IL139344A0 - Soluble t cell receptor - Google Patents

Soluble t cell receptor

Info

Publication number
IL139344A0
IL139344A0 IL13934499A IL13934499A IL139344A0 IL 139344 A0 IL139344 A0 IL 139344A0 IL 13934499 A IL13934499 A IL 13934499A IL 13934499 A IL13934499 A IL 13934499A IL 139344 A0 IL139344 A0 IL 139344A0
Authority
IL
Israel
Prior art keywords
cell receptor
mhc
soluble
cell
multivalent
Prior art date
Application number
IL13934499A
Other languages
English (en)
Original Assignee
Avidex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810759.2A external-priority patent/GB9810759D0/en
Priority claimed from GBGB9821129.5A external-priority patent/GB9821129D0/en
Application filed by Avidex Ltd filed Critical Avidex Ltd
Publication of IL139344A0 publication Critical patent/IL139344A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56977HLA or MHC typing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13934499A 1998-05-19 1999-05-19 Soluble t cell receptor IL139344A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9810759.2A GB9810759D0 (en) 1998-05-19 1998-05-19 Soluble t cell receptor
GBGB9821129.5A GB9821129D0 (en) 1998-09-29 1998-09-29 Multimeric T cell receptor
PCT/GB1999/001588 WO1999060120A2 (en) 1998-05-19 1999-05-19 Soluble t cell receptor

Publications (1)

Publication Number Publication Date
IL139344A0 true IL139344A0 (en) 2001-11-25

Family

ID=26313710

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13934499A IL139344A0 (en) 1998-05-19 1999-05-19 Soluble t cell receptor
IL13934599A IL139345A0 (en) 1998-05-19 1999-05-19 Multivalent t cell receptor complexes

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL13934599A IL139345A0 (en) 1998-05-19 1999-05-19 Multivalent t cell receptor complexes

Country Status (28)

Country Link
US (4) US20020119149A1 (no)
EP (2) EP1080193A2 (no)
JP (2) JP2002515244A (no)
KR (2) KR100530309B1 (no)
CN (2) CN1249229C (no)
AT (1) ATE208819T1 (no)
AU (2) AU758949B2 (no)
BG (1) BG105053A (no)
BR (1) BR9910253A (no)
CA (2) CA2328144A1 (no)
DE (1) DE69900468T2 (no)
DK (1) DK1066380T3 (no)
EA (1) EA200001216A1 (no)
EE (1) EE200000697A (no)
ES (1) ES2168866T3 (no)
HK (1) HK1035739A1 (no)
HR (1) HRP20000790A2 (no)
HU (1) HUP0103614A2 (no)
ID (1) ID28040A (no)
IL (2) IL139344A0 (no)
IS (1) IS5697A (no)
NO (2) NO20005811L (no)
NZ (2) NZ507886A (no)
PL (1) PL364734A1 (no)
PT (1) PT1066380E (no)
SK (1) SK17332000A3 (no)
TR (1) TR200003391T2 (no)
WO (2) WO1999060120A2 (no)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1249229C (zh) * 1998-05-19 2006-04-05 阿维德克斯有限公司 可溶性t细胞受体
EP1118661A1 (en) * 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries
WO2001090747A2 (en) * 2000-05-25 2001-11-29 Sunol Molecular Corporation Modulation of t-cell receptor interactions
PL208712B1 (pl) * 2001-08-31 2011-05-31 Avidex Ltd Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd
EP1435776A4 (en) 2001-09-24 2006-01-25 Univ Pittsburgh VACCINE AGAINST CANCER AND DIAGNOSTIC PROCEDURE AND REAGENTS
JP2005519980A (ja) * 2002-03-01 2005-07-07 ブラッコ インターナショナル ビー.ヴイ. 治療および診断用途の多価構成物
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP2292638A3 (en) 2002-09-27 2011-03-23 Ludwig Institute For Cancer Research MAGE-C2 antigenic peptides and uses thereof
AU2003271904B2 (en) * 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
EP2048159B1 (en) 2002-11-09 2014-01-01 Immunocore Ltd. T cell receptor display
GB0227351D0 (en) * 2002-11-22 2002-12-31 Isis Innovation Soluble T-cell receptors
JP2006523437A (ja) * 2002-12-03 2006-10-19 アヴィデックス リミテッド レセプター複合体
GB0304068D0 (en) * 2003-02-22 2003-03-26 Avidex Ltd Substances
EP1640458B1 (en) 2003-06-27 2011-12-28 International Institute of Cancer Immunology, Inc. Method of selecting patients suitable for wt1 vaccine
JP4773361B2 (ja) 2003-11-10 2011-09-14 アルター・バイオサイエンス・コーポレーション 可溶性tcr分子とその使用方法
US9090673B2 (en) * 2003-12-12 2015-07-28 City Of Hope Synthetic conjugate of CpG DNA and T-help/CTL peptide
US20060014941A1 (en) * 2003-12-22 2006-01-19 University Of Tennessee Research Foundation, Inc. Isolated T lymphocyte receptors specific for human autoantigens complexed with human MHC molecules and methods of making and using same
GB0411125D0 (en) * 2004-05-19 2004-06-23 Avidex Ltd Method of improving T-cell receptors
WO2007044033A2 (en) 2004-12-07 2007-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Therapeutic and diagnostic cloned mhc-unrestricted receptor specific for the muc1 tumor associated antigen
GB0427585D0 (en) * 2004-12-16 2005-01-19 Avidex Ltd Assay
NZ584523A (en) 2005-04-01 2010-11-26 Immunocore Ltd High affinity hiv t cell receptors
EP2277918B1 (en) 2005-05-13 2012-11-14 Oxford BioMedica (UK) Limited Mhc class I and II peptide antigens derived from tumour antigen 5t4
GB0510627D0 (en) 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
EP2463307A1 (en) * 2005-08-31 2012-06-13 CBIO Limited Modified chaperonin 10
WO2007085266A1 (en) * 2006-01-30 2007-08-02 Dako Denmark A/S High-speed quantification of antigen specific t-cells in whole blood by flow cytometry
WO2007117588A2 (en) * 2006-04-05 2007-10-18 The General Hospital Corporation Soluble virus-specific t-cell receptor compositions
US8088379B2 (en) 2006-09-26 2012-01-03 The United States Of America As Represented By The Department Of Health And Human Services Modified T cell receptors and related materials and methods
JP5484041B2 (ja) * 2007-02-23 2014-05-07 学校法人関西学院 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
AU2013206501B2 (en) * 2007-03-05 2016-05-19 International Institute Of Cancer Immunology, Inc. Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene and use of them
WO2008108257A1 (ja) * 2007-03-05 2008-09-12 International Institute Of Cancer Immunology, Inc. 癌抗原特異的t細胞のレセプター遺伝子およびそれによりコードされるペプチドならびにそれらの使用
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
KR100877480B1 (ko) * 2007-06-08 2009-01-07 왕성호 숫자 기억 게임 방법
EP2167536A1 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
EP2197908A2 (en) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
WO2010011994A2 (en) 2008-07-25 2010-01-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polypeptides and uses thereof
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
GB0908613D0 (en) 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
ES2862580T5 (es) 2009-06-25 2024-06-13 Amgen Inc Procesos de purificación por captura para proteínas expresadas en un sistema no de mamífero
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
US10464987B2 (en) 2009-10-06 2019-11-05 Abbvie Inc. Human single-chain T cell receptors
GB201002730D0 (en) * 2010-02-18 2010-04-07 Uni I Oslo Product
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
EP2746393A4 (en) 2011-06-28 2015-06-10 Int Inst Cancer Immunology Inc RECEPTOR GENE FOR A SPECIFIC LYMPHOCYTE OF A CANCER PEPTIDE ANTIGEN
EP2831109B1 (en) 2012-03-28 2017-12-06 Gadeta B.V. Combinatorial gamma 9 delta 2 t cell receptor chain exchange
WO2014018863A1 (en) 2012-07-27 2014-01-30 The Board Of Trustees Of The University Of Illinois Engineering t-cell receptors
WO2014036562A2 (en) 2012-08-31 2014-03-06 University Of Virginia Patent Foundation Target peptides for immunotherapy and diagnostics
CA2883673A1 (en) 2012-09-05 2014-03-13 University Of Virginia Patent Foundation Target peptides for colorectal cancer therapy and diagnostics
CA2894885A1 (en) 2012-12-13 2014-06-19 University Of Virginia Patent Foundation Target peptides for ovarian cancer therapy and diagnostics
GB201223172D0 (en) 2012-12-21 2013-02-06 Immunocore Ltd Method
EP3736573A1 (en) * 2013-03-15 2020-11-11 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
RU2729383C2 (ru) 2013-11-22 2020-08-06 Зэ Борд оф Трастиз оф зэ Юниверсити оф Иллинойс Сконструированные высокоаффинные t-клеточные рецепторы человека
US10370427B2 (en) 2013-12-19 2019-08-06 Friedrich-Alexander Universität Erlangen-Nürnberg Influenza-specific T-cell receptor and its uses in the detection, prevention and/or treatment of influenza
WO2015136072A1 (en) 2014-03-14 2015-09-17 Immunocore Limited Tcr libraries
AU2015247727A1 (en) 2014-04-15 2016-11-03 University Of Virginia Patent Foundation Isolated T cell receptors and methods of use therefor
GB201409558D0 (en) * 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
CN106279404A (zh) * 2015-05-20 2017-01-04 广州市香雪制药股份有限公司 一种可溶且稳定的异质二聚tcr
MA45352A (fr) 2015-08-07 2018-06-13 Univ Birmingham Identification de glycopeptides associés à mhc de catégorie i comme cibles d'immunothérapie de cancer
GB201514875D0 (en) * 2015-08-20 2015-10-07 Autolus Ltd Receptor
CN108137670A (zh) 2015-09-09 2018-06-08 免疫设计股份有限公司 Ny-eso-1特异性tcr及其使用方法
GB201516274D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516269D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516265D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516270D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516275D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
RU2752528C2 (ru) 2016-01-06 2021-07-29 Хэлф Ресерч, Инк. Композиции и библиотеки, содержащие рекомбинантные полинуклеотиды, кодирующие Т-клеточные рецепторы, и способы применения рекомбинантных Т-клеточных рецепторов
JP7161938B2 (ja) 2016-01-10 2022-10-27 ネオティーエックス セラピューティクス リミテッド スーパー抗原媒介性癌免疫療法の能力を増強するための方法および組成物
CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
KR20230038299A (ko) 2016-05-06 2023-03-17 주노 쎄러퓨티크스 인코퍼레이티드 유전자 조작된 세포 및 그의 제조 방법
AU2017273147B2 (en) 2016-06-02 2024-06-13 Immunocore Limited Dosing regimen for GP100-specific TCR - anti-CD3 SCFV fusion protein
CA3027124A1 (en) * 2016-06-10 2017-12-14 Umc Utrecht Holding B.V. Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
EP3475446A1 (en) 2016-06-27 2019-05-01 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
US11072660B2 (en) 2016-10-03 2021-07-27 Juno Therapeutics, Inc. HPV-specific binding molecules
CN110381963A (zh) 2016-10-13 2019-10-25 朱诺治疗学股份有限公司 涉及色氨酸代谢途径调节剂的免疫治疗方法和组合物
MA46716A (fr) 2016-11-03 2019-09-11 Juno Therapeutics Inc Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie
JP2019532997A (ja) 2016-11-03 2019-11-14 ジュノー セラピューティクス インコーポレイテッド T細胞療法とbtk阻害剤との併用療法
CA3045508A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods for modulation of car-t cells
ES2961666T3 (es) 2016-12-03 2024-03-13 Juno Therapeutics Inc Métodos para determinar la dosificación de células CAR-T
AU2017368331A1 (en) 2016-12-03 2019-06-13 Acerta Pharma B.V. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
KR20190098747A (ko) 2016-12-05 2019-08-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 위한 조작된 세포의 제조방법
CN110691792A (zh) 2017-01-10 2020-01-14 朱诺治疗学股份有限公司 细胞疗法的表观遗传学分析及相关方法
MA47325A (fr) 2017-01-20 2019-11-27 Juno Therapeutics Gmbh Conjugués de surface cellulaire et compositions cellulaires et méthodes associées
IL267990B2 (en) 2017-01-25 2024-04-01 Molecular Templates Inc Cell-targeted molecules containing Shiga toxin A subunit activators and nonimmune CD8 T-cell epitopes
WO2018148224A1 (en) 2017-02-07 2018-08-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (ple) car t cell tumor targeting (ctct) agents
WO2018148180A2 (en) 2017-02-07 2018-08-16 Immune Design Corp. Materials and methods for identifying and treating cancer patients
US11845803B2 (en) 2017-02-17 2023-12-19 Fred Hutchinson Cancer Center Combination therapies for treatment of BCMA-related cancers and autoimmune disorders
MX2019010171A (es) 2017-02-27 2019-10-15 Juno Therapeutics Inc Composiciones, articulos de fabricacion y metodos relacionados con la dosificacion en la terapia celular.
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
BR112019019005A2 (pt) 2017-03-14 2020-04-14 Sara Elizabeth Church métodos para armazenagem criogênica
EP3607319A1 (en) 2017-04-07 2020-02-12 Juno Therapeutics, Inc. Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods
CA3059584A1 (en) 2017-04-14 2018-10-18 Juno Therapeutics, Inc. Methods for assessing cell surface glycosylation
CN111182909A (zh) 2017-05-01 2020-05-19 朱诺治疗学股份有限公司 细胞疗法与免疫调节化合物的组合
CN107216371B (zh) * 2017-05-27 2020-09-18 浙江师范大学 一种成人t细胞白血病的特异性靶向多肽及其应用
MA48781A (fr) 2017-06-02 2020-04-08 Juno Therapeutics Inc Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire
CA3065120A1 (en) 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
EP3644721A1 (en) 2017-06-29 2020-05-06 Juno Therapeutics, Inc. Mouse model for assessing toxicities associated with immunotherapies
US20230242654A1 (en) 2017-07-29 2023-08-03 Juno Therapeutics, Inc. Reagents for expanding cells expressing recombinant receptors
WO2019032927A1 (en) 2017-08-09 2019-02-14 Juno Therapeutics, Inc. METHODS FOR PRODUCING GENETICALLY MODIFIED CELL COMPOSITIONS AND COMPOSITIONS THEREOF
KR20200046045A (ko) 2017-08-09 2020-05-06 주노 쎄러퓨티크스 인코퍼레이티드 유전자 조작된 세포를 제조하기 위한 방법 및 조성물
MA50057A (fr) 2017-09-01 2020-07-08 Juno Therapeutics Inc Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire
EP3679370A1 (en) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Methods of identifying cellular attributes related to outcomes associated with cell therapy
JP2020537515A (ja) 2017-10-03 2020-12-24 ジュノー セラピューティクス インコーポレイテッド Hpv特異的結合分子
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
US11564946B2 (en) 2017-11-01 2023-01-31 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
MX2020004240A (es) 2017-11-01 2020-09-25 Juno Therapeutics Inc Proceso para generar composiciones terapeuticas de celulas modificadas.
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
EP3704229B1 (en) 2017-11-01 2023-12-20 Juno Therapeutics, Inc. Process for producing a t cell composition
AU2018358250A1 (en) 2017-11-01 2020-05-14 Editas Medicine, Inc. Methods, compositions and components for CRISPR-CAS9 editing of TGFBR2 in T cells for immunotherapy
KR20200079312A (ko) 2017-11-06 2020-07-02 에디타스 메디신, 인코포레이티드 면역요법을 위한 t 세포 내 cblb의 crispr-cas9 편집 방법, 조성물 및 성분
SG11202003427XA (en) 2017-11-06 2020-05-28 Juno Therapeutics Inc Combination of a cell therapy and a gamma secretase inhibitor
GB201719169D0 (en) 2017-11-20 2018-01-03 Univ College Cardiff Consultants Ltd Novel T-cell receptor and ligand
WO2019109053A1 (en) 2017-12-01 2019-06-06 Juno Therapeutics, Inc. Methods for dosing and for modulation of genetically engineered cells
AU2018379094A1 (en) 2017-12-08 2020-06-25 Juno Therapeutics, Inc. Phenotypic markers for cell therapy and related methods
WO2019113556A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Serum-free media formulation for culturing cells and methods of use thereof
JP2021505168A (ja) 2017-12-08 2021-02-18 ジュノー セラピューティクス インコーポレイテッド 操作されたt細胞の組成物を製造するための方法
CN112055595A (zh) 2018-01-22 2020-12-08 恩多塞特公司 Car t细胞的使用方法
JP7181517B2 (ja) * 2018-01-23 2022-12-01 国立大学法人三重大学 T細胞レセプター
MA54118A (fr) 2018-01-31 2021-09-15 Celgene Corp Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle
BR112020019313A2 (pt) 2018-04-05 2021-01-05 Juno Therapeutics Inc Receptores de células t e células modificadas que expressam os mesmos
BR112020020073A2 (pt) 2018-04-05 2021-01-05 Juno Therapeutics Inc Células t que expressam um receptor recombinante, polinucleotídeos relacionados e métodos
JP2021520202A (ja) 2018-04-05 2021-08-19 ジュノー セラピューティクス インコーポレイテッド 組換え受容体を発現する細胞の作製方法および関連組成物
US20220275043A1 (en) * 2018-07-17 2022-09-01 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
US20210163893A1 (en) 2018-08-09 2021-06-03 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
CN112805378A (zh) 2018-08-09 2021-05-14 朱诺治疗学股份有限公司 用于评估整合核酸的方法
US20220050114A1 (en) 2018-09-11 2022-02-17 Juno Therapeutics, Inc. Methods for mass spectrometry analysis of engineered cell compositions
US20210380661A1 (en) * 2018-10-16 2021-12-09 Texas Tech University System Method to Express, Purify, and Biotinylate Eukaryotic Cell-Derived Major Histocompatibility Complexes
EP3870602A1 (en) 2018-10-23 2021-09-01 Regeneron Pharmaceuticals, Inc. Ny-eso-1 t cell receptors and methods of use thereof
WO2020089343A1 (en) 2018-10-31 2020-05-07 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
KR20210087959A (ko) * 2018-11-02 2021-07-13 유니버시티 오브 워싱톤 직교 단백질 이종이량체
CN113272018A (zh) 2018-11-06 2021-08-17 朱诺治疗学股份有限公司 产生基因工程化t细胞的方法
EP3876958A1 (en) 2018-11-08 2021-09-15 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
PT3886875T (pt) 2018-11-30 2024-06-27 Juno Therapeutics Inc Métodos para tratamento utilizando terapia celular adotiva
EP4393547A2 (en) 2018-11-30 2024-07-03 Juno Therapeutics, Inc. Methods for dosing and treatment of b cell malignancies in adoptive cell therapy
SG11202111360YA (en) 2019-05-01 2021-11-29 Juno Therapeutics Inc Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
EA202193121A1 (ru) 2019-05-15 2022-02-21 Неоткс Терапьютикс Лтд. Лечение рака
EP3980530A1 (en) 2019-06-07 2022-04-13 Juno Therapeutics, Inc. Automated t cell culture
CA3142361A1 (en) 2019-06-12 2020-12-17 Juno Therapeutics, Inc. Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein
US20220298222A1 (en) 2019-08-22 2022-09-22 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
KR20220101641A (ko) 2019-10-30 2022-07-19 주노 테라퓨틱스 게엠베하 세포 선택 및/또는 자극 장치 및 사용 방법
IL293393A (en) 2019-12-06 2022-07-01 Juno Therapeutics Inc Cell therapy-related toxicity and response-related methods for the treatment of b-cell malignancies
MX2022009137A (es) 2020-01-24 2022-10-21 Regeneron Pharma Antígeno expresado preferentemente en receptores de linfocitos t de melanoma (prame) y sus métodos de uso.
AU2021214142A1 (en) 2020-01-28 2022-09-08 Juno Therapeutics, Inc. Methods for T cell transduction
MX2022010936A (es) 2020-03-05 2022-11-16 Neotx Therapeutics Ltd ³métodos y composiciones para el tratamiento del cáncer con células inmunológicas.
EP4150640A1 (en) 2020-05-13 2023-03-22 Juno Therapeutics, Inc. Methods of identifying features associated with clinical response and uses thereof
KR20230022868A (ko) 2020-05-13 2023-02-16 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
US20210403528A1 (en) * 2020-05-21 2021-12-30 University College Cardiff Consultants Ltd. Novel T-Cell Receptor and Ligand
WO2021260186A1 (en) 2020-06-26 2021-12-30 Juno Therapeutics Gmbh Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
WO2022060904A1 (en) 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells
AU2021364387A1 (en) 2020-10-23 2023-06-15 Asher Biotherapeutics, Inc. Fusions with cd8 antigen binding molecules for modulating immune cell function
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
US20240108654A1 (en) 2021-03-03 2024-04-04 Juno Therapeutics, Inc. Combination of a t cell therapy and a dgk inhibitor
WO2022204070A1 (en) 2021-03-22 2022-09-29 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
AU2022246593A1 (en) 2021-03-29 2023-10-12 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
JP2024517863A (ja) 2021-05-06 2024-04-23 ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 細胞を刺激し、形質導入する方法
WO2023283446A1 (en) * 2021-07-09 2023-01-12 The Johns Hopkins University Method for surface expression of membrane proteins that have a cytoplasmic c-terminal tail
WO2023147515A1 (en) 2022-01-28 2023-08-03 Juno Therapeutics, Inc. Methods of manufacturing cellular compositions
WO2023213969A1 (en) 2022-05-05 2023-11-09 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
WO2024006960A1 (en) 2022-06-29 2024-01-04 Juno Therapeutics, Inc. Lipid nanoparticles for delivery of nucleic acids
WO2024054944A1 (en) 2022-09-08 2024-03-14 Juno Therapeutics, Inc. Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing
WO2024097642A1 (en) 2022-10-31 2024-05-10 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a combination of adoptive cell therapy and a targeted immunocytokine
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells
WO2024124132A1 (en) 2022-12-09 2024-06-13 Juno Therapeutics, Inc. Machine learning methods for predicting cell phenotype using holographic imaging
WO2024161021A1 (en) 2023-02-03 2024-08-08 Juno Therapeutics Gmbh Methods for non-viral manufacturing of engineered immune cells

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5620689A (en) * 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5216132A (en) * 1990-01-12 1993-06-01 Protein Design Labs, Inc. Soluble t-cell antigen receptor chimeric antigens
US5582996A (en) * 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
DE4040669A1 (de) * 1990-12-19 1992-06-25 Behringwerke Ag Verwendung von peptidpaaren mit extrem hoher spezifischer affinitaet zueinander im bereich der in vitro diagnostik
US5328985A (en) * 1991-07-12 1994-07-12 The Regents Of The University Of California Recombinant streptavidin-protein chimeras useful for conjugation of molecules in the immune system
AR246435A1 (es) * 1992-08-20 1994-08-31 Moreno Saul Jeringa descartable para uso con cubreagujas
WO1996021028A2 (en) * 1995-01-03 1996-07-11 Procept, Inc. Soluble heterodimeric t cell receptors and their antibodies
US5635363A (en) * 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US5968511A (en) * 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
CA2250166A1 (en) * 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US5776746A (en) * 1996-05-01 1998-07-07 Genitope Corporation Gene amplification methods
DK0935607T3 (da) * 1996-08-16 2004-12-06 Harvard College Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf
CN1249229C (zh) * 1998-05-19 2006-04-05 阿维德克斯有限公司 可溶性t细胞受体

Also Published As

Publication number Publication date
CA2328144A1 (en) 1999-11-25
EE200000697A (et) 2002-06-17
SK17332000A3 (sk) 2001-06-11
US20060093613A1 (en) 2006-05-04
WO1999060120A2 (en) 1999-11-25
US20060155115A1 (en) 2006-07-13
ID28040A (id) 2001-05-03
EP1066380A2 (en) 2001-01-10
US20020119149A1 (en) 2002-08-29
HRP20000790A2 (en) 2001-06-30
WO1999060119A2 (en) 1999-11-25
KR20010043675A (ko) 2001-05-25
PT1066380E (pt) 2002-05-31
NO20005812D0 (no) 2000-11-17
TR200003391T2 (tr) 2001-02-21
ES2168866T3 (es) 2002-06-16
NZ507887A (en) 2002-12-20
EP1080193A2 (en) 2001-03-07
AU3945699A (en) 1999-12-06
BG105053A (bg) 2001-09-28
CN1306572A (zh) 2001-08-01
IL139345A0 (en) 2001-11-25
AU3945999A (en) 1999-12-06
BR9910253A (pt) 2002-09-17
NO20005812L (no) 2001-01-19
ATE208819T1 (de) 2001-11-15
JP2002515244A (ja) 2002-05-28
JP2002515243A (ja) 2002-05-28
IS5697A (is) 2000-10-31
WO1999060119A3 (en) 2000-02-03
CA2327314A1 (en) 1999-11-25
DE69900468D1 (de) 2001-12-20
PL364734A1 (en) 2004-12-13
EA200001216A1 (ru) 2001-06-25
NO20005811D0 (no) 2000-11-17
HUP0103614A2 (hu) 2002-01-28
NO20005811L (no) 2001-01-19
HK1035739A1 (en) 2001-12-07
WO1999060120A3 (en) 2000-02-03
DE69900468T2 (de) 2002-07-18
EP1066380B1 (en) 2001-11-14
CN1249229C (zh) 2006-04-05
KR20010085250A (ko) 2001-09-07
DK1066380T3 (da) 2002-01-28
AU746164B2 (en) 2002-04-18
CN1308674A (zh) 2001-08-15
AU758949B2 (en) 2003-04-03
NZ507886A (en) 2003-05-30
US20020142389A1 (en) 2002-10-03
KR100530309B1 (ko) 2005-11-22

Similar Documents

Publication Publication Date Title
HK1035739A1 (en) Soluble t cell receptor
PL331091A1 (en) Therapeutic multispecific compounds encompassing antibodies against the fcalpha receptor
YU20600A (sh) Nova upotreba antagonista 5-ht3 receptora
DE69814878D1 (de) 1-amino-alkylcyclohexane als nmda-rezeptor-antagonisten
IL142905A0 (en) Functional antagonists of hedgehog activity
IL154227A0 (en) Chemokine receptor binding heterocyclic compounds
DK1482042T3 (da) Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren
EP0975374A4 (en) RADIO METAL BINDING PEPTIDE ANALOG
DK1007537T3 (da) Receptor-protein med betegnelsen 2F1
EP1003494A4 (en) (d) -METHADONE, NON-OPIOID ANALGESIC
CO5460266A1 (es) Novedosos analogos de la somatostatina
HUP9904516A3 (en) Soluble lymphotoxin-betha receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases
TR200102041T2 (tr) Progesteron reseptör bağlama aktif maddeleri olarak ikameli 2-arilimino heterosaykıllar
NZ504471A (en) An Ox receptor distinct from known alpha 2-adenoreceptors and imidazoline receptors (I1 and I2) with an affinity for compounds of the oxazoline class
WO1990013643A3 (en) Glycoprotein hormone receptor molecules
MX9606179A (es) Agonistas y antagonistas de los receptores del acido acetilcolina nicotinico de insectos para el control de endoparasitos.
EP0862627A4 (en) Y-Y5 NEUROPEPTIDE RECEPTOR
BG104022A (en) New beta-amino and beta-azidocarboxylic acid derivatives, the production thereof and the use thereof as endothelin receptor antagonists
GB0008321D0 (en) Biological material and uses thereof
EP1447414A3 (en) Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
WO2001023563A3 (en) Compositions and therapeutic methods using morphogenic proteins, hormones and hormone receptors
ZA200204455B (en) Use of dopamine-D3 receptor agonists for the therapy of salt-dependent hypertension.