IL145643A0 - C7 carbamoyloxy substituted taxanes as antitumor agents - Google Patents
C7 carbamoyloxy substituted taxanes as antitumor agentsInfo
- Publication number
- IL145643A0 IL145643A0 IL14564301A IL14564301A IL145643A0 IL 145643 A0 IL145643 A0 IL 145643A0 IL 14564301 A IL14564301 A IL 14564301A IL 14564301 A IL14564301 A IL 14564301A IL 145643 A0 IL145643 A0 IL 145643A0
- Authority
- IL
- Israel
- Prior art keywords
- antitumor agents
- substituted taxanes
- carbamoyloxy substituted
- carbamoyloxy
- taxanes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17967000P | 2000-02-02 | 2000-02-02 | |
PCT/US2001/003592 WO2001057028A1 (en) | 2000-02-02 | 2001-02-02 | C7 carbamoyloxy substituted taxanes as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145643A0 true IL145643A0 (en) | 2002-06-30 |
Family
ID=22657498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14564301A IL145643A0 (en) | 2000-02-02 | 2001-02-02 | C7 carbamoyloxy substituted taxanes as antitumor agents |
Country Status (23)
Country | Link |
---|---|
US (3) | US6359154B2 (zh) |
EP (1) | EP1165549B1 (zh) |
JP (1) | JP2003522168A (zh) |
KR (1) | KR20020002417A (zh) |
CN (1) | CN1362956A (zh) |
AT (1) | ATE392422T1 (zh) |
AU (1) | AU778991B2 (zh) |
BR (1) | BR0104355A (zh) |
CA (1) | CA2368510A1 (zh) |
CZ (1) | CZ20013521A3 (zh) |
DE (1) | DE60133600T2 (zh) |
DK (1) | DK1165549T3 (zh) |
ES (1) | ES2305056T3 (zh) |
HK (1) | HK1047937A1 (zh) |
HU (1) | HUP0200752A3 (zh) |
IL (1) | IL145643A0 (zh) |
MX (1) | MXPA01009923A (zh) |
NO (1) | NO20014757L (zh) |
NZ (1) | NZ514410A (zh) |
PL (1) | PL350024A1 (zh) |
PT (1) | PT1165549E (zh) |
WO (1) | WO2001057028A1 (zh) |
ZA (1) | ZA200108056B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020002417A (ko) * | 2000-02-02 | 2002-01-09 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 항종양제로서의 c7 카르바모일옥시 치환된 탁산 |
PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
CN110227164B (zh) * | 2018-03-06 | 2021-11-23 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
ES2149800T3 (es) | 1992-01-15 | 2000-11-16 | Squibb & Sons Inc | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos. |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
BR9405687C1 (pt) * | 1993-02-05 | 2001-08-07 | Bryn Mawr College | Processo quìmico utilizável na produção de análogos de taxol e, composto quìmico |
IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
JPH10508022A (ja) | 1994-10-28 | 1998-08-04 | ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク | タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用 |
US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
CN1221412A (zh) | 1996-05-06 | 1999-06-30 | 佛罗里达州立大学 | 1-脱氧浆果赤霉素ⅲ,1-脱氧紫杉醇和1-脱氧紫杉醇类似物及其制备方法 |
US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
KR20020002417A (ko) * | 2000-02-02 | 2002-01-09 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 항종양제로서의 c7 카르바모일옥시 치환된 탁산 |
-
2001
- 2001-02-02 KR KR1020017012622A patent/KR20020002417A/ko active IP Right Grant
- 2001-02-02 DE DE60133600T patent/DE60133600T2/de not_active Expired - Fee Related
- 2001-02-02 BR BR0104355-2A patent/BR0104355A/pt not_active IP Right Cessation
- 2001-02-02 CA CA002368510A patent/CA2368510A1/en not_active Withdrawn
- 2001-02-02 CN CN01800316A patent/CN1362956A/zh active Pending
- 2001-02-02 EP EP01905421A patent/EP1165549B1/en not_active Expired - Lifetime
- 2001-02-02 CZ CZ20013521A patent/CZ20013521A3/cs unknown
- 2001-02-02 HU HU0200752A patent/HUP0200752A3/hu unknown
- 2001-02-02 AU AU33302/01A patent/AU778991B2/en not_active Ceased
- 2001-02-02 PT PT01905421T patent/PT1165549E/pt unknown
- 2001-02-02 IL IL14564301A patent/IL145643A0/xx unknown
- 2001-02-02 DK DK01905421T patent/DK1165549T3/da active
- 2001-02-02 MX MXPA01009923A patent/MXPA01009923A/es active IP Right Grant
- 2001-02-02 ES ES01905421T patent/ES2305056T3/es not_active Expired - Lifetime
- 2001-02-02 AT AT01905421T patent/ATE392422T1/de not_active IP Right Cessation
- 2001-02-02 US US09/776,494 patent/US6359154B2/en not_active Expired - Fee Related
- 2001-02-02 WO PCT/US2001/003592 patent/WO2001057028A1/en active Application Filing
- 2001-02-02 NZ NZ514410A patent/NZ514410A/en unknown
- 2001-02-02 JP JP2001557860A patent/JP2003522168A/ja not_active Withdrawn
- 2001-02-02 PL PL01350024A patent/PL350024A1/xx not_active Application Discontinuation
- 2001-10-01 ZA ZA200108056A patent/ZA200108056B/en unknown
- 2001-10-01 NO NO20014757A patent/NO20014757L/no not_active Application Discontinuation
-
2002
- 2002-02-06 US US10/071,924 patent/US6750245B2/en not_active Expired - Fee Related
-
2003
- 2003-01-07 HK HK03100171.8A patent/HK1047937A1/zh unknown
-
2004
- 2004-06-14 US US10/867,275 patent/US20050020635A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0200752A2 (en) | 2002-10-28 |
HK1047937A1 (zh) | 2003-03-14 |
CA2368510A1 (en) | 2001-08-09 |
DE60133600T2 (de) | 2009-06-10 |
AU3330201A (en) | 2001-08-14 |
BR0104355A (pt) | 2002-01-02 |
ATE392422T1 (de) | 2008-05-15 |
MXPA01009923A (es) | 2003-08-01 |
PL350024A1 (en) | 2002-10-21 |
US20010051640A1 (en) | 2001-12-13 |
DE60133600D1 (de) | 2008-05-29 |
US6750245B2 (en) | 2004-06-15 |
AU778991B2 (en) | 2004-12-23 |
HUP0200752A3 (en) | 2005-02-28 |
WO2001057028A1 (en) | 2001-08-09 |
US20050020635A1 (en) | 2005-01-27 |
EP1165549A1 (en) | 2002-01-02 |
KR20020002417A (ko) | 2002-01-09 |
PT1165549E (pt) | 2008-06-20 |
CZ20013521A3 (cs) | 2002-03-13 |
EP1165549B1 (en) | 2008-04-16 |
DK1165549T3 (da) | 2008-08-11 |
NZ514410A (en) | 2005-01-28 |
JP2003522168A (ja) | 2003-07-22 |
US6359154B2 (en) | 2002-03-19 |
ES2305056T3 (es) | 2008-11-01 |
NO20014757D0 (no) | 2001-10-01 |
US20030060638A1 (en) | 2003-03-27 |
NO20014757L (no) | 2001-11-29 |
ZA200108056B (en) | 2003-12-01 |
CN1362956A (zh) | 2002-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG105967A (en) | C(7) ester substituted taxanes and their use as antitumor agents | |
IL145639A0 (en) | C10 heterosubstituted acetate taxanes as antitumor agents | |
PL350328A1 (en) | C7 heterosubstituted acetate taxanes as antitumor agents | |
BG105964A (en) | C(10) carbonate substituted taxanes and their use as antitumor agents | |
PL350024A1 (en) | C7 carbamoyloxy substituted taxanes as antitumor agents | |
NZ514407A (en) | C10 carbamoyloxy substituted taxanes as antitumor agents | |
PL351380A1 (en) | C10 ester substituted taxanes as antitumor agents | |
DE60107238D1 (en) | Stolonoxide | |
SG125889A1 (en) | C7 ester subsituted taxanes | |
SG125888A1 (en) | C10 carbonate substituted taxanes |