IL145643A0 - C7 carbamoyloxy substituted taxanes as antitumor agents - Google Patents

C7 carbamoyloxy substituted taxanes as antitumor agents

Info

Publication number
IL145643A0
IL145643A0 IL14564301A IL14564301A IL145643A0 IL 145643 A0 IL145643 A0 IL 145643A0 IL 14564301 A IL14564301 A IL 14564301A IL 14564301 A IL14564301 A IL 14564301A IL 145643 A0 IL145643 A0 IL 145643A0
Authority
IL
Israel
Prior art keywords
antitumor agents
substituted taxanes
carbamoyloxy substituted
carbamoyloxy
taxanes
Prior art date
Application number
IL14564301A
Other languages
English (en)
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of IL145643A0 publication Critical patent/IL145643A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
IL14564301A 2000-02-02 2001-02-02 C7 carbamoyloxy substituted taxanes as antitumor agents IL145643A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967000P 2000-02-02 2000-02-02
PCT/US2001/003592 WO2001057028A1 (en) 2000-02-02 2001-02-02 C7 carbamoyloxy substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
IL145643A0 true IL145643A0 (en) 2002-06-30

Family

ID=22657498

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14564301A IL145643A0 (en) 2000-02-02 2001-02-02 C7 carbamoyloxy substituted taxanes as antitumor agents

Country Status (23)

Country Link
US (3) US6359154B2 (zh)
EP (1) EP1165549B1 (zh)
JP (1) JP2003522168A (zh)
KR (1) KR20020002417A (zh)
CN (1) CN1362956A (zh)
AT (1) ATE392422T1 (zh)
AU (1) AU778991B2 (zh)
BR (1) BR0104355A (zh)
CA (1) CA2368510A1 (zh)
CZ (1) CZ20013521A3 (zh)
DE (1) DE60133600T2 (zh)
DK (1) DK1165549T3 (zh)
ES (1) ES2305056T3 (zh)
HK (1) HK1047937A1 (zh)
HU (1) HUP0200752A3 (zh)
IL (1) IL145643A0 (zh)
MX (1) MXPA01009923A (zh)
NO (1) NO20014757L (zh)
NZ (1) NZ514410A (zh)
PL (1) PL350024A1 (zh)
PT (1) PT1165549E (zh)
WO (1) WO2001057028A1 (zh)
ZA (1) ZA200108056B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020002417A (ko) * 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ7 카르바모일옥시 치환된 탁산
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
CN100522955C (zh) 2002-08-02 2009-08-05 伊缪诺金公司 含有新型强效紫杉烷的细胞毒性剂及其治疗用途
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
CN110227164B (zh) * 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
ES2149800T3 (es) 1992-01-15 2000-11-16 Squibb & Sons Inc Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
BR9405687C1 (pt) * 1993-02-05 2001-08-07 Bryn Mawr College Processo quìmico utilizável na produção de análogos de taxol e, composto quìmico
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
JPH10508022A (ja) 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
CN1221412A (zh) 1996-05-06 1999-06-30 佛罗里达州立大学 1－脱氧浆果赤霉素ⅲ,1－脱氧紫杉醇和1－脱氧紫杉醇类似物及其制备方法
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
KR20020002417A (ko) * 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ7 카르바모일옥시 치환된 탁산

Also Published As

Publication number Publication date
HUP0200752A2 (en) 2002-10-28
HK1047937A1 (zh) 2003-03-14
CA2368510A1 (en) 2001-08-09
DE60133600T2 (de) 2009-06-10
AU3330201A (en) 2001-08-14
BR0104355A (pt) 2002-01-02
ATE392422T1 (de) 2008-05-15
MXPA01009923A (es) 2003-08-01
PL350024A1 (en) 2002-10-21
US20010051640A1 (en) 2001-12-13
DE60133600D1 (de) 2008-05-29
US6750245B2 (en) 2004-06-15
AU778991B2 (en) 2004-12-23
HUP0200752A3 (en) 2005-02-28
WO2001057028A1 (en) 2001-08-09
US20050020635A1 (en) 2005-01-27
EP1165549A1 (en) 2002-01-02
KR20020002417A (ko) 2002-01-09
PT1165549E (pt) 2008-06-20
CZ20013521A3 (cs) 2002-03-13
EP1165549B1 (en) 2008-04-16
DK1165549T3 (da) 2008-08-11
NZ514410A (en) 2005-01-28
JP2003522168A (ja) 2003-07-22
US6359154B2 (en) 2002-03-19
ES2305056T3 (es) 2008-11-01
NO20014757D0 (no) 2001-10-01
US20030060638A1 (en) 2003-03-27
NO20014757L (no) 2001-11-29
ZA200108056B (en) 2003-12-01
CN1362956A (zh) 2002-08-07

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