IL155317A0 - Methods for detecting modulators of ion channels using thallium (i) sensitive assays - Google Patents

Methods for detecting modulators of ion channels using thallium (i) sensitive assays

Info

Publication number
IL155317A0
IL155317A0 IL15531701A IL15531701A IL155317A0 IL 155317 A0 IL155317 A0 IL 155317A0 IL 15531701 A IL15531701 A IL 15531701A IL 15531701 A IL15531701 A IL 15531701A IL 155317 A0 IL155317 A0 IL 155317A0
Authority
IL
Israel
Prior art keywords
thallium
methods
ion channels
sensitive assays
detecting modulators
Prior art date
Application number
IL15531701A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL155317A0 publication Critical patent/IL155317A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL15531701A 2000-10-13 2001-10-12 Methods for detecting modulators of ion channels using thallium (i) sensitive assays IL155317A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24052300P 2000-10-13 2000-10-13
PCT/US2001/032132 WO2002031508A1 (fr) 2000-10-13 2001-10-12 Methodes de detection de modulateurs de canaux ioniques au moyen de dosages sensibles au thallium (i)

Publications (1)

Publication Number Publication Date
IL155317A0 true IL155317A0 (en) 2003-11-23

Family

ID=22906876

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15531701A IL155317A0 (en) 2000-10-13 2001-10-12 Methods for detecting modulators of ion channels using thallium (i) sensitive assays

Country Status (8)

Country Link
US (2) US20020168625A1 (fr)
EP (1) EP1327150A1 (fr)
JP (2) JP2004530100A (fr)
AU (2) AU1535002A (fr)
CA (1) CA2425806A1 (fr)
IL (1) IL155317A0 (fr)
MX (1) MXPA03003223A (fr)
WO (1) WO2002031508A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10078087B2 (en) 2001-05-01 2018-09-18 Senomyx, Inc. Assays and enhancers of the human delta ENaC sodium channel
US6770484B2 (en) * 2001-11-29 2004-08-03 Dong C. Liang Using flame and graphite furnace atomic absorption spectrometry for analysis of sodium channel activity
DE10243599A1 (de) * 2002-09-19 2004-04-01 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Messvorrichtung und -verfahren für ein Screening bei auf Elektroden immobilisierten Zellen
EP1644738A2 (fr) 2003-07-10 2006-04-12 Senomyx Inc. Dosages electrophysiologiques ameliores mettant en oeuvre des ovocytes d'expression du canal sodique epithelial humain et l'utilisation de phenamil pour ameliorer l'effet d'amplificateurs de canal sodique epithelial dans des dosages au moyen de colorants rapporteurs a potentiel membranaire
WO2005069008A1 (fr) * 2004-01-15 2005-07-28 Evotec Ag Procede pour etudier l'activite de canaux ioniques
CA2571540A1 (fr) * 2004-06-23 2006-01-26 Ortho-Mcneil Pharmaceutical, Inc. Procedes de mesure de conductivite de canal chlorure
US20070092970A1 (en) * 2005-10-25 2007-04-26 Liang Dong C High-throughput screening assay for Na, K-ATPase using atomic absorption spectroscopy
DE102007011913A1 (de) * 2007-03-13 2008-10-23 Sanofi-Aventis Fluoreszenz-basiertes Assay zum Erkennen von Verbindungen zum Modulieren des Natrium-Calcium-Austauschers (NCX) im "Vorwärtsmodus"
DE102007012029A1 (de) * 2007-03-13 2008-09-18 Grünenthal GmbH Verfahren zur Identifizierung der agonistischen Aktivität einer Zielverbindung auf einen Kaliumkanal
US8318502B2 (en) * 2007-06-05 2012-11-27 Life Technologies Corporation Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol
WO2009002423A2 (fr) 2007-06-21 2008-12-31 Schering Corporation Dérivés de guanine polycycliques et leurs procédés d'utilisation
JP2011501155A (ja) * 2007-10-15 2011-01-06 ライフ テクノロジーズ コーポレーション タリウムの流入および流出測定のための組成物および方法
EP2103944A1 (fr) * 2008-03-20 2009-09-23 sanofi-aventis Test de détection, basé sur la fluorescence, de composés qui modulent le "forward mode" des canaux ioniques échangeurs de sodium/calcium
US9134323B2 (en) 2009-12-01 2015-09-15 The Rockefeller University Antibody that specifically binds to an epitope in the tureet region of a human Kir channel
US9579106B2 (en) 2010-03-31 2017-02-28 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Shoulder arthroplasty instrumentation
US9103791B1 (en) 2012-09-26 2015-08-11 Vanderbilt University Thallium fluorescent ion indicator and assay
EP2712702B1 (fr) * 2012-10-01 2014-12-03 Supfina Grieshaber GmbH & Co. KG Dispositif de finition de bande, système de finition de bande et procédé de fabrication d'un dispositif de finition de bande
CN109690317B (zh) * 2016-08-17 2023-05-02 生命科技股份有限公司 用于测量细胞中离子通道活性的组合物和方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
WO1994019464A2 (fr) * 1993-02-19 1994-09-01 The Upjohn Company Sequence d'adn humain codant une vanne a potassium dependant de l'atp du rein
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
GB9925799D0 (en) * 1999-11-02 1999-12-29 Cambridge Drug Discovery Ltd Ion channel permeability

Also Published As

Publication number Publication date
AU2002215350B2 (en) 2006-12-07
JP2004530100A (ja) 2004-09-30
WO2002031508A1 (fr) 2002-04-18
AU1535002A (en) 2002-04-22
EP1327150A1 (fr) 2003-07-16
US20070172815A1 (en) 2007-07-26
JP2008264004A (ja) 2008-11-06
MXPA03003223A (es) 2003-09-10
CA2425806A1 (fr) 2002-04-18
US20020168625A1 (en) 2002-11-14

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