IL147447A0 - Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines - Google Patents

Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines

Info

Publication number: IL147447A0
Authority: IL; Israel
Prior art keywords: rsv; human; genome; bovine; chimeric
Prior art date: 1999-07-09

Application number

IL14744700A

Other languages

English (en)

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-09

Filing date

2000-06-24

Publication date

2002-08-14

2000-06-24 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2002-08-14 Publication of IL147447A0 publication Critical patent/IL147447A0/xx

Links

241000725643 Respiratory syncytial virus Species 0.000 title abstract 7
230000002238 attenuated effect Effects 0.000 title abstract 2
229960005486 vaccine Drugs 0.000 title abstract 2
241000711895 Bovine orthopneumovirus Species 0.000 abstract 2
241000711920 Human orthopneumovirus Species 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000282412 Homo Species 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000002458 infectious effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000002157 polynucleotide Substances 0.000 abstract 1
102000040430 polynucleotide Human genes 0.000 abstract 1
108091033319 polynucleotide Proteins 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Mycology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL14744700A 1999-07-09 2000-06-24 Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines IL147447A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14313299P	1999-07-09	1999-07-09
PCT/US2000/017755 WO2001004335A2 (en)	1999-07-09	2000-06-23	Human-bovine chimeric respiratory syncytial virus vaccines

Publications (1)

Publication Number	Publication Date
IL147447A0 true IL147447A0 (en)	2002-08-14

Family

ID=22502738

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14744700A IL147447A0 (en)	1999-07-09	2000-06-24	Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines
IL147447A IL147447A (en)	1999-07-09	2002-01-03	Immunogenic composition comprising an infectious bovine-human chimeric respiratory syncytial virus and polynucletide molecule comprising the genome of said virus

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL147447A IL147447A (en)	1999-07-09	2002-01-03	Immunogenic composition comprising an infectious bovine-human chimeric respiratory syncytial virus and polynucletide molecule comprising the genome of said virus

Country Status (13)

Country	Link
US (2)	US7829102B2 (de)
EP (1)	EP1287152B1 (de)
JP (1)	JP2003530073A (de)
KR (1)	KR100905450B1 (de)
CN (2)	CN100354425C (de)
AT (1)	ATE419369T1 (de)
AU (2)	AU784216B2 (de)
BR (1)	BR0013195A (de)
CA (1)	CA2378552A1 (de)
DE (1)	DE60041280D1 (de)
IL (2)	IL147447A0 (de)
MX (1)	MXPA02000220A (de)
WO (1)	WO2001004335A2 (de)

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US7485440B2 (en)	1995-09-27	2009-02-03	The United States Of America As Represented By The Department Of Health And Human Services	Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
US7632508B2 (en)	1997-05-23	2009-12-15	The United States Of America	Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7201907B1 (en)	1997-05-23	2007-04-10	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
US7951383B2 (en)	1997-05-23	2011-05-31	The United States Of America As Represented By The Department Of Health And Human Services	Attenuated parainfluenza virus (PIV) vaccines
US20030082209A1 (en)	2000-07-05	2003-05-01	Skiadopoulos Mario H.	Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US20040005542A1 (en)	2001-06-22	2004-01-08	Krempl Christine D	Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
US7662397B2 (en)	1997-07-15	2010-02-16	The United States Of America As Represented By The Department Of Health And Human Services	Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
MXPA02000490A (es) *	1999-07-13	2004-09-27	Us Gov Health & Human Serv	Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras.
WO2004027037A2 (en)	2002-09-18	2004-04-01	The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HPIV2) FROM cDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS
WO2005014626A2 (en)	2003-02-28	2005-02-17	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Recombinant human metapneumovirus and its use
CA2528002A1 (en)	2003-06-09	2004-12-29	Wyeth	Improved method for the recovery of non-segmented, negative-stranded rna viruses from cdna
EP1713824A2 (de) *	2003-12-10	2006-10-25	The Uab Research Foundation	Rekombinante viren mit heterologen füllproteinen
WO2007060725A1 (ja) *	2005-11-24	2007-05-31	The Research Foundation For Microbial Diseases Of Osaka University	組換え多価ワクチン
CA2703066A1 (en) *	2007-10-22	2009-04-30	University Of Rochester	Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres
WO2010003032A2 (en) *	2008-07-01	2010-01-07	The Government Of The United States Of America, Represented By The Secretary, Department Of Health A	Recombinant human parainfluenza type 1 viruses (hpiv1s) containing mutations in or deletion of the c protein are attenuated in african green monkeys and in ciliated human airway epithelial cells and are potential vaccine candidates for hpiv1
EP2346990B1 (de)	2008-11-05	2016-01-06	Merck Sharp & Dohme Corp.	Lebendes attenuiertes respiratory-syncytial-virus
GB201019240D0 (en) *	2010-11-15	2010-12-29	Vib Vzw	Respiratory syncytical virus vaccine
WO2012085936A2 (en) *	2010-12-20	2012-06-28	Panacea Biotech Ltd	Recombinant respiratory syncytial virus plasmids and vaccines
CN102210859B (zh) *	2011-05-31	2012-11-21	昆明理工大学	一种结核分枝杆菌esat-6-f2融合蛋白亚单位疫苗及其制备方法
ES2863477T3 (es)	2012-04-13	2021-10-11	Us Health	Vacuna genéticamente estable viva atenuada contra el virus respiratorio sincitial y su producción
JP2014236748A (ja) *	2014-08-26	2014-12-18	一般財団法人阪大微生物病研究会	組換え多価ワクチン
CN107406835A (zh)	2015-01-20	2017-11-28	***合众国,由健康及人类服务部部长代表	表达嵌合rsv/bpiv3f蛋白的重组人/牛副流感病毒3(b/hpiv3)及其用途
AU2018241252A1 (en) *	2017-03-30	2019-10-03	The University Of Queensland	Chimeric molecules and uses thereof
US20210189425A1 (en) *	2018-04-23	2021-06-24	The United States Of America,As Represented By The Secretary,Department Of Health And Human Services	Chimeric vectors
BR112021006970A2 (pt) *	2018-10-12	2021-07-27	Sk Bioscience Co., Ltd.	cepa de vacina viva de rsv recombinante e método para produzir a mesma
CN110229219B (zh) *	2019-06-21	2021-03-30	中国科学院武汉病毒研究所	一种新型的呼吸道合胞病毒疫苗抗原的制备方法及其用途
WO2023183700A2 (en) *	2022-03-22	2023-09-28	Mayo Foundation For Medical Education And Research	Morreton viruses and methods of use
CN116676275B (zh) *	2023-03-17	2024-06-07	北京赛尔富森生物科技有限公司	A基因型嵌合腮腺炎病毒株和制备方法及用途

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JP4434478B2 (ja)	1997-07-11	2010-03-17	イエールユニバーシティー	リエンジニアリングされた外被を有するラブドウイルス
WO1999024564A1 (en) *	1997-11-10	1999-05-20	University Of Maryland	PRODUCTION OF NOVEL BOVINE RESPIRATORY SYNCYTIAL VIRUSES FROM cDNAs
CA2369200A1 (en)	1999-04-13	2000-10-19	Peter L. Collins	Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
BR0011159A (pt)	1999-04-13	2002-07-23	Government Of The Us Dept Of H	Método para produzir vacinas de vìrus rna de fita negativa atenuado a partir de sequências de nucleotìdeos clonados
AU5918100A (en)	1999-07-09	2001-01-30	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
MXPA02000490A (es)	1999-07-13	2004-09-27	Us Gov Health & Human Serv	Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras.
ATE416251T1 (de) *	2000-06-23	2008-12-15	Us Gov Health & Human Serv	Respiratorische synzytialvirus impfstoffe, welche schützende antigene von promotor-proximalen genen exprimieren

2000
- 2000-06-23 CN CNB008101191A patent/CN100354425C/zh not_active Expired - Fee Related
- 2000-06-23 CA CA002378552A patent/CA2378552A1/en not_active Abandoned
- 2000-06-23 CN CNA2007101671126A patent/CN101260386A/zh active Pending
- 2000-06-23 KR KR1020027000318A patent/KR100905450B1/ko not_active IP Right Cessation
- 2000-06-23 AT AT00941756T patent/ATE419369T1/de not_active IP Right Cessation
- 2000-06-23 JP JP2001509539A patent/JP2003530073A/ja not_active Ceased
- 2000-06-23 EP EP00941756A patent/EP1287152B1/de not_active Expired - Lifetime
- 2000-06-23 WO PCT/US2000/017755 patent/WO2001004335A2/en active Application Filing
- 2000-06-23 DE DE60041280T patent/DE60041280D1/de not_active Expired - Lifetime
- 2000-06-23 BR BR0013195-4A patent/BR0013195A/pt not_active IP Right Cessation
- 2000-06-23 MX MXPA02000220A patent/MXPA02000220A/es not_active Application Discontinuation
- 2000-06-24 IL IL14744700A patent/IL147447A0/xx unknown
- 2000-06-24 AU AU56415/00A patent/AU784216B2/en not_active Ceased
2002
- 2002-01-03 IL IL147447A patent/IL147447A/en not_active IP Right Cessation
2005
- 2005-03-31 US US11/097,946 patent/US7829102B2/en not_active Expired - Fee Related
- 2005-08-11 US US11/203,620 patent/US7842798B2/en not_active Expired - Fee Related
2006
- 2006-05-23 AU AU2006202170A patent/AU2006202170B2/en not_active Ceased

Also Published As

Publication number	Publication date
KR100905450B1 (ko)	2009-07-02
JP2003530073A (ja)	2003-10-14
MXPA02000220A (es)	2005-08-16
EP1287152B1 (de)	2008-12-31
AU784216B2 (en)	2006-02-23
IL147447A (en)	2010-05-31
AU5641500A (en)	2001-01-30
AU2006202170B2 (en)	2009-10-08
US7842798B2 (en)	2010-11-30
CN100354425C (zh)	2007-12-12
BR0013195A (pt)	2002-07-23
EP1287152A2 (de)	2003-03-05
WO2001004335A3 (en)	2002-12-19
US20070184069A1 (en)	2007-08-09
AU2006202170A1 (en)	2006-06-15
CA2378552A1 (en)	2001-01-18
US20060057158A1 (en)	2006-03-16
US7829102B2 (en)	2010-11-09
KR20020092343A (ko)	2002-12-11
ATE419369T1 (de)	2009-01-15
WO2001004335A8 (en)	2003-02-06
WO2001004335A2 (en)	2001-01-18
CN1402792A (zh)	2003-03-12
CN101260386A (zh)	2008-09-10
DE60041280D1 (de)	2009-02-12

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