IL146409A - Furanone derivatives as inhibitors of cathepsin s - Google Patents
Furanone derivatives as inhibitors of cathepsin sInfo
- Publication number
- IL146409A IL146409A IL14640900A IL14640900A IL146409A IL 146409 A IL146409 A IL 146409A IL 14640900 A IL14640900 A IL 14640900A IL 14640900 A IL14640900 A IL 14640900A IL 146409 A IL146409 A IL 146409A
- Authority
- IL
- Israel
- Prior art keywords
- cathepsin
- inhibitors
- furanone derivatives
- furanone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9911417.5A GB9911417D0 (en) | 1999-05-18 | 1999-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Publications (1)
Publication Number | Publication Date |
---|---|
IL146409A true IL146409A (en) | 2005-11-20 |
Family
ID=10853598
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14640988A IL146409A0 (en) | 1999-05-18 | 2000-05-18 | Furanone derivatives as inhibitors of cathepsin s |
IL14640900A IL146409A (en) | 1999-05-18 | 2000-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14640988A IL146409A0 (en) | 1999-05-18 | 2000-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1178986B1 (da) |
JP (1) | JP2002544274A (da) |
AR (1) | AR024040A1 (da) |
AT (1) | ATE260274T1 (da) |
AU (1) | AU763694B2 (da) |
BR (1) | BR0010553A (da) |
CA (1) | CA2374297A1 (da) |
DE (1) | DE60008524T2 (da) |
DK (1) | DK1178986T3 (da) |
ES (1) | ES2215048T3 (da) |
GB (1) | GB9911417D0 (da) |
IL (2) | IL146409A0 (da) |
MX (1) | MXPA01011872A (da) |
MY (1) | MY130768A (da) |
PT (1) | PT1178986E (da) |
WO (1) | WO2000069855A2 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171434A1 (en) * | 2000-05-17 | 2003-09-11 | Jackson Richard Francis William | Branched amino acids |
DE60118793T2 (de) * | 2000-11-17 | 2007-04-26 | Medivir Ab | Cystein protease inhibitoren |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
CA2433520A1 (en) | 2000-12-22 | 2002-07-04 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
DK1362052T3 (da) * | 2001-01-17 | 2007-07-09 | Amura Therapeutics Ltd | Inhibitorer af cruzipain og andre cysteinproteaser |
EP1362042A1 (en) * | 2001-01-17 | 2003-11-19 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
US6958358B2 (en) | 2001-01-17 | 2005-10-25 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
IL160819A0 (en) * | 2001-09-14 | 2004-08-31 | Aventis Pharma Inc | Novel compounds and compositions as cathepsin inhibitors |
JP2005508979A (ja) | 2001-10-29 | 2005-04-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | システインプロテアーゼの可逆性インヒビターとして有用な化合物 |
BR0214104A (pt) | 2001-11-14 | 2004-09-28 | Aventis Pharma Inc | Oligopeptìdeos e composições contendo os mesmos como inibidores de catepsina |
US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
BR0312662A (pt) * | 2002-07-16 | 2005-05-03 | Amura Therapeutics Ltd | Compostos biologicamente ativos |
MXPA05003254A (es) | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
WO2005082876A1 (en) * | 2004-03-01 | 2005-09-09 | Medivir Uk Ltd | C-5 substituted furanone dipeptide cathepsin s inhibitors |
WO2006064286A1 (en) * | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
EP1916248A1 (en) * | 2006-10-24 | 2008-04-30 | Medivir Ab | Furanone derivatives as cysteine protease inhibitors |
EP2117605B1 (en) * | 2007-02-28 | 2012-09-26 | Sanofi | Imaging probes |
EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
JP2011525189A (ja) | 2008-06-20 | 2011-09-15 | ノバルティス アーゲー | 多発性硬化症を治療するための小児科の組成物 |
EP3946332A1 (en) | 2019-04-05 | 2022-02-09 | Université de Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
NZ332390A (en) * | 1996-04-22 | 2000-07-28 | Brigham & Womens Hospital | Suppression of immune response via inhibition of Cathepsin S by vinyl sulfone derivatives |
AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
-
1999
- 1999-05-18 GB GBGB9911417.5A patent/GB9911417D0/en not_active Ceased
-
2000
- 2000-05-17 MY MYPI20002178A patent/MY130768A/en unknown
- 2000-05-18 DK DK00929721T patent/DK1178986T3/da active
- 2000-05-18 ES ES00929721T patent/ES2215048T3/es not_active Expired - Lifetime
- 2000-05-18 AT AT00929721T patent/ATE260274T1/de not_active IP Right Cessation
- 2000-05-18 JP JP2000618272A patent/JP2002544274A/ja active Pending
- 2000-05-18 EP EP00929721A patent/EP1178986B1/en not_active Expired - Lifetime
- 2000-05-18 CA CA002374297A patent/CA2374297A1/en not_active Abandoned
- 2000-05-18 AU AU47722/00A patent/AU763694B2/en not_active Ceased
- 2000-05-18 MX MXPA01011872A patent/MXPA01011872A/es active IP Right Grant
- 2000-05-18 IL IL14640988A patent/IL146409A0/xx unknown
- 2000-05-18 BR BR0010553-8A patent/BR0010553A/pt not_active Withdrawn
- 2000-05-18 WO PCT/GB2000/001894 patent/WO2000069855A2/en active IP Right Grant
- 2000-05-18 EP EP20040002432 patent/EP1413580A1/en not_active Withdrawn
- 2000-05-18 DE DE60008524T patent/DE60008524T2/de not_active Expired - Fee Related
- 2000-05-18 PT PT00929721T patent/PT1178986E/pt unknown
- 2000-05-18 IL IL14640900A patent/IL146409A/xx not_active IP Right Cessation
- 2000-05-19 AR ARP000102445A patent/AR024040A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE60008524T2 (de) | 2004-12-23 |
EP1178986B1 (en) | 2004-02-25 |
MY130768A (en) | 2007-07-31 |
PT1178986E (pt) | 2004-07-30 |
ATE260274T1 (de) | 2004-03-15 |
JP2002544274A (ja) | 2002-12-24 |
WO2000069855A2 (en) | 2000-11-23 |
EP1413580A1 (en) | 2004-04-28 |
WO2000069855A3 (en) | 2001-02-08 |
AU763694B2 (en) | 2003-07-31 |
CA2374297A1 (en) | 2000-11-23 |
BR0010553A (pt) | 2002-07-02 |
AR024040A1 (es) | 2002-09-04 |
AU4772200A (en) | 2000-12-05 |
MXPA01011872A (es) | 2003-09-04 |
DK1178986T3 (da) | 2004-07-05 |
DE60008524D1 (de) | 2004-04-01 |
ES2215048T3 (es) | 2004-10-01 |
GB9911417D0 (en) | 1999-07-14 |
EP1178986A2 (en) | 2002-02-13 |
IL146409A0 (en) | 2002-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |