode" des canaux ioniques échangeurs de sodium/calcium |
US9134323B2 (en) | 2009-12-01 | 2015-09-15 | The Rockefeller University | Antibody that specifically binds to an epitope in the tureet region of a human Kir channel |
US9579106B2 (en) | 2010-03-31 | 2017-02-28 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Shoulder arthroplasty instrumentation |
US9103791B1 (en) | 2012-09-26 | 2015-08-11 | Vanderbilt University | Thallium fluorescent ion indicator and assay |
EP2712702B1 (fr) * | 2012-10-01 | 2014-12-03 | Supfina Grieshaber GmbH & Co. KG | Dispositif de finition de bande, système de finition de bande et procédé de fabrication d'un dispositif de finition de bande |
CN109690317B (zh) * | 2016-08-17 | 2023-05-02 | 生命科技股份有限公司 | 用于测量细胞中离子通道活性的组合物和方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
WO1994019464A2 (fr) * | 1993-02-19 | 1994-09-01 | The Upjohn Company | Sequence d'adn humain codant une vanne a potassium dependant de l'atp du rein |
US5985214A (en) * | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
GB9925799D0 (en) * | 1999-11-02 | 1999-12-29 | Cambridge Drug Discovery Ltd | Ion channel permeability |
-
2001
- 2001-10-12 AU AU1535002A patent/AU1535002A/xx active Pending
- 2001-10-12 AU AU2002215350A patent/AU2002215350B2/en not_active Ceased
- 2001-10-12 MX MXPA03003223A patent/MXPA03003223A/es not_active Application Discontinuation
- 2001-10-12 IL IL15531701A patent/IL155317A0/xx unknown
- 2001-10-12 WO PCT/US2001/032132 patent/WO2002031508A1/fr active Application Filing
- 2001-10-12 US US09/975,891 patent/US20020168625A1/en not_active Abandoned
- 2001-10-12 CA CA002425806A patent/CA2425806A1/fr not_active Abandoned
- 2001-10-12 EP EP01983962A patent/EP1327150A1/fr not_active Withdrawn
- 2001-10-12 JP JP2002534842A patent/JP2004530100A/ja not_active Withdrawn
-
2007
- 2007-04-04 US US11/696,242 patent/US20070172815A1/en not_active Abandoned
-
2008
- 2008-07-24 JP JP2008191135A patent/JP2008264004A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2002215350B2 (en) | 2006-12-07 |
JP2004530100A (ja) | 2004-09-30 |
WO2002031508A1 (fr) | 2002-04-18 |
AU1535002A (en) | 2002-04-22 |
EP1327150A1 (fr) | 2003-07-16 |
US20070172815A1 (en) | 2007-07-26 |
JP2008264004A (ja) | 2008-11-06 |
MXPA03003223A (es) | 2003-09-10 |
CA2425806A1 (fr) | 2002-04-18 |
US20020168625A1 (en) | 2002-11-14 |
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