IL149069A0 - Regulators of the hedgehog pathway, compositions and uses related thereto - Google Patents

Regulators of the hedgehog pathway, compositions and uses related thereto

Info

Publication number
IL149069A0
IL149069A0 IL14906900A IL14906900A IL149069A0 IL 149069 A0 IL149069 A0 IL 149069A0 IL 14906900 A IL14906900 A IL 14906900A IL 14906900 A IL14906900 A IL 14906900A IL 149069 A0 IL149069 A0 IL 149069A0
Authority
IL
Israel
Prior art keywords
regulators
compositions
function
hedgehog pathway
uses related
Prior art date
Application number
IL14906900A
Other languages
English (en)
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26855755&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL149069(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Publication of IL149069A0 publication Critical patent/IL149069A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
IL14906900A 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto IL149069A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15921599P 1999-10-13 1999-10-13
US22927300P 2000-08-30 2000-08-30
PCT/US2000/028479 WO2001027135A2 (fr) 1999-10-13 2000-10-13 Regulateurs du signal hedgehog, compositions et utilisations desdits regulateurs

Publications (1)

Publication Number Publication Date
IL149069A0 true IL149069A0 (en) 2002-11-10

Family

ID=26855755

Family Applications (4)

Application Number Title Priority Date Filing Date
IL14906900A IL149069A0 (en) 1999-10-13 2000-10-13 Regulators of the hedgehog pathway, compositions and uses related thereto
IL149069A IL149069A (en) 1999-10-13 2002-04-10 Hedgehog route regulators, preparations and their use associated with these regulators
IL179814A IL179814A (en) 1999-10-13 2006-12-04 Preparations containing HEDGEHOG route regulators for use in regulating differentiation and proliferation of cells, controlling the growth and development of pancreatic tissue and treating hyperproliferative disorders
IL213594A IL213594A (en) 1999-10-13 2011-06-16 Use of a type and rectum alkaloid for in vitro drug preparation and method to inhibit mitotic cell proliferation using this alkaloid

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL149069A IL149069A (en) 1999-10-13 2002-04-10 Hedgehog route regulators, preparations and their use associated with these regulators
IL179814A IL179814A (en) 1999-10-13 2006-12-04 Preparations containing HEDGEHOG route regulators for use in regulating differentiation and proliferation of cells, controlling the growth and development of pancreatic tissue and treating hyperproliferative disorders
IL213594A IL213594A (en) 1999-10-13 2011-06-16 Use of a type and rectum alkaloid for in vitro drug preparation and method to inhibit mitotic cell proliferation using this alkaloid

Country Status (9)

Country Link
US (5) US7098196B1 (fr)
EP (2) EP1235851B1 (fr)
JP (2) JP5420128B2 (fr)
AT (1) ATE328002T1 (fr)
AU (2) AU781524B2 (fr)
CA (1) CA2386190C (fr)
DE (1) DE60028411T2 (fr)
IL (4) IL149069A0 (fr)
WO (1) WO2001027135A2 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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US7098196B1 (en) 1999-10-13 2006-08-29 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
US7291626B1 (en) * 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1387674B1 (fr) * 2000-10-13 2017-01-18 Curis, Inc. Antagonistes hedgehog, procedes et utilisations associees
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
WO2002044344A2 (fr) * 2000-11-28 2002-06-06 Curis, Inc. Cultures d'epithelioma cutane basocellulaire, compositions et methodes associees
CA2452152A1 (fr) 2001-07-02 2002-10-10 Sinan Tas Utilisation de cyclopamine dans le traitement du psoriasis
CA2452151C (fr) * 2001-07-02 2012-01-03 Sinan Tas Utilisation de cyclopamine, un inducteur de la differenciation et de l'apoptose des cellules du carcinome baso-cellulaire, dans le traitement du carcinome baso-cellulaire et d'autres tumeurs utilisant la voie hedgehog/smoothened aux fins de la proliferation de l'apoptose
US20080118493A1 (en) * 2003-07-15 2008-05-22 Beachy Philip A Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity
US20070231828A1 (en) * 2003-10-01 2007-10-04 Johns Hopkins University Methods of predicting behavior of cancers
WO2005032343A2 (fr) * 2003-10-01 2005-04-14 The Johns Hopkins University Signalisation hedgehog dans la regeneration, la neoplasie et la metastase prostatique
US20080057071A1 (en) * 2003-10-20 2008-03-06 Watkins David N Use Of Hedgehog Pathway Inhibitors In Small-Cell Lung Cancer
CN101044139B (zh) * 2004-08-27 2011-06-08 无限药品股份有限公司 环杷明类似物及其使用方法
WO2006026430A2 (fr) * 2004-08-27 2006-03-09 Infinity Pharmaceuticals, Inc. Analogues de cyclopamine et procedes d'utilisation de ceux-ci
WO2006039569A1 (fr) * 2004-09-30 2006-04-13 The University Of Chicago Polytherapie d'inhibiteurs hedgehog, de rayonnement et d'agents chimiotherapeutiques
AU2006246923A1 (en) * 2005-05-16 2006-11-23 Island Laboratories Inc. System and method for promoting hair growth and improving hair and scalp health
US20110034498A1 (en) * 2006-03-24 2011-02-10 Mcgovern Karen J Dosing regimens for the treatment of cancer
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
KR20090117956A (ko) * 2007-03-07 2009-11-16 인피니티 디스커버리, 인코포레이티드 시클로파민 락탐 유사체 및 그의 사용 방법
JP2010520295A (ja) * 2007-03-07 2010-06-10 インフィニティ・ディスカバリー・インコーポレイテッド へテロ環状シクロパミン類似体及びその使用方法
EP2224807B1 (fr) * 2007-12-27 2016-11-09 Infinity Pharmaceuticals, Inc. Procédés de réduction stéréosélective
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
CA2710377A1 (fr) * 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Traitements therapeutiques contre le cancer
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
WO2009155283A2 (fr) * 2008-06-17 2009-12-23 Duke University Dosage radiomarqué de la cyclopamine destiné au récepteur smoothened
EP2334686B1 (fr) 2008-08-28 2019-02-27 President and Fellows of Harvard College Analogues de cortistatine et leurs synthèses
US20110275576A1 (en) * 2009-01-06 2011-11-10 Utah State University Carbohydrate-Cyclopamine Conjugates as Anticancer Agents
JP2009143963A (ja) * 2009-03-25 2009-07-02 Sinan Tas 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物
WO2010117800A2 (fr) * 2009-03-30 2010-10-14 The Trustees Of Columbia University In The City Of New York Régulation shh et méthodes associées
FR2948367A1 (fr) 2009-07-24 2011-01-28 Centre Nat Rech Scient Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog
ES2567134T3 (es) 2009-08-05 2016-04-20 Infinity Pharmaceuticals, Inc. Transaminación enzimática de análogos de ciclopamina
CN102711479A (zh) * 2009-11-06 2012-10-03 无限药品股份有限公司 Hedgehog通道抑制剂的口服制剂
WO2011088404A1 (fr) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Traitement de pathologies fibrotiques à l'aide d'inhibiteurs de la voie hedgehog
CA2799579A1 (fr) 2010-05-21 2011-11-24 Intellikine, Inc. Composes chimiques, compositions et procedes pour modulation de kinases
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
FR2967498B1 (fr) 2010-11-16 2015-01-02 Centre Nat Rech Scient Utilisation de derives de quinolinone comme outil de recherche
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
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AU2006202843A1 (en) 2006-08-03
AU781524B2 (en) 2005-05-26
US20110263519A1 (en) 2011-10-27
EP1235851A2 (fr) 2002-09-04
EP1728797A3 (fr) 2011-03-02
IL179814A0 (en) 2007-05-15
JP5420128B2 (ja) 2014-02-19
DE60028411D1 (de) 2006-07-06
WO2001027135A2 (fr) 2001-04-19
ATE328002T1 (de) 2006-06-15
DE60028411T2 (de) 2007-01-04
EP1728797A2 (fr) 2006-12-06
CA2386190A1 (fr) 2001-04-19
IL213594A0 (en) 2011-07-31
US20120135066A1 (en) 2012-05-31
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US20080255059A1 (en) 2008-10-16
US7476661B2 (en) 2009-01-13
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US8163719B2 (en) 2012-04-24
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AU781524C (en) 2001-04-23
US20060128639A1 (en) 2006-06-15
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US7998946B2 (en) 2011-08-16
US7098196B1 (en) 2006-08-29
CA2386190C (fr) 2009-04-14
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US9440988B2 (en) 2016-09-13

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